专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1995027708A1 PREPARATION OF 10-DEACETYLBACCATIN III AND 7-PROTECTED-10-DEACETYLBACCATIN III DERIVATIVES FROM 10-DEACETYL TAXOL A, 10-DEACETYL TAXOL B, AND 10-DEACETYL TAXOL C 审中-公开
标题翻译： 10-脱乙酰氨基丁三醇和7-保护的10-脱乙酰氨基三乙酸衍生物的制备从10-脱乙酰壳多糖A，10-脱乙酰壳多糖B和10-脱乙酰壳多糖
公开(公告)号：WO1995027708A1
公开(公告)日：1995-10-19
申请号：PCT/US1995004172
申请日：1995-04-05
申请人： HAUSER CHEMICAL RESEARCH, INC.
发明人： HAUSER CHEMICAL RESEARCH, INC. , ZHENG, Qun, Y. , MURRAY, Christopher, K.
IPC分类号： C07D305/14
CPC分类号： C07D305/14 , Y02P20/55
摘要： The present invention relates to a process for converting purified, partially purified or crude taxane mixtures into a protected precursor of 10-deacetylbaccatin III and into 10-deacetylbaccatin III. The process comprises three steps, the first of which includes contacting a mixture containing at least one naturally occurring taxane compound having the structure (II) in which R1 is phenyl, (a), or n-C5H11 with at least one hydroxy protecting group. The second step involves cleaving the ester linkage of the protected taxane thus giving rise to a protected precursor of 10-deacetylbaccatin III, the deprotection of which leads to 10-deacetylbaccatin III.
摘要翻译：本发明涉及一种将纯化的，部分纯化的或粗制的紫杉烷混合物转化成10-脱乙酰基浆果赤霉素III的受保护的前体并转化为10-脱乙酰基浆果赤霉素III的方法。该方法包括三个步骤，第一步包括将含有至少一种具有结构（II）的天然存在的紫杉烷化合物的混合物与其中的R 1为苯基，（a）或n-C 5 H 11与至少一个羟基保护基团接触。第二步涉及切割受保护的紫杉烷的酯键，从而产生10-脱乙酰基浆果赤霉素III的被保护的前体，其脱保护得到10-脱乙酰基浆果赤霉素III。

2. 发明申请

WO1997001548A1 ARTEMISININ DIMER COMPOUNDS HAVING ANTICANCER ACTIVITY 审中-公开
标题翻译：具有抗病毒活性的阿司匹林二异氰酸酯化合物
公开(公告)号：WO1997001548A1
公开(公告)日：1997-01-16
申请号：PCT/US1996011163
申请日：1996-06-27
申请人： HAUSER CHEMICAL RESEARCH, INC.
发明人： HAUSER CHEMICAL RESEARCH, INC. , ZHENG, Qun, Y. , DARBIE, Lynn, G.
IPC分类号： C07D321/02
CPC分类号： C07D519/00 , A61K47/55
摘要： Novel artemisinin dimers of structure (IV) which possess anticancer activity.
摘要翻译：具有抗癌活性的结构（IV）的新型青蒿素二聚体。

3. 发明申请

WO1996028435A1 CEPHALOMANNINE EPOXIDE, ITS ANALOGUES AND A METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：环丙沙星环氧化物，其类似物及其制备方法
公开(公告)号：WO1996028435A1
公开(公告)日：1996-09-19
申请号：PCT/US1996003242
申请日：1996-03-08
申请人： HAUSER CHEMICAL RESEARCH, INC.
发明人： HAUSER CHEMICAL RESEARCH, INC. , ZHENG, Qun, Y. , MURRAY, Christopher, K. , DAUGHENBAUGH, Randall, J.
IPC分类号： C07D305/14
CPC分类号： C07D407/12 , C07D305/14
摘要： An antitumor compound of formula (5), in which R = Ac or H, and R1 = R2 = an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu, R3 = H; R1 = R2 = R3 = H; R1 = an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu, R2 = R3 = H; R1 = R3 = H, R2 = an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu; R1 = H, R2 = R3 = an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu; R1 = R2 = R3 = an alkyl group Me, Et, Pr, i-Pr, n-Bu or t-Bu. Me is an abbreviation for methyl, Et is ethyl, Pr is propyl, i-Pr is isopropyl, n-Bu is n-butyl, and t-Bu is tert-butyl. Also provided by the invention is a one-step method of preparing a compound of formula (5) whereby a taxane having a tiglate group attached to the side chain is contacted with an oxidizing reagent resulting in the formation of an epoxide having antitumor activity.
摘要翻译：式（5）的抗肿瘤化合物，其中R = Ac或H，且R1 = R2 =烷基，例如Me，Et，Pr，i-Pr，n-Bu或t-Bu，R3 = H; R1 = R2 = R3 = H; R1 =烷基，例如Me，Et，Pr，i-Pr，n-Bu或t-Bu，R2 = R3 = H; R1 = R3 = H，R2 =烷基，例如Me，Et，Pr，i-Pr，n-Bu或t-Bu; R1 = H，R2 = R3 =烷基，例如Me，Et，Pr，i-Pr，n-Bu或t-Bu; R1 = R2 = R3 =烷基Me，Et，Pr，i-Pr，n-Bu或t-Bu。 Me是甲基的缩写，Et是乙基，Pr是丙基，i-Pr是异丙基，n-Bu是正丁基，t-Bu是叔丁基。本发明还提供一种制备式（5）化合物的一步法，其中具有连接在侧链上的特加根基的紫杉烷与氧化剂接触，导致形成具有抗肿瘤活性的环氧化物。

4. 发明申请

WO1996002527A1 SELECTIVE PROCESS FOR THE DEACYLATION AND DEACETYLATION OF TAXOL AND TAXANES 审中-公开
标题翻译：紫杉醇和紫杉醇脱乙酰化的选择过程
公开(公告)号：WO1996002527A1
公开(公告)日：1996-02-01
申请号：PCT/US1995008849
申请日：1995-07-18
申请人： HAUSER CHEMICAL RESEARCH, INC.
发明人： HAUSER CHEMICAL RESEARCH, INC. , ZHENG, Qun, Y. , DARBIE, Lynn, G. , MURRAY, Christopher, K.
IPC分类号： C07D305/14
CPC分类号： C07D305/14
摘要： The present invention relates to a highly selective method for the deacetylation and deacylation of taxol and taxanes compounds. Specifically, the present invention relates to a one step process wherein acyl groups located at the carbon 2', 10 and 7 positions of taxol and other taxane compounds may be selectively removed.
摘要翻译：本发明涉及紫杉醇和紫杉烷化合物的脱乙酰化和脱酰基化的高选择性方法。具体地，本发明涉及一步法，其中可以选择性地除去位于紫杉醇和其他紫杉烷化合物的碳2'，10和7位的酰基。

5. 发明公开

EP0815096A1 CEPHALOMANNINE EPOXIDE, ITS ANALOGUES AND A METHOD FOR PREPARING THE SAME 失效
标题翻译：三尖杉EPOXY，其模拟及其制造方法
公开(公告)号：EP0815096A1
公开(公告)日：1998-01-07
申请号：EP96909628.0
申请日：1996-03-08
申请人： HAUSER CHEMICAL RESEARCH, INC.
发明人： ZHENG, Qun, Y. , MURRAY, Christopher, K. , DAUGHENBAUGH, Randall, J.
IPC分类号： A61K31 , A61P35 , C07D305 , C07D407
CPC分类号： C07D407/12 , C07D305/14
摘要： An antitumor compound of formula (5), in which R = Ac or H, and R1 = R2 = an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu, R3 = H; R1 = R2 = R3 = H; R1 = an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu, R2 = R3 = H; R1 = R3 = H, R2 = an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu; R1 = H, R2 = R3 = an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu; R1 = R2 = R3 = an alkyl group Me, Et, Pr, i-Pr, n-Bu or t-Bu. Me is an abbreviation for methyl, Et is ethyl, Pr is propyl, i-Pr is isopropyl, n-Bu is n-butyl, and t-Bu is tert-butyl. Also provided by the invention is a one-step method of preparing a compound of formula (5) whereby a taxane having a tiglate group attached to the side chain is contacted with an oxidizing reagent resulting in the formation of an epoxide having antitumor activity.

6. 发明公开

EP0755388A1 PREPARATION OF 10-DEACETYLBACCATIN III AND 7-PROTECTED-10-DEACETYLBACCATIN III DERIVATIVES FROM 10-DEACETYL TAXOL A, 10-DEACETYL TAXOL B, AND 10-DEACETYL TAXOL C 失效
标题翻译： 10-脱乙酰基III和7保护的10-脱乙酰基衍生物III从10-脱乙酰基紫杉醇A的合成，10-脱乙酰基紫杉醇B和10-脱乙酰基紫杉醇Ç
公开(公告)号：EP0755388A1
公开(公告)日：1997-01-29
申请号：EP95915543.0
申请日：1995-04-05
申请人： HAUSER CHEMICAL RESEARCH, INC.
发明人： ZHENG, Qun, Y. , MURRAY, Christopher, K.
IPC分类号： C07D305
CPC分类号： C07D305/14 , Y02P20/55
摘要： The present invention relates to a process for converting purified, partially purified or crude taxane mixtures into a protected precursor of 10-deacetylbaccatin III and into 10-deacetylbaccatin III. The process comprises three steps, the first of which includes contacting a mixture containing at least one naturally occurring taxane compound having the structure (II) in which R1 is phenyl, (a), or n-C5H11 with at least one hydroxy protecting group. The second step involves cleaving the ester linkage of the protected taxane thus giving rise to a protected precursor of 10-deacetylbaccatin III, the deprotection of which leads to 10-deacetylbaccatin III.

7. 发明授权

EP0882037B1 ARTEMISININ DIMER COMPOUNDS HAVING ANTICANCER ACTIVITY 失效
标题翻译：二聚体青蒿素Connections活动对抗癌症
公开(公告)号：EP0882037B1
公开(公告)日：2001-09-12
申请号：EP96923582.9
申请日：1996-06-27
申请人： HAUSER CHEMICAL RESEARCH, INC.
发明人： ZHENG, Qun, Y. , DARBIE, Lynn, G.
IPC分类号： C07D519/00 , C07D321/02 , A61K31/335
CPC分类号： C07D519/00 , A61K47/55
摘要： Novel artemisinin dimers of structure (IV) which possess anticancer activity.

8. 发明公开

EP0882037A1 ARTEMISININ DIMER COMPOUNDS HAVING ANTICANCER ACTIVITY 失效
标题翻译：二聚体青蒿素Connections活动对抗癌症
公开(公告)号：EP0882037A1
公开(公告)日：1998-12-09
申请号：EP96923582.0
申请日：1996-06-27
申请人： HAUSER CHEMICAL RESEARCH, INC.
发明人： ZHENG, Qun, Y. , DARBIE, Lynn, G.
IPC分类号： C07D519
CPC分类号： C07D519/00 , A61K47/55
摘要： Novel artemisinin dimers of structure (IV) which possess anticancer activity.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式