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1. 发明申请

WO2008034118A3 METHODS AND DEVICES FOR MEASUREMENTS USING PUMP-PROBE SPECTROSCOPY IN HIGH-Q MICROCAVITIES 审中-公开
标题翻译：使用高Q值微泵浦探针光谱法进行测量的方法和装置
公开(公告)号：WO2008034118A3
公开(公告)日：2008-07-03
申请号：PCT/US2007078586
申请日：2007-09-15
申请人： HARVARD COLLEGE , VOLLMER FRANK , TOPOLANCIK JURAJ
发明人： VOLLMER FRANK , TOPOLANCIK JURAJ
IPC分类号： H01S3/00
CPC分类号： G01N21/77 , G01N2021/7789 , G02B6/29343
摘要： The use of optical micro cavities, high-Q resonators and slow-light structures as tools for detecting molecules and probing conformations and measuring polarizability and anisotropy of molecules and molecular assemblies using a pump-probe approach is described. Resonances are excited simultaneously or sequentially with pump and probe beams coupled to the same microcavity, so that a pump beam wavelength can be chosen to interact with molecules adsorbed to the microcavity surface, whereas a probe beam wavelength can be chosen to non-invasively measure pump-induced perturbations. The induced perturbations are manifest due to changes of resonance conditions and measured from changes in transfer characteristics or from changes of the scattering spectra of a micocavity-waveguide system. The perturbations induced by the pump beam may be due to polarizability changes, changes in molecular conformation, breakage or formation of chemical bonds, triggering of excited states, and formation of new chemical species. Furthermore, heat may be generated due to absorption of the pump beam. Furthermore, the use resonant modes with different states of polarization allows for measurements of polarizability and its anisotropy in samples interacting with the optical device.
摘要翻译：描述了使用光学微腔，高Q共振器和慢光结构作为检测分子和探测构象以及使用泵 - 探针方法测量分子和分子组装的极化性和各向异性的工具。谐振同时或顺序地与耦合到相同微腔的泵浦光束和探针光束激发，使得可以选择泵浦波长与吸附到微腔表面的分子相互作用，而可以选择探测光束波长以非侵入式地测量泵浦诱发的扰动。由于谐振条件的变化以及由传输特性的变化或微腔 - 波导系统的散射光谱的变化来测量，引起的扰动是显而易见的。泵浦光束引起的干扰可能是由于极化率的变化，分子构象的变化，化学键的断裂或形成，激发态的触发以及新化学物质的形成。此外，由于吸收泵浦光束可能会产生热量。此外，具有不同偏振状态的使用谐振模式允许测量与光学器件相互作用的样本中的极化率及其各向异性。

2. 发明申请

WO2007134177A3 METHODS, MATERIALS AND DEVICES FOR LIGHT MANIPULATION WITH ORIENTED MOLECULAR ASSEMBLIES IN MICRONSCALE PHOTONIC CIRCUIT ELEMENTS WITH HIGH-Q OR SLOW LIGHT 审中-公开
标题翻译：用于在具有高Q或慢光的微型光电元件中用于具有定向分子组装的光学操作的方法，材料和装置
公开(公告)号：WO2007134177A3
公开(公告)日：2008-04-10
申请号：PCT/US2007068683
申请日：2007-05-10
申请人： HARVARD COLLEGE , VOLLMER FRANK , TOPOLANCIK JURAJ
发明人： VOLLMER FRANK , TOPOLANCIK JURAJ
IPC分类号： G02F1/03 , G02F1/07
CPC分类号： G02B6/1225 , G02F1/0126 , G02F1/3511 , G02F2202/32 , G02F2203/15
摘要： An optical device that comprises an input waveguide, an output waveguide, a high-Q resonant or photonic structure that generate slow light connected to the input waveguide and the output waveguide, and an interface, surface or mode volume modified with at least one material formed from a single molecule, an ordered aggregate of molecules or nanostructures. The optical device may include more than one input waveguide, output waveguide, high-Q resonant or photonic structure and interface, surface or mode volume. The high-Q resonant or photonic structure may comprise at least one selected from the group of: microspherical cavities, microtoroidal cavities, microring-cavities, photonic crystal defect cavities, fabry-perot cavities, photonic crystal waveguides. The ordered aggregate of molecules or nanostructures comprises at least one selected from the group of: organic or biological monolayers, biological complexes, cell membranes, bacterial membranes, virus assemblies, nanowire or nanotube assemblies, quantum-dot assemblies, one or more assemblies containing one ore more rhodopsins, green fluorescence proteins, diarylethers, lipid bilayers, chloroplasts or components, mitochondria or components, cellular or bacterial organelles or components, bacterial S-layers, photochromic molecules. Further, the molecular aggregate may exhibit a photoinduced response.
摘要翻译：一种包括输入波导，输出波导，产生连接到输入波导和输出波导的慢光的高Q谐振或光子结构的光学装置，以及形成有至少一种材料的界面，表面或模式体积来自单个分子，分子或纳米结构的有序聚集体。光学器件可以包括多于一个的输入波导，输出波导，高Q谐振或光子结构以及界面，表面或模式体积。高Q谐振或光子结构可以包括选自以下的组中的至少一个：微球腔，微孔腔，微环腔，光子晶体缺陷腔，fabry-perot腔，光子晶体波导。分子或纳米结构的有序聚集体包括选自以下组中的至少一种：有机或生物单层，生物复合物，细胞膜，细菌膜，病毒组件，纳米线或纳米管组件，量子点组件，一个或多个包含一个更多的视紫红质，绿色荧光蛋白，二芳基醚，脂质双层，叶绿体或组分，线粒体或组分，细胞或细菌细胞器或组分，细菌S层，光致变色分子。此外，分子聚集体可以表现出光诱导的反应。

3. 发明申请

WO2012170560A3 MICROFLUIDIC DEVICE FOR EXTRACTING, ISOLATING, AND ANALYZING DNA FROM CELLS 审中-公开
标题翻译：用于从细胞中提取，分离和分析DNA的微流体装置
公开(公告)号：WO2012170560A3
公开(公告)日：2013-03-07
申请号：PCT/US2012041136
申请日：2012-06-06
申请人： UNIV CORNELL , CRAIGHEAD HAROLD G , TOPOLANCIK JURAJ , TIAN HARVEY , WALLIN CHRISTOPHER
发明人： CRAIGHEAD HAROLD G , TOPOLANCIK JURAJ , TIAN HARVEY , WALLIN CHRISTOPHER
IPC分类号： C12Q1/68 , C12M1/00 , C12N15/10
CPC分类号： C12N15/1017 , B01L3/502761 , B01L2200/0663 , B01L2400/0415 , B01L2400/0487 , B01L2400/086 , C12M47/10 , C12Q1/6806 , Y10T29/49826
摘要： The present invention relates to a microfluidic device for extracting and isolating DNA from cells. The device includes a support having an inlet port for receiving a sample containing a cell, an outlet port for dispensing DNA isolated from the cell, and a microfluidic channel disposed within the support and extending from the inlet port to the outlet port. The microfluidic channel includes a micropillar array, an inflow channel disposed between the inlet port and the micropillar array, and an outflow channel disposed between the micropillar array and the outlet port. The micropillar array includes micropillars spatially configured to entrap, by size exclusion, the cell, to immobilize DNA released from the cell, and to maintain the immobilized DNA in elongated or non-elongated form when hydrodynamic force is applied to the microfluidic channel. Systems and methods of making and using the device are also provided herein.
摘要翻译：本发明涉及从细胞中提取和分离DNA的微流体装置。该装置包括具有用于接收含有细胞的样品的入口端口，用于分配从该细胞分离出的DNA的出口端口和设置在该支架内并从该入口端口延伸到该出口端口的微流体通道的支架。微流体通道包括微柱阵列，设置在入口和微柱阵列之间的流入通道以及设置在微柱阵列和出口之间的流出通道。微柱阵列包括微空间，其空间配置为通过尺寸排除捕获细胞，以固定从细胞释放的DNA，并且当流体动力被施加到微流体通道时将固定的DNA保持在细长或非细长形式。本文还提供了制造和使用该装置的系统和方法。

4. 发明专利

IL262447D0 Photonic stucture-based devices and compositions for use in luminescent imaging of multiple sites within a pixel, and methods of using the same 未知
公开(公告)号：IL262447D0
公开(公告)日：2018-12-31
申请号：IL26244718
申请日：2018-10-17
申请人： ILLUMINA INC , TOPOLANCIK JURAJ , ZHONG CHENG FRANK
发明人： TOPOLANCIK JURAJ , ZHONG CHENG FRANK
IPC分类号： G02B20060101
摘要： A device for luminescent imaging includes an array of imaging pixels, a photonic structure over the array of imaging pixels, and an array of features over the photonic structure. A first feature of the array of features is over a first pixel of the array of imaging pixels, and a second feature of the array of features is over the first pixel and spatially displaced from the first feature. A first luminophore is within or over the first feature, and a second luminophore is within or over the second feature. The device includes a radiation source to generate first photons having a first characteristic at a first time, and generate second photons having a second characteristic at a second time. The first pixel selectively receives luminescence emitted by the first and second luminophores responsive to the first photons at the first time and second photons at the second time, respectively.

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