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1. 发明申请

US20070249648A1 Novel Diazaspiroalkanes and Their Use for Treatment of Ccr8 Mediated Diseases 审中-公开
标题翻译：新型二氮茚螺甾烷及其用于治疗Ccr8介导的疾病
公开(公告)号：US20070249648A1
公开(公告)日：2007-10-25
申请号：US10575525
申请日：2004-10-21
申请人： Håkan Bladh , Stephen Connolly , Hazel Dyke , Annea Lisius , Stephen Price , Igor Shamovsky , Marco Van Den Heuvel
发明人： Håkan Bladh , Stephen Connolly , Hazel Dyke , Annea Lisius , Stephen Price , Igor Shamovsky , Marco Van Den Heuvel
IPC分类号： A61K31/438 , A61P11/06 , C07D221/20
CPC分类号： C07D471/10
摘要： The invention provides compounds of general formula. wherein A, B, W, X, Y, Z, D, E, R1 and n are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明提供了通式的化合物。其中A，B，W，X，Y，Z，D，E，R 1和n如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。

2. 发明申请

US20090156575A1 NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES 审中-公开
标题翻译：新西兰双倍体药物及其用于治疗CCR8介导性疾病的用途
公开(公告)号：US20090156575A1
公开(公告)日：2009-06-18
申请号：US12065822
申请日：2006-09-04
申请人： Lena Borjesson , Henrik Johansson , Anna Kristoffersson , Igor Shamovsky , Marco Skrinjar , Stephen Connolly , Tero Linnanen
发明人： Lena Borjesson , Henrik Johansson , Anna Kristoffersson , Igor Shamovsky , Marco Skrinjar , Stephen Connolly , Tero Linnanen
IPC分类号： C07D471/10 , A61K31/438 , A61K31/444 , A61K31/501 , A61P11/00
CPC分类号： C07D487/10 , C07D471/10
摘要： The invention provides compounds of general formula wherein A, B, p, w, x, y, and z are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明提供了通式的化合物，其中A，B，p，w，x，y和z如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。

3. 发明授权

US08735413B2 Compound 有权
标题翻译：复合
公开(公告)号：US08735413B2
公开(公告)日：2014-05-27
申请号：US13546444
申请日：2012-07-11
申请人： Stephen Connolly , Mark Richard Ebden , Iain Alastair Stewart Walters , Thomas Langer , Alan Robert Steven , Craig Robert Stewart , Paula Margaret Tomlin , Andrew John Williams
发明人： Stephen Connolly , Mark Richard Ebden , Iain Alastair Stewart Walters , Thomas Langer , Alan Robert Steven , Craig Robert Stewart , Paula Margaret Tomlin , Andrew John Williams
IPC分类号： A01N43/54 , A61K31/505 , A61K31/506 , C07D239/56
CPC分类号： C07D403/12 , A61K31/506 , C07C65/21 , C07C69/78 , C07C69/92 , C07D205/04 , C07D239/56 , C07D307/12 , C07D317/18 , C07D317/20 , C07D317/24 , C07D317/26
摘要： There is provided a compound which is (a) a pyrimidine sulfonamide of formula (I) or (b) a pharmaceutically acceptable salt thereof, crystalline forms of the compound, processes for obtaining the compound, pharmaceutical intermediates used in the manufacture of the compound, and pharmaceutical compositions containing the compound. The compound is useful in the treatment of a disease/condition in which modulation of chemokine receptor activity is beneficial.
摘要翻译：提供了化合物，其为（a）式（I）或（b）的嘧啶磺酰胺或其药学上可接受的盐，化合物的结晶形式，获得化合物的方法，用于制备化合物的药物中间体，和含有该化合物的药物组合物。该化合物可用于治疗调节趋化因子受体活性有益的疾病/病症。

4. 发明申请

US20110053969A1 NOVEL DIAZASIPIROAKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES 审中-公开
标题翻译：新西兰药物及其用于治疗CCR8介导性疾病的用途
公开(公告)号：US20110053969A1
公开(公告)日：2011-03-03
申请号：US11910580
申请日：2006-03-30
申请人： Stephen Connolly , Marco Skrinjar
发明人： Stephen Connolly , Marco Skrinjar
IPC分类号： A61K31/438 , C07D221/20 , A61P11/06 , A61P11/00
CPC分类号： C07D471/10
摘要： The invention provides compounds of general formula. (II) wherein R and are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明提供了通式的化合物。（II）其中R和如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。

5. 发明申请

US20100249200A1 Novel Compounds 569 审中-公开
标题翻译：新化合物569
公开(公告)号：US20100249200A1
公开(公告)日：2010-09-30
申请号：US12750014
申请日：2010-03-30
申请人： Stephen Connolly , Alexander Humphries , Premji Meghani
发明人： Stephen Connolly , Alexander Humphries , Premji Meghani
IPC分类号： A61K31/428 , A61P29/00 , A61P11/06 , A61P11/00
CPC分类号： C07D277/14 , C07D417/12
摘要： The present invention provides compounds of formula (I) wherein Ra, Rb, R1, R2, R3, R4, R5, R6 and R29 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明提供式（I）化合物，其中R a，R b，R 1，R 2，R 3，R 4，R 5，R 6和R 29如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。

6. 发明申请

US20100144606A1 COMBINATION 408 审中-公开
标题翻译：组合408
公开(公告)号：US20100144606A1
公开(公告)日：2010-06-10
申请号：US12488027
申请日：2009-06-19
申请人： Stephen Connolly , Adrian Fisher , Alexander Humphries , Andrew Watts , Katherine Wiley
发明人： Stephen Connolly , Adrian Fisher , Alexander Humphries , Andrew Watts , Katherine Wiley
IPC分类号： A61K38/12 , C07C229/28 , A61P11/06
CPC分类号： A61K45/06 , A61K31/428 , A61K2300/00
摘要： The invention provides a pharmaceutical product, kit or composition comprising a first active ingredient which is N-Cyclohexyl-N3-[2-(3-fluorophenyl)ethyl]-N-(2-{[2-(4-hydroxy-2-oxo-2,3-dihydro-1,3-benzothiazol-7-yl)ethyl]amino}ethyl)-β-alaninamide or a salt thereof, and a second active ingredient selected from: a non-steroidal Glucocorticoid Receptor (GR Receptor) Agonist; an antioxidant; a CCR1 antagonist; a chemokine antagonist (not CCR1); a corticosteroid; a CRTh2 antagonist; a DP1 antagonist; an Histone Deacetylase Inducer; an IKK2 inhibitor; a COX inhibitor; a lipoxygenase inhibitor; a leukotriene receptor antagonist; an MPO inhibitor; a muscarinic antagonist; a p38 inhibitor; a PDE inhibitor; a PPARγ agonist; a protease inhibitor; a Statin; a thromboxane antagonist; a vasodilator; or, an ENAC blocker (Epithelial Sodium-channel blocker); and its use in the treatment of respiratory disease (for example chronic obstructive pulmonary disease (COPD) or asthma); to certain salts of N-Cyclohexyl-N3-[2-(3-fluorophenyl)ethyl]-N-(2-{[2-(4-hydroxy-2-oxo-2,3-dihydro-1,3-benzothiazol-7-yl)ethyl]amino}ethyl)-β-alaninamide and to an intermediate useful in the manufacture of this pharmaceutically active substance and salts thereof.
摘要翻译：本发明提供了包含N-环己基-N3- [2-（3-氟苯基）乙基] -N-（2 - {[2-（4-羟基-2- -2-氧代-2,3-二氢-1,3-苯并噻唑-7-基）乙基]氨基}乙基） - 丙氨酰胺或其盐，和第二活性成分，选自：非甾体糖皮质激素受体（GR 受体）激动剂; 抗氧化剂 CCR1拮抗剂; 趋化因子拮抗剂（不是CCR1）; 皮质类固醇 CRTh2拮抗剂; DP1拮抗剂; 组蛋白脱乙酰酶诱导剂; IKK2抑制剂; COX抑制剂; 脂氧合酶抑制剂; 白细胞三烯受体拮抗剂; MPO抑制剂; 毒蕈碱拮抗剂一种p38抑制剂; PDE抑制剂; PPARγ激动剂; 蛋白酶抑制剂; 他汀类血栓素拮抗剂; 血管扩张剂或ENAC阻断剂（上皮钠通道阻断剂）; 及其用于治疗呼吸系统疾病（如慢性阻塞性肺疾病（COPD）或哮喘））; 对于N-环己基-N3- [2-（3-氟苯基）乙基] -N-（2 - {[2-（4-羟基-2-氧代-2,3-二氢-1,3-苯并噻唑） -7-基）乙基]氨基}乙基） - 乙酰氨基脲和可用于制备该药物活性物质及其盐的中间体。

7. 发明申请

US20100056508A1 AMINE DERIVATIVES AND THEIR USE IN BETA-2-ADRENORECEPTOR MEDIATED DISEASES 审中-公开
标题翻译：胺衍生物及其在β-2受体介导的疾病中的应用
公开(公告)号：US20100056508A1
公开(公告)日：2010-03-04
申请号：US12519591
申请日：2007-12-19
申请人： Lilian Alcaraz , Roger Victor Bonnert , Stephen Connolly , Anthony Ronald Cook , Adrian Fisher , Alexander Humphries , Piotr Raubo
发明人： Lilian Alcaraz , Roger Victor Bonnert , Stephen Connolly , Anthony Ronald Cook , Adrian Fisher , Alexander Humphries , Piotr Raubo
IPC分类号： A61K31/536 , C07D265/36 , A61K31/16 , C07C237/00
CPC分类号： C07D265/36 , C07C233/43 , C07C2601/14 , C07D209/34 , C07D215/26 , C07D409/12 , C07D413/12
摘要： The present invention provides compounds of formula (I), wherein k, Ar, R2, R3, R4, R5, R4′, R5′, R6, R7, A, D, m and E are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明提供式（I）化合物，其中k，Ar，R2，R3，R4，R5，R4'，R5'，R6，R7，A，D，m和E如说明书中所定义，其制剂，含有它们的药物组合物及其在治疗中的用途。

8. 发明申请

US20060194847A1 Novel 6-substituted 2-aminopyridine derivatives 审中-公开
标题翻译：新的6-取代的2-氨基吡啶衍生物
公开(公告)号：US20060194847A1
公开(公告)日：2006-08-31
申请号：US10551494
申请日：2004-03-30
申请人： David Cheshire , Stephen Connolly , Timothy Luker
发明人： David Cheshire , Stephen Connolly , Timothy Luker
IPC分类号： C07D213/75 , A61K31/44
CPC分类号： C07D213/73
摘要： There are provided novel compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, L1, L2, L3 and Q are are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.
摘要翻译：提供了新的式（I）化合物，其中R 1，R 2，R 3，R 4， R 5，R 6，R 7，R 8，R 9，R 9，，L 1，L 2，L 3和Q如说明书中所定义，及其药学上可接受的盐; 以及其制备方法，含有它们的组合物及其在治疗中的用途。这些化合物是一氧化氮合酶的抑制剂，因此特别可用于治疗或预防炎性疾病和疼痛。

9. 发明申请

US20050143379A1 Arylheteroalkylamine derivatives and their use as inhibitors of nitric oxide synthase 失效
标题翻译：芳基烷基胺衍生物及其作为一氧化氮合酶抑制剂的用途
公开(公告)号：US20050143379A1
公开(公告)日：2005-06-30
申请号：US10483163
申请日：2002-07-26
申请人： David Cheshire , Stephen Connolly , Antonio Mete
发明人： David Cheshire , Stephen Connolly , Antonio Mete
IPC分类号： A61K31/145 , A61K31/277 , A61K31/42 , A61K31/44 , A61K31/4402 , A61K45/06 , A61P1/00 , A61P19/02 , A61P25/00 , A61P25/02 , A61P25/06 , A61P29/00 , A61P43/00 , C07C255/54 , C07C257/14 , C07C323/29 , C07C323/62 , C07D213/32 , C07D213/85 , C07D261/08 , A61K31/53 , A61K31/496
CPC分类号： C07C323/29 , A61K45/06 , C07C255/54 , C07C257/14 , C07C323/62 , C07D213/32 , C07D213/85 , C07D261/08
摘要： There are provided novel compounds of formula (I), wherein R1, R2, R3, T, U, X, Y, V and W are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.
摘要翻译：提供式（I）的新化合物，其中R 1，R 2，R 3，T，U，X，Y， V和W如说明书中所定义，及其药学上可接受的盐，及其对映异构体和外消旋体; 以及其制备方法，含有它们的组合物及其在治疗中的用途。这些化合物是一氧化氮合酶的抑制剂，因此特别可用于治疗或预防炎性疾病和疼痛。

10. 发明申请

US20160229595A1 DISPOSIBLE WASTE BAG 审中-公开
标题翻译：废弃垃圾袋
公开(公告)号：US20160229595A1
公开(公告)日：2016-08-11
申请号：US14618496
申请日：2015-02-10
申请人： Stephen Connolly
发明人： Stephen Connolly
IPC分类号： B65D33/25 , B65D33/16
CPC分类号： B65D33/25 , A47K11/02 , B65D33/1691 , B65F1/002 , B65F2210/1026 , B65F2250/105 , Y02A50/454
摘要： A human waste disposal bag, intended for use when permanent or temporary toilet facilities are unavailable. The human waste disposal bag has a zipper closure system on the interior surface, near the opening. The human waste disposal bag has two pressure sensitive adhesive strips disposed further from the opening than the zipper closure.
摘要翻译：人造废物处理袋，用于永久或临时厕所设施不可用。人体废物处理袋在内表面附近具有拉链封闭系统，靠近开口。人体废物处理袋具有比拉链封闭件更远离开口设置的两个压敏粘合带。

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