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1. 发明申请

WO1996005854A2 COMBINATION PREPARATION, CONTAINING CYCLOSPORIN A OR FK506 OR RAPAMYCIN AND A XANTHINE DERIVATIVE 审中-公开
标题翻译：含CYPOSPORIN A或FK506或RAPAMYCIN和XANTHINE DERIVATIVE的组合制剂
公开(公告)号：WO1996005854A2
公开(公告)日：1996-02-29
申请号：PCT/EP1995003126
申请日：1995-08-07
申请人： HOECHST AKTIENGESELLSCHAFT , KATHOLIEKE UNIVERSITEIT LEUVEN , SCHÖNHARTING, Martin , GEBERT, Ulrich , WAER, Mark
发明人： HOECHST AKTIENGESELLSCHAFT , KATHOLIEKE UNIVERSITEIT LEUVEN
IPC分类号： A61K38/13
CPC分类号： A61K31/453 , A61K38/12 , A61K38/13 , A61K31/52 , A61K31/445 , A61K31/522 , A61K2300/00
摘要： Combination preparations which contain cyclosporin A and a xanthine derivative or FK506 and a xanthine derivative or rapamycin and a xanthine derivative are suitable for use in organ transplantation, cancer, viral diseases or in autoimmune disorders such as systemic lupus erythematosus, rheumatoid arthritis, psoriasis, pemphigus, atopic dermatitis, myositis, multiple sclerosis, nephrotic syndrome (in particular glomerulonephritis), ulcerative colitis or juvenile diabetes.
摘要翻译：含有环孢菌素A和黄嘌呤衍生物或FK506和黄嘌呤衍生物或雷帕霉素和黄嘌呤衍生物的组合制剂适用于器官移植，癌症，病毒性疾病或自身免疫性疾病如系统性红斑狼疮，类风湿性关节炎，牛皮癣，天疱疮，特应性皮炎，肌炎，多发性硬化，肾病综合征（特别是肾小球性肾炎），溃疡性结肠炎或青少年糖尿病。

2. 发明申请

WO1996005838A3 COMBINED PREPARATION FOR THE THERAPY OF IMMUNE DISEASES 审中-公开
公开(公告)号：WO1996005838A3
公开(公告)日：1996-02-29
申请号：PCT/EP1995003125
申请日：1995-08-07
申请人： HOECHST AKTIENGESELLSCHAFT , SCHÖNHARTING, Martin , MÜLLNER, Stefan , ZABEL, Peter
发明人： HOECHST AKTIENGESELLSCHAFT
IPC分类号： A61K45/06

3. 发明申请

WO1987000523A2 TERTIARY HYDROXYALKYLXANTHINES, THEIR MANUFACTURING PROCESS, MEDICINES CONTAINING THEM AND USE THEREOF 审中-公开
标题翻译：其中羟基甲基丝氨酸，其制备方法，含有它们的药物及其用途
公开(公告)号：WO1987000523A2
公开(公告)日：1987-01-29
申请号：PCT/EP1986000401
申请日：1986-07-08
申请人： HOECHST AKTIENGESELLSCHAFT , GEBERT, Ulrich , OKYAYUZ-BAKLOUTI, Ismahan , THORWART, Werner
发明人： HOECHST AKTIENGESELLSCHAFT
IPC分类号： C07D473/04
CPC分类号： C07D473/06 , C07D473/08
摘要： Tertiary hydroxyalkylxanthines having the general formula (I), characterized by the fact that at least one of the residues R1 and R3 represents a tertiary hydroxyalkyl group of formula (Ia) in which R4 represents an alkyl group having up to 3 carbon atoms and n a whole number from 2 to 5; the other residue which may remain R1 or R3 is a hydrogen atom or an aliphatic hydrocarbon residue R5 having up to 6 carbon atoms, in which the carbon chain may be separated by a maximum of two oxygen atoms or be substituted by an oxo group or two hydroxy groups at the most, and R2 represents an alkyl group with 1 to 4 carbon atoms. Also described is a process for manufacturing these compounds, which are suitable for the manufacture of medicines, in particular for use in the prevention and/or treatment of peripheral and/or cerebral irrigation disorders.

4. 发明申请

WO1995026727A1 USE OF XANTHINE DERIVATIVES FOR REDUCING THE PATHOLOGICAL HYPER-REACTIVITY OF EOSINOPHILIC GRANULOCYTES, NOVEL XANTHINE COMPOUNDS AND PROCESS FOR PRODUCING THEM 审中-公开
标题翻译：克桑西衍生物的病理高反应性嗜酸性粒细胞，新的克桑西化合物用于还原和使用过程及其
公开(公告)号：WO1995026727A1
公开(公告)日：1995-10-12
申请号：PCT/EP1995001060
申请日：1995-03-21
申请人： HOECHST AKTIENGESELLSCHAFT , GEBERT, Ulrich , ANAGNOSTOPULOS, Hiristo , KROEGEL, Claus , KAPP, Alexander
发明人： HOECHST AKTIENGESELLSCHAFT
IPC分类号： A61K31/52
CPC分类号： C07D473/04 , A61K31/522
摘要： Tertiary 1-(hydroxy alkyl)-4-alkyl xanthines are suitable for the preparation of medicaments for the treatment of diseases connected with a pathologically raised reactivity of eosinophilic granulocytes. The description relates to novel xanthine derivatives and to a process for producing them.
摘要翻译：叔1-（羟烷基）-4-烷基黄嘌呤适于生产药物用于治疗与嗜酸性粒细胞的病理性增加反应性相关的疾病的治疗的。它描述了它们的制备新颖黄嘌呤衍生物和过程。

5. 发明申请

WO1992007585A1 THE USE OF ANTIBODIES TO TNF OR FRAGMENTS DERIVED THEREOF AND XANTHINE DERIVATIVES FOR COMBINATION THERAPY AND COMPOSITIONS THEREFOR 审中-公开
标题翻译：抗体对TNF或其衍生物的片段的使用和用于组合治疗的Xanthine衍生物及其组合物
公开(公告)号：WO1992007585A1
公开(公告)日：1992-05-14
申请号：PCT/GB1991001907
申请日：1991-10-30
申请人： CELLTECH LIMITED , HOECHST AKTIENGESELLSCHAFT , ANAGNOSTOPULOS, Hiristo , GEBERT, Ulrich , HANEL, Heinz , LIMBERT, Michael , BODMER, Mark, William , HIGGS, Gerald, Anthony
发明人： CELLTECH LIMITED , HOECHST AKTIENGESELLSCHAFT
IPC分类号： A61K39/395
CPC分类号： A61K39/395 , A61K31/52 , A61K2300/00
摘要： A combined preparation for simultaneous combined, simultaneous separate, or sequential use in the therapy or prophylaxis of disorders associated with undesirably high levels of TNF, e.g. septic or endotoxic shock and immunoregulatory and inflammatory disorders, which comprises an antibody to TNF or a TNF binding fragment thereof and a xanthine derivative. Particular preferred xanthine derivatives are 3,7-dimethyl-1-(5-oxo-hexyl)xanthine (known as Pentoxifylline or Trental) and 1-(5-hydroxy-5-methylhexyl)-3-methylxanthine and similar compounds. The anti-TNF antibody or fragment is preferably monospecific especially a humanised recombinant antibody or fragment. The ratio of xanthine derivative to anti-TNF antibody component used may be in the range between 450:1 and 1:10 and doses of anti-TNF component in the range 0.001-30mg/kg/day and doses of xanthine derivative in the range 0.5 to 100mg/kg/day may be administered during treatment of human or animal subjects. It has been found that when an anti-TNF antibody and a xanthine derivative are used together in some experimental models of septic shock, a surprising combination effect is observed.
摘要翻译：用于同时组合，同时分开或顺序使用的联合制剂，用于治疗或预防与不期望的高水平的TNF相关的病症，例如，脓毒性或内毒素性休克和免疫调节性和炎症性疾病，其包含TNF抗体或其TNF结合片段和黄嘌呤衍生物。特别优选的黄嘌呤衍生物是3,7-二甲基-1-（5-氧代 - 己基）黄嘌呤（称为己酮可可碱或特伦塔尔）和1-（5-羟基-5-甲基己基）-3-甲基黄嘌呤和类似化合物。抗TNF抗体或片段优选是单特异性的，特别是人源化的重组抗体或片段。黄嘌呤衍生物与抗TNF抗体组分的比例可以在450:1至1:10的范围内，抗TNF成分的剂量范围为0.001-30mg / kg /天，黄嘌呤衍生物的剂量范围为在人或动物受试者的治疗期间可以施用0.5至100mg / kg /天。已经发现，当在一些感染性休克的实验模型中一起使用抗TNF抗体和黄嘌呤衍生物时，观察到惊人的组合效应。

6. 发明申请

WO1998030526A1 PROCESS FOR PREPARING ALDEHYDES IN THE PRESENCE OF AN AQUEOUS PHASE CONTAINING RHODIUM AND SULPHONATED TRIARYLPHOSPHINES AS CATALYST 审中-公开
标题翻译：用于作者铑和磺化三芳基膦作催化剂存在下对含水相醛PRODUCING
公开(公告)号：WO1998030526A1
公开(公告)日：1998-07-16
申请号：PCT/EP1997007314
申请日：1997-12-30
申请人： HOECHST AKTIENGESELLSCHAFT , BOGDANOVIC, Sandra , FROHNING, Carl-Dieter , BAHRMANN, Helmut
发明人： HOECHST AKTIENGESELLSCHAFT
IPC分类号： C07C45/50
CPC分类号： B01J31/2404 , B01J31/068 , B01J31/2409 , B01J31/2447 , B01J31/2452 , B01J2231/321 , B01J2531/0266 , B01J2531/822 , B01J2531/96 , B01J2540/32 , C07C45/50 , C07F9/5027 , C07C47/225 , C07C47/45
摘要： The invention concerns a process for preparing aldehydes by reacting with hydrogen and carbon monoxide at a temperature of between 20 and 170 DEG C and a pressure of between 1 and 300 bar an olefinically unsaturated C6-C16 compound in the presence of an aqueous phase containing rhodium and sulphonated triarylphosphines as catalyst and between 10 and 70 wt % of a compound of formula (1), R(OCH2CH2)nOR , R standing for hydrogen, a straight-chain or branched C1-C4 alkyl group or a C1-C4 hydroxyalkyl group, R standing for hydrogen or a methyl group, and n standing for an integer from 3 to 50.
摘要翻译：本发明涉及一种用于通过从在铑和磺化三芳基膦作为催化剂和10的存在6至16个碳原子的烯属不饱和化合物制备醛的方法以70重量下式的化合物的％（1）R是（OCH 2 CH 2）也不<1>含水相，其中R是氢，直链或具有1至4个碳原子或具有1至4个碳原子，R的羟烷基支化烷基<1>表示氢或甲基，n是3的整数 50在20与氢气和一氧化碳反应至170℃和1至300巴反应。

7. 发明申请

WO1998014503A1 PROCESS FOR PREPARING SULPHUROUS POLYMERS 审中-公开
标题翻译：用于生产硫含氯聚合物
公开(公告)号：WO1998014503A1
公开(公告)日：1998-04-09
申请号：PCT/EP1997005229
申请日：1997-09-24
申请人： HOECHST AKTIENGESELLSCHAFT , HAUBS, Michael , WAGNER, Stephan , BESSER, Olaf
发明人： HOECHST AKTIENGESELLSCHAFT
IPC分类号： C08G75/02
CPC分类号： C08G75/0254
摘要： The invention concerns a process for preparing linear or branched sulphurous polymers such as polyarylene sulphides, in particular polyphenylene sulphide, from an aromatic dihalide compound and a sulphide in a solvent, wherein: a) the aromatic dihalide compound and the sulphide are partially reacted; b) the resultant salt which is not dissolved in the reaction medium is separated off; and c) the reaction mixture largely freed of the salt is further polymerized.
摘要翻译：本发明涉及一种用于线性或支化的含硫聚合物如聚亚芳基硫化物的制备方法，特别是聚苯硫醚，芳族二卤代化合物和在溶剂中的一种硫化物，其中a）被带到芳族二卤代化合物和硫化物到部分反应B的）在反应介质中，和c）得到的分离的未溶解的盐是进一步聚合，基本上从盐反应混合物中解放出来。

8. 发明申请

WO1998013043A1 USE OF 1-HYDROXY-2-PYRIDONES FOR THE TREATMENT OF SKIN DISEASES 审中-公开
标题翻译： 1-羟基-2-吡啶酮用于皮肤感染中的用途
公开(公告)号：WO1998013043A1
公开(公告)日：1998-04-02
申请号：PCT/EP1997005069
申请日：1997-09-16
申请人： HOECHST AKTIENGESELLSCHAFT , BOHN, Manfred , KRAEMER, Karl, Theodor , MARKUS, Astrid
发明人： HOECHST AKTIENGESELLSCHAFT
IPC分类号： A61K31/44
CPC分类号： A61K31/4412 , Y02A50/473
摘要： Compounds of the formula (I) are suitable for producing pharmaceuticals for topical treatment of skin diseases caused by fungi or bacteria.
摘要翻译：式（I）的化合物是适用于制备药物所造成的真菌和细菌性皮肤感染的局部治疗。

9. 发明申请

WO1998007768A1 ELASTOMERIC CYCLOOLEFINPOLYMER 审中-公开
标题翻译：弹性体环烯烃
公开(公告)号：WO1998007768A1
公开(公告)日：1998-02-26
申请号：PCT/EP1997004363
申请日：1997-08-11
申请人： HOECHST AKTIENGESELLSCHAFT , HATKE, Wilfried , HELMER-METZMANN, Freddy , OSAN, Frank , WEHRMEISTER, Thomas
发明人： HOECHST AKTIENGESELLSCHAFT
IPC分类号： C08F232/00
CPC分类号： C08F210/02 , C08F232/00
摘要： Disclosed is an elastomeric cycloolefinpolymer containing 1 to 50 mol/ % of polymerized units derived from one or a plurality of polycyclic olefins, with one or several norbornene units and 50to 99 mol/ % of polymerized units derived from one or more acyclic olefins of formula (a), where R , R , R and R are the same or different and a hydrogen atom is a straight, branched, saturated or unsaturated C1-C20 hydrocarbon residue or a C6-C18 aryl residue, and 50 to 99 mol/% of polymerized units derived from one or several monocyclic olefins of formula (VIII), where n is a number between 2 and 10.
摘要翻译：本发明涉及含有1〜50摩尔％的弹性体的环烯烃共聚物，基于环烯烃共聚物的总组合物，其从与一个或多个降冰片烯单元的一个或更多个多环烯烃和50至99摩尔％衍生的聚合单元，基于环烯烃共聚物的总组合物，其由下式的一个或多个无环烯烃衍生的聚合单元中，（a），其中R的，R ，R 和R 是相同的或不同表示氢原子，直链，支链，饱和或不饱和的C1-C20烃基或C6-C18芳基和50〜99摩尔％，基于环烯烃共聚物的总组合物的配方中的一个或多个单环烯烃的聚合单元，（VIII）其中，n是一个数为2〜10。

10. 发明申请

WO1997044299A1 PROCESS FOR THE SELECTIVE PRODUCTION OF ACETIC ACID 审中-公开
标题翻译：用于生产乙酸
公开(公告)号：WO1997044299A1
公开(公告)日：1997-11-27
申请号：PCT/EP1997002522
申请日：1997-05-16
申请人： HOECHST AKTIENGESELLSCHAFT , BORCHERT, Holger , DINGERDISSEN, Uwe , WEIGUNY, Jens
发明人： HOECHST AKTIENGESELLSCHAFT
IPC分类号： C07C05/48
CPC分类号： C07C51/215 , B01J23/6567 , C07C51/25 , C07C53/08
摘要： A process for the selective production of acetic acid from a gaseous supply of ethane, ethylene or mixtures thereof and oxygen at high temperature, in which the gaseous supply is brought into contact with a catalyst containing the elements Mo, Pd, Re, X and Y in the atom-gram ratios a:b:c:d:e in combination with oxygen, of formula (I) MoaPdbRecXdYe, where X is Cr, Mn, B, Ta, Ti, V and/or W; Y is Bi, Ce, Co, Cu, Te, Fe, Li, K, Na, Rb, Be, Mg, Ca, Sr, Ba, Ni, P, Pb, Sb, Si, Sn, Tl and/or U; the indices a, b, c, d and e stand for the atom-gram ratios of the corresponding elements, where a = 1, b > 0, c > 0, d = 0.05 to 2 and e = 0 to 3.
摘要翻译：一种用于从在高温下乙烷，乙烯或它们的混合物加氧气的气态进料选择性生产乙酸的方法，其特征在于所述气态进料与包含元素Mo，钯中，Re，X和Y中的一种催化剂接触克原子比A：b：C：D：E在与氧的组合包括：MoaPdbRecXdYe（I）其中各符号X，Y具有以下含义：X =铬，锰，铌，硼，钽，Ti，V和/或W ; Y =，铜，碲，铁，锂，钾，钠，RB，铍，镁，钙，锶，钡，镍，磷，铅，锑，硅，锡，铊和/或U铋，铈，钴; 指数a，B，C，D和E代表相应元素，其中a = 1，B> 0，C> 0时，D = 0.05〜2的克原子比率，E = 0〜第三

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