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1. 发明申请

US20050048590A1 Choline binding proteins for anti-pneumococcal vaccines 有权
标题翻译：用于抗肺炎球菌疫苗的胆碱结合蛋白
公开(公告)号：US20050048590A1
公开(公告)日：2005-03-03
申请号：US10901305
申请日：2004-07-28
申请人： H. Masure , Carsten Rosenow , Elaine Tuomanen , Theresa Wizemann
发明人： H. Masure , Carsten Rosenow , Elaine Tuomanen , Theresa Wizemann
IPC分类号： A61K38/00 , A61K39/00 , A61K39/395 , A61K48/00 , A61P31/04 , C07H21/04 , C07K14/315 , C12N1/21 , C12N15/31 , G01N33/569 , C12N15/74 , G01N33/554
CPC分类号： G01N33/56944 , A61K38/00 , A61K39/00 , A61K39/3955 , A61K48/00 , A61K2039/505 , A61K2039/51 , A61K2039/53 , C07H21/04 , C07K14/3156 , Y10S530/825
摘要： The invention relates to bacterial choline binding proteins (CBPs) which bind choline. Such proteins are particularly desirable for vaccines against appropriate strains of Gram positive bacteria, particularly streptococcus, and more particularly pneumococcus. Also provided are DNA sequences encoding the bacterial choline binding proteins or fragment thereof, antibodies to the bacterial choline binding proteins, pharmaceutical compositions comprising the bacterial choline binding proteins, antibodies to the bacterial choline binding proteins suitable for use in passive immunization, and small molecule inhibitors of choline binding protein mediated adhesion. Methods for diagnosing the presence of the bacterial choline binding protein, or of the bacteria, are also provided. In a specific embodiment, a streptococcal choline binding protein is an enolase, which demonstrates strong affinity for fibronectin.
摘要翻译：本发明涉及结合胆碱的细菌胆碱结合蛋白（CBP）。对于针对革兰氏阳性菌，特别是链球菌，更特别是肺炎球菌的合适菌株的疫苗，这种蛋白质是特别需要的。还提供了编码细菌胆碱结合蛋白或其片段的DNA序列，细菌胆碱结合蛋白的抗体，包含细菌胆碱结合蛋白的药物组合物，适用于被动免疫的细菌胆碱结合蛋白的抗体和小分子抑制剂的胆碱结合蛋白介导的粘附。还提供了用于诊断细菌胆碱结合蛋白或细菌存在的方法。在具体实施方案中，链球菌胆碱结合蛋白是烯醇化酶，其对纤连蛋白表现出强亲和力。

2. 发明申请

US20050208069A1 Polypeptide comprising the amino acid of an N-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof 审中-公开
标题翻译：包含N-末端胆碱结合蛋白的氨基酸的截短的多肽，来源于其的疫苗及其用途
公开(公告)号：US20050208069A1
公开(公告)日：2005-09-22
申请号：US11032644
申请日：2005-01-10
申请人： Elaine Tuomanen , Theresa Wizemann , H. Masure , Leslie Johnson , Scott Koenig
发明人： Elaine Tuomanen , Theresa Wizemann , H. Masure , Leslie Johnson , Scott Koenig
IPC分类号： A61K38/00 , A61K39/00 , A61P31/04 , C07K14/315 , C12Q1/68 , A61K39/02 , C07H21/04 , C12N15/74
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00
摘要： This invention provides an isolated polypeptide comprising an amino acid sequence of a N-terminal choline binding protein A truncate in which the amino acid sequence is set forth in any of SEQ ID NOS: 1, 3-7, or 9-11, including fragments, mutants, variants, analogs, or derivatives, thereof. Also, this invention provides a isolated polypeptide comprising an amino acid sequence of a N-terminal choline binding protein A truncate, wherein the amino acid is set forth in SEQ ID NO: 24, wherein the polypeptide retains its native tertiary structure and methods of preparation. This invention provides an isolated polypeptide comprising an amino acid sequence of a N-terminal choline binding protein A truncate, wherein the polypeptide has lectin activity and does not bind to choline. This invention provides an isolated immunogenic polypeptide comprising an amino acid sequence of a N— terminal choline binding protein A truncate. This invention provides an isolated nucleic acid encoding a polypeptide comprising an amino acid sequence of a N— terminal choline binding protein A truncate. Lastly, this invention provides pharmaceutical compositions, vaccines, and diagnostic and therapeutic methods of use.
摘要翻译：本发明提供了分离的多肽，其包含N-末端胆碱结合蛋白A截短物的氨基酸序列，其中氨基酸序列在SEQ ID NO：1,3-7或9-11中任一项所述，包括片段，突变体，变体，类似物或衍生物。此外，本发明提供了包含N-末端胆碱结合蛋白A截短物的氨基酸序列的分离的多肽，其中所述氨基酸如SEQ ID NO：24所示，其中所述多肽保留其天然三级结构和制备方法。本发明提供了分离的多肽，其包含N-末端胆碱结合蛋白A截短物的氨基酸序列，其中所述多肽具有凝集素活性并且不与胆碱结合。本发明提供了分离的免疫原性多肽，其包含N-末端胆碱结合蛋白A截短体的氨基酸序列。本发明提供编码包含N-末端胆碱结合蛋白A截短物的氨基酸序列的多肽的分离的核酸。最后，本发明提供药物组合物，疫苗以及诊断和治疗使用方法。

3. 发明申请

US20050142145A1 Derivatives of choline binding proteins for vaccines 失效
标题翻译：用于疫苗的胆碱结合蛋白的衍生物
公开(公告)号：US20050142145A1
公开(公告)日：2005-06-30
申请号：US11062080
申请日：2005-02-18
申请人： Theresa Wizemann , Scott Koenig , Leslie Johnson
发明人： Theresa Wizemann , Scott Koenig , Leslie Johnson
IPC分类号： C12N15/09 , A61K39/00 , A61K39/09 , A61K39/395 , A61K39/40 , A61P31/04 , A61P37/04 , C07K14/315 , C07K16/12 , A61K39/02 , C07H21/04 , C12N9/52
CPC分类号： C07K14/3156 , A61K39/00
摘要： The present invention provides bacterial immunogenic agents for administration to humans and non-human animals to stimulate an immune response. It particularly relates to the vaccination of mammalian species with pneumococcal derived polypeptides that include an alpha helix but exclude a choline binding region as a mechanism for stimulating production of antibodies that protect the vaccine recipient against infection by pathogenic bacterial species. In another aspect the invention provides antibodies against such proteins and protein complexes that may be used as diagnositics and/or as protective/treatment agents for pathogenic bacterial species.
摘要翻译：本发明提供用于给予人和非人动物以刺激免疫应答的细菌免疫原性试剂。其特别涉及哺乳动物物种与肺炎球菌来源的多肽的免疫接种，包括α螺旋，但不排除胆碱结合区域，作为刺激保护疫苗接受者免受病原菌种感染的抗体产生的机制。在另一方面，本发明提供抗这种蛋白质和蛋白质复合物的抗体，其可以用作诊断和/或作为病原菌物种的保护/治疗剂。

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