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1. 发明申请

US20060235013A1 Tricyclic azole derivatives 审中-公开
标题翻译：三环唑衍生物
公开(公告)号：US20060235013A1
公开(公告)日：2006-10-19
申请号：US11384058
申请日：2006-03-17
申请人： Guy Georges , Bernhard Goller , Hans-Willi Krell , Anja Limberg , Ulrike Reiff , Petra Rueger , Matthias Rueth
发明人： Guy Georges , Bernhard Goller , Hans-Willi Krell , Anja Limberg , Ulrike Reiff , Petra Rueger , Matthias Rueth
IPC分类号： A61K31/5377 , A61K31/4745 , A61K31/4188 , C07D487/04
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明涉及式I化合物：其药学上可接受的盐或酯，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物组合物及其制备，以及这些化合物的用途控制或预防癌症等疾病。

2. 发明申请

US20090143375A1 Tricyclic Lactam Derivatives, Their Manufacture and Use as Pharmaceutical Agents 审中-公开
标题翻译：三环内酰胺衍生物，其制造和用作药剂
公开(公告)号：US20090143375A1
公开(公告)日：2009-06-04
申请号：US12084531
申请日：2006-12-13
申请人： Guy Georges , Bernhard Goller , Hans-Willi Krell , Anja Limberg , Ulrike Reiff , Petra Rueger , Matthias Rueth , Christine Schuell , Mark Stahl
发明人： Guy Georges , Bernhard Goller , Hans-Willi Krell , Anja Limberg , Ulrike Reiff , Petra Rueger , Matthias Rueth , Christine Schuell , Mark Stahl
IPC分类号： A61K31/4188 , C07D487/04 , A61P29/00 , A61P9/00 , A61P35/00 , A61P25/00 , A61K31/5377
CPC分类号： C07D487/04
摘要： Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明的目的是式I化合物，其药学上可接受的盐，对映体形式，非对映异构体和外消旋物，上述化合物的制备，含有它们的药物及其制备，以及上述化合物控制或预防癌症等疾病。

3. 发明授权

US07285569B2 Tricycles, their manufacture and use as pharmaceutical agents 失效
标题翻译：三轮车，其制造和用作药剂
公开(公告)号：US07285569B2
公开(公告)日：2007-10-23
申请号：US11233408
申请日：2005-09-23
申请人： Georges Guy , Bernhard Goller , Hans-Willi Krell , Klaus-Peter Kuenkele , Anja Limberg , Petra Rueger , Matthias Rueth
发明人： Georges Guy , Bernhard Goller , Hans-Willi Krell , Klaus-Peter Kuenkele , Anja Limberg , Petra Rueger , Matthias Rueth
IPC分类号： A61K31/4184 , A61K31/4155 , C07D487/02 , C07D403/04
CPC分类号： A61K31/4184 , C07D487/04 , C07D487/10
摘要： The present invention relates to compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明涉及式I化合物的药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备，以及上述化合物在控制或预防癌症等疾病。

4. 发明申请

US20060069145A1 Tricycles, their manufacture and use as pharmaceutical agents 失效
标题翻译：三轮车，其制造和用作药剂
公开(公告)号：US20060069145A1
公开(公告)日：2006-03-30
申请号：US11233408
申请日：2005-09-23
申请人： Georges Guy , Bernhard Goller , Hans-Willi Krell , Klaus-Peter Kuenkele , Anja Limberg , Petra Rueger , Matthias Rueth
发明人： Georges Guy , Bernhard Goller , Hans-Willi Krell , Klaus-Peter Kuenkele , Anja Limberg , Petra Rueger , Matthias Rueth
IPC分类号： A61K31/4184 , C07D487/02
CPC分类号： A61K31/4184 , C07D487/04 , C07D487/10
摘要： The present invention relates to compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明涉及式I化合物

5. 发明申请

US20090264485A1 Pyrazole Derivatives, Their Manufacture and Their Use as Pharmaceutical Agents 审中-公开
标题翻译：吡唑衍生物，其制造及其作为药剂的用途
公开(公告)号：US20090264485A1
公开(公告)日：2009-10-22
申请号：US11989218
申请日：2006-08-07
申请人： Hans-Willi Krell , Joerg Middeldorff , Ulrike Reiff , Thomas von Hirschheydt , Edgar Voss
发明人： Hans-Willi Krell , Joerg Middeldorff , Ulrike Reiff , Thomas von Hirschheydt , Edgar Voss
IPC分类号： A61K31/422 , C07D413/12 , A61P35/00
CPC分类号： C07D413/12
摘要： Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明的目的是式I化合物，其药学上可接受的盐，对映异构体形式，非对映异构体和外消旋物，上述化合物的制备，含有它们的药物组合物及其制备方法以及使用上述控制或预防疾病如癌症的化合物。

6. 发明授权

US08859737B2 Anti-HER3 antibodies and uses thereof 有权
标题翻译：抗HER3抗体及其用途
公开(公告)号：US08859737B2
公开(公告)日：2014-10-14
申请号：US12971300
申请日：2010-12-17
申请人： Birgit Bossenmaier , Nikolaos Dimoudis , Thomas Friess , Guy Georges , Irene Kolm , Hans-Willi Krell , Valeria Lifke , Ekkehard Moessner
发明人： Birgit Bossenmaier , Nikolaos Dimoudis , Thomas Friess , Guy Georges , Irene Kolm , Hans-Willi Krell , Valeria Lifke , Ekkehard Moessner
IPC分类号： C12P21/08 , C07K16/32 , A61K39/00
CPC分类号： C07K16/32 , A61K2039/505 , C07K16/40 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies binding to human HER3 (anti-HER3 antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译：本发明涉及与人HER3（抗HER3抗体）结合的抗体，其制备方法，含有所述抗体的药物组合物及其用途。

7. 发明申请

US20110171222A1 ANTI-HER3 ANTIBODIES AND USES THEREOF 有权
标题翻译：抗HER3抗体及其用途
公开(公告)号：US20110171222A1
公开(公告)日：2011-07-14
申请号：US12971300
申请日：2010-12-17
申请人： Birgit Bossenmaier , Nikolaos Dimoudis , Thomas Friess , Guy Georges , Irene Kolm , Hans-Willi Krell , Valeria Lifke , Ekkehard Moessner
发明人： Birgit Bossenmaier , Nikolaos Dimoudis , Thomas Friess , Guy Georges , Irene Kolm , Hans-Willi Krell , Valeria Lifke , Ekkehard Moessner
IPC分类号： A61K39/395 , C07K16/32 , C07H21/00 , C12N15/63 , C12N5/10 , C12N1/00 , C12P21/02 , A61P35/00
CPC分类号： C07K16/32 , A61K2039/505 , C07K16/40 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies binding to human HER3 (anti-HER3 antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译：本发明涉及与人HER3（抗HER3抗体）结合的抗体，其制备方法，含有所述抗体的药物组合物及其用途。

8. 发明申请

US20110070246A1 Antibodies Against CDCP1 for the Treatment of Cancer 有权
标题翻译：抗CDCP1治疗癌症的抗体
公开(公告)号：US20110070246A1
公开(公告)日：2011-03-24
申请号：US12868849
申请日：2010-08-26
申请人： Birgit Bossenmaier , Georg Fertig , Hans-Willi Krell , Reiner Lammers , Alexander Lifke , Gerhard Niederfellner
发明人： Birgit Bossenmaier , Georg Fertig , Hans-Willi Krell , Reiner Lammers , Alexander Lifke , Gerhard Niederfellner
IPC分类号： A61K39/395 , C07K16/30 , C12N15/13 , C12N15/85 , C12N5/10 , C12P21/02 , A61P35/04
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76
摘要： The present invention relates to antibodies against human CDCP1 binding to the same epitope as CUB4 (Deposition No. DSM ACC2551) for the treatment of cancer.
摘要翻译：本发明涉及抗CDCP1与CUB4（沉积号DSM ACC2551）相同表位的抗体用于治疗癌症的抗体。

9. 发明授权

US06506755B2 Thiazolidinecarboxyl acids 失效
标题翻译：噻唑烷羧酸
公开(公告)号：US06506755B2
公开(公告)日：2003-01-14
申请号：US09767306
申请日：2001-01-23
申请人： Walter-Gunar Friebe , Hans-Willi Krell , Sabine Woelle , Hans-Peter Wolff
发明人： Walter-Gunar Friebe , Hans-Willi Krell , Sabine Woelle , Hans-Peter Wolff
IPC分类号： C07D27720
CPC分类号： C07D277/20 , C07D417/12 , C07D417/14
摘要： 5-Arylidene-4-oxo-2-thioxo-3-thiazolidinecarboxylic acids of formula I in which the symbols R1, R2, A, A1 and A2 have the significance given in the description as medicaments for the treatment of cancer diseases.
摘要翻译：符号R1，R2，A，A1和A2具有在描述中给出的用于治疗癌症疾病的药物的含义的式Iin的5-亚芳基-4-氧代-2-硫代-3-噻唑烷羧酸。

10. 发明授权

US06472396B1 Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds 失效
标题翻译：巴比妥酸衍生物，其制备方法和含有这些化合物的药剂
公开(公告)号：US06472396B1
公开(公告)日：2002-10-29
申请号：US09594700
申请日：2000-06-16
申请人： Elmar Bosies , Angelika Esswein , Frank Grams , Hans-Willi Krell , Ernesto Menta
发明人： Elmar Bosies , Angelika Esswein , Frank Grams , Hans-Willi Krell , Ernesto Menta
IPC分类号： C07D23962
CPC分类号： C07D401/04 , C07D239/62
摘要： Compounds of formula I, useful as matrix metalloprotease inhibitors, wherein X, Y and Z are each oxygen; R1 is selected from the group consisting of (a) n-octyl, (b) n-decyl, (c) biphenyl and (d) (4-phenoxy)phenyl, wherein the terminal monocycle for moieties (c)-(d) is unsubstituted or substituted by a substituent selected from the group consisting of —NH2, —NO2, —SO2NH2, —SO2CH3, acetyl, hydroxy, methoxy, ethoxy, cyano and halogen; R2 and R3 are each hydrogen; and R4 and R5, together with the nitrogen atom to which they are bound, form a piperazinyl or piperidyl ring, wherein the piperazinyl ring is substituted in the 4-position with a substituent selected from the group consisting of (a) a 6-membered aromatic monocycle having 0, 1 or 2 nitrogen atoms and the remainder of the atoms in the monocycle being carbon and (b) hydroxy-C1-C6 alkyl, wherein the monocycle is unsubstituted or substituted by a substituent selected from the group consisting of halogen, —NH2, —NO2, —SO2NH2, —SO2CH3, acetyl and cyano.
摘要翻译：可用作基质金属蛋白酶抑制剂的式I化合物，其中X，Y和Z各自为氧; R 1选自（a）正辛基，（b）正癸基，（c）联苯和（d）（4-苯氧基）苯基，其中部分（c） - （d）的末端单环是未取代的或被选自-NH 2，-NO 2，-SO 2 NH 2，-SO 2 CH 3，乙酰基，羟基，甲氧基，乙氧基，氰基和卤素; R 2和R 3各自为氢; 和R 4和R 5与它们所连接的氮原子一起形成哌嗪基或哌啶基环，其中哌嗪环在4位被取代基取代，所述取代基选自（a）6元芳族具有0,1或2个氮原子的单环，并且单环中的其余原子为碳和（b）羟基-C 1 -C 6烷基，其中所述单环是未取代的或被选自以下的取代基取代：卤素， NH 2，-NO 2，-SO 2 NH 2，-SO 2 CH 3，乙酰基和氰基。

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