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    • 3. 发明申请
    • NOVEL DNA SEQUENCES, VECTORS AND PROTEINS OF AVIAN INFLUENZA HEMAGGLUTININ
    • AVIAN INFLUENZA HEMAGGLUTININ的新型DNA序列,载体和蛋白
    • WO2007149715A3
    • 2008-07-24
    • PCT/US2007070755
    • 2007-06-08
    • DOW AGROSCIENCES LLCHENRY MATTHEWLARRINUA IGNACIO MRUSSELL SEAN M
    • HENRY MATTHEWLARRINUA IGNACIO MRUSSELL SEAN M
    • A61K39/12A61K39/145
    • A61K39/145A61K39/12A61K2039/517A61K2039/545C07K14/005C07K2319/00C12N15/8258C12N2760/16122C12N2760/16134
    • The subject invention provides novel amino acid sequences (including a consensus sequence) of the Avian Influenza A virus hemagglutinin protein. These newly constructed genes are designed to provide a broader spectrum of activity across the serotype family thus providing a basis for a vaccine that has broad heterologous disease protection. The novel genes have been further improved by the addition of strategic glycosylation sites into the amino acids sequences that they encode. These genes can also, optionally, be codon optimized for plant expression, inserted into the appropriate vector and cloned into plants for expression. Polypeptides produced by recombinant host cells or transgenic plants can also be used as source of antigen for the formulation of vaccines for the control of influenza in susceptible individuals. Additionally, transgenic plant material may also be used as source of antigen for the formulation of vaccines for the control of influenza in susceptible individuals.
    • 本发明提供禽流感A病毒血凝素蛋白的新型氨基酸序列(包括共有序列)。 这些新构建的基因被设计为提供跨血清型家族的更广泛的活性范围,从而为具有广泛异源疾病保护的疫苗提供基础。 通过在其编码的氨基酸序列中加入战略糖基化位点,进一步改善了这些新基因。 这些基因也可任选地优化用于植物表达的密码子,插入合适的载体中并克隆到植物中用于表达。 通过重组宿主细胞或转基因植物产生的多肽也可以用作疫苗来源,用于制定用于控制易感个体中的流感的疫苗。 另外,转基因植物材料也可以用作疫苗的来源,用于制定用于控制易感个体中的流感的疫苗。
    • 6. 发明申请
    • LASER MULTIPLEXING
    • 激光多路复用
    • WO2005081372A3
    • 2005-12-08
    • PCT/GB2005000608
    • 2005-02-21
    • POWERLASE LTDCOMLEY ANDREW JAMESELLWI SAMIR SHAKIRHAY NICKHENRY MATTHEW
    • COMLEY ANDREW JAMESELLWI SAMIR SHAKIRHAY NICKHENRY MATTHEW
    • B23K26/06B23K26/067G02B3/00G02B27/09G03F7/20H01S3/00H05G2/00
    • G02B27/0955B23K26/0604B23K26/0608B23K26/067B82Y10/00G02B27/0905G02B27/0972G03F7/70033G03F7/7005
    • A laser multiplexing system and method for use with high power pulsed lasers in Extreme Ultraviolet Lithography i.e. EUL. In a first embodiment, a high power EUV laser multiplexing element (200) for laser produced plasma generation comprises a compound lens comprising at least two focusing elements (210) arranged to focus at least two respective laser beams (208) to a focal point (204) on a common workpiece. In a second embodiment, a laser multiplexing apparatus comprises at least two pulsed laser sources for generating pulsed laser beams and a temporal multiplexing element (302) arranged to temporally interleave at least two pulsed laser beams (300). In a third embodiment, laser multiplexing assembly comprises a beam shaping element (401) in which the beam shaping element is arranged to direct a first laser beam (406a) along an axis common with a second laser beam (406b) axis onto a common focussing element (405) arranges about said common axis.
    • 用于极紫外光刻技术(EUL)的大功率脉冲激光器的激光复用系统和方法。 在第一实施例中,用于激光产生等离子体产生的高功率EUV激光多路复用元件(200)包括复合透镜,该复合透镜包括至少两个聚焦元件(210),其被布置成将至少两个相应的激光束(208)聚焦到焦点 204)在公共工件上。 在第二实施例中,激光多路复用装置包括用于产生脉冲激光束的至少两个脉冲激光源和设置成在时间上交错至少两个脉冲激光束(300)的时间多路复用元件(302)。 在第三实施例中,激光多路复用组件包括光束成形元件(401),其中光束成形元件布置成沿着与第二激光束(406b)轴线共同的轴将第一激光束(406a)引导到公共聚焦 元件(405)围绕所述公共轴线布置。