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    • 5. 发明申请
    • PHOSPHANES, THEIR METHOD OF PRODUCTION AND USE IN METAL COMPLEXES
    • 膦,其制造方法相同,它们在金属络合物
    • WO1998028315A1
    • 1998-07-02
    • PCT/EP1997006931
    • 1997-12-11
    • HOECHST RESEARCH & TECHNOLOGY DEUTSCHLAND GMBH & CO. KGBOGDANOVIC, SandraBELLER, MatthiasZAPF, AlexanderKRAUTER, Jürgen
    • HOECHST RESEARCH & TECHNOLOGY DEUTSCHLAND GMBH & CO. KG
    • C07H15/203
    • B01J31/2404B01J31/20B01J31/2447B01J2231/321B01J2231/4205B01J2231/4211B01J2231/4261B01J2531/0272B01J2531/821B01J2531/824C07H15/203Y02P20/55
    • The invention relates to a method for producing phosphanes of the generic formula (I) Ar 3-xP(Ar (OZ)y)x, in which Ar and Ar independently of each other represent aromatic C6-20 radicals possibly substituted by halogen atoms, carboxyl groups, hydroxyl groups, alkyl C1-6 groups, phenyl groups or naphthyl groups, or represent heteroaromatic C4-9 radicals, whereby Ar has one free valence and Ar has y+1 free valences; Z is a carbohydrate radical with a glycosidic bond; x has a value of 1, 2 or 3; and y has a value of 1 or 2. According to said method, (1) carbohydrate halogenoses of the generic formula (II) Z'-X, in which Z' represents a radical Z as described above, in which the hydroxyl groups are substituted by protective groups and X represents Br, Cl or F, are reacted with a phosphane of the generic formula (III) Ar 3-xP(Ar (OH)y)x, in which Ar , Ar , x and y have the meaning given above, in a multiple-phase reaction medium in the presence of a base and a phase-transfer catalyst, to yield a phosphane of the generic formula (IV) Ar 3-xP(Ar (OZ')y)x, in which Ar , Ar , x, y and Z' have the meaning given above, and (2) the protective groups are separated from Z'.
    • 在通式(I)的膦的方法,包括:氩<1> 3-XP(AR <2>(OZ)Y)X,其中Ar <1>和Ar <2>独立地任选被卤素原子,羧基,羟基的基团取代 ,C 1-6烷基,苯基或萘基取代的芳族C 6-20基团或C4-9杂芳基,其中Ar <1>和a及Ar <2>具有Y + 1个自由价,Z是一个糖苷连接的糖基部分 中,x是1,2或3,y是1或2,是(1)Kohlenhydrathalogenosen通式(II):Z'-X,如先前所指示的,其中Z“是一个基团Z,其中 的羟基基团被保护基团取代,和X是Br,Cl或F,其一般式(III)的膦:氩<1> 3-XP(AR <2>(OH)Y)X其中Ar <1 >中,Ar <2>中,x,y具有在碱的存在下和相转移催化剂的多相反应介质的上述的含义,为具有以下通式的磷烷(IV):(AR <1> 3-XP的Ar <2>( OZ“) Y)X,其中Ar <1>中,Ar <2>中,X,Y和Z '具有上面给出的含义,进行反应和保护基团Z' 被除去。