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1. 发明申请

WO2008013569A2 SMALL MOLECULE PRINTING 审中-公开
标题翻译：小分子印刷
公开(公告)号：WO2008013569A2
公开(公告)日：2008-01-31
申请号：PCT/US2007000003
申请日：2007-01-03
申请人： HARVARD COLLEGE , DANA FARBER CANCER INST INC , BARNES DAVID W , KOEHLER ANGELA N , BRADNER JAMES E , MAZITSCHEK RALPH , SCHREIBER STUART L
发明人： BARNES DAVID W , KOEHLER ANGELA N , BRADNER JAMES E , MAZITSCHEK RALPH , SCHREIBER STUART L
IPC分类号： C40B40/04
CPC分类号： G01N33/6803 , B01J19/0046 , B01J2219/00527 , B01J2219/00605 , B01J2219/00626 , B01J2219/00659 , B01J2219/0072 , B01J2219/0074 , C40B30/04 , C40B40/04 , C40B80/00 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/54353 , G01N33/547 , G01N33/552 , G01N33/553
摘要： The present invention provides compositions and methods to facilitate the identification of compounds that are capable of interacting with a biological macromolecule of interest. In one aspect, a composition is provided that comprises an array of one or more types of chemical compounds attached to a solid support using isocyanate or isothiocyanate chemistry, wherein the density of the array of compounds is at least 1000 spots per cm 2 . In general, these inventive arrays are generated by: (1) providing a solid support, wherein said solid support is functionalized with an isocyanate or isothiocyanate moiety capable of interacting with a desired chemical compound to form a covalent attachment; (2) providing one or more solutions of one or more types of compounds to be attached to the solid support; (3) delivering said one or more types of compounds to the solid support; and (4) catalyzing the attachment of the compound to the solid support, whereby an array is formed and the array of compounds has a density of at least 1000 spots per cm 2 . In another aspect, the present invention provides methods for utilizing these arrays to identify small molecule partners for biological macromolecules of interest.
摘要翻译：本发明提供了有助于鉴定能够与感兴趣的生物大分子相互作用的化合物的组合物和方法。在一个方面，提供了一种组合物，其包含使用异氰酸酯或异硫氰酸酯化学连接到固体支持物上的一种或多种类型的化合物的阵列，其中化合物阵列的密度为至少1000个点/ cm 2 。通常，这些本发明的阵列通过以下方式产生：（1）提供固体支持物，其中所述固体支持物用能够与所需化学化合物相互作用以形成共价连接的异氰酸酯或异硫氰酸酯部分官能化; （2）提供待连接到固体支持物上的一种或多种类型化合物的一种或多种溶液; （3）将所述一种或多种类型的化合物递送至固体支持物; 和（4）催化化合物与固体支持物的连接，从而形成阵列，化合物阵列的密度至少为1000个/ cm 2。在另一方面，本发明提供了利用这些阵列鉴定感兴趣的生物大分子的小分子伴侣的方法。

2. 发明专利

AU2007277445A1 Small molecule printing 未知
公开(公告)号：AU2007277445A1
公开(公告)日：2008-01-31
申请号：AU2007277445
申请日：2007-01-03
申请人： DANA FARBER CANCER INST INC , HARVARD COLLEGE
发明人： MAZITSCHEK RALPH , BRADNER JAMES E , SCHREIBER STUART L , KOEHLER ANGELA N , BARNES DAVID W
IPC分类号： C40B30/04
摘要： The present invention provides compositions and methods to facilitate the identification of compounds that are capable of interacting with a biological macromolecule of interest. In one aspect, a composition is provided that comprises an array of one or more types of chemical compounds attached to a solid support using isocyanate or isothiocyanate chemistry, wherein the density of the array of compounds is at least 1000 spots per cm2. In general, these inventive arrays are generated by: (1) providing a solid support, wherein said solid support is functionalized with an isocyanate or isothiocyanate moiety capable of interacting with a desired chemical compound to form a covalent attachment; (2) providing one or more solutions of one or more types of compounds to be attached to the solid support; (3) delivering said one or more types of compounds to the solid support; and (4) catalyzing the attachment of the compound to the solid support, whereby an array is formed and the array of compounds has a density of at least 1000 spots per cm2. In another aspect, the present invention provides methods for utilizing these arrays to identify small molecule partners for biological macromolecules of interest.

3. 发明专利

SG176453A1 SMALL MOLECULE PRINTING 未知
公开(公告)号：SG176453A1
公开(公告)日：2011-12-29
申请号：SG2011081163
申请日：2007-01-03
申请人： HARVARD COLLEGE , DANA FARBER CANCER INST INC
发明人： BARNES DAVID W , KOEHLER ANGELA N , BRADNER JAMES E , MAZITSCHEK RALPH , SCHREIBER STUART L
摘要： Abstract SMALL MOLECULE PRINTINGThe present invention provides compositions and methods to facilitate the identification of compounds that are capable of interacting with a biological macromolecule of interest. In one aspect, a composition is provided that comprises an array of one or more types of chemical compounds attached to a solid support using isocyanate or isothiocyanate chemistry, wherein the density of the array of compounds is at least 1000 spots per cm2. In general, these inventive arrays are generated by: (1) providing a solid support, wherein said solid support is functionalized with an isocyanate or isothiocyanate moiety capable of interacting with a desired chemical compound to form a covalent attachment; (2) providing one or more solutions of one or more types of compounds to be attached to the solid support; (3) delivering said one or more types of compounds to the solid support; and (4) catalyzing the attachment of the compound to the solid support, whereby an array is formed and the array of compounds has a density of at least 1000 spots per cm2. In another aspect, the present invention provides methods for utilizing these arrays to identify small molecule partners for biological macromolecules of interest.Figure 2

4. 发明专利

CA2635929A1 SMALL MOLECULE PRINTING 未知
公开(公告)号：CA2635929A1
公开(公告)日：2008-01-31
申请号：CA2635929
申请日：2007-01-03
申请人： DANA FARBER CANCER INST INC , HARVARD COLLEGE
发明人： SCHREIBER STUART L , BARNES DAVID W , KOEHLER ANGELA N , MAZITSCHEK RALPH , BRADNER JAMES E
IPC分类号： C40B30/04
摘要： The present invention provides compositions and methods to facilitate the identification of compounds that are capable of interacting with a biological macromolecule of interest. In one aspect, a composition is provided that comprises an array of one or more types of chemical compounds attached to a solid support using isocyanate or isothiocyanate chemistry, wherein the density of the array of compounds is at least 1000 spots per cm2. In general, these inventive arrays are generated by: (1) providing a solid support, wherein said solid support is functionalized with an isocyanate or isothiocyanate moiety capable of interacting with a desired chemical compound to form a covalent attachment; (2) providing one or more solutions of one or more types of compounds to be attached to the solid support; (3) delivering said one or more types of compounds to the solid support; and (4) catalyzing the attachment of the compound to the solid support, whereby an array is formed and the array of compounds has a density of at least 1000 spots per cm2. In another aspect, the present invention provides methods for utilizing these arrays to identify small molecule partners for biological macromolecules of interest.

5. 发明公开

EP1994209A4 SMALL MOLECULE PRINTING 审中-公开
标题翻译：配用小分子
公开(公告)号：EP1994209A4
公开(公告)日：2013-11-13
申请号：EP07835647
申请日：2007-01-03
申请人： HARVARD COLLEGE , DANA FARBER CANCER INST INC
发明人： BARNES DAVID W , KOEHLER ANGELA N , BRADNER JAMES E , MAZITSCHEK RALPH , SCHREIBER STUART L
IPC分类号： C40B30/04 , B01J19/00 , C40B40/04 , C40B80/00 , G01N33/543 , G01N33/68
CPC分类号： G01N33/6803 , B01J19/0046 , B01J2219/00527 , B01J2219/00605 , B01J2219/00626 , B01J2219/00659 , B01J2219/0072 , B01J2219/0074 , C40B30/04 , C40B40/04 , C40B80/00 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/54353 , G01N33/547 , G01N33/552 , G01N33/553

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