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    • 6. 发明授权
    • Compounds and process for measuring c-reactive protein
    • c反应蛋白的化合物和方法
    • US5003065A
    • 1991-03-26
    • US206592
    • 1988-06-14
    • Carey MerrittJames WinkelmanRuth Silberman-Hazony
    • Carey MerrittJames WinkelmanRuth Silberman-Hazony
    • C07D323/00C07F1/00C07F9/6561G01N33/68
    • C07F1/005C07D323/00C07F9/6561G01N33/6863
    • New compounds are described of the formula: ##STR1## wherein Z is selected from ##STR2## each x is selected from ##STR3## n is an integer from 1-10; each Y is selected from hydrogen, --NH.sub.2, --COQ, --COOQ, --COONHQ, --COOH, --OH, W, halogen and Q; wherein each Q is independently selected from substituted and unsubstituted lower alkenyl and lower alkyl and wherein the substitutuents are selected from --NH.sub.2 halogen, --OH, and --COOH; D is selected from hydroxy, hydrogen and --NH.sub.2 ; and W is selected from ##STR4## wherein each R is independently selected from hydrogen and lower alkyl; R' is selected from ethylene, propylene, isopropylene and phenylene; M is selected from chlorine and hydroxy; A is selected from hydrogen, lower alkyl, lower alkenyl, cycloalkyl, and phenyl; (B) is selected from ##STR5## --CO--, --NHCO--, --O--, --COO--, --N.dbd.N--, or represents a confugate bond; L.sub.1 and L.sub.2 are selected from hydroxy substituted or unsubstituted lower alkyl, cycloalkyl, lower alkenyl, or phenyl; providing L.sub.2 can be a conjugate bond. These compounds have specific utility in a process, for measuring c-reactive protein by binding with c-reactive protein and acting to release metal ions and/or inhibit the flow of the metal ion complex under electrochemically measurable conditions.
    • 新化合物被描述为下式:其中Z选自,每个x选自 + TR ,n是1-10的整数; 每个Y选自氢,-NH 2,-COQ,-COOQ,-COONHQ,-COOH,-OH,W,卤素和Q; 其中每个Q独立地选自取代和未取代的低级烯基和低级烷基,并且其中所述取代基选自-NH 2 + L,卤素,-OH和-COOH; D选自羟基,氢和-NH 2; 并且W选自 + TR ,其中每个R独立地选自氢和低级烷基; R'选自乙烯,丙烯,异丙烯和亚苯基; M选自氯和羟基; A选自氢,低级烷基,低级烯基,环烷基和苯基; (B)选自 -CO-,-NHCO-,-O - , - COO - , - N = N-,或表示配位键; L1和L2选自羟基取代或未取代的低级烷基,环烷基,低级烯基或苯基; 提供L2可以是共轭键。 这些化合物在一个方法中具有特异性的用途,用于通过与c-反应蛋白结合并在电化学测量条件下用于释放金属离子和/或抑制金属离子络合物的流动来测量c-反应蛋白。