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1. 发明申请

WO2012165915A3 COMPOSITION FOR TREATING DIABETES COMPRISING LONG-ACTING INSULIN CONJUGATE AND LONG-ACTING INSULINOTROPIC PEPTIDE CONJUGATE 审中-公开
公开(公告)号：WO2012165915A3
公开(公告)日：2012-12-06
申请号：PCT/KR2012/004367
申请日：2012-06-01
申请人： HANMI SCIENCE CO., LTD. , WOO, Young Eun , JANG, Myung Hyun , PARK, Young Jin , PARK, Young Kyung , LIM, Chang Ki , KWON, Se Chang
发明人： WOO, Young Eun , JANG, Myung Hyun , PARK, Young Jin , PARK, Young Kyung , LIM, Chang Ki , KWON, Se Chang
IPC分类号： A61K47/48 , A61K38/28 , A61K47/30 , A61P3/10
摘要： The present invention relates to a composition for the prevention or treatment of diabetes comprising a long-acting insulin conjugate and a long-acting insulinotropic peptide conjugate, and a therapeutic method for the treatment of diabetes, and more particularly, concurrent administration of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate inhibits weight gain caused by insulin treatment, and vomiting and nausea caused by insulinotropic peptide treatment, and reduces the required dose of insulin, thereby remarkably improving drug compliance. Moreover, each of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate of the present invention is prepared by linking insulin or insulinotropic peptide with an immunoglobulin Fc region via a non-peptidyl linker, thereby showing improved in-vivo duration of efficacy and stability.

2. 发明申请

WO2012169798A2 NOVEL OXYNTOMODULIN DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR TREATING OBESITY COMPRISING THE SAME 审中-公开
标题翻译：用于治疗包含其的肥胖症的新型氧化色氨酸衍生物和药物组合物
公开(公告)号：WO2012169798A2
公开(公告)日：2012-12-13
申请号：PCT/KR2012/004494
申请日：2012-06-07
申请人： HANMI SCIENCE CO., LTD. , JUNG, Sung Youb , JANG, Myung Hyun , SHEN, Ling Ai , PARK, Young Kyung , PARK, Young Jin , KWON, Se Chang
发明人： JUNG, Sung Youb , JANG, Myung Hyun , SHEN, Ling Ai , PARK, Young Kyung , PARK, Young Jin , KWON, Se Chang
IPC分类号： C07K14/605 , A61K38/26 , A61P3/04
CPC分类号： C07K14/605 , A61K38/00 , A61K38/177 , A61K38/22 , A61K38/26 , A61K45/06 , C07K14/575 , C07K14/705
摘要： The present invention relates to a novel peptide showing more excellent activities on a glucagon like peptide-1 receptor and a glucagon receptor than native oxyntomodulin, and a composition for the prevention or treatment of obesity comprising the peptide as an active ingredient. Unlike native oxyntomodulin, the novel peptide of the present invention reduces food intake, suppresses gastric emptying, and facilitates lipolysis with reduced side-effects, and also shows excellent receptor-activating effects. Thus, it can be widely used in the treatment of obesity with safety and efficacy.
摘要翻译：本发明涉及一种与天然胃泌酸调节素相比，胰高血糖素样肽-1受体和胰高血糖素受体的活性更优异的新型肽，以及用于预防或治疗包含该肽作为活性成分的肥胖症的组合物。与本发明的胃泌酸调节蛋白不同，本发明的新型肽减少食物摄入，抑制胃排空，促进脂肪分解，副作用降低，并且还显示出优异的受体激活作用。因此，可广泛用于治疗肥胖症的安全性和有效性。

3. 发明申请

WO2011122921A2 AN INSULIN CONJUGATE USING AN IMMUNOGLOBULIN FRAGMENT 审中-公开
标题翻译：胰岛素联合使用免疫球蛋白片段
公开(公告)号：WO2011122921A2
公开(公告)日：2011-10-06
申请号：PCT/KR2011/002331
申请日：2011-04-04
申请人： HANMI HOLDINGS CO., LTD. , SONG, Dae Hae , SHIN, Jae Hee , PARK, Young Jin , IM, Dae Seong , BAE, Sung Min , KWON, Se Chang
发明人： SONG, Dae Hae , SHIN, Jae Hee , PARK, Young Jin , IM, Dae Seong , BAE, Sung Min , KWON, Se Chang
IPC分类号： A61K38/28 , A61K9/20 , A61K47/40 , A61K47/34
CPC分类号： A61K38/28 , A61K47/68 , A61K47/6883 , C07K14/62 , C07K2319/30
摘要： The present invention relates to an insulin conjugate having improved in vivo duration and stability, which is prepared by covalently linking insulin with an immunoglobulin Fc region via a non-peptidyl polymer, a long-acting formulation comprising the same, and a preparation method thereof. The insulin conjugate of the present invention maintains in vivo activity of the peptide at a relatively high level and remarkably increases the serum half-life thereof, thereby greatly improving drug compliance upon insulin treatment.
摘要翻译：本发明涉及具有改善的体内持续时间和稳定性的胰岛素缀合物，其通过非肽基聚合物共价连接胰岛素与免疫球蛋白Fc区，包含其的长效制剂及其制备方法制备。本发明的胰岛素结合物以较高水平保持肽的体内活性，并显着增加血清的半衰期，从而大大提高了胰岛素治疗后的药物依从性。

4. 发明申请

WO2009069983A3 A PHARMACEUTICAL COMPOSITION FOR TREATING OBESITY-RELATED DISEASE COMPRISING INSULINOTROPIC PEPTIDE CONJUGATE 审中-公开
公开(公告)号：WO2009069983A3
公开(公告)日：2009-06-04
申请号：PCT/KR2008/007074
申请日：2008-11-28
申请人： HANMI PHARMACEUTICAL CO., LTD. , SONG, Dae Hae , KIM, Min Young , PARK, Young Jin , KANG, Eun Hee , JUNG, Sung Youb , KWON, Se Chang , LEE, Gwan Sun
发明人： SONG, Dae Hae , KIM, Min Young , PARK, Young Jin , KANG, Eun Hee , JUNG, Sung Youb , KWON, Se Chang , LEE, Gwan Sun
IPC分类号： A61K38/16 , A61P3/04 , A61K39/395
摘要： The present invention relates to a composition for treating obesity-related diseases comprising an insulinotropic peptide conjugate, more particularly, to a composition for treating obesity-related diseases comprising a conjugate prepared by covalently linking the insulinotropic peptide with a carrier substance via a non-peptidyl linker, and a method for treating obesity-related diseases by using the same. In particular, the composition for treating obesity-related diseases according to the present invention remarkably improves the efficacy of suppressing food intake and its duration to reduce body weight and body fat, thereby being useful for the treatment of obesity-related diseases.

5. 发明申请

WO2007058466A1 PORTABLE SPHINCTER TRAINING TOOL 审中-公开
标题翻译：便携式培训工具
公开(公告)号：WO2007058466A1
公开(公告)日：2007-05-24
申请号：PCT/KR2006/004804
申请日：2006-11-15
申请人： PARK, Young Jin
发明人： PARK, Young Jin
IPC分类号： A63B23/20
CPC分类号： A63B23/20 , A61H9/005 , A61H19/32 , A61H23/02 , A61H2201/1635 , A61H2201/165 , A61H2205/04
摘要： Disclosed is a portable sphincter training tool in that the general male can wear on his body and naturally exercise his sphincter at recess or in the course of daily life, whereby improving physically and spiritually in vitality and confidence. The portable sphincter training tool comprises a penis induction pipe for receiving a penis; an adhesive plate coupled to the penis induction pipe, adhered to an user's body during wear and having a vacuum pump for making the penis induction pipe vacuous; and a sphincter tension necklace coupled to one side of the adhesive plate and hanged on an user's neck in order to stably adhere the penis induction pipe to the adhesive plate and apply a tension to the sphincter according to a predetermined movement during adhesion; wherein an insertion portion of the penis induction pipe is bent inward in such a manner that the penis is stably received upward.
摘要翻译：公开了一种便携式括约肌训练工具，其中一般的男性可以佩戴在他的身体上，并且在休息或在日常生活中自然地运动其括约肌，从而在身体和精神上改善生命力和信心。便携式括约肌训练工具包括用于接收阴茎的阴茎感应管; 耦合到阴茎诱导管的粘合板，在磨损期间粘附到使用者的身体，并具有用于使阴茎诱导管真空的真空泵; 和一根括约肌紧张项链，其连接在粘合板的一侧并悬挂在使用者的颈部上，以便将阴茎感应管稳定地粘附到粘合剂板上，并在粘合期间根据预定的运动向括约肌施加张力; 其特征在于，所述阴茎感应管的插入部向内侧弯曲，使得所述阴茎被稳定地向上方收容。

6. 发明申请

WO2011142600A2 PHOTORESIST STRIPPER COMPOSITION 审中-公开
标题翻译：光电剥离组合物
公开(公告)号：WO2011142600A2
公开(公告)日：2011-11-17
申请号：PCT/KR2011/003501
申请日：2011-05-12
申请人： ENF TECHNOLOGY CO., LTD. , PARK, Young Jin , HAN, Doo Seok , LEE, Sang Dai , SHIN, Hyoseop
发明人： PARK, Young Jin , HAN, Doo Seok , LEE, Sang Dai , SHIN, Hyoseop
IPC分类号： G03F7/42
CPC分类号： G03F7/425 , G03F7/426
摘要： A photoresist stripper composition comprising 0.5 to 5 % by weight of alkyl ammonium hydroxide; 60 to 90 % by weight of aprotic polar solvent; 0.1 to 3 % by weight of aromatic polyhydric alcohol; 0.1 to 5 % by weight of linear polyhydric alcohol; and 5 to 30 % by weight of water has an excellent capacity for stripping a positive and a negative photoresists, and dose not corrode a metal wiring under the photoresist.
摘要翻译：一种光致抗蚀剂剥离剂组合物，其包含0.5-5重量％的烷基氢氧化铵; 60〜90重量％的非质子极性溶剂; 0.1〜3重量％的芳族多元醇; 0.1〜5重量％的线性多元醇; 和5至30重量％的水具有优异的剥离正极和负极光致抗蚀剂的能力，并且不会腐蚀光刻胶下的金属布线。

7. 发明申请

WO2009104826A1 APPARATUS AND METHOD FOR DETERMINING A FEEDBACK CHANNEL OF OFDMA COMMUNICATION SYSTEM 审中-公开
标题翻译：用于确定OFDMA通信系统的反馈信道的装置和方法
公开(公告)号：WO2009104826A1
公开(公告)日：2009-08-27
申请号：PCT/KR2008/000973
申请日：2008-02-19
申请人： KOREA UNIVERSITY INDUSTRIAL & ACADEMIC COLLABORATION FOUNDATION , KANG, Chung Gu , KIM, Jin Woo , PARK, Young Jin
发明人： KANG, Chung Gu , KIM, Jin Woo , PARK, Young Jin
IPC分类号： H04L27/26 , H04J11/00
CPC分类号： H04L5/0007 , H04L1/0029 , H04L27/2601
摘要： Provided are an apparatus and method for determining a feedback channel of OFDMA communication system. Specifically, provided are an apparatus and method for determining feedback channel of OFDMA communication system using an OFDMA scheme that is an improved version of an opportunistic feedback scheme in which the number of channels to be fed back is selectively determined by considering the number of channels allocated to a receiving terminal so as to reduce an overhead generated in a transmitter due to feedback channel information. Accordingly, a feedback transport channel is determined by using channel allocation information allocated during communication. Thus, the total number of feedbacks can be maintained to be equal to that of an opportunistic feedback scheme while performing channel resource allocation more systematically than the opportunistic feedback scheme, thereby reducing unnecessary feedback information. In addition, a feedback channel is configured based on channel information allocated to each user by considering that the total number of feedbacks is increased in proportion to the total number of users. Thus, feedback information can be provided through a channel having high efficiency. Further, whether receiving- side feedback is provided is effectively controlled to reduce a channel allocation overhead in a receiving side and a transmitting side, thereby increasing a system throughput.
摘要翻译：提供了一种用于确定OFDMA通信系统的反馈信道的装置和方法。具体地，提供了一种用于使用作为机会性反馈方案的改进版本的OFDMA方案来确定OFDMA通信系统的反馈信道的装置和方法，其中通过考虑分配的信道数量来选择性地确定要反馈的信道数量到接收终端，以便减少由于反馈信道信息而在发射机中产生的开销。因此，通过使用在通信期间分配的信道分配信息来确定反馈传输信道。因此，与机会性反馈方案相比，更系统地进行信道资源分配，可以将反馈的总数保持为等于机会反馈方案的总数，从而减少不必要的反馈信息。此外，基于分配给每个用户的信道信息，通过考虑到与总用户数量成比例地增加反馈的总数来配置反馈信道。因此，可以通过具有高效率的信道来提供反馈信息。此外，是否有效地控制提供接收侧反馈，以减少接收侧和发送侧的信道分配开销，从而提高系统吞吐量。

8. 发明申请

WO2007027523A3 VIDEO RELAY SYSTEM AND METHOD 审中-公开
公开(公告)号：WO2007027523A3
公开(公告)日：2007-03-08
申请号：PCT/US2006/033245
申请日：2006-08-25
申请人： HAMILTON RELAY, INC. , PARK, Young Jin , HAHN, Wayne , STEPHENS, Gregory
发明人： PARK, Young Jin , HAHN, Wayne , STEPHENS, Gregory
IPC分类号： H04N7/173
摘要： A video relay system for allowing impaired individuals to communicate across a network includes a first device capable of sending and receiving audio and video signals where the first device is coupled to a network and includes an application. The application on the first device is configured to communicate with a second device, regardless of whether the second device includes the application. The application is also configured to transmit to and receive from the second device a sign language video signal. When the first device is in a voice carryover mode, the application is configured to transmit an audio signal to the second device. When the first device is in a hearing carryover mode, the application is configured to receive an audio signal from the second device.

9. 发明公开

EP2717918A2 COMPOSITION FOR TREATING DIABETES COMPRISING LONG-ACTING INSULIN CONJUGATE AND LONG-ACTING INSULINOTROPIC PEPTIDE CONJUGATE 有权转让
标题翻译：组合物对于糖尿病的WITH A LANGWIRKENDEM胰岛素缀合于治疗和长效促胰岛素肽缀合物
公开(公告)号：EP2717918A2
公开(公告)日：2014-04-16
申请号：EP12792243.3
申请日：2012-06-01
申请人： Hanmi Science Co., Ltd.
发明人： WOO, Young Eun , JANG, Myung Hyun , PARK, Young Jin , PARK, Young Kyung , LIM, Chang Ki , KWON, Se Chang
IPC分类号： A61K47/48 , A61K38/28 , A61K47/30 , A61P3/10
CPC分类号： A61K47/48415 , A61K38/26 , A61K38/28 , A61K47/68 , A61K47/6811 , A61K47/6883
摘要： The present invention relates to a composition for the prevention or treatment of diabetes comprising a long-acting insulin conjugate and a long-acting insulinotropic peptide conjugate, and a therapeutic method for the treatment of diabetes, and more particularly, concurrent administration of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate inhibits weight gain caused by insulin treatment, and vomiting and nausea caused by insulinotropic peptide treatment, and reduces the required dose of insulin, thereby remarkably improving drug compliance. Moreover, each of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate of the present invention is prepared by linking insulin or insulinotropic peptide with an immunoglobulin Fc region via a non-peptidyl linker, thereby showing improved
in-vivo duration of efficacy and stability.

10. 发明授权

EP2718318B1 NOVEL OXYNTOMODULIN DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR TREATING OBESITY COMPRISING THE SAME 有权转让
公开(公告)号：EP2718318B1
公开(公告)日：2018-07-25
申请号：EP12797363.4
申请日：2012-06-07
申请人： Hanmi Science Co., Ltd.
发明人： JUNG, Sung Youb , JANG, Myung Hyun , SHEN, Ling Ai , PARK, Young Kyung , PARK, Young Jin , KWON, Se Chang
IPC分类号： C07K14/605 , A61K38/26 , A61P3/04
CPC分类号： C07K14/605 , A61K38/00 , A61K38/177 , A61K38/22 , A61K38/26 , A61K45/06 , C07K14/575 , C07K14/705
摘要： The present invention relates to a novel peptide showing more excellent activities on a glucagon like peptide-1 receptor and a glucagon receptor than native oxyntomodulin, and a composition for the prevention or treatment of obesity comprising the peptide as an active ingredient. Unlike native oxyntomodulin, the novel peptide of the present invention reduces food intake, suppresses gastric emptying, and facilitates lipolysis with reduced side-effects, and also shows excellent receptor-activating effects. Thus, it can be widely used in the treatment of obesity with safety and efficacy.

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