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1. 发明申请

WO2008088139A1 SPINE INSERT 审中-公开
标题翻译：脊柱插入
公开(公告)号：WO2008088139A1
公开(公告)日：2008-07-24
申请号：PCT/KR2008/000014
申请日：2008-01-02
申请人： HANS BIOMED. COR , HWANG, Ho-Chan , PARK, Sung-Eun , LEE, Sung-Hoon , OH, Jong-Kwon , KANG, Ke-Won , SEO, Seog-Jin , LEE, Jung-Suk , SONG, Seok-Beam , KIM, Jin-Young , AHN, Jae-Hyoung , CHAE, Ji-Hwa
发明人： HWANG, Ho-Chan , PARK, Sung-Eun , LEE, Sung-Hoon , OH, Jong-Kwon , KANG, Ke-Won , SEO, Seog-Jin , LEE, Jung-Suk , SONG, Seok-Beam , KIM, Jin-Young , AHN, Jae-Hyoung , CHAE, Ji-Hwa
IPC分类号： A61F2/44
CPC分类号： A61F2/4455 , A61F2/28 , A61F2/4465 , A61F2/447 , A61F2/4611 , A61F2002/30434 , A61F2002/30436 , A61F2002/30772 , A61F2002/30904 , A61F2220/0041 , A61F2310/00359
摘要： A spine insert which is inserted between vertebrae is provided. The spine insert includes: a top surface contacting with an upper vertebra; a bottom surface formed at an opposite side of the top surface; and both side surfaces connecting the top surface and the bottom surface. The top surface is formed in a curved surface matching with a shape of a lower surface of a vertebra. Accordingly, the spine insert can be easily inserted and more strongly fixed to the spine after the insertion.
摘要翻译：提供插入椎骨之间的脊柱插入物。脊柱插入件包括：与上椎骨接触的顶表面; 形成在所述顶面的相反侧的底面; 以及连接顶表面和底表面的两个侧表面。上表面形成为与椎骨的下表面形状匹配的曲面。因此，在插入后，脊柱插入物可以容易地插入并且更牢固地固定到脊柱。

2. 发明申请

WO2008088117A1 COMPOSITION FOR PROMOTING BONE REGENERATION AND RESTORATION 审中-公开
标题翻译：促进骨骼再生和恢复的组合物
公开(公告)号：WO2008088117A1
公开(公告)日：2008-07-24
申请号：PCT/KR2007/005090
申请日：2007-10-17
申请人： HANS BIOMED. COR , KIM, Jin-Young , AHN, Jae-Hyoung , SONG, Seok-Beam , CHAE, Ji-Hwa , SEO, Seog-Jin , KANG, Ke-Won , HWANG, Ho-Chan , LEE, Jung-Suk
发明人： KIM, Jin-Young , AHN, Jae-Hyoung , SONG, Seok-Beam , CHAE, Ji-Hwa , SEO, Seog-Jin , KANG, Ke-Won , HWANG, Ho-Chan , LEE, Jung-Suk
IPC分类号： A61K47/38 , A61K35/00
CPC分类号： A61L27/365 , A61K35/32 , A61L27/3608 , A61L27/48 , A61L2430/02 , Y10S514/944 , C08L89/00
摘要： A bone grafting material composite is provided. The bone grafting material composite includes a demineralized bone matrix (DBM) and a carboxymethyl cellulose (CMC)/glycerol gel carrier. Due to the CMC/glycerol gel carrier, the implantation ability thereof is better than that of the DBM. Therefore, the bone grafting material composite can be easily used, so that a curative effect can be greatly improved. In addition, since the CMC/glycerol gel is used as a carrier, the composite with a mobility maintained is washed out by water after surgery, so that the composite can be fixed on a damaged portion of a bone.
摘要翻译：提供骨移植材料复合材料。骨移植材料复合材料包括脱矿骨基质（DBM）和羧甲基纤维素（CMC）/甘油凝胶载体。由于CMC /甘油凝胶载体，其注入能力优于DBM。因此，可以容易地使用骨移植材料复合物，从而可以大大提高治疗效果。此外，由于使用CMC /甘油凝胶作为载体，所以具有流动性保持的复合体在手术后被水洗掉，使得复合体可以固定在骨的损伤部分上。

3. 发明申请

WO2008088136A1 LONG-TERM PRESERVATION METHOD FOR SKIN TISSUE 审中-公开
标题翻译：皮肤组织的长期保存方法
公开(公告)号：WO2008088136A1
公开(公告)日：2008-07-24
申请号：PCT/KR2007/006767
申请日：2007-12-21
申请人： HANS BIOMED. COR , KIM, Jin-Young , AHN, Jae-Hyoung , SONG, Seok-Beam , CHAE, Ji-Hwa , SEO, Seog-Jin , KANG, Ke-Won , HWANG, Ho-Chan , LEE, Jung-Suk
发明人： KIM, Jin-Young , AHN, Jae-Hyoung , SONG, Seok-Beam , CHAE, Ji-Hwa , SEO, Seog-Jin , KANG, Ke-Won , HWANG, Ho-Chan , LEE, Jung-Suk
IPC分类号： A01N1/02 , A01N1/00 , C12N1/04 , A61L27/36
CPC分类号： A01N1/02 , A01N1/0221
摘要： Provided is a long-term preservation method for a skin tissue and a dermal layer of a skin cell for transplantation, including: a first glycerol solution processing step of cleaning a skin tissue taken out of a skin tissue donor, immersing the skin tissue into a 45-55% glycerol solution at normal temperature, and performing stirring thereon; a second glycerol solution processing step of immersing and preserving the first glycerol solution processed skin tissue into a 65-75% glycerol solution at normal temperature! and a third glycerol solution processing step of immersing the second glycerol solution processed skin tissue into an 80-90% glycerol solution at normal temperature and continuously preserving the skin tissue at a temperature of 4°C to stabi lize the skin tissue. Therefore, any state of dehydrated skin tissue or an acellular dermal layer for transplantation preserved in the aforementioned method contains the glycerol solution instead of water. Accordingly, shapes and functions of various elements such as protein/collagen used to re-construct the skin for transplantation can be maintained, and a basement membrane for correcting re-attachment of a living endothelial cell or epithelial cell can be provided safely. In addition, a structure of an original tissue can be maintained without structural changes and damages.
摘要翻译：本发明提供一种用于移植皮肤细胞的皮肤组织和真皮层的长期保存方法，其包括：清洁从皮肤组织供体取出的皮肤组织的第一甘油溶液加工步骤，将皮肤组织浸入 45-55％甘油溶液，并在其上进行搅拌; 在常温下将第一甘油溶液处理的皮肤组织浸入并保存在65-75％甘油溶液中的第二甘油溶液加工步骤！以及第三甘油溶液处理步骤，将常规温度下的第二甘油溶液加工的皮肤组织浸入80-90％的甘油溶液中并在4℃的温度下连续地保存皮肤组织以使皮肤组织稳定。因此，在上述方法中保存的脱水皮肤组织或用于移植的无细胞真皮层的任何状态都含有甘油溶液而不是水。因此，可以维持各种元素的形状和功能，例如用于重新构建移植皮肤的蛋白质/胶原蛋白，并且可以安全地提供用于校正生物内皮细胞或上皮细胞的再附着的基底膜。此外，可以保持原始组织的结构而没有结构变化和损坏。

4. 发明授权

EP2114457B1 COMPOSITION FOR PROMOTING BONE REGENERATION AND RESTORATION 有权转让
标题翻译：成分用于促进骨再生和恢复
公开(公告)号：EP2114457B1
公开(公告)日：2013-02-20
申请号：EP07833399.4
申请日：2007-10-17
申请人： Hans Biomed. Cor
发明人： KIM, Jin-Young , AHN, Jae-Hyoung , SONG, Seok-Beom , CHAE, Ji-Hwa , SEO, Seog-Jin , KANG, Ke-Won , HWANG, Ho-Chan , LEE, Jung-Suk
IPC分类号： A61L27/36 , A61L27/48
CPC分类号： A61L27/365 , A61K35/32 , A61L27/3608 , A61L27/48 , A61L2430/02 , Y10S514/944 , C08L89/00
摘要： A bone grafting material composite is provided. The bone grafting material composite includes a demineralized bone matrix (DBM) and a carboxymethyl cellulose (CMC)/glycerol gel carrier. Due to the CMC/glycerol gel carrier, the implantation ability thereof is better than that of the DBM. Therefore, the bone grafting material composite can be easily used, so that a curative effect can be greatly improved. In addition, since the CMC/glycerol gel is used as a carrier, the composite with a mobility maintained is washed out by water after surgery, so that the composite can be fixed on a damaged portion of a bone.

5. 发明公开

EP2114457A1 COMPOSITION FOR PROMOTING BONE REGENERATION AND RESTORATION 有权转让
标题翻译：成分用于促进骨再生和恢复
公开(公告)号：EP2114457A1
公开(公告)日：2009-11-11
申请号：EP07833399.4
申请日：2007-10-17
申请人： Hans Biomed. Cor
发明人： KIM, Jin-Young , AHN, Jae-Hyoung , SONG, Seok-Beom , CHAE, Ji-Hwa , SEO, Seog-Jin , KANG, Ke-Won , HWANG, Ho-Chan , LEE, Jung-Suk
IPC分类号： A61K47/38 , A61K35/00
CPC分类号： A61L27/365 , A61K35/32 , A61L27/3608 , A61L27/48 , A61L2430/02 , Y10S514/944 , C08L89/00
摘要： A bone grafting material composite is provided. The bone grafting material composite includes a demineralized bone matrix (DBM) and a carboxymethyl cellulose (CMC)/glycerol gel carrier. Due to the CMC/glycerol gel carrier, the implantation ability thereof is better than that of the DBM. Therefore, the bone grafting material composite can be easily used, so that a curative effect can be greatly improved. In addition, since the CMC/glycerol gel is used as a carrier, the composite with a mobility maintained is washed out by water after surgery, so that the composite can be fixed on a damaged portion of a bone.

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