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1. 发明专利

BRPI0614991A2 未知
公开(公告)号：BRPI0614991A2
公开(公告)日：2011-04-26
申请号：BRPI0614991
申请日：2006-08-17
申请人： HISAMITSU PHARMACEUTICAL CO
发明人： IWAHASHI HIDEAKI , OTA SHIGEO , MIYACHIKA TAKAFUMI , TSUTSUMI NOBUO
IPC分类号： A61F13/02
摘要： A patch permitting division of only its release sheet by simply pulling right and left, wherein detachment of the release sheet is easy. There is provided a patch comprising a stretchable support, a plaster applied substantially all over one major surface of the support and a release sheet attached to the whole surface of the plaster wherein only the release sheet is divided at a division zone by simply pulling right and left, and wherein one or two or more precut parts that open when the patch is pulled right and left are disposed in the neighborhood on the division zone.

2. 发明专利

AU2009210117A1 Adhesive patch 未知
公开(公告)号：AU2009210117A1
公开(公告)日：2009-08-06
申请号：AU2009210117
申请日：2009-01-22
申请人： HISAMITSU PHARMACEUTICAL CO
发明人： OTA SHIGEO , TSUTSUMI NOBUO , OKADA TOMOMI
IPC分类号： A61K31/618 , A61K9/70 , A61K47/32 , A61K47/34 , A61P17/00 , A61P29/00
摘要： An adhesive patch comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a woven fabric knitted in stockinette stitch on both sides having two or more rows of crimped polyethylene terephthalate multifilament yarns, the adhesive layer contains 25 to 50% by mass of a liquid organic ingredient and 25 to 50% by mass of a thermoplastic elastomer based on the total mass of the layer and contains 10% by mass or more of methyl salicylate as the liquid organic ingredient based on the total mass of the layer, and the storage elastic modulus (G') of the adhesive layer is 30000 to 75000 Pa at 10 rad/s and 37°C.

3. 发明专利

ES2530201T3 Parche que tiene lámina desprendible fácilmente separable 未知
公开(公告)号：ES2530201T3
公开(公告)日：2015-02-27
申请号：ES06782793
申请日：2006-08-17
申请人： HISAMITSU PHARMACEUTICAL CO
发明人： IWAHASHI HIDEAKI , OTA SHIGEO , TSUTSUMI NOBUO , MIYACHIKA TAKAFUMI
IPC分类号： A61F13/00 , A61F13/02
摘要： Un parche (1) que comprende un soporte estirable (2), una masa adhesiva (3) estratificada sustancialmente sobre toda una superficie del soporte (2) y una lámina desprendible (4) unida a toda la superficie de la masa adhesiva (3), en donde sólo la lámina desprendible (4) se divide en una zona (10) de división por simple tracción en direcciones opuestas debido a la diferencia en tasa de elongación entre la lámina desprendible (4) y el soporte (2), caracterizado porque están provistas a uno o ambos lados de la zona (10) de división una o más partes (20) de precorte que se abren cuando se aplica tracción en sentidos opuestos al parche (1), en donde la zona (10) de división está formada por una parte de corte somero, un parte de corte de perforación, una línea debilitada o una mortaja, y las partes (20) de precorte están provistas en una forma de abanico, un patrón recto, un patrón en forma de T en el cual el trazo longitudinal de una forma de T es paralelo a la dirección de tracción del parche y la punta de dicho trazo longitudinal está apuntada hacia la zona (10) de división, o bien patrón con forma de V o un patrón de arco de círculo que están provistos de manera convexa hacia las direcciones de tracción desde la zona (10) de división.

4. 发明专利

JPH11228398A AEROSOL PREPARATION 失效
公开(公告)号：JPH11228398A
公开(公告)日：1999-08-24
申请号：JP3598698
申请日：1998-02-18
申请人： HISAMITSU PHARMACEUTICAL CO
发明人： SHIROMIZU TOSHIHIRO , OTA SHIGEO , MUTA KAZUNORI
IPC分类号： A61K9/12 , A61K31/135 , A61K31/165 , A61K31/167 , A61P17/00
摘要： PROBLEM TO BE SOLVED: To provide an aerosol preparation stable for a long period manifesting humectant effects and sufficient immediate analgesic effectivity and capable of simply spraying on a wide range of parts. SOLUTION: This aerosol preparation comprising the stock solution composed of active ingredient, humectant and base and mixing with propellant in which the stock solution includes 0.1 to 3 wt.%. of lidocaine, 0.1 to 2 wt.%. of diphenhydramine and 1 to 10 wt.%. of crotamiton and 0.1 to 10 wt.%. of glycerin as the humectant, and the viscosity of the stock solution is 1 to 10 cSt.

5. 发明专利

JPH0776518A PATCH FOR EXAMINING TUMOR AND EXAMINING METHOD USING THE SAME 失效
公开(公告)号：JPH0776518A
公开(公告)日：1995-03-20
申请号：JP24645793
申请日：1993-09-07
申请人： HISAMITSU PHARMACEUTICAL CO
发明人： SHIMOZONO YUJI , OKAYAMA AKIRA , OTA SHIGEO , HIRASHIMA NOBUCHIKA , IMAYAMA SHUHEI
IPC分类号： A61B10/02 , A61B10/00 , A61K9/70 , G01N33/50
摘要： PURPOSE:To obtain an examining patch capable of extremely readily collecting a specimen without requiring surgical ablation or centesis suction on the surface of skin and without making a patient feel a pain. CONSTITUTION:A patch for examining tumor comprises a substrate layer and a tacky layer for releasing and immobilizing organism tissue, cells or another substance formed on the substrate layer. A patch for examining tumor further comprises a carrier for adsorbing and immobilizing a substance secreted from the organism tissue released and immobilized by the tacky layer or another substance. A method for examining tumor measures organism tissue, etc., released and immobilized or adsorbed and immobilized by the patch for examining tumor, by an immunologlcal method or chemical method. Even in the case of a tumor in a very initial, period to be difficult to judge, existence of tumor related antigen, tumor related marker and other tumor related substances can be confirmed and tumors can be diagnosed in an early stage.

6. 发明专利

JPH0632733A PATCH FOR ASSAYING ATOPIC DERMATITIS AND METHOD FOR TESTING ATOPIC DERMATITIS 失效
公开(公告)号：JPH0632733A
公开(公告)日：1994-02-08
申请号：JP35390192
申请日：1992-12-16
申请人： HISAMITSU PHARMACEUTICAL CO
发明人： SAIDA MASARU , SHIMOZONO YUJI , OTA SHIGEO , YONEMURA KEIJI , MUKAI MIZUE , OKAYAMA AKIRA , IMAYAMA SHUHEI
IPC分类号： A61K9/70 , A61K49/00 , G01N33/53
摘要： PURPOSE:To obtain the subject patch capable of assaying atopic dermatitides in a short time and simply without limiting a place by adsorbing a secretion type immunoglobulin A material secreted in vivo. CONSTITUTION:A polyurethane film or polyethylene film is used as a backing substrate and a blended mixture of polyisoprene rubber, rosin, silicone rubber, etc., is used as a tacky agent. The tacky agent is blended with a cellulose derivative, filter paper, nitrocellulose, etc., as an adsorption carrier having water retention to give a patch for testing atopic dermatitides. The patch, for example, is applied to skin, mucosa or a lesion for a fixed time, e.g. one minutes to 30 hours. A secreted material is adsorbed on the adsorption carrier of the patch and made into a solid phase. Then, sIgA in the secreted material is selectively measured by immunoassay.

7. 发明专利

JP2001328935A PATCH 失效
公开(公告)号：JP2001328935A
公开(公告)日：2001-11-27
申请号：JP2000148260
申请日：2000-05-19
申请人： HISAMITSU PHARMACEUTICAL CO
发明人： OTA SHIGEO , TSURUTA KIYOMI
IPC分类号： A61F13/02 , A61K9/70 , A61L15/58
摘要： PROBLEM TO BE SOLVED: To obtain a patch sufficiently preventing peeling during while attached, sufficiently controlling rash of the skin and an ache in peeling. SOLUTION: This patch is characterized in that the patch 1 is provided with a substrate 2 composed of synthetic fiber and an adhesive layer 3 laminated to the substrate, has 10-30 mm bending resistance and 0.25-1.2N probe tack value.

8. 发明专利

JP2001011062A THIAZOLE SIMULANT COMPOUND AND SKIN LOTION 失效
公开(公告)号：JP2001011062A
公开(公告)日：2001-01-16
申请号：JP2000182344
申请日：2000-06-16
申请人： HISAMITSU PHARMACEUTICAL CO
发明人： SAIDA MASARU , INOUE TOSHITAKA , TAGAMI YOSHIHIRO , BEPPU KOICHI , SHIMOZONO YUJI , MUKAI MIZUE , OTA SHIGEO
IPC分类号： C07D277/74 , A61K8/00 , A61K8/49 , A61K31/428 , A61K31/454 , A61P17/00 , A61P43/00 , A61Q19/00 , A61Q19/02 , C07D277/60 , C07D277/82 , A61K7/00 , A61K7/48
摘要： PROBLEM TO BE SOLVED: To obtain a new thiazole simulant compound inhibiting tyrosinase activity which has strong influence on biosynthesis of melanin, and useful as bleaching cosmetics. SOLUTION: This new compound is expressed by formula I wherein a ring X is a compound of formula II (wherein R1 is H, a halogen, a lower alkyl or the like) or III (wherein R2 is H, a halogen, a lower alkyl or the like); Y is a cyclic amino or is expressed by formula IV [wherein (n) is 1 to 5; R3 is expressed by formula V (wherein R4 and R5 are each H or a lower alkyl)]}, and is e.g. D [4-(2-benzothiazolylthio)butoxy]phenylacetic acid. The compound of formula I is obtained e.g. by treating 2-mercaptobenzothiazole with an alkali metal base (e.g. sodium hydride, etc.), in an inactive solvent (e.g. dimethylformamide, etc.), and then by reaction with p-(4-bromobutoxy) phenylacetic acid.

9. 发明专利

JP2000297033A CATAPLASM 失效
公开(公告)号：JP2000297033A
公开(公告)日：2000-10-24
申请号：JP10698299
申请日：1999-04-14
申请人： HISAMITSU PHARMACEUTICAL CO
发明人： OTA SHIGEO , HITANI SATOYUKI
IPC分类号： A61K9/70 , A61L15/58
摘要： PROBLEM TO BE SOLVED: To obtain a cataplasm made of a substrate and a hydrous paste layer and so designed that both the shearing tackiness and 50% modulus of the cataplasm satisfy given requirements, respectively, so as to be adequately prevented from being peeled off after applied and excellent in the accuracy of punching (cutting) operation in its production process. SOLUTION: This cataplasm is made up of a substrate and a hydrous paste layer laminated thereon, and satisfies such requirements as to be (A) 0.1-5 N/cm2 in the shearing tackiness determined according to the following procedure: a test piece of 25 mm width × 80 mm length is prepared from this cataplasm, such a portion of the hydrous paste layer as to be 25 mm width × 25 mm length is applied onto a test plate specified in accordance with the JIS Z 0237-1991 8.2.2 standard, the part thus applied is pressure-bonded under a force of 5 kgf for 15 min, and the test piece is then stressed at a rate of 300±30 mm/min using a tensile tester so as to align the centerline of the test piece with that of the chucks of the tester and also set the force applied onto the test piece in parallel to the centerline of the test piece until the applied part is peeled off or the test piece is broken, and (B) 0.1-5 N/cm in 50% modulus.

10. 发明专利

JPH06206805A TYROSINASE INHIBITOR AND EXTERNAL PREPARATION FOR SKIN USING THE SAME 失效
公开(公告)号：JPH06206805A
公开(公告)日：1994-07-26
申请号：JP36220092
申请日：1992-02-17
申请人： HISAMITSU PHARMACEUTICAL CO
发明人： SAIDA MASARU , INOUE TOSHITAKA , TAGAMI YOSHIHIRO , SHIMOZONO YUJI , MUKAI MIZUE , OTA SHIGEO
IPC分类号： A61K8/30 , A61K8/00 , A61K8/33 , A61K8/36 , A61K8/368 , A61K8/41 , A61K8/46 , A61K8/49 , A61K31/17 , A61K31/385 , A61K31/39 , A61K31/42 , A61K31/423 , A61K31/44 , A61K31/4406 , A61K31/4427 , A61K31/47 , A61P17/00 , A61P43/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/08 , B60D1/04 , B60D1/14 , C07D213/73 , C07D213/82 , C07D215/36 , C07D263/58 , C07D277/14 , C07D327/04 , C07D339/06 , C07D401/12 , A61K7/00 , A61K7/42 , A61K7/48
摘要： PURPOSE:To obtain an external preparation for skin, especially a beautifying cosmetic and an agent for preventing aging of skin, comprising an active ingredi ent having inhibitory action on tyrosinase activity. CONSTITUTION:An external preparation for skin comprises a tyrosinase activity inhibitor composed of (A) a heterocyclic compound such as a benzoxazole derivative of formula I [R1 and Y1 are H, halogen, alkyl, OH, alkoxy or CF3; Z is group of formula II (R2 and R3 are H or alkyl; n is 0-9); m is 1-8] or a thiourea derivative of formula II (X is CH or N; Y2 is H, halogen, lower alkyl or lower alkoxy; R4 is H, lower alkyl, substituted benzylalkoxycarbonylalkyl or indolylmethyl; R5 is lower alkyl) or (B) a di-tert-butyl-4-hydroxyphenyl derivative such as chalcone derivative of formula IV (R9 is H or lower alkyl; A5 is aromatic ring which may contain 1-3 substituent groups) or (C) a cinnamic acid derivative such as a compound of formula V (A7 is benzene ring or heterocyclic ring which may be replaced).

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