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1. 发明公开

EP2327419A4 MICRONEEDLE DEVICE, AND METHOD FOR ENHANCING THE EFFICACY OF INFLUENZA VACCINE BY USING MICRONEEDLE DEVICE 有权转让
标题翻译：微针装置和方法改进流感疫苗的效率利用微针装置
公开(公告)号：EP2327419A4
公开(公告)日：2015-12-30
申请号：EP09773249
申请日：2009-05-22
申请人： HISAMITSU PHARMACEUTICAL CO , CHEMO SERO THERAPEUT RES INST
发明人： NOZAKI CHIKATERU , KAMINAKA KAZUYOSHI , MATSUDA JUNICHI , TERAHARA TAKAAKI , KUWAHARA TETSUJI , TOKUMOTO SEIJI
IPC分类号： A61K39/145 , A61K9/00 , A61K9/70 , A61K39/00 , A61K39/39 , A61K47/10 , A61K47/34 , A61K47/36 , A61L31/00 , A61M37/00 , A61P31/16
CPC分类号： A61K39/145 , A61B17/205 , A61K39/12 , A61K2039/5252 , A61K2039/541 , A61K2039/545 , A61K2039/55511 , A61K2039/70 , A61M37/0015 , A61M2037/0046 , A61M2037/0061 , C12N2760/16134 , C12N2760/16234
摘要： The present invention provides a method for enhancing the immunogenicity using a microneedle device capable of enhancing the immunogenicity of an influenza vaccine. According to the method for enhancing the immunogenicity using the present microneedle device, a microneedle device having microneedles made of polylactic acid, coated with an influenza vaccine composed of an antigen having type A strain (H1N1), type A strain (H3N2), and type B strain as active ingredients is brought into direct contact with the skin so as to transcutaneously administer the aforementioned influenza vaccine. After the transcutaneous administration, lauryl alcohol is applied to the site of the skin where the microneedle device has been brought into direct contact.

2. 发明公开

EP1759718A4 TISSUE CLOSING PREPARATION 审中-公开
标题翻译：制备织物FINAL
公开(公告)号：EP1759718A4
公开(公告)日：2011-03-02
申请号：EP05741543
申请日：2005-05-18
申请人： CHEMO SERO THERAPEUT RES INST
发明人： IMAMURA TAKAYUKI , SHINYA NORIKO , KAWAMURA RYOICHI , NOZAKI CHIKATERU
IPC分类号： A61L15/32 , A61F13/00 , A61K9/70 , A61K33/06 , A61K38/36 , A61K38/43 , A61K38/48 , A61K45/00 , A61K45/06 , A61L15/64 , A61L17/00 , A61L24/00 , A61L24/10 , A61L27/00 , A61P7/04
CPC分类号： A61K38/363 , A61K38/4833 , A61K45/06 , A61L24/0042 , A61L24/106

3. 发明公开

EP2348042A4 MODIFIED AMYLOID BETA PEPTIDE 有权转让
标题翻译：改性AMYLOID-BETA-PEPTID
公开(公告)号：EP2348042A4
公开(公告)日：2012-03-28
申请号：EP09820642
申请日：2009-10-16
申请人： CHEMO SERO THERAPEUT RES INST
发明人： MATSUDA JUNICHI , KAMINAKA KAZUYOSHI , NOZAKI CHIKATERU
IPC分类号： C07K14/435 , A61K39/00 , A61K48/00 , A61P25/28 , C12N15/09
CPC分类号： C07K14/4711 , A61K39/0007 , A61K2039/53

4. 发明公开

EP1393746A4 HUMAN POLYCLONAL ANTIBODY COMPOSITIONS 审中-公开
标题翻译：与人多克隆抗体组合物
公开(公告)号：EP1393746A4
公开(公告)日：2008-09-10
申请号：EP02717170
申请日：2002-04-16
申请人： CHEMO SERO THERAPEUT RES INST , KIRIN PHARMA KK
发明人： MAEDA HIROAKI , UMEHASHI MISAKO , NOZAKI CHIKATERU
IPC分类号： C12P21/08 , A61K39/085 , A61K39/09 , A61K39/104 , A61K39/108 , A61K39/20 , A61K39/245 , A61K39/395 , A61P31/00 , A61P31/04 , A61P31/12 , C07K16/06 , C07K16/08 , C07K16/10 , C07K16/12
CPC分类号： C07K16/1214 , A01K2217/05 , A61K2039/505 , C07K16/06 , C07K16/088 , C07K16/1081 , C07K16/1232 , C07K16/1271 , C07K16/1275
摘要： A human polyclonal antibody having an antibacterial and/or antiviral activity with a desired titer and a wide spectrum; and human polyclonal antibody composition for preventing and treating infections which contain this antibody. The human polyclonal antibody composition for preventing or treating infections contain the human polyclonal antibody which is obtained by administering as immunogen a bacterium and/or a virus or a component of the bacterium and/or the virus to a non-human animal having a human antibody gene locus and has an antibody titer against the bacterium and/or the virus exceeding that of human pool plasma.

5. 发明公开

EP1544293A4 ANTIBODY AGAINST ENZYME SPECIFICALLY CLEAVING VON VILLEBRAND FACTOR AND ASSAY SYSTEM USING THE SAME 有权转让
标题翻译：单克隆抗体抗血管性血友病因子特异性切割酶和测定系统及其使用
公开(公告)号：EP1544293A4
公开(公告)日：2006-03-15
申请号：EP03798512
申请日：2003-09-25
申请人： CHEMO SERO THERAPEUT RES INST
发明人： SOEJIMA KENJI , MIMURA NORIKO , MAEDA HIROAKI , NOZAKI CHIKATERU , HAMAMOTO TAKAYOSHI , NAKAGAKI TOMOHIRO
IPC分类号： A61P7/02 , C07K16/40 , C12N9/64 , C12N15/02 , C12P21/08 , A61K38/43 , A61K39/395 , C12N5/10 , G01N33/532 , G01N33/573 , G01N33/577
CPC分类号： C12N9/6489 , C07K16/40
摘要： It is intended to provide an antibody showing a selective immunoreactivity for ADAMTS-13 and employ this antibody in epitope analysis or diagnosis of an ADAMTS-13 autoantibody-positive patient. Moreover, it is intended to provide a process for producing a modified ADAMTS-13 molecule having a partial deletion aiming at the application thereof to drugs and use thereof. Namely, an antibody specific for ADAMTS-13 which can be obtained from a warm-blooded animal immunologically sensitized with a polypeptide containing the whole ADAMTS-13 amino acid sequence or a part thereof; a process for producing an antibody involving the step of immunologically sensitizing a warm-blooded animal with a polypeptide containing the whole ADAMTS-13 amino acid sequence or a part thereof; use of the above-described antibody involving a method of detecting ADAMTS-13 and a purification method; and a modified ADAMTS-13 molecule having a partial deletion.

6. 发明公开

EP2684572A4 ADJUVANT COMPOSITION CONTAINING CITRULLINE 有权转让
标题翻译： CITRULLINHALTIGE辅助材料组成
公开(公告)号：EP2684572A4
公开(公告)日：2014-09-10
申请号：EP12757500
申请日：2012-03-09
申请人： CHEMO SERO THERAPEUT RES INST
发明人： NOZAKI CHIKATERU , KAMINAKA KAZUYOSHI , MATSUDA JUNICHI
IPC分类号： A61K39/39 , A61K39/00 , A61K39/145 , A61P25/28 , A61P31/16 , A61P37/04
CPC分类号： A61K39/39 , A61K39/0007 , A61K39/12 , A61K39/145 , A61K2039/55511 , A61K2039/55516 , A61K2039/575 , C12N2760/16134 , C12N2760/16171
摘要： A novel adjuvant composition is provided that is excellent in safety and convenience as compared to the conventional adjuvant such as Alum. An adjuvant composition comprising citrullines, which are water soluble substance present in the living body, and/or a salt thereof; a vaccine composition comprising said adjuvant composition and an antigen; a process for preparing said adjuvant composition and said vaccine composition; and a method for administering said adjuvant composition and said vaccine composition are provided.

7. 发明公开

EP2471915A4 MODIFIED PEPTIDE VACCINE DERIVED FROM INFLUENZA M2 有权转让
标题翻译：流感疫苗多肽表面修饰的M2获得
公开(公告)号：EP2471915A4
公开(公告)日：2013-05-01
申请号：EP10811798
申请日：2010-08-23
申请人： CHEMO SERO THERAPEUT RES INST
发明人： KAMINAKA KAZUYOSHI , NOZAKI CHIKATERU , MATSUDA JUNICHI , NISHIYAMA KIYOTO
IPC分类号： C12N15/09 , A61K39/145 , A61K39/155 , A61P31/16 , C07K14/005 , C07K14/11 , C07K16/10 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10
CPC分类号： A61K39/145 , A61K39/00 , A61K39/12 , A61K2039/55505 , C07K14/005 , C12N2760/16122 , C12N2760/16134
摘要： A modified peptide derived from matrix protein 2 (hereinafter also referred to as "M2"), one of surface layer proteins of influenza virus, and a method for utilization of the modified peptide are provided. A peptide (hereinafter also referred to as "M2eC peptide") that is made up by inserting cysteine residue(s) into a peptide (hereinafter also referred to as "M2e") consisting of 23 amino acid residues of from positions No. 2 to No. 24 of M2 in influenza virus type A, a fusion protein consisting of said modified peptide and a polypeptide, an influenza vaccine comprising said modified peptide or said fusion protein as an active ingredient, a device which can be delivered into the body comprising said influenza vaccine, a nucleic acid fragment consisting of a nucleotide sequence encoding the amino acid sequence of said modified peptide or said fusion protein, an expression vector in which said nucleic acid fragment is incorporated, a host in which said expression vector is introduced, and an antibody that has a protective effect against influenza virus.

8. 发明公开

EP1132402A4 PEPTIDE FRAGMENTS HAVING CELL DEATH INHIBITORY ACTIVITY 有权
标题翻译：与细胞死亡抑制活性肽片段
公开(公告)号：EP1132402A4
公开(公告)日：2005-12-21
申请号：EP99972642
申请日：1999-11-12
申请人： CHEMO SERO THERAPEUT RES INST
发明人： HIRASHIMA MASAKI , MAEDA HIROAKI , NOZAKI CHIKATERU
IPC分类号： A61K38/00 , C07K14/47 , A61K38/17 , C07K16/18 , C12N5/06
CPC分类号： C07K14/4747 , A61K38/00
摘要： Peptide fragment(s) having an activity of inhibiting cell death which contain the amino acid sequence consisting of 103 amino acid residues in the C-terminal side of selenoprotein P, an amino acid sequence derived from the above amino acid sequence by deletion, substitution or addition of one or several amino acids therein, or a partial sequence of either of the above amino acid sequences; remedies containing the above peptide fragment(s); antibodies against the above peptide fragment(s); and a method for screening a cell death inhibitory activity with the use of the above peptide fragment(s). Preferable examples of the above peptide fragment(s) are those containing the amino acid sequence(s) represented by SEQ ID NO:1 and/or 2 or partial sequences thereof.

9. 发明公开

EP2298344A4 USE OF INACTIVATED JAPANESE ENCEPHALITIS VIRUS PARTICLE AS ADJUVANT 有权转让
标题翻译：灭活日本脑炎病毒颗粒作为佐剂使用
公开(公告)号：EP2298344A4
公开(公告)日：2013-04-24
申请号：EP09758247
申请日：2009-05-27
申请人： CHEMO SERO THERAPEUT RES INST
发明人： MORIYAMA MAKOTO , KAMINAKA KAZUYOSHI , MATSUDA JUNICHI , NOZAKI CHIKATERU
IPC分类号： A61K39/39 , A61P31/04 , A61P31/06 , A61P31/14 , A61P31/16 , A61P31/20
CPC分类号： A61K39/00 , A61K2039/5252 , A61K2039/55588
摘要： A method for using inactivated Japanese encephalitis virus particles as an adjuvant of a vaccine is provided. A method for using inactivated Japanese encephalitis virus (JEV) particles as an adjuvant of various vaccines or a mixed vaccine, said JEW particles being obtained by inoculating JEV Beijing-1 strain to Vero cells, culturing said JEV-infected cells to give cultured cells or culture supernatant, purifying JEV particles from said cultured cells or culture supernatant and inactivating said JEV particles with formalin, a method for preparing a (mixed) vaccine which comprises a step of letting inactivated Japanese encephalitis virus be contained, and a mixed vaccine prepared by said method.

10. 发明公开

EP2149584A4 METHOD FOR ENHANCING IMMUNE RESPONSE WITH PEPTIDE 有权转让
标题翻译： VERFAHREN ZURVERSTÄRKUNGDER IMMUNREAKIT MIT EINEM PEPTID
公开(公告)号：EP2149584A4
公开(公告)日：2010-07-07
申请号：EP08751882
申请日：2008-04-18
申请人： CHEMO SERO THERAPEUT RES INST
发明人： MATSUDA JUNICHI , KAMINAKA KAZUYOSHI , NOZAKI CHIKATERU
IPC分类号： C07K14/47 , A61K31/711 , A61K38/00 , A61K39/00 , A61K48/00 , A61P25/28
CPC分类号： A61K39/0007 , A61K31/711 , C07K14/4711
摘要： An object of the present invention is to provide a safe and effective method for enhancing an immune response and a medicament for preventing or treating Alzheimer disease comprising amyloid ² peptide that induces an enhanced immune response. An amyloid ² peptide or a portion thereof with addition or insertion of cysteine and a method for enhancing an immune response using the peptide or a method for enhancing an immune response using the peptide together with an adjuvant. A medicament for preventing or treating Alzheimer disease comprising an amyloid ² peptide or a portion thereof that induces an enhanced immune response. A DNA vaccine, that may have the same effect, comprising the gene encoding an amyloid ² peptide or a portion thereof that induces an enhanced immune response with addition or insertion of cysteine.
摘要翻译：本发明的目的是提供一种用于增强免疫应答的安全有效的方法和用于预防或治疗阿尔茨海默病的药物，其包含诱导增强的免疫应答的淀粉样蛋白2肽。具有添加或插入半胱氨酸的淀粉样蛋白2肽或其部分以及使用肽增强免疫应答的方法或使用肽与佐剂一起增强免疫应答的方法。一种用于预防或治疗阿尔茨海默病的药物，其包含诱导增强的免疫应答的淀粉样蛋白2肽或其部分。可以具有相同效果的DNA疫苗，其包含编码淀粉样蛋白2肽或其部分的基因，其通过加入或插入半胱氨酸诱导增强的免疫应答。

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