专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

KR800000488B1 PROCESS FOR PREPARING BENZENESULFONYL UREAS 失效
公开(公告)号：KR800000488B1
公开(公告)日：1980-06-04
申请号：KR770003048
申请日：1977-12-27
申请人： HOECHST AG
发明人： BEYER R , AUMUELLER W , HITSEL V , SCHMIDT F
IPC分类号： C07D213/36
摘要： Benzenesulfonyl ureas (I; X = pyridyl, pyrimidinyl, quinolyl, benzothiazolyl, benzoxazolyl; R = C1-3 alkyl; R1 = C3-6 alkyl, C5-9 cycloalkenyl, cycloalkeny, bicycloheptyl, adamantyl, benzyl), useful as hyperglycemic agent, were prepd. by substituting S with O from II-substituted benzenesulfonylthiourea. Thus, 5 g N-[4-(β-(N'-methyl-N'-pyridyl-ureido)-ethyl) benzenesulfonyl -N'-cyclohexyl-thiourea(4(β-

2. 发明授权

KR800000489B1 PROCESS FOR PREPARING BENZENESULFONYL UREAS 失效
公开(公告)号：KR800000489B1
公开(公告)日：1980-06-04
申请号：KR770003050
申请日：1977-12-27
申请人： HOECHST AG
发明人： BEYER R , AUMUELLER W , HITSEL V , SCHMIDT F
IPC分类号： C07D213/36
摘要： Benzenesulfonyl ures and its salts(I; x = pyridyl, pyrimidinyl, quinolyl, benzothiazolyl, benzoxazolyl; R = C1-3 alkyl; R1 = C3-6 alkyl, C5-9 cycloalkenyl, cycloalkenyl, bicycloheptyl, bicycloheptenyl, adamantyl, benzyl), useful as hyperglycemic agent, were prepd. by oxidn. of benzenesulfinyl urea and benzenesulfenyl uresa. Thus, 3.4 g 4-(β-(N'-methyl-N'-pyridyl -ureidoethyl)-benzenesulfinic chloride and 1.7 g cyclohexyl urea were treaed at room temp. for 20 min in 20ml pyridine to give N-[4-(β-(N'-methyl-N'-pyridyl-ureidoethyl)-benzenesulfonyl urea.

3. 发明授权

US3790630A Benzenesulfonyl-ureas 失效
标题翻译：苯并呋喃类
公开(公告)号：US3790630A
公开(公告)日：1974-02-05
申请号：US3790630D
申请日：1969-07-28
申请人： HOECHST AG
发明人： SCHMIDT F , WEBER H , MUTH K , WEYER R , AUMUELLER W
IPC分类号： C07C311/58 , C07C303/36 , C07C303/38 , C07C311/59 , C07D233/96 , C07D333/20 , C07C127/00
CPC分类号： C07D233/96 , C07C303/36 , C07C2601/16 , Y10S514/866 , C07C311/59
摘要： BENZENESULFONYL-UREAS OF THE FORMULA

1-(X-CO-NH-CH2-CH2-),4-(2-CYCLOHEXEN-1-YL-NH-CO-NH-SO2-)

BENZENE

WHICH IN THE FREE FROM OR IN THE FORM OF THEIR SALTS HAVE BLOOD SUGAR LOWERING PROPERTIES AND ARE DISTINGUISHED BY A STRONG AND LONG-LASTING HYPOGLYCEMIC ACTION. IN THE FORMULA X REPRESENTS (R-O-),Z-PHENYL OR 3-(R-O-),5-Z''-THIEN-2-YL WHEREIN R STANDS FOR AN ALKYL GROUP HAVING 1 TO 4 CARBON ATOMS, Z STANDS FOR A HALOGEN ATOM, AN ALKYL OR ALKOXY GROUP BOTH HAVING 1 TO 4 CARBON ATOMS, AND Z'' STANDS FOR A HALOGEN ATOM OR AN ALKYL GROUP HAVING 1 TO 4 CARBON ATOMS.

4. 发明授权

US3825665A Benzenesulfonyl ureas and their use in treating diabetes 失效
标题翻译：苯并呋喃及其在治疗糖尿病中的应用
公开(公告)号：US3825665A
公开(公告)日：1974-07-23
申请号：US11109071
申请日：1971-01-29
申请人： HOECHST AG
发明人： WEBER H , AUMUELLER W , SCHMIDT F , WEYER R , MUTH K
IPC分类号： A61K31/64 , C07C311/54 , A61K27/00
CPC分类号： A61K31/64 , C07C311/54
摘要： N-(4-(B-BENZAMIDO-ETHYL)-BENZENESULFONYL) -N''(ENDOALKYLENECYCLOHEXYL- OR CYCLOHEXENYL)-UREAS BEING SUBSTITUTED AT THE BENZAMIDO GROUP AND HAVING HYPOGLYCEMIC ACTIVITY AND USEFUL FOR PREPARING PHARMACEUTICAL COMPOSITIONS AND USED IN A METHOD FOR LOWERING BLOOD SUGAR LEVEL IN THE TREATMENT OF DIABETES MELLITUS.

5. 发明专利

IN139940B PROCESS FOR THE MANUFACTURE OF BENZENESULFONYL UREAS 未知
公开(公告)号：IN139940B
公开(公告)日：1976-08-21
申请号：IN1197CA1975
申请日：1975-06-17
申请人： HOECHST AG
发明人： WEBER H , AUMULLER W , WEYER R , MUTH K , SCHMIDT F
IPC分类号： C07C127/14

6. 发明专利

IN139506B PROCESS FOR THE MANUFACTURE OF BENZENESULFONYL-UREAS 未知
公开(公告)号：IN139506B
公开(公告)日：1976-06-26
申请号：IN1917CA1974
申请日：1974-08-24
申请人： HOECHST AG
发明人： WEYER R , MUTH K , WEBER H , AUMULLER W , SCHMIDT F
IPC分类号： A61K31/64 , C07C67/00 , C07C301/00 , C07C303/36 , C07C303/40 , C07C311/58 , C07C311/59 , C07D309/14 , C07C127/16 , C07C143/78

7. 发明专利

IN139501B PROCESS FOR THE MANUFACTURE OF BENZENSULFONYL-UREAS 未知
公开(公告)号：IN139501B
公开(公告)日：1976-06-26
申请号：IN1912CA1974
申请日：1974-08-24
申请人： HOECHST AG
发明人： WEBER H , AUMULLER W , SCHMIDT F , WEYER R , MUTH K
IPC分类号： A61K31/64 , C07C67/00 , C07C301/00 , C07C303/36 , C07C303/40 , C07C311/58 , C07C311/59 , C07D309/14 , C07C127/16 , C07C143/78

8. 发明专利

SE363326B 未知
公开(公告)号：SE363326B
公开(公告)日：1974-01-14
申请号：SE1074868
申请日：1968-08-09
申请人： HOECHST AG
发明人： WEBER H , AUMUELLER W , WEYER R , SCHMIDT F
IPC分类号： C07D209/44 , C07D209/70 , C07D209/72 , C07D221/20 , C07D295/215 , C07D333/38 , C07D451/02 , C07D451/14 , C07D453/06 , C07C143/84 , C07D29/30 , C07D41/00 , C07D63/12

9. 发明专利

NO127707B 未知
公开(公告)号：NO127707B
公开(公告)日：1973-08-06
申请号：NO315269
申请日：1969-07-31
申请人： HOECHST AG
发明人： WEYER R , AUMUELLER W , WEBER H , MUTH K , SCHMIDT F
IPC分类号： C07C311/58 , C07C303/36 , C07C303/38 , C07C311/59 , C07D233/96 , C07D333/20 , C07C143/78
摘要： 1,233,354. Benzenesulphonyl-ureas. FARBWERKE HOECHST A.G. 14 Feb., 1969 [2 Aug., 1968], No. 8218/69. Heading C2C. Novel compounds I (including salts thereof) wherein X signifies the groups II or III in which R signifies C 1-4 alkyl, Z signifies halogen, C 1-4 alkyl or C 1-4 alkoxy and Z 1 signifies halogen or C 1-4 alkyl are obtained according to standard methods. N - [4 - (# - Aminoethyl) - benzenesulphonyl]. N 1 - (# 2 - cyclohexenyl) - urea is prepared by saponifying the #-acetamidoethyl-compound. 1 - [4 - (# - - ethyl) - benzenesulphonyl] - 3 - (#2. cyclohexenyl)-parabanic acid is prepared by the interaction of 1-(#2-cyclohexenyl)-parabanic acid and 4 - (# - - ethyl) - benzenesulphochloride. #2 - Cyclohexenyl isocyanate is prepared by heating N - (#2 - cyclohexenyl) - N 1 ,N 1 - diphenyl-urea. The cyclohexenylamine salt of N-[4 - (# - - ethyl) - benzenesulphonyl] - N 1 - aceryl - urea is obtained by mixing the individual compounds and heating. N - (#2 - Cyclohexenyl) - carbamic acid phenyl ester is prepared by the interaction of phenyl chloroformate and #2-cyclohexenylamine. N - Acetyl - N 1 - (#2 - cyclohexenyl) - urea is prepared by the interaction of acetic anhydride and #2-cyclohexenyl-urea. N,N - Diphenyl - N 1 - (#2 - cyclohexenyl)- urea is prepared from diphenyl carbamoyl chloride and #2-cyclohexenylamine. N,N 1 - Di - (#2 - cyclohexenyl) - urea is prepared from #2 - cyclohdxenyl isocyanate and #2-cyclohexenylamine. N - [4 - (# - - ethyl) - benzenesulphonyl] - phenylurethane, -N 1 N 1 - diphenyl - urea, - iminodithio - carbonic acid potassium salt and dimethyl ester, -N 1 - (#2 - cyclohexenyl) - isothiourea methyl ether, -N 1 -(#2-cyclohexenyl)- thiourea and - N 1 - (#2 - cyclohexenyl) - isourea methyl ether and 4-(#- - ethyl) - benzene sulphonamide are also prepared as intermediates. Pharmaceutical preparations exhibiting blood sugar lowering properties and hypoglycemic activity contain I as active ingredient; administration is orally.

10. 发明专利

DK125642B 未知
公开(公告)号：DK125642B
公开(公告)日：1973-03-19
申请号：DK416869
申请日：1969-08-01
申请人： HOECHST AG
发明人： WEYER R , AUMUELLER W , WEBER H , MUTH K , SCHMIDT F
IPC分类号： C07C311/58 , C07C303/36 , C07C303/38 , C07C311/59 , C07D233/96 , C07D333/20 , C07C143/78
摘要： 1,233,354. Benzenesulphonyl-ureas. FARBWERKE HOECHST A.G. 14 Feb., 1969 [2 Aug., 1968], No. 8218/69. Heading C2C. Novel compounds I (including salts thereof) wherein X signifies the groups II or III in which R signifies C 1-4 alkyl, Z signifies halogen, C 1-4 alkyl or C 1-4 alkoxy and Z 1 signifies halogen or C 1-4 alkyl are obtained according to standard methods. N - [4 - (# - Aminoethyl) - benzenesulphonyl]. N 1 - (# 2 - cyclohexenyl) - urea is prepared by saponifying the #-acetamidoethyl-compound. 1 - [4 - (# - - ethyl) - benzenesulphonyl] - 3 - (#2. cyclohexenyl)-parabanic acid is prepared by the interaction of 1-(#2-cyclohexenyl)-parabanic acid and 4 - (# - - ethyl) - benzenesulphochloride. #2 - Cyclohexenyl isocyanate is prepared by heating N - (#2 - cyclohexenyl) - N 1 ,N 1 - diphenyl-urea. The cyclohexenylamine salt of N-[4 - (# - - ethyl) - benzenesulphonyl] - N 1 - aceryl - urea is obtained by mixing the individual compounds and heating. N - (#2 - Cyclohexenyl) - carbamic acid phenyl ester is prepared by the interaction of phenyl chloroformate and #2-cyclohexenylamine. N - Acetyl - N 1 - (#2 - cyclohexenyl) - urea is prepared by the interaction of acetic anhydride and #2-cyclohexenyl-urea. N,N - Diphenyl - N 1 - (#2 - cyclohexenyl)- urea is prepared from diphenyl carbamoyl chloride and #2-cyclohexenylamine. N,N 1 - Di - (#2 - cyclohexenyl) - urea is prepared from #2 - cyclohdxenyl isocyanate and #2-cyclohexenylamine. N - [4 - (# - - ethyl) - benzenesulphonyl] - phenylurethane, -N 1 N 1 - diphenyl - urea, - iminodithio - carbonic acid potassium salt and dimethyl ester, -N 1 - (#2 - cyclohexenyl) - isothiourea methyl ether, -N 1 -(#2-cyclohexenyl)- thiourea and - N 1 - (#2 - cyclohexenyl) - isourea methyl ether and 4-(#- - ethyl) - benzene sulphonamide are also prepared as intermediates. Pharmaceutical preparations exhibiting blood sugar lowering properties and hypoglycemic activity contain I as active ingredient; administration is orally.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式