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1. 发明专利

ES2029759A6 PROCEDIMIENTO PARA PREPARAR DERIVADOS DE NAFTALENSULFONAMIDA Y DE ISOQUINOLINSULFONAMIDA. 未知
公开(公告)号：ES2029759A6
公开(公告)日：1992-09-01
申请号：ES8904335
申请日：1989-12-22
申请人： HIDAKA HIROYOSHI , TOBISHI YAKUHIN KABUSHIKI KAIS
发明人： HIDAKA HIROYOSHI , ISHIKAWA TOMOHIKO , HAGIWARA MASATOSHI , INOYE TSUTOMU , NAITO KENJI , SAKUMA OSAMU , YUASA MASAYUKI , MORITA TADASHI , TOSHIOKA TADASHI , UMEZAWA ISAO , INABA TAKASHI
IPC分类号： C07C311/16 , C07D217/02 , C07D217/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D491/10 , C07D217/12 , C07D295/12
摘要： PROCEDIMIENTO PARA PREPARAR DERIVADOS DE NAFTALEN-5 SULFONAMIDA Y DE ISOQUINOLINSULFONAMIDA DE FORMULA FORMULA DONDE Y REPRESENTA N, NSI3 C-N O CH; RSI1 REPRESENTA HIDROGENO O UN GRUPO ORGANICO Y RSI2 REPRESENTA UN GRUPO ORGANICO AROMATICO. COMPRENDE HACER REACCIONAR UN COMPUESTO DE FORMULA (IV) CON UN COMPUESTO DE FORMULA (V) FORMULA DONDE Y Y RSI1 SON COMO ANTES, W, X Y B REPRESENTAN UN GRUPO ORGANICO, RSI3 Y RSI7 REPRESENTAN HIDROGENO O UN GRUPO ORGANICO, RSI5 REPRESENTA HIDROGENO, HALOGENO, NITRO O UN GRUPO ORGANICO, RSI6 REPRESENTA HIDROGENO, HALOGENO O ALCOXI, AR REPRESENTA UN GRUPO AROMATICO Y M VALE 1 A 3, SEGUIDO POR REACCIONES OPCIONALES DE REDUCCION, ALQUILACION Y CONVERSION. LOS COMPUESTOS OBTENIDOS SON UTILES COMO RELAJANTES DE LOS MUSCULOS LISOS DE LOS VASOS Y COMO INHIBIDORES DE LA AGREGACION DE LAS PLAQUETAS.

2. 发明专利

DK175678B1 未知
公开(公告)号：DK175678B1
公开(公告)日：2005-01-17
申请号：DK666289
申请日：1989-12-22
申请人： HIDAKA HIROYOSHI , TOBISHI PHARMACEUTICAL CO
发明人： HIDAKA HIROYOSHI , ISHIKAWA TOMOHIKO , HAGIWARA MASATOSHI , INOUE TSUTOMU , NAITOH KENJI , SAKUMA OSAMU , YUASA MASAYUKI , MORITA TADASHI , TOSHIOKA TADASHI , UMEZAWA ISAO , INABA TAKASHI
IPC分类号： C07C311/16 , C07D217/02 , C07D217/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D491/10 , A61K31/47
摘要： Novel quinoline sulfonamino derivatives having a vessel smooth muscle relaxation activity as well as a platelet agglutination inhibitory activity and inhibitory activity to protein kinase A, myosin light chain kinase, proteinkinase C, and calmodulindependent proteinkinase II, but having little action or cardio function; a process for the production of the derivatives, and a pharmaceutical composition containing the derivative.

3. 发明专利

NL194549B 未知
公开(公告)号：NL194549B
公开(公告)日：2002-03-01
申请号：NL9900004
申请日：1999-05-17
申请人： HIDAKA HIROYOSHI , TOBISHI PHARMACEUTICAL CO
发明人： HIDAKA HIROYOSHI , ISHIKAWA TOMOHIKO , HAGIWARA MASATOSHI , INOUE TSUTOMU , NAITO KENJI , SAKUMA OSAMU , YUASA MASAYUKI , MORITA TADASHI , TOSHIOKA TADASHI , UMEZAWA ISAO , INABA TAKASHI
IPC分类号： C07C311/16 , C07D217/02 , C07D217/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D491/10 , A61K31/47

4. 发明专利

DE69011246D1 未知
公开(公告)号：DE69011246D1
公开(公告)日：1994-09-08
申请号：DE69011246
申请日：1990-08-31
申请人： HIDAKA HIROYOSHI , TOBISHI YAKUHIN KOGYO K K
发明人： HIDAKA HIROYOSHI , ISHIKAWA TOMOHIKO , INOUE TSUTOMU , YUASA MASAYUKI , INABA TAKASHI , NAITO KENJI , SAKUMA OSAMU , MORITA TADASHI , KIDOKORO SHINPEI
IPC分类号： C07D495/04 , C07D495/14 , A61K31/435
摘要： Novel compounds represented by the formula: wherein R1 represents an alkyl group having 1 to 3 carbon atoms, R2 represents an amino group or a group of formula in which R4 represents an alkyl group having 1 to 3 carbon atoms, R5 represents an alkyl group having 1 to 3 carbon atoms or may combine with R6 to form a five or six membered ring containing 4 to 5 carbon atoms, R6 represents a hydrogen atom or may combine with R5 to form a five or six membered ring containing 4 to 5 carbon atoms, R3 represents a hydrogen atom, an alkyl group having 1 to 3 carbon atoms or a halogen atom, X represents a carbonyl group or a methylene group, Y represents a sulfur atom or a vinylene group and pharmaceutically acceptable salts thereof which exhibit a vasodilating activity and inhibitory activity for platelet aggregation. Thus, they are useful as therapeutic agents for treatment of angina pectoris, hypertension, thrombosis and the like.

5. 发明专利

CA2005741C QUINOLINE SULFONOAMINO COMPOUNDS HAVING VESSEL SMOOTH MUSCLE RELAXATION ACTIVITY 未知
公开(公告)号：CA2005741C
公开(公告)日：1998-06-02
申请号：CA2005741
申请日：1989-12-15
申请人： HIDAKA HIROYOSHI , TOBISHI PHARMACEUTICAL CO
发明人： ISHIKAWA TOMOHIKO , HAGIWARA MASATOSHI , INOUE TSUTOMU , NAITOH KENJI , SAKUMA OSAMU , YUASA MASAYUKI , MORITA TADASHI , TOSHIOKA TADASHI , UMEZAWA ISAO , INABA TAKASHI , HIDAKA HIROYOSHI
IPC分类号： C07C311/16 , C07D217/02 , C07D217/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D491/10 , C07D401/00 , C07D413/00
摘要： The present invention discloses a compound represented by the formula: (see fig. I) wherein R1 is selected from the group consisting of a hydrogen atom, a lower alkyl, an amino-substituted lower alkyl, a dimethyl amino-substituted lower alkyl, an acetoxy-substituted lower alkyl and a hydroxy-substituted lower alkyl; R10 is selected from the group consisting of a hydrogen atom, hydroxy, a lower alkoxy, benzyloxy, methylphenylsulfonyloxy, isoquinolylsulfonyloxy, naphthylsulfonyloxy, amino, methylamino, isoquinolylsulfonylamino, methyl/isoquinolylsulfonyldisubstituted amino, phthalidyl, nitro, methylsulfonylamino, methyl/methylsulfonyl-disubstituted amino, methyl naphthyl-sulfonyl-disubstituted amino, and methyl/methylphenylsulfonyldisubstituted amino; R11 is selected from the group consisting of a hydrogen atom, hydroxy and benzyloxy; R12 and R13 are hydrogen atom, or together form a carbonyl group; and R14 is selected from the group consisting of a hydrogen atom, phenyl, halogen-substituted phenyl, methyl phenyl, methoxy phenyl, phenylcarbonyl, benzylcarbonyl, phenylethylcarbonyl, butoxycarbonyl, benzylaminocarbonyl, benzyloxycarbonyl, aralkyl, phenylsulfonyl, benzylsulfonyl, isoquinolylsulfonyl, and phenylaminocarbonyl. Such compounds have a vessel smooth muscle relaxation activity as well as a platelet agglutination inhibitory activity and inhibitory activity to protein kinase A, myosin light chain kinase, proteinkinase C, and calmodul-independent proteinkinase II, but have little action or cardio function.

6. 发明专利

GB2228933A N-substituted isoquinolinyl-or naphthyl-sulphonamides 未知
公开(公告)号：GB2228933A
公开(公告)日：1990-09-12
申请号：GB8928895
申请日：1989-12-21
申请人： HIDAKA HIROYOSHI , TOBISHI PHARMACEUTICAL CO
发明人： HIDAKA HIROYOSHI , ISHIKAWA TOMOHIKO , HAGIWARA MASATOSHI , INOUE TSUTOMU , NAITO KENJI , SAKUMA OSAMU , YUASA MASAYUKI , MORITA TADASHI , TOSHIOKA TADASHI , UMEZAWA ISAO , INABA TAKASHI
IPC分类号： C07C311/16 , C07D217/02 , C07D217/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D491/10
摘要： Novel sulfonamine derivatives have a vessel smooth muscle relaxation activity as well as a platelet agglutination inhibitory activity and inhibitory acitivity to protein kinase A, myosin light chain kinase, proteinkinase C, and calmodulindependent proteinkinase II. The compounds are of formula I wherein Y is CH or N; R1 is H, an optionally substitued alkyl aryl or aralkyl group, formyl or halophenyl propargyl; R2 a group of formula II wherein R3 represents hydrogen, an optionally substituted alkyl aryl or aralkyl group, formyl, or halophenyl propargyl; or R1 and R3 together form an alkylene group; R4 represents hydrogen or lower alkyl group; R5 represents hydrogen, halogen, nitro, alkyl, optionally substituted hydroxyl, optionally N-substituted amino, optionally substituted carboxy, polyfluoro alkyl, cyano, hydroxymethyl, methylthio, methylsulfinyl or methylsulfonyl; R6 represents hydrogen, halogen or alkoxy; or R5 and R6 together form an alkylenedioxy group; R7 represents hydrogen or alkoxy; X represents vinylene or ethynylene; Ar represents phenyl, naphthyl or heteroaryl; m represents 1 to 3; and W represents alkylene, optionally substituted phenylene or optionally substituted phenylene- alkylene; or R2 is a group of formula III wherein R10 represents hydrogen, nitro, optionally substituted amino, optionally substituted hydroxyl, alkyl, or halogen; or R1 and R10 together form an alkylene group; R11 represents hydrogen, hydroxyl or alkoxy; R12 and R13 each represent hydrogen, or together represent = 0; Ar has the same meaning as defined under (II); n represents 1 to 3; and A represents > CR14R15 or > NR14; wherein R14 represents hydrogen, optionally substituted hydroxy, optionally substituted phenyl, acyl, optionally substituted alkoxy-carbonyl, substituted carbamoyl, optionally substituted amino, arylsulfonyl, aralkylsulfonyl, aralkyl, or a heterocyclyl group; and R15 represent hydrogen or alkyl, or R15 and R14 together represent alkylenedioxy or = 0; and quaternary ammonium salts, or salts of the compound of the formula (I).

7. 发明专利

DE3942114A1 New isoquinoline:sulphonamide and naphthalene:sulphonamide cpds. 未知
公开(公告)号：DE3942114A1
公开(公告)日：1990-06-28
申请号：DE3942114
申请日：1989-12-20
申请人： HIDAKA HIROYOSHI , TOBISHI PHARMACEUTICAL CO
发明人： HIDAKA HIROYOSHI , ISHIKAWA TOMOHIKO , HAGIWARA MASATOSHI , INOUE TSUTOMU , NAITOH KENJI , SAKUMA OSAMU , YUASA MASAYUKI , MORITA TADASHI , TOSHIOKA TADASHI , UMEZAWA ISAO , INABA TAKASHI
IPC分类号： C07C311/16 , C07D217/02 , C07D217/10 , C07D233/64 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D491/10
摘要： Bicyclic sulphonamides and their addn. and quat. salts are new: where Y = N, N-CH3 or CH; R1 = H, opt. substd. lower alkyl, formyl, halophenylpropargyl, opt. substd. aralkyl or opt. substd. phenyl; and R2 = -W-N(R3)-CH(R4)-(X)m-Ar(R5)(R6)(R7) (II) or (III); R3 = H, opt. substd. lower alkyl, formyl, halophenylpropargyl, opt. substd. aralkyl or opt. substd. phenyl or R3 + R1 = lower alkylene; R4 = H or lower alkyl; R5 = H, halogen, nitro, lower alkyl, opt. substd. hydroxyl, opt. N-substd. amino, opt. substd. carboxy, polyfluoro-lower alkyl, cyano, hydroxymethyl, methylthio, methylsulphinyl or methylsulphonyl; and R6 = H, halogen or lower alkoxy; or R5 + R6 = lower alkylenedioxy; R7 = H or lower alkoxy; X = vinylene or ethynylene; Ar = phenyl, naphthyl or heterocyclyl gp.; m = 1-3; W = lower alkylene, opt. substd. phenylene or opt. substd. phenylene-lower alkylene; R10 = H, nitro, opt. substd. amino, opt. substd. hydroxyl, lower alkyl or halogen or R10 + R1 = lower alkylene; R11 = H, hydroxyl or lower alkoxy; R12 = R13 = H or R12+R13 = oxo; n = 1-3; A = CR14R15 or NR14; R14 = H, opt. substd. hydroxyl, opt. substd. phenyl, acryl, substd. carbonyl, opt. substd. alkoxycarbonyl, substd. carbamoyl, opt. substd. amino, arylsulphonyl, aralkylsulphonyl, aralkyl or heterocyclyl gp.; and R15 = H or lower alkyl; or R14+R15 = alkylenedioxy or oxo.

8. 发明专利

IT8968178D0 未知
公开(公告)号：IT8968178D0
公开(公告)日：1989-12-22
申请号：IT6817889
申请日：1989-12-22
申请人： HIDAKA HIROYOSHI , TOBISHI PHARMACEUTICAL CO
发明人： HIDAKA HIROYOSHI , ISHIKAWA TOMOHIKO , HAGIWARA MASATOSHI , INOUE TSUTOMU , NAITO KENJI , SAKUMA OSAMU , YUASA MASAYUKI , MORITA TADASHI , TOSHIOKA TADASHI , UMEZAWA ISAO , INABA TAKASHI
IPC分类号： C07C311/16 , C07D217/02 , C07D217/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D491/10 , A61K

9. 发明专利

DK666289D0 未知
公开(公告)号：DK666289D0
公开(公告)日：1989-12-22
申请号：DK666289
申请日：1989-12-22
申请人： HIDAKA HIROYOSHI , TOBISHI PHARMACEUTICAL CO
发明人： HIDAKA HIROYOSHI , ISHIKAWA TOMOHIKO , HAGIWARA MASATOSHI , INOUE TSUTOMU , NAITO KENJI , SAKUMA OSAMU , YUASA MASAYUKI , MORITA TADASHI , TOSHIOKA TADASHI , UMEZAWA ISAO , INABA TAKASHI
IPC分类号： C07C311/16 , C07D217/02 , C07D217/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D491/10 , C07D217/12 , C07D295/12 , C07D295/20
摘要： Novel quinoline sulfonamino derivatives having a vessel smooth muscle relaxation activity as well as a platelet agglutination inhibitory activity and inhibitory activity to protein kinase A, myosin light chain kinase, proteinkinase C, and calmodulindependent proteinkinase II, but having little action or cardio function; a process for the production of the derivatives, and a pharmaceutical composition containing the derivative.

10. 发明专利

NL193726C 未知
公开(公告)号：NL193726C
公开(公告)日：2000-08-04
申请号：NL8903143
申请日：1989-12-22
申请人： TOBISHI PHARMACEUTICAL CO , HIDAKA HIROYOSHI
发明人： HIDAKA HIROYOSHI , ISHIKAWA TOMOHIKO , HAGIWARA MASATOSHI , INOUE TSUTOMU , NAITOH KENJI , SAKUMA OSAMU , YUASA MASAYUKI , MORITA TADASHI , TOSHIOKA TADASHI , UMEZAWA ISAO , INABA TAKASHI
IPC分类号： C07C311/16 , C07D217/02 , C07D217/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D491/10 , C07D295/13 , A61K31/47 , A61K31/495
摘要： Novel quinoline sulfonamino derivatives having a vessel smooth muscle relaxation activity as well as a platelet agglutination inhibitory activity and inhibitory activity to protein kinase A, myosin light chain kinase, proteinkinase C, and calmodulindependent proteinkinase II, but having little action or cardio function; a process for the production of the derivatives, and a pharmaceutical composition containing the derivative.

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