专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2012011752A3 NOVEL LONG-ACTING GLUCAGON CONJUGATE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME FOR THE PREVENTION AND TREATMENT OF OBESITY 审中-公开
标题翻译：新型长效GLUCAGON CONJUGATE和药物组合物，包括预防和治疗肥胖症
公开(公告)号：WO2012011752A3
公开(公告)日：2012-05-31
申请号：PCT/KR2011005375
申请日：2011-07-21
申请人： HANMI HOLDINGS CO LTD , WOO YOUNG EUN , LEE JONG SOO , SHEN LING AI , KIM DAE JIN , JUNG SUNG YOUB , CHOI IN YOUNG , KWON SE CHANG
发明人： WOO YOUNG EUN , LEE JONG SOO , SHEN LING AI , KIM DAE JIN , JUNG SUNG YOUB , CHOI IN YOUNG , KWON SE CHANG
IPC分类号： A61K38/26 , A61K31/4164 , A61P3/00 , A61P3/04 , C07K14/605
CPC分类号： A61K47/48415 , A61K31/4164 , A61K38/26 , A61K45/06 , A61K47/68 , A61K47/6811 , A61K47/6883 , C07K14/605 , A61K2300/00
摘要： Disclosed is a novel long-acting glucagon conjugate in which glucagon or its derivative is covalently linked to a polymer carrier via a non-peptide linker, and a pharmaceutical composition comprising the same as an effective ingredient useful for the prevention and treatment of obesity. Since the long-acting glucagon conjugate of the present invention shows improved in vivo durability and stability, when used in combination with an anti-obesity drug, it is possible to induce synergistic effects on the loss of body weight and decrease in food intake without causing any side-effects such as fluctuation in blood glucose level. Accordingly, the long-acting peptide conjugate of the present invention is very effective for the prevention and treatment of obesity.
摘要翻译：公开了一种新颖的长效胰高血糖素缀合物，其中胰高血糖素或其衍生物通过非肽接头共价连接到聚合物载体，以及包含其作为有效成分的药物组合物，其用于预防和治疗肥胖症。由于本发明的长效胰高血糖素缀合物显示出改善的体内耐久性和稳定性，当与抗肥胖药物组合使用时，可以对体重的损失和食物摄取减少引起协同效应，而不引起任何副作用，如血糖水平波动。因此，本发明的长效肽结合物对于预防和治疗肥胖症是非常有效的。

2. 发明申请

WO2011122922A3 LONG-ACTING HUMAN FOLLICLE-STIMULATING HORMONE FORMULATION USING IMMUNOGLOBULIN FRAGMENT 审中-公开
标题翻译：使用免疫抑制蛋白片段长效人体激素激素配方
公开(公告)号：WO2011122922A3
公开(公告)日：2012-03-08
申请号：PCT/KR2011002332
申请日：2011-04-04
申请人： HANMI HOLDINGS CO LTD , KIM CHANG HWAN , HONG SUNG KAP , LEE BYUNG SUN , KWAK SOO YOUNG , LEE MI JI , CHOI IN YOUNG , KWON SE CHANG
发明人： KIM CHANG HWAN , HONG SUNG KAP , LEE BYUNG SUN , KWAK SOO YOUNG , LEE MI JI , CHOI IN YOUNG , KWON SE CHANG
IPC分类号： A61K9/22 , A61K47/34 , A61K47/40
CPC分类号： A61K47/48215 , A61K47/60 , A61K47/68
摘要： The present invention relates to a long-acting human follicle-stimulating hormone formulation having improved in vivo duration and stability, comprising a human follicle-stimulating hormone conjugate that is prepared by covalently linking human follicle-stimulating hormone with an immunoglobulin Fc region via a non-peptidyl polymer, and a preparation method thereof. The long-acting human follicle-stimulating hormone formulation of the present invention maintains in vivo activity of human follicle-stimulating hormone at a relatively high level and remarkably increases the serum half-life thereof.
摘要翻译：本发明涉及具有改善的体内持续时间和稳定性的长效促卵泡激素制剂，其包含人促卵泡激素缀合物，其通过非激素共价连接人卵泡刺激激素与免疫球蛋白Fc区而制备 - 肽基聚合物及其制备方法。本发明的长效人促卵泡激素制剂在较高水平维持人卵泡刺激激素的体内活性，并且显着增加其血清半衰期。

3. 发明专利

AR081755A1 FORMULACION DE ACCION PROLONGADA DE LA HORMONA ESTIMULADORA DE LOS FOLICULOS DONDE SE USA UN FRAGMENTO DE INMUNOGLOBULINA, METODO DE PREPARACION Y METODO PARA TRATAR A UN SUJETO QUE SUFRE UN TRASTORNO REPRODUCTIVO 未知
公开(公告)号：AR081755A1
公开(公告)日：2012-10-17
申请号：ARP110101119
申请日：2011-04-01
申请人： HANMI HOLDINGS CO LTD
发明人： LEE BYUNG SUN , KWAK SOO YOUNG , LEE MI JI , CHOI IN YOUNG , KWON SE CHANG , KIM CHANG HWAN , HONG SUNG KAP
IPC分类号： A61K38/24 , A61K39/395 , A61K47/48 , A61P15/08
摘要： Reivindicación 1: Una formulación de acción prolongada de la hormona estimuladora de los folículos humana que presenta una duración y una estabilidad in vivo mejoradas, que comprende un conjugado de la hormona estimuladora de los folículos humana que se prepara uniendo de manera covalente la hormona estimuladora de los folículos humana a una región Fc de inmunoglobulina a través de un polímero no peptidílico seleccionado del grupo que consiste en el polietilenglicol, el polipropilenglicol, los copolímeros de etilenglicol y propilenglicol, los polioles polioxietilados, el alcohol polivinílico, los polisacáridos, el dextrano, el éter polivinil etílico, los polímeros biodegradables, los polímeros lipídicos, las quitinas, el ácido hialurónico y las combinaciones de éstos.Reivindicación 2: La formulación de acción prolongada de la hormona estimuladora de los folículos humana de acuerdo con la reivindicación 1, donde la hormona estimuladora de los folículos humana se selecciona del grupo que consiste en la FSH (hormona estimuladora de los folículos) o los agonistas, los derivados, los fragmentos y las variantes de ésta, así como las combinaciones de los anteriores. Reivindicación 8: La formulación de acción prolongada de la hormona estimuladora de los folículos humana de acuerdo con la reivindicación 1, donde la región Fc de la inmunoglobulina es una región Fc derivada de la IgG, la IgA, la lgD, la lgE o la lgM.

4. 发明专利

HK1137481A1 A NOVEL VECTOR AND EXPRESSION CELL LINE FOR MASS PRODUCTION OF RECOMBINANT PROTEIN AND A PROCESS OF PRODUCING RECOMBINANT PROTEIN USING SAME 未知
公开(公告)号：HK1137481A1
公开(公告)日：2010-07-30
申请号：HK10101256
申请日：2010-02-04
申请人： HANMI HOLDINGS CO LTD
发明人： CHOI IN YOUNG , KIM CHANG HWAN , LEE HYUN JI , PARK SEONG HEE , KWON SE CHANG , LEE GWAN SUN
IPC分类号： C12N20060101
摘要： Disclosed herein is an inducible high-expression cassette comprising a dihydrofolate reductase (DHFR) promoter from which GC-rich repeat sequences are partially or entirely removed, the cassette capable of more effectively improving a gene amplification system. Also disclosed are an expression vector comprising the inducible expression cassette and optionally a gene encoding a recombinant protein of interest, an animal cell line transformed with the expression vector, and a method of mass producing and purifying a recombinant protein by culturing the transformant. The present invention enables the shortening of the time required to establish a cell line producing a recombinant protein of interest at high levels using a low concentration of a DHFR inhibitor, thereby allowing more effective production of the recombinant protein.

5. 发明专利

ES2366061T3 UN VECTOR Y UNA LINEA CELULAR DE EXPRESION NOVEDOSOS PARA LA PRODUCCION EN MASA DE UNA PROTEINA RECOMBINANTE Y UN PROCESO DE PRODUCCION DE PROTEINA RECOMBINANTE USANDO LOS MISMOS. 未知
公开(公告)号：ES2366061T3
公开(公告)日：2011-10-14
申请号：ES07833373
申请日：2007-10-16
申请人： HANMI PHARMACEUTICAL CO LTD , HANMI HOLDINGS CO LTD
发明人： CHOI IN YOUNG , KIM CHANG HWAN , LEE HYUN JI , PARK SEONG HEE , KWON SE CHANG , LEE GWAN SUN
IPC分类号： C12N15/63 , C12N15/09 , C12N15/79
摘要： Un modulo de alta expresión inducible que comprende una secuencia nucleotídica que codifica una dihidrofolato reductasa y una secuencia nucleotídica que está ligada con la secuencia nucleotídica y codifica un promotor de dihidrofolato reductasa del que se han eliminado una o más secuencias CCGCCC repetidas.

6. 发明专利

AR082320A1 CONJUGADO DE GLUCAGON DE EFECTO PROLONGADO Y COMPOSICION FARMACEUTICA QUE LO COMPRENDE PARA LA PREVENCION Y EL TRATAMIENTO DE LA OBESIDAD 未知
公开(公告)号：AR082320A1
公开(公告)日：2012-11-28
申请号：ARP110102650
申请日：2011-07-21
申请人： HANMI HOLDINGS CO LTD
发明人： LEE JONG , SOO-WOO YOUNG EUN , SHEN LING AI , KIM DAE JIN , CHOI IN YOUNG , KWON SE CHANG , JUNG SUNG YOUB
IPC分类号： C07K14/605 , A61K38/26 , C07K1/00
摘要： Un conjugado de glucagón de efecto prolongado en el cual el glucagón o su derivado están ligados en forma covalente a un vehículo polimérico mediante una unión no peptídica, y una composición farmacéutica que lo comprende como ingrediente eficaz para la prevención y tratamiento de la obesidad. A causa de su efecto prolongado, el conjugado de glucagón de la presente solicitud muestra características diferentes de durabilidad y estabilidad in vivo cuando se lo utiliza en combinación con una droga anti-obesidad es posible inducir efectos sinérgicos en la pérdida de peso corporal y en la reducción de la ingesta de alimentos sin provocar efectos colaterales como una fluctuación en los niveles de glucosa en sangre. Por lo tanto, el conjugado peptídico de efecto prolongado de la presente es eficaz para la prevención y el tratamiento de la obesidad.

7. 发明专利

NZ577812A AN INSULINOTROPIC EXENDIN-4 COMPLEX USING AN IMMUNOGLOBULIN FRAGMENT 未知
公开(公告)号：NZ577812A
公开(公告)日：2012-01-12
申请号：NZ57781208
申请日：2008-01-04
申请人： HANMI HOLDINGS CO LTD
发明人： SONG DAE HAE , LIM CHANG KI , SONG TAE HUN , KIM YOUNG HOON , KWON SE CHANG , LEE GWAN SUN , JUNG SUNG YOUB , CHOI IN YOUNG
IPC分类号： A61K38/28 , A61P3/08 , C07K14/62 , C07K16/46
摘要： Disclosed is an insulinotropic peptide conjugate, comprising: an insulinotropic peptide and an immunoglobulin Fc region, which are linked by a non-peptidyl polymer, wherein the insulinotropic peptide is selected from the group consisting of: exendin-4, an exendin-4 derivative prepared by deleting N-terminal amine group, an exendin-4 derivative prepared by substituting N-terminal amine group with hydroxyl group, an exendin-4 derivative prepared by modifying N-terminal amine group with dimethyl group, an exendin-4 derivative prepared by deleting á-carbon of histidine, the first amino acid of exendin-4, an exendin-4 derivative prepared by substituting 12th amino acid(lysine) for serine, and an exendin-4 derivative prepared by substituting 12th amino acid(lysine) with arginine, wherein the nonpeptidyl polymer is selected from the group consisting of: polyethylene glycol, polypropylene glycol, copolymers of ethylene glycol and propylene glycol, polyoxyethylated polyols, polyvinyl alcohol, polysaccharides, dextran, polyvinyl ethyl ether, biodegradable polymers, lipid polymers, chitins, hyaluronic acid, and combinations thereof, and wherein one end of the non-peptidyl polymer is linked to an amino acid residue other than the N-terminus of the insulinotropic peptide. Further disclosed is an insulinotropic peptide conjugate represented by the following Chemical Formula 1: R1-X-Y-Z-R2 wherein, R1 is selected from the group consisting of histidine, des-aminohistidyl group, N-dimethyl-histidyl group, beta-hydroxy imidazopropyl group and 4-imidazoacetyl group; R2 is selected from the group consisting of -NH2, -OH and -Lys; X is selected from the group consisting of GIy-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-R3-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-R4-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser, GIy-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-R3-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-R4-Asn-Gly-Gly, and Ser-Asp-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-R3-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-R4-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser, wherein R3 is selected from the group consisting of Lys, Ser and Arg; and R4 is selected from the group consisting of Lys, Ser and Arg; Y is polyethylene glycol, polypropylene glycol, copolymers of ethylene glycol and propylene glycol, polyoxyethylated polyols, polyvinyl alcohol, polysaccharides, dextran, polyvinyl ethyl ether, biodegradable polymers, lipid polymers, chitins, hyaluronic acid, and combinations thereof; and Z is an immunoglobulin Fc region.

8. 发明专利

AT512229T 未知
公开(公告)号：AT512229T
公开(公告)日：2011-06-15
申请号：AT07833373
申请日：2007-10-16
申请人： HANMI HOLDINGS CO LTD
发明人： CHOI IN YOUNG , KIM CHANG HWAN , LEE HYUN JI , PARK SEONG HEE , KWON SE CHANG , LEE GWAN SUN
IPC分类号： C12N15/63 , C12N15/09 , C12N15/79
摘要： Disclosed herein is an inducible high-expression cassette comprising a dihydrofolate reductase (DHFR) promoter from which GC-rich repeat sequences are partially or entirely removed, the cassette capable of more effectively improving a gene amplification system. Also disclosed are an expression vector comprising the inducible expression cassette and optionally a gene encoding a recombinant protein of interest, an animal cell line transformed with the expression vector, and a method of mass producing and purifying a recombinant protein by culturing the transformant. The present invention enables the shortening of the time required to establish a cell line producing a recombinant protein of interest at high levels using a low concentration of a DHFR inhibitor, thereby allowing more effective production of the recombinant protein.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式