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1. 发明申请

WO2010060996A3 PREDICTION OF LIPID-METABOTYPE-RELATED PHYSIOLOGICAL SUSCEPTIBILITIES 审中-公开
标题翻译：脂肪代谢相关生理学可能性的预测
公开(公告)号：WO2010060996A3
公开(公告)日：2010-08-12
申请号：PCT/EP2009066003
申请日：2009-11-27
申请人： HELMHOLTZ ZENTRUM MUENCHEN , SUHRE KARSTEN , GIEGER CHRISTIAN
发明人： SUHRE KARSTEN , GIEGER CHRISTIAN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： The present invention relates to a method for determining a predisposition of a human subject for physiological susceptibilities that result from alterations in lipid metabolism, wherein the physiological susceptibilities are selected from sensitivity to functional food, physical health schemes, identification of non-responsiveness to treatment by diet or physical activity. The present invention further relates to a method for determining a predisposition of a human subject for physiological susceptibilities that result from alterations in lipid metabolism, wherein the physiological susceptibilities are selected from sensitivity to drug treatment or identification of non- responsiveness to treatment by medication. The methods of the present invention comprise determining, in a sample obtained from the human subject, the genotype of that person with respect to at least two genetic polymorphisms selected from the group consisting of a) rs2014355; b) rs11161510; c) rs2286963; d) rs174548; e) rs9393903; f) rs168622; g) rs541503; h) rs2046813; i) rs272889; j) rs2216405; k) rs7156144; l) rs8396; m) rs7094971; and n) rs603424; wherein the presence of one or two copies of the minor allele of at least two genetic polymorphisms is indicative of a predisposition for said physiological susceptibilities. The polymorphisms listed above are located in the following genes: SCAD, MCAD, LCAD, FADS1, EL0VL2, SPTLC3, PHGDH, ACSL1, OCTN1, CPS1, PLEKHH1, ETFDH, SLC16A9 and SCD.
摘要翻译：本发明涉及一种用于确定人类受试者对由脂质代谢改变引起的生理敏感性的易感性的方法，其中所述生理敏感性选自对功能性食物的敏感性，身体健康方案，对对治疗的无反应性的鉴定饮食或身体活动。本发明还涉及一种用于确定人类受试者对由脂质代谢改变引起的生理敏感性的倾向的方法，其中所述生理敏感性选自药物治疗的敏感性或通过药物治疗的不敏感性。本发明的方法包括在从人受试者获得的样品中确定该人对于至少两种选自以下的遗传多态性的基因型：a）rs2014355; b）rs11161510; c）rs2286963; d）rs174548; e）rs9393903; f）rs168622; g）rs541503; h）rs2046813; i）rs272889; j）rs2216405; k）rs7156144; l）rs8396; m）rs7094971; 和n）rs603424; 其中至少两个遗传多态性的次要等位基因的一个或两个拷贝的存在表示所述生理敏感性的易感性。以上列出的多态性位于以下基因：SCAD，MCAD，LCAD，FADS1，EL0VL2，SPTLC3，PHGDH，ACSL1，OCTN1，CPS1，PLEKHH1，ETFDH，SLC16A9和SCD。

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