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    • 6. 发明专利
    • Topical cosmetic and dermatological composition containing alkylurea and other active agent, useful for treating e.g. ageing of the skin and pigmentation disorders
    • DE102005026357A1
    • 2006-12-28
    • DE102005026357
    • 2005-06-07
    • HENKEL KGAA
    • DOERING THOMASTRAEGER ANEMONEWALDMANN-LAUE MARIANNEWADLE ARMIN
    • A61K8/49A61K8/34A61K8/362A61K8/44A61K8/60A61K8/66A61K8/67A61K8/97A61Q17/00A61Q19/06A61Q19/08
    • Topical cosmetic or dermatological composition (X) contains at least one hydroxyalkylurea (A) and at least one other active agent (B). Topical cosmetic or dermatological composition (X) contains at least one hydroxyalkylurea of formula (A) and at least one other active agent (B). R 1R 2N-CO-NR 3R 4 (A) (B) is: (a) a monomer, oligomer or polymer of (2-24C acyl) amino acids, their esters and/or metal salts; (b) DNA or RNA oligonucleotides; (c) natural betaines; (d) (pro)vitamins or their precursors of groups A, B, C, E, H or K and their esters; (e) alpha - or beta -hydroxy- or alpha -keto-carboxylic acids, or their esters, lactones or salts (excluding compositions containing 5wt.% 2-hydroxyethylurea and 0.05-5wt.% ammonium lactate or those containing 2-hydroxypropylurea and alpha - and/or beta -hydroxyacids); (f) specified flavonoids (e.g. naringin, alpha -glucosylquercitin, hesperidin or rutin); (g) isoflavonoids and plant extracts rich in them; (h) ubiquinone, ubiquinol and their derivatives; (i) silymarin; (j) natural xanthine derivatives, e.g. caffeine, theophylline, theobromine and aminophylline; (k) ectoin; (l) creatine; (m) olive leaf extracts, ursolic acid, olive oil and/or oleanolic acid; (n) mono- and poly-hydroxystilbenes and their esters; (o) derivatives of methylated silanol; (p) phytic acid; (q) maize or (r) oats kernel extracts; (s) Saccharomyces, xylinum, black tea ferment; (t) apple or (u) lotus seed extracts; (v) red wine extract; (w) grape seed extract, preferably of the Chardonnay strain; (x) extract of Sambucus nigra flowers; (y) agents that stimulate beta -endorphin synthesis in keratinocytes; (z) (in)organic UV filters; (aa) self-tanning agents; (bb) skin-lightening agents; (cc) agents that inhibit synthesis of prostaglandins (PG) and/or leukotrienes (LT); (dd) sebum-regulating agents and (ee) polysaccharides that contain deoxysugars or their components. R 1-R 4hydrogen, 1-4C alkyl, 2-6C hydroxyalkyl with 1-5 hydroxy groups, or 1-4C hydroxyalkyl, provided that at least one is hydroxyalkyl. ACTIVITY : Dermatological. No details of tests for dermatological activity are given. MECHANISM OF ACTION : None given.
    • 8. 发明专利
    • Cosmetic or dermatological composition for topical skin treatment, used e.g. to increase epidermal thickness, contains a Vitamin B6 component and a compound that stimulates collagen synthesis
    • DE102005063179A1
    • 2006-09-28
    • DE102005063179
    • 2005-12-30
    • HENKEL KGAA
    • TRAEGER ANEMONEWALDMANN-LAUE MARIANNEJASSOY CLAUDIAKESLER-BECKER DANIELAHOLTKOETTER OLAF
    • A61K8/97A61K8/43A61K8/49A61K8/63A61K8/64A61K8/67A61K8/99A61K38/01A61Q17/00A61Q19/00
    • Cosmetic or dermatological composition (A) for topical treatment of the skin comprises, in a suitable carrier, at least one Vitamin B6 component (I) and, the new feature, at least one agent (II) that stimulates synthesis of collagen. Cosmetic or dermatological composition (A) for topical treatment of the skin comprises, in a suitable carrier, at least one Vitamin B6 component (I) and, the new feature, at least one agent (II) that stimulates synthesis of collagen. (II) is: (a) a soya protein hydrolyzate (SPH) with mean molecular weight 600-1000, preferably 800, D; (b)hydroxyproline N-acylated and esterified with two, preferably linear 2-22C fatty acid residues, especially dipalmitoylhydroxyproline; (c) the tripeptides Gly-His-Lys, Lys-Val-Lys, Lys-Val-Dab (= diaminobutyric acid), Lys-Phe-Lys, Lys-Ile-Lys, Dab-Val-Lys, Lys-Val-Orn (= ornithine), Lys-Val-Dap (=diaminopropionic acid), Dap-Val-Lys or Gly-His-Arg; (d) the tetrapeptides Gly-Gln-Pro-Arg (rigin), Gly-Gln-Arg-Pro, Val-Val-Arg-Pro, rigin analogs and ALAM-CAT peptides; (e) Lys-Thr-Thr-Lys-Ser; (f) Val-Gly-Val-Ala-Pro-Gly, Ala-Asp-Leu-Lys-Pro-Thr, and hexapeptides 4 to 10; (g) any of (c)-(f) N-acylated and/or esterified with at least one, preferably linear, 2-22C fatty acid residue, especially N-palmitoyl-Gly-His-Lys, N-palmitoyl-Lys-Val-Lys, N-myristoyl-Gly-His-Arg, N-palmitoyl-Gly-Gln-Pro-Arg, N-palmitoyl-Lys-Thr-Thr-Lys-Ser, N-palmitoyl-Val-Gly-Val-Ala-Pro-Gly, acetyl-hexapeptide-3, myristoyl hexapeptide-5 or -8, and mixtures of N-palmitoyl-Gly-His-Lys and N-palmitoyl-Gly-Gln-Pro-Arg; (h) retinoids, especially retinol and its 2-22C fatty acid esters; (i) Saccharomyces/xylinum/black tea ferment; (j) olive leaf extract; (k) oleanolic acid; (l) oleanol; (m) oat kernel extract; (n) liposome-encapsulated green tea extract; and/or (o) creatine. Independent claims are also included for the following: (1) similar composition (A1) that contains (I) and at least one agent (III) that increases/improves interaction between the extracellular matrix (ECM) and fibroblasts; (2) similar composition (A2) that contains (I) and an additional cosmetic agent (IV); and (3) similar composition (A3) that contains (I), SPH of mean molecular weight 1200-1800, preferably 1400-1700, D; SPH of mean molecular weight 600-1000, preferably 800, D and a wheat protein hydrolyzate. ACTIVITY : Dermatological. No details of tests for dermatological activity are given. MECHANISM OF ACTION : Stimulating biosynthesis of collagent and/or increasing interaction between extracellular matrix and fibroblasts.