专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4851411A 5-monoaryl as.-triazin-3-ones substituted in 2-position, and their use as medicaments 失效
标题翻译： 2-取代的5-单芳基三嗪-3-酮及其作为药物的用途
公开(公告)号：US4851411A
公开(公告)日：1989-07-25
申请号：US4169
申请日：1987-01-15
申请人： Guy Pitet , Henri Cousse , Antoine Stenger , Michel Briley , Philippe Chopin
发明人： Guy Pitet , Henri Cousse , Antoine Stenger , Michel Briley , Philippe Chopin
IPC分类号： A61K31/53 , A61P25/24 , A61P25/26 , C07D253/06 , C07D253/07 , C07D401/06 , C07D405/04 , C07D405/10 , C07D405/12 , C07D409/04
CPC分类号： C07D253/06 , C07D253/07 , C07D401/06 , C07D405/10 , C07D405/12 , C07D409/04
摘要： The present invention concerns new 5-monoaryl as.-triazin-3-ones substituted in 2-position, a method of preparing them, and their use as medicaments.The compounds according to the present invention have general formula (I) ##STR1## in which: the bond represented by a dashed line indicates the presence of an optional double bond;A represents a direct N--C bond, a straight or branched C.sub.1 to C.sub.5 alkylene, possibly substituted one or more times by --COOR' or by Ar;R represents --H, --OH, ##STR2## R' represents --H, --OH, straight or branched C.sub.1 to C.sub.7 alkyl, --NH.sub.2 ;Ar represents an aromatic ring having 5 or 6 members possibly containing a heteroatom such as O, N, S and possibly substituted one or more times by a radical selected from among --OH, C.sub.1 to C.sub.4 alkyl, C.sub.1 and C.sub.4 alkoxy, halogen, --CF.sub.3, acetonyloxy, ##STR3## and .gamma.-butyrolactone; as well as their pharmaceutically acceptable salts.
摘要翻译：本发明涉及2-位取代的新的5-单芳基三嗪-3-酮，其制备方法及其作为药物的用途。根据本发明的化合物具有通式（I）其中：由虚线表示的键表示存在任选的双键; A表示直接的N-C键，直链或支链C1至C5亚烷基，可能被-COOR'或Ar取代一次或多次; R表示-H，-OH，R 3表示-H，-OH，直链或支链C 1 -C 7烷基，-NH 2; Ar表示具有5或6个可能含有杂原子如O，N，S的芳环，并且可能被选自-OH，C 1至C 4烷基，C 1和C 4烷氧基，卤素， CF 3，乙酰氧基，γ-丁内酯; 以及它们的药学上可接受的盐。

2. 发明授权

US4188387A Amino-aryl 1,24-triazines useful in the treatment of diverse pain 失效
标题翻译：氨基 - 芳基1,24-三嗪可用于治疗多种疼痛
公开(公告)号：US4188387A
公开(公告)日：1980-02-12
申请号：US884732
申请日：1978-03-09
申请人： Guy Pitet , Henri Cousse , Gilbert Mouzin , Antoine Stenger
发明人： Guy Pitet , Henri Cousse , Gilbert Mouzin , Antoine Stenger
IPC分类号： C07D253/06 , A61K31/53 , A61K31/535 , A61P29/00 , C07D253/07 , C07D413/10
CPC分类号： C07D253/065 , C07D253/07 , Y10S514/825
摘要： The invention relates to new chemical compounds which can be used as analgesic drugs and their preparation.The new chemical compounds have the general formula: ##STR1## in which: R is a lower alkylR.sub.1, which is always other than H, is a linear or branched lower alkyl, an allyl, amino alkyl of type ##STR2## in which n=2 to 4, R.sub.2 R.sub.3 represent a lower alkyl; they may also form a heterocycle with the nitrogen atom.Y is a hydrogen, halogen, lower alkyl, alkoxy, ##STR3## R being a lower alkyl. The position of Y is variable on the ring.X=oxygen or sulfur atom.The drugs containing these active principles may be used in the treatment of rheumatismal disturbances and various pains.
摘要翻译：本发明涉及可用作止痛药及其制剂的新化合物。新的化合物具有以下通式：其中：R为低级烷基，其总是不是H，是直链或支链的低级烷基，类型为“IMAGE”的烯丙基，氨基烷基，其中n = 2〜4，R2R3表示低级烷基; 它们也可以与氮原子形成杂环。 Y是氢，卤素，低级烷基，烷氧基，R是低级烷基。 Y的位置在环上是可变的。 X =氧或硫原子。含有这些活性成分的药物可用于治疗风湿性疾病和各种疼痛。

3. 发明授权

US4511566A 2-N-Cycloalkylmethyl 3-oxo 5,6-diaryl-as-triazines 失效
标题翻译： 2-N-环烷基甲基3-氧代5,6-二芳基 - 三嗪
公开(公告)号：US4511566A
公开(公告)日：1985-04-16
申请号：US600473
申请日：1984-04-16
申请人： Guy Pitet , Henri Cousse , Gilbert Mouzin
发明人： Guy Pitet , Henri Cousse , Gilbert Mouzin
IPC分类号： C07D253/06 , A61K31/53 , A61P7/02 , A61P25/04 , C07C17/16 , C07D253/07 , C07D401/14 , C07D405/14 , C07D409/14 , C07D401/04
CPC分类号： C07D409/14 , C07C17/16 , C07D253/07 , C07D401/14 , C07D405/14
摘要： The present invention concerns new 2-N-cycloalkylmethyl 3-oxo 5,6-diaryl as-triazines, their method of production, pharmaceutical compositions thereof, and their use as medicaments, for treating pain.The derivatives of 2-N-cycloalkylmethyl 3-oxo 5,6-diaryl as-triazine according to the invention have the general formula I ##STR1## in which Ar represents a phenyl, furyl, thienyl, or pyridyl group, which group may possibly be substituted by a lower C.sub.1 to C.sub.4 alkoxy radical, in particular by the methoxy radical, andn is a whole number having a value of 1 to 4.
摘要翻译：本发明涉及新的2-N-环烷基甲基3-氧代5,6-二芳基三嗪，它们的制备方法，其药物组合物及其作为药物的用途，用于治疗疼痛。根据本发明的2-N-环烷基甲基3-氧代5,6-二芳基 - 三嗪的衍生物具有通式I（I），其中Ar表示苯基，呋喃基，噻吩基或吡啶基，其中基团可能被低级C1至C4烷氧基取代，特别是被甲氧基取代，n为整数，其值为1至4。

4. 发明授权

US4167566A Antithrombotic 2-prenyl-3-oxo-5,6-diaryl-as-triazenes 失效
标题翻译：抗血栓2-异戊烯基-3-氧代-5,6-二芳基 - 三氮烯
公开(公告)号：US4167566A
公开(公告)日：1979-09-11
申请号：US884733
申请日：1978-03-09
申请人： Guy Pitet , Henri Cousse , Gilbert Mouzin , Andre Delhon
发明人： Guy Pitet , Henri Cousse , Gilbert Mouzin , Andre Delhon
IPC分类号： C07D253/07 , C07D253/06 , A61K31/53
CPC分类号： C07D253/065 , C07D253/07 , Y10S514/822
摘要： The invention relates to compounds of the formula ##STR1## in which R and R' are identical or different and may be a hydrogen, an alkyl, a dialkylamino, an alkoxy, a halogen, or a hydroxy. These compounds are useful as drugs in the control of thromboses.
摘要翻译：本发明涉及式（I）的化合物，其中R和R'相同或不同并且可以是氢，烷基，二烷基氨基，烷氧基，卤素或羟基。这些化合物可用作控制血栓形成的药物。

5. 发明授权

US5198441A Derivatives of 1,2-dihydro 2-oxo quinoxalines, their preparation and their use in therapy 失效
标题翻译： 1,2-二羟基喹喔啉衍生物的制备及其在治疗中的应用
公开(公告)号：US5198441A
公开(公告)日：1993-03-30
申请号：US688536
申请日：1991-06-17
申请人： Guy Pitet , Christian Faure , Francoise Couret , Dennis Bigg , Jean-Pierre Tarayre
发明人： Guy Pitet , Christian Faure , Francoise Couret , Dennis Bigg , Jean-Pierre Tarayre
IPC分类号： A61K31/495 , A61P11/08 , C07D241/44 , C07D401/06
CPC分类号： C07D401/06 , C07D241/44
摘要： New derivatives of 1,2-dihydro 2-oxo quinoxalines corresponding to the general formula I: ##STR1## in which: R is a hydrogen or halogen atomR.sub.1 is a hydrogen atom or a straight or branched C.sub.1 -C.sub.4 alkyl radicalR.sub.2 is:a hydrogen atoma C(O)R.sub.4 radical in which R.sub.4 is a straight or branched C.sub.1 -C.sub.4 alkyl groupa C(O)NHR.sub.5 radical in which R.sub.5 is a straight or branched C.sub.1 -C.sub.4 alkyl radical or a phenyl groupA is a C.sub.1 -C.sub.4 alkaline chainR.sub.3 represents:a hydrogen atom, a C.sub.1 -C.sub.4 alkyl radical, a C.sub.3 -C.sub.6 cycloalkyl radical, an alcynyl, nitrile, hydroxyl, carboxamido, pyridyl, phenyl group, or a phenyl group substituted by a halogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.1 -C.sub.4 alkoxy group or a nitro groupan alkenyl radical of the formula: ##STR2## in which R.sub.6, R.sub.7 may, independently of each other, be a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group, a phenyl group or an alkoxycarbonyl groupa radical of the formula:--OC(O)R.sub.8 in which R.sub.8 represents a C.sub.1 -C.sub.4 alkyl radicala radical of the formula:--OC(O)NHR.sub.9 in which R.sub.9 represents a straight or branched C.sub.1 -C.sub.4 alkyl group, or a phenyl groupmay assume values from 2 to 4.as well as the therapeutically acceptable organic or inorganic salts of these molecules. The compounds are useful in the treatment of respiratory disorders.
摘要翻译： PCT No.PCT / FR90 / 00752 Sec。 371日期1991年6月17日 102（e）日期1991年6月17日PCT提交1990年10月17日PCT公布。第WO91 / 05772号公报日期：1991年5月2日。对应于通式I的1,2-二氢-2-氧代喹喔啉的新衍生物：其中：R为氢或卤素原子，R 1为氢原子或直链或支链C1 -C4烷基R2是：氢原子，C（O）R4基，其中R4是直链或支链C1-C4烷基，C（O）NHR5基，其中R5是直链或支链C1-C4烷基或苯基A是C1-C4碱基链R3表示：氢原子，C1-C4烷基，C3-C6环烷基，烷酰基，腈，羟基，甲酰氨基，吡啶基，苯基或苯基被卤素原子取代的基团，C 1 -C 4烷基，C 1 -C 4烷氧基或硝基，下式的链烯基：其中R 6，R 7可以彼此独立地为氢原子，C 1 -C 4烷基，苯基或烷氧基羰基，式-OC（O）R 8基团，其中R 8表示C 1 -C 4烷基，式：-OC（O）NHR 9基团在其中R 9表示直链或支链C 1 -C 4烷基，或苯基可以为2至4的值，以及这些分子的治疗上可接受的有机或无机盐。该化合物可用于治疗呼吸系统疾病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式