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1. 发明申请

WO2011119466A2 DECORRELATED CHANNEL SAMPLING FOR DIGITAL IMAGING 审中-公开
标题翻译：用于数字成像的装饰通道采样
公开(公告)号：WO2011119466A2
公开(公告)日：2011-09-29
申请号：PCT/US2011/029148
申请日：2011-03-21
申请人： HOLOGIC INC. , SUDHIRBHAI SHAH, Dhruvish , POLISCHUK, Brad , PALECKI, Eugene , CELONA, Anthony , MYERS, Douglas , WALKER, Glenn
发明人： SUDHIRBHAI SHAH, Dhruvish , POLISCHUK, Brad , PALECKI, Eugene , CELONA, Anthony , MYERS, Douglas , WALKER, Glenn
IPC分类号： G06T7/40
CPC分类号： H04N5/3575 , H04N5/32 , H04N5/378
摘要： In association with an imaging device which generates a portion of an image from a plurality of channels within a first row by sampling each channel during a sampling time corresponding to the channel, circuitry offsets sampling times of at least first and second channels within the first row, thereby reducing noise correlation between the first and second channels in the first row. Pixel sampling times may be defined by start times of the channels within a row, end times or both. Offsetting may be accomplished using a predetermined set of sampling time values or by randomizing sampling time values. Offsetting pixel sampling times of channels within a row relative to each other decorrelates channel sampling because different phases of the noise signal are sampled on each channel, effectively blurring or dithering the channel noise within each row. Random sampling within the channel, such as by varying a channel sampling time between rows, further dithers the noise within each channel. Undesirable correlated noise effects are reduced as a result.
摘要翻译：与通过在对应于该信道的采样时间期间对每个信道进行采样来生成来自第一行内的多个信道的图像的一部分的成像设备相关联，电路抵消第一行内的至少第一和第二信道的采样时间从而降低第一行中的第一和第二通道之间的噪声相关性。像素采样时间可以由一行中的通道的开始时间，结束时间或两者定义。可以使用预定的采样时间值集合或通过随机化采样时间值来实现偏移。对每个通道中的噪声信号的不同相位进行取样，对每行内的通道噪声进行模糊或抖动，从而使一行内的通道相对于彼此进行偏移的像素采样时间进行解相关。通道内的随机采样，例如通过改变行之间的通道采样时间，进一步抖动每个通道内的噪声。结果，减少了不期望的相关噪声效应。

2. 发明申请

WO2011017086A2 THERMALLY RESPONSIVE COMPOSITE MATERIALS 审中-公开
标题翻译：热响应复合材料
公开(公告)号：WO2011017086A2
公开(公告)日：2011-02-10
申请号：PCT/US2010/043348
申请日：2010-07-27
申请人： NORTH CAROLINA STATE UNIVERSITY , WALKER, Glenn , SACHAR, Ravish , DONG, Hua
发明人： WALKER, Glenn , SACHAR, Ravish , DONG, Hua
IPC分类号： B32B15/08 , B32B17/10 , B29C45/14
CPC分类号： B32B27/08 , A61B2017/00955 , A61L29/126 , A61L29/14 , B32B1/08 , B32B3/08 , B32B7/02 , B32B27/281 , B32B27/302 , B32B27/306 , B32B27/308 , B32B27/34 , B32B27/36 , B32B27/365 , B32B2250/24 , B32B2307/30 , B32B2307/302 , B32B2307/50 , B32B2307/72 , B32B2535/00 , B32B2597/00 , Y10T428/1393 , Y10T428/24942 , Y10T428/2495 , Y10T428/24975
摘要： The present invention provides a thermally responsive composite material comprising a first layer, a second layer and a third layer where the third layer is between the first and second layers. The third layer comprises a material having a low glass transition or melting temperature while the first and second layers comprise material having higher glass transition or melting temperatures than the third material. The thermally responsive composite material also comprises a heating element in contact with the third layer. Methods for using the thermally responsive composite material are also provided.
摘要翻译：本发明提供了一种热响应复合材料，其包括第一层，第二层和第三层，其中第三层位于第一层和第二层之间。第三层包含具有低玻璃化转变或熔融温度的材料，而第一和第二层包含具有比第三材料更高的玻璃化转变或熔融温度的材料。热响应复合材料还包括与第三层接触的加热元件。还提供了使用热响应复合材料的方法。

3. 发明申请

WO2015006580A1 MICROFLUIDIC SYSTEMS AND METHODS FOR THERMAL FLOW CYTOMETRY 审中-公开
标题翻译：微流体系统和热流式细胞计数法
公开(公告)号：WO2015006580A1
公开(公告)日：2015-01-15
申请号：PCT/US2014/046185
申请日：2014-07-10
申请人： NORTH CAROLINA STATE UNIVERSITY , WALKER, Glenn , LEE, Chung, Hoon , DAVAJI, Benyamin
发明人： WALKER, Glenn , LEE, Chung, Hoon , DAVAJI, Benyamin
IPC分类号： G01N27/08 , G01N15/02 , B81B1/00
CPC分类号： G01N15/1484 , G01K7/16 , G01K17/006
摘要： Microfluidic systems and methods for thermal flow cytometry are disclosed. According to an aspect, a system for thermal flow cytometry includes a microfluidic device including one or more channels for passage of one or more particles. The system also includes a temperature detector configured to change resistance in response to a temperature change within the channel(s). The system also includes a computing device configured to detect the resistance change and to count the one or more particles based on the detected resistance change.
摘要翻译：公开了用于热流式细胞术的微流体系统和方法。根据一个方面，用于热流式细胞术的系统包括微流体装置，其包括用于一个或多个颗粒通过的一个或多个通道。该系统还包括温度检测器，其被配置成响应于通道内的温度变化而改变电阻。该系统还包括被配置为基于检测到的电阻变化来检测电阻变化并对一个或多个微粒进行计数的计算装置。

4. 发明申请

WO2005007866A2 BIOCHIP DEVICES FOR ION TRANSPORT MEASUREMENT, METHODS OF MANUFACTURE, AND METHODS OF USE 审中-公开
标题翻译：用于离子运输测量的生物装置，制造方法和使用方法
公开(公告)号：WO2005007866A2
公开(公告)日：2005-01-27
申请号：PCT/US2004/017134
申请日：2004-06-01
申请人： AVIVA BIOSCIENCES CORPORATION , GUIA, Antonio , XU, Jia , WU, Lei , SITHIPHONG, Khachonesin , SPASSOVA, Maria , TAO, Huimin , WALKER, George , HUANG, Mingxian , TAO, Guoliang , SAYA, Steven , WALKER, Glenn , ZOZULYA, Zoya
发明人： GUIA, Antonio , XU, Jia , WU, Lei , SITHIPHONG, Khachonesin , SPASSOVA, Maria , TAO, Huimin , WALKER, George , HUANG, Mingxian , TAO, Guoliang , SAYA, Steven , WALKER, Glenn , ZOZULYA, Zoya
IPC分类号： C12Q
CPC分类号： G01N33/6872 , G01N33/48728 , G01R19/0061
摘要： The present invention provides biochips for ion transport measurement, ion transport measuring devices that comprise biochips, and methods of using ion transport measuring devices and biochips that allow for the direct analysis of ion transport functions or properties. The present invention provides biochips, devices, apparatuses, and methods that allow for automated detection of ion transport functions or properties. The present invention also provides methods of making biochips and devices for ion transport measurement that reduce the cost and increase the efficiency of manufacture, as well as improve the performance of the biochips and devices. These biochips and devices are particularly appropriate for automating the detection of ion transport functions or properties, particularly for screening purposes.
摘要翻译：本发明提供了用于离子传输测量的生物芯片，包括生物芯片的离子传输测量装置，以及使用离子传输测量装置和允许直接分析离子传递功能或性质的生物芯片的方法。本发明提供允许自动检测离子迁移功能或性质的生物芯片，装置，装置和方法。本发明还提供了制造用于离子传输测量的生物芯片和装置的方法，其降低成本并提高制造效率，以及提高生物芯片和装置的性能。这些生物芯片和装置特别适用于自动化离子迁移功能或性质的检测，特别是用于筛选目的。

5. 发明公开

EP2550801A2 DECORRELATED CHANNEL SAMPLING FOR DIGITAL IMAGING 有权转让
标题翻译：去相关CHANNEL SCAN数码影像
公开(公告)号：EP2550801A2
公开(公告)日：2013-01-30
申请号：EP11759969.6
申请日：2011-03-21
申请人： HOLOGIC, INC.
发明人： SUDHIRBHAI SHAH, Dhruvish , POLISCHUK, Brad , PALECKI, Eugene , CELONA, Anthony , MYERS, Douglas , WALKER, Glenn
IPC分类号： H04N5/335
CPC分类号： H04N5/3575 , H04N5/32 , H04N5/378
摘要： An imaging device generates a portion of an image from a plurality of channels within a first row by sampling each channel during a sampling time, wherein circuitry offsets sampling times of at least first and second channels within the first row, thereby reducing noise correlation between the channels. Pixel sampling times may be defined by start times of the channels within a row, end times or both. Offsetting may be accomplished using a predetermined set of sampling time values or by randomizing sampling time values. Offsetting pixel sampling times of channels within a row relative to each other decorrelates channel sampling because different phases of the noise signal are sampled on each channel, effectively blurring or dithering the channel noise within each row. Random sampling within the channel, such as by varying a channel sampling time between rows, further dithers the noise within each channel.

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