专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

JPS62207468A APPARATUS FOR ADMINISTERING DRUG SUSPENSION 失效
公开(公告)号：JPS62207468A
公开(公告)日：1987-09-11
申请号：JP4047687
申请日：1987-02-25
申请人： HOECHST AG
发明人： GRAU ULRICH , POHLER WOLFGANG
IPC分类号： A61J1/05 , A61J1/06 , A61M5/24 , A61M5/31

2. 发明专利

DK172712B1 未知
公开(公告)号：DK172712B1
公开(公告)日：1999-06-14
申请号：DK447786
申请日：1986-09-18
申请人： HOECHST AG
发明人： GRAU ULRICH
IPC分类号： C07K1/30 , C07K1/107 , C07K1/113 , C07K14/575 , C07K14/62 , C07K14/625
摘要： PCT No. PCT/EP86/00008 Sec. 371 Date Sep. 2, 1986 Sec. 102(e) Date Sep. 2, 1986 PCT Filed Jan. 11, 1986 PCT Pub. No. WO86/04335 PCT Pub. Date Jul. 31, 1986.A process for the preparation of insulin precursors of the formula (I) (I) in which R is hydrogen or the presequence Pm-Qn-, in which P is a sequence of naturally occurring amino acids with m being from 0 to 50, Q are basic natural amino acids, and n is an integer from 1 to 4, Y represents -LysB29-ZB30-, in which Z denotes Ala, Thr or Ser, and the bridge extending from A-1 to A-21 is an insulin A-chain, the bridge extending from B-1 to B-30 represents an insulin B-chain, and X is a bridge which is bonded to the insulin A-chain at the amino group of A-1 and is bonded to the insulin B-chain at the epsilon -amino group of B-29- in which case it is bonded to the free bond of ZB30OH- or at the carboxyl group of B-30, from reaction mixtures which result from folding of insulin precursors from S-sulfonates of the formula (II) (II) in which R, X and Y have the abovementioned meanings, which comprises the false recombinants contained in the reaction mixture being precipitated by adjustment of the reaction mixture to pH 4 to 6, the precipitate being removed in customary manner and converted by sulfitolysis into the S-sulfonate of the formula (II), and the latter then being subjected to renewed folding.

3. 发明专利

DK172456B1 未知
公开(公告)号：DK172456B1
公开(公告)日：1998-08-24
申请号：DK358384
申请日：1984-07-20
申请人： HOECHST AG
发明人： GRAU ULRICH
IPC分类号： A61K38/00 , A61K38/28 , C07K14/62 , C07K14/625
摘要： The invention relates to medicaments consisting of a physiologically acceptable excipient and an active compound combination of (a) an insulin derivative of the formula I (I) in which R1 denotes H or H-Phe, R30 represents the radical of a neutral L-aminoacid and R31 represents a physiologically acceptable organic group of basic character with up to 50 carbon atoms, with an isoelectric point between 5.8 and 8.5, and (b) an insulin of the formula I in which R1 denotes H or H-Phe, R30 represents Ala, Thr or Ser and R31 denotes OH, and to its use for the treatment of diabetes mellitus.

4. 发明专利

DK172209B1 未知
公开(公告)号：DK172209B1
公开(公告)日：1998-01-05
申请号：DK1790
申请日：1990-01-04
申请人： HOECHST AG
发明人： GRAU ULRICH
IPC分类号： A61K38/00 , A61K38/28 , A61P3/08 , A61P3/10 , C07K14/575 , C07K14/62 , C12P21/04 , C12P21/06
摘要： The invention relates to insulin derivatives of the formula I (I) in which R1 denotes H or H-Phe, R30 represents the radical of a neutral L-aminoacid and R31 represents a physiologically acceptable organic group of basic character with up to 50 carbon atoms, these derivatives having an isoelectric point between 5.8 and 8.5, processes for their preparation and their use, and agents containing these derivatives for the treatment of diabetes mellitus.

5. 发明专利

DK162255C 未知
公开(公告)号：DK162255C
公开(公告)日：1992-03-16
申请号：DK254585
申请日：1985-06-06
申请人： HOECHST AG
发明人： GRAU ULRICH , ROSS GERHARD , HILLER DIETRICH , NEUBAUER HORST PAUL
IPC分类号： A61K38/28 , A61K45/08 , A61K47/10 , A61K47/36 , A61K47/42 , A61K37/26

6. 发明专利

DK162255B 未知
公开(公告)号：DK162255B
公开(公告)日：1991-10-07
申请号：DK254585
申请日：1985-06-06
申请人： HOECHST AG
发明人： GRAU ULRICH , ROSS GERHARD , HILLER DIETRICH , NEUBAUER HORST PAUL
IPC分类号： A61K38/28 , A61K45/08 , A61K47/10 , A61K47/36 , A61K47/42 , A61K37/26

7. 发明专利

NO167207B 未知
公开(公告)号：NO167207B
公开(公告)日：1991-07-08
申请号：NO843048
申请日：1984-07-27
申请人： HOECHST AG
发明人： GRAU ULRICH
IPC分类号： A61K38/28 , A61K38/00 , C07K14/575 , C07K14/62 , C07K7/40 , C07K1/02
摘要： 1. Claims (for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE) Process for the preparation of suspensions of uniformly shaped crystals having a substantially homogeneous size distribution, in particular prisms about 10 mu m in size, of one or more insulin derivatives of the formula I see diagramm : EP0133285,P10,F1 in which R**1 denotes H or H-Phe, R**30 represents the residue of a neutral, genetically encodable L-amino acid and R**31 represents a physiologically tolerated organic group which is basic in character and has up to 50 C atoms, and in whose structure 0 to 3 alpha-amino acids and involved, and whose terminal carboxyl group, which is present where appropriate, can be in the free form, or in the form of an ester group, an amide group, a lactone or reduced to CH2 OH, having an isoelectric point between 5.8 and 8.5, characterized in that the crystallization is carried out in an aqueous medium in the neighbourhood of the isoelectric point of the derivative(s) in the presence of glycerol as tonicizing agent and at least one phenol. 1. Claims (for the Contracting State AT) Process for the preparation of suspensions of uniformly shaped crystals having a substantially homogeneous size distribution, in particular prisms about 10 mu m in size, of one or more insulin derivatives of the formula I see diagramm : EP0133285,P11,F1 in which R**1 denotes H or H-Phe, R**30 represents the residue of a neutral, genetically endocable L-amino acid and R**31 represents a physiologically tolerated organic group which is basic in character and has up to 50 C atoms, and in whose structure 0 to 3 alpha-amino acids are involved, and whose terminal carboxyl group, which is present where appropriate, can be in the free form, or in the form of an ester group, an amide group, a lactone or reduced to CH2 OH, having an isoelectric point between 5.8 and 8.5, characterized in that the crystallization is carried out in an aqueous medium in the neighbourhood of the isoelectric point of the derivative(s) in the presence of glycerol as tonicizing agent and at least one phenol.

8. 发明专利

NO167187B 未知
公开(公告)号：NO167187B
公开(公告)日：1991-07-08
申请号：NO842978
申请日：1984-07-20
申请人： HOECHST AG
发明人： GRAU ULRICH
IPC分类号： A61K38/00 , A61K38/28 , C07K14/62 , C07K14/625 , A61K37/26 , C07K7/40 , C07K7/42
摘要： The invention relates to medicaments consisting of a physiologically acceptable excipient and an active compound combination of (a) an insulin derivative of the formula I (I) in which R1 denotes H or H-Phe, R30 represents the radical of a neutral L-aminoacid and R31 represents a physiologically acceptable organic group of basic character with up to 50 carbon atoms, with an isoelectric point between 5.8 and 8.5, and (b) an insulin of the formula I in which R1 denotes H or H-Phe, R30 represents Ala, Thr or Ser and R31 denotes OH, and to its use for the treatment of diabetes mellitus.

9. 发明专利

NO167036B 未知
公开(公告)号：NO167036B
公开(公告)日：1991-06-17
申请号：NO843109
申请日：1984-08-02
申请人： HOECHST AG
发明人： GRAU ULRICH
IPC分类号： C07K14/575 , A61K38/28 , C07K14/62 , C07K1/00 , C07K7/40
摘要： The invention relates to a process for the preparation of insulin derivatives of the formula I (I) in which R30 represents the radical of a neutral L-amino acid which can be genetically coded, X represents identical or different radicals of L-amino acids which can be genetically coded, at least one of which is a basic amino acid, it being possible for the C-terminal member to be homoserine-lactone, Y denotes Phe or H and n denotes 1, 2 or 3, by splitting of intermediates, proinsulin, preproinsulin or analogs thereof, which comprises carrying out the splitting reaction close to the isoelectric point of the insulin derivatives of the formula I in the presence of an aromatic hydroxy compound.

10. 发明专利

AT61727T VORRICHTUNG ZUR APPLIKATION VON ARZNEIMITTELSUSPENSIONEN. 未知
公开(公告)号：AT61727T
公开(公告)日：1991-04-15
申请号：AT87102367
申请日：1987-02-19
申请人： HOECHST AG
发明人： GRAU ULRICH , POHLER WOLFGANG
IPC分类号： A61J1/05 , A61J1/06 , A61M5/24 , A61M5/31

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式