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1. 发明授权

US07822249B2 Systems and methods for high-throughput radiation biodosimetry 有权
标题翻译：用于高通量辐射生物测定法的系统和方法
公开(公告)号：US07822249B2
公开(公告)日：2010-10-26
申请号：US11895417
申请日：2007-08-24
申请人： Guy Garty , David J. Brenner , Gerhard Randers-Pehrson , Y. Lawrence Yao , Nabil Simaan , Alessio Salerno , Anubha Bhatla , Jian Zhang , Oleksandra V. Lyulko , Aparajita Dutta
发明人： Guy Garty , David J. Brenner , Gerhard Randers-Pehrson , Y. Lawrence Yao , Nabil Simaan , Alessio Salerno , Anubha Bhatla , Jian Zhang , Oleksandra V. Lyulko , Aparajita Dutta
IPC分类号： G06K9/00
CPC分类号： C40B30/10 , C40B60/12
摘要： Systems and methods for high-throughput radiation biodosimetry are disclosed herein. In some embodiments, a high-throughput methods of analyzing a population for radiation exposure can include, in various possible sequences: marking a first capillary designed to retain a first sample from the population with a first identifier; transporting a plurality of samples to a biodosimetry system; inputting the samples into the biodosimetry system; centrifuging the plurality of samples including the first sample wherein each sample can be retained in a capillary and the first sample can be retained in the first capillary; transferring the plurality of capillaries including the first capillary from the centrifuge to a cutting device using a robotic device; cutting the first capillary; reading the first identifier; transferring at least one portion of the first sample from the first capillary to a well in an array, wherein the array can include one or more filters in a multi-well plate; correlating the first identifier to a location of the array that includes the at least one portion of the first sample; one or more cycles of biological processing, which can include addition of a reagent and/or incubation of a selected temperature such as, for example, 37° C., 4° C., room temperature, and the like; sealing the array; positioning the array adjacent to an imaging element; focusing the imaging element; capturing an image of the first sample in the array; and analyzing the image to determine whether the first sample indicates a level of radiation exposure exceeding a predetermined threshold.
摘要翻译：本文公开了用于高通量辐射生物测定法的系统和方法。在一些实施例中，用于分析用于辐射暴露的群体的高通量方法可以以各种可能的顺序包括：标记设计成用第一标识符从群体保留第一样本的第一毛细管; 将多个样品运送到生物测定系统; 将样品输入生物测定系统; 将包括第一样品的多个样品离心，其中每个样品可以保留在毛细管中，并且第一样品可以保留在第一毛细管中; 使用机器人装置将包括第一毛细管的多个毛细管从离心机转移到切割装置; 切割第一根毛细管; 阅读第一个标识符; 将所述第一样品的至少一部分从所述第一毛细管转移到阵列中的阱，其中所述阵列可以包括多孔板中的一个或多个过滤器; 将所述第一标识符与包括所述第一样本的所述至少一部分的所述阵列的位置相关联; 一个或多个生物处理循环，其可以包括添加试剂和/或选择温度的温育，例如37℃，4℃，室温等; 密封阵列; 将阵列定位成与成像元件相邻; 聚焦成像元件; 捕获阵列中第一个样本的图像; 并分析图像以确定第一样本是否指示超过预定阈值的辐射暴露水平。

2. 发明申请

US20080181473A1 Systems and methods for high-throughput radiation biodosimetry 有权
标题翻译：用于高通量辐射生物测定法的系统和方法
公开(公告)号：US20080181473A1
公开(公告)日：2008-07-31
申请号：US11895417
申请日：2007-08-24
申请人： Guy Garty , David J. Brenner , Gerhard Randers-Pehrson , Y. Lawrence Yao , Nabil Simaan , Alessio Salerno , Anubha Bhatla , Jian Zhang , Oleksandra V. Lyulko , Aparajita Dutta
发明人： Guy Garty , David J. Brenner , Gerhard Randers-Pehrson , Y. Lawrence Yao , Nabil Simaan , Alessio Salerno , Anubha Bhatla , Jian Zhang , Oleksandra V. Lyulko , Aparajita Dutta
IPC分类号： G06K9/00
CPC分类号： C40B30/10 , C40B60/12
摘要： Systems and methods for high-throughput radiation biodosimetry are disclosed herein. In some embodiments, a high-throughput methods of analyzing a population for radiation exposure can include, in various possible sequences: marking a first capillary designed to retain a first sample from the population with a first identifier; transporting a plurality of samples to a biodosimetry system; inputting the samples into the biodosimetry system; centrifuging the plurality of samples including the first sample wherein each sample can be retained in a capillary and the first sample can be retained in the first capillary; transferring the plurality of capillaries including the first capillary from the centrifuge to a cutting device using a robotic device; cutting the first capillary; reading the first identifier; transferring at least one portion of the first sample from the first capillary to a well in an array, wherein the array can include one or more filters in a multi-well plate; correlating the first identifier to a location of the array that includes the at least one portion of the first sample; one or more cycles of biological processing, which can include addition of a reagent and/or incubation of a selected temperature such as, for example, 37° C., 4° C., room temperature, and the like; sealing the array; positioning the array adjacent to an imaging element; focusing the imaging element; capturing an image of the first sample in the array; and analyzing the image to determine whether the first sample indicates a level of radiation exposure exceeding a predetermined threshold.
摘要翻译：本文公开了用于高通量辐射生物测定法的系统和方法。在一些实施例中，用于分析用于辐射暴露的群体的高通量方法可以以各种可能的顺序包括：标记设计成用第一标识符从群体保留第一样本的第一毛细管; 将多个样品运送到生物测定系统; 将样品输入生物测定系统; 将包括第一样品的多个样品离心，其中每个样品可以保留在毛细管中，并且第一样品可以保留在第一毛细管中; 使用机器人装置将包括第一毛细管的多个毛细管从离心机转移到切割装置; 切割第一根毛细管; 阅读第一个标识符; 将所述第一样品的至少一部分从所述第一毛细管转移到阵列中的阱，其中所述阵列可以包括多孔板中的一个或多个过滤器; 将所述第一标识符与包括所述第一样本的所述至少一部分的所述阵列的位置相关联; 一个或多个生物处理循环，其可以包括添加试剂和/或选择温度的温育，例如37℃，4℃，室温等; 密封阵列; 将阵列定位成与成像元件相邻; 聚焦成像元件; 捕获阵列中第一个样本的图像; 并分析图像以确定第一样本是否指示超过预定阈值的辐射暴露水平。

3. 发明申请

US20080179301A1 Systems and methods for etching materials 审中-公开
标题翻译：蚀刻材料的系统和方法
公开(公告)号：US20080179301A1
公开(公告)日：2008-07-31
申请号：US11895517
申请日：2007-08-24
申请人： Guy Garty , Gerhard Randers-Pehrson , Anubha Bhatla , Alessio Salerno , Nabil Simaan , Y. Lawrence Yao , David J. Brenner
发明人： Guy Garty , Gerhard Randers-Pehrson , Anubha Bhatla , Alessio Salerno , Nabil Simaan , Y. Lawrence Yao , David J. Brenner
IPC分类号： B23K26/00 , G06K7/10
CPC分类号： C40B30/10 , C40B60/12
摘要： Systems and methods for etching materials are disclosed herein. Embodiments of the disclosed subject matter include methods for marking at least one capillary, including etching the at least one capillary with a laser, as well as methods for reading the resulting markings using a second laser. Further embodiments incorporate the second laser within a barcode reader. Various embodiments of the disclosed subject matter include capillaries having outer diameters of about 2 mm. In some embodiments, the capillary is moved while the first laser marks the capillary.
摘要翻译：本文公开了蚀刻材料的系统和方法。所公开的主题的实施例包括用于标记至少一个毛细管的方法，包括用激光蚀刻至少一个毛细管，以及使用第二激光读取所得到的标记的方法。另外的实施例将第二激光器并入条形码读取器内。所公开的主题的各种实施例包括外径约2mm的毛细管。在一些实施例中，当第一激光器标记毛细管时毛细管被移动。

4. 发明申请

US20120132313A1 Systems and methods for cutting materials 审中-公开
标题翻译：切割材料的系统和方法
公开(公告)号：US20120132313A1
公开(公告)日：2012-05-31
申请号：US11895557
申请日：2007-08-24
申请人： Anubha Bhatla , Alessio Salerno , Nabil Simaan , Y. Lawrence Yao , Gerhard Randers-Pehrson , Guy Y. Garty , Aparajita Dutta , David J. Brenner
发明人： Anubha Bhatla , Alessio Salerno , Nabil Simaan , Y. Lawrence Yao , Gerhard Randers-Pehrson , Guy Y. Garty , Aparajita Dutta , David J. Brenner
IPC分类号： B65B3/26
CPC分类号： C40B30/10 , C40B60/12
摘要： Systems and methods for cutting materials are disclosed herein In some embodiments, methods of at least partially severing a capillary vessel can include: focusing a laser on a predetermined point on the capillary vessel, said capillary vessel containing a biological sample; and cutting the capillary vessel using a laser at the predetermined point. In some embodiments, the methods further can include capturing an image of the capillary vessel and analyzing the image to determine the predetermined point. In some embodiments, a beam of the laser can be moved using one or more galvanometric mirrors. In some embodiments, the methods further can include cutting a plurality of capillary vessels using the laser. In some embodiments, the methods can include utilizing a plurality of lasers, and/or further can include rotating the capillary vessel while the laser can be cutting the capillary vessel. In some embodiments, cutting the capillary vessel can include cutting only a portion of the capillary vessel.
摘要翻译：用于切割材料的系统和方法在一些实施例中，至少部分地切断毛细管的方法可以包括：将激光聚焦在毛细血管上的预定点上，所述毛细血管容纳生物样品; 以及在预定点处使用激光切割毛细血管。在一些实施例中，所述方法还可包括捕获毛细管血管的图像并分析图像以确定预定点。在一些实施例中，可以使用一个或多个电流计反射镜移动激光束。在一些实施例中，所述方法还可包括使用所述激光切割多个毛细血管。在一些实施例中，该方法可以包括利用多个激光器，和/或还可以包括旋转毛细血管，同时激光器可以切割毛细血管。在一些实施例中，切割毛细血管可包括仅切割毛细血管的一部分。

5. 发明授权

US07787681B2 Systems and methods for robotic transport 有权
标题翻译：机器人运输的系统和方法
公开(公告)号：US07787681B2
公开(公告)日：2010-08-31
申请号：US11895485
申请日：2007-08-24
申请人： Jian Zhang , Alessio Salerno , Nabil Simaan , Y. Lawrence Yao , Gerhard Randers-Pehrson , Guy Garty , Aparajita Dutta , David J. Brenner
发明人： Jian Zhang , Alessio Salerno , Nabil Simaan , Y. Lawrence Yao , Gerhard Randers-Pehrson , Guy Garty , Aparajita Dutta , David J. Brenner
IPC分类号： G06K9/00
CPC分类号： C40B30/10 , C40B60/12
摘要： Systems and methods for robotic transport are disclosed herein. In some embodiments, robotic systems for transporting biological samples include: a plurality of capillary vessels, in which each capillary vessel can contain a biological sample from a population; a receptacle that can contain the plurality of capillary vessels; a centrifuge; a first robotic device that can transport the receptacle between an input module and the centrifuge; a second robotic device that can transport the receptacle between the centrifuge and a sample harvest location; a cutting device that can cut each of the plurality of capillary vessels; a multi-well plate having a plurality of wells arranged in an array; and a third robotic device that can transfer at least one portion of each of the plurality of biological samples from each of the plurality of capillary vessels to a corresponding well in the array.
摘要翻译：本文公开了用于机器人运输的系统和方法。在一些实施例中，用于输送生物样品的机器人系统包括：多个毛细血管，其中每个毛细血管可以包含来自群体的生物样品; 可容纳多个毛细血管的容器; 离心机能够在输入模块和离心机之间输送容器的第一机器人装置; 第二机器人装置，其可以在离心机和样品收集位置之间运输容器; 切割装置，其可以切割所述多个毛细血管中的每一个; 具有排列成阵列的多个孔的多孔板; 以及第三机器人装置，其可以将多个生物样品中的每一个的至少一部分从多个毛细血管中的每一个转移到阵列中的对应的孔中。

6. 发明申请

US20090054222A1 Systems and methods for robotic transport 有权
标题翻译：机器人运输的系统和方法
公开(公告)号：US20090054222A1
公开(公告)日：2009-02-26
申请号：US11895485
申请日：2007-08-24
申请人： Jian Zhang , Alessio Salerno , Nabil Simaan , Y. Lawrence Yao , Gerhard Randers-Pehrson , Guy Garty , Aparajita Dutta , David J. Brenner
发明人： Jian Zhang , Alessio Salerno , Nabil Simaan , Y. Lawrence Yao , Gerhard Randers-Pehrson , Guy Garty , Aparajita Dutta , David J. Brenner
IPC分类号： B04B5/10
CPC分类号： C40B30/10 , C40B60/12
摘要： Systems and methods for robotic transport are disclosed herein. In some embodiments, robotic systems for transporting biological samples include: a plurality of capillary vessels, in which each capillary vessel can contain a biological sample from a population; a receptacle that can contain the plurality of capillary vessels; a centrifuge; a first robotic device that can transport the receptacle between an input module and the centrifuge; a second robotic device that can transport the receptacle between the centrifuge and a sample harvest location; a cutting device that can cut each of the plurality of capillary vessels; a multi-well plate having a plurality of wells arranged in an array; and a third robotic device that can transfer at least one portion of each of the plurality of biological samples from each of the plurality of capillary vessels to a corresponding well in the array.
摘要翻译：本文公开了用于机器人运输的系统和方法。在一些实施例中，用于输送生物样品的机器人系统包括：多个毛细血管，其中每个毛细血管可以包含来自群体的生物样品; 可容纳多个毛细血管的容器; 离心机能够在输入模块和离心机之间输送容器的第一机器人装置; 第二机器人装置，其可以在离心机和样品收集位置之间运输容器; 切割装置，其可以切割所述多个毛细血管中的每一个; 具有排列成阵列的多个孔的多孔板; 以及第三机器人装置，其可以将多个生物样品中的每一个的至少一部分从多个毛细血管中的每一个转移到阵列中的对应的孔中。

7. 发明授权

US07898673B2 Systems and methods for focusing optics 有权
标题翻译：用于聚焦光学系统和方法
公开(公告)号：US07898673B2
公开(公告)日：2011-03-01
申请号：US11895360
申请日：2007-08-24
申请人： Gerhard Randers-Pehrson , Guy Garty , David J. Brenner
发明人： Gerhard Randers-Pehrson , Guy Garty , David J. Brenner
IPC分类号： G01B11/24
CPC分类号： C40B30/10 , C40B60/12
摘要： Systems and methods for focusing optics are disclosed herein. In some embodiments, methods are disclosed for focusing an optical device, wherein the methods can include: collecting light from a region of an object to be imaged with an objective lens, said region having a feature with a known geometric characteristic; splitting the collected light into a first portion and a second portion, and directing said first portion through a weak cylindrical lens to a focusing sensor, and directing said second portion to an imager; observing, with said focusing sensor, a shape of the feature; focusing the optical device by moving at least one of the objective lens and the object to be imaged until the observed shape of the feature has a predetermined relationship to the known geometric characteristic. In some embodiments, the feature can be a fluorescent bead. In some embodiments, the splitting step can be accomplished with a dichroic mirror. In other embodiments, the splitting step can be accomplished with a partial mirror. In some embodiments, the known geometric characteristic of the feature can be substantially spherical, the observed shape can be an oval, and the predetermined relationship can be an allowable aspect ratio of the oval. In some embodiments, the allowable aspect ratio can be approximately one.
摘要翻译：本文公开了用于聚焦光学器件的系统和方法。在一些实施例中，公开了用于聚焦光学装置的方法，其中所述方法可以包括：利用物镜收集来自待成像物体的区域的光，所述区域具有已知几何特征的特征; 将收集的光分成第一部分和第二部分，并将所述第一部分通过弱圆柱形透镜引导到聚焦传感器，并将所述第二部分引导到成像器; 用所述聚焦传感器观察该特征的形状; 通过移动物镜和待成像对象中的至少一个来聚焦光学装置，直到观察到的特征形状与已知的几何特征具有预定的关系。在一些实施例中，该特征可以是荧光珠。在一些实施例中，分裂步骤可以用二向色镜来完成。在其他实施例中，分割步骤可以用部分反射镜来实现。在一些实施例中，特征的已知几何特征可以是基本上是球形的，观察到的形状可以是椭圆形，并且预定关系可以是椭圆的允许纵横比。在一些实施例中，允许的纵横比可以是大约一个。

8. 发明授权

US07826977B2 Systems and methods for high-speed image scanning 有权
标题翻译：高速图像扫描的系统和方法
公开(公告)号：US07826977B2
公开(公告)日：2010-11-02
申请号：US11895470
申请日：2007-08-24
申请人： Guy Garty , Gerhard Randers-Pehrson , David J. Brenner , Oleksandra V. Lyulko
发明人： Guy Garty , Gerhard Randers-Pehrson , David J. Brenner , Oleksandra V. Lyulko
IPC分类号： G01N33/00
CPC分类号： C40B30/10 , C40B60/12
摘要： Systems and methods for high-speed image scanning are disclosed herein One aspect of the invention is directed to a method for high speed image scanning. The method for high speed image scanning includes adjusting an object using a positioning element; directing a portion of an image of the object toward a sensor by positioning a first mirror relative to the object, and by positioning a second mirror relative to the object and the first mirror; controlling the positioning element, the position of the first mirror and the position of the second mirror using a processor; and detecting the portion of the image of the object using the sensor positioned relative to the first mirror and the second mirror. In accord with this method, the first mirror directs the portion of the image of the object in a first direction and the second mirror directs the portion of the image of the object in a second direction.
摘要翻译：本文公开了用于高速图像扫描的系统和方法。本发明的一个方面涉及一种用于高速图像扫描的方法。用于高速图像扫描的方法包括使用定位元件来调整物体; 通过相对于物体定位第一反射镜并通过相对于物体和第一反射镜定位第二反射镜来将物体的图像的一部分引向传感器; 使用处理器控制定位元件，第一反射镜的位置和第二反射镜的位置; 以及使用相对于第一反射镜和第二反射镜定位的传感器来检测物体的图像的部分。根据该方法，第一反射镜将物体的图像的一部分沿第一方向引导，并且第二反射镜将物体的图像的部分沿第二方向引导。

9. 发明申请

US20110176051A1 SYSTEM AND METHOD FOR FOCUSING OPTICS 失效
标题翻译：用于聚焦光学的系统和方法
公开(公告)号：US20110176051A1
公开(公告)日：2011-07-21
申请号：US13004923
申请日：2011-01-12
申请人： Gerhard Randers-Pehrson , Guy Garty , David J. Brenner
发明人： Gerhard Randers-Pehrson , Guy Garty , David J. Brenner
IPC分类号： G03B13/18 , H04N7/18 , G02B21/00 , G02B7/09
CPC分类号： C40B30/10 , C40B60/12
摘要： In an apparatus and system for focusing optics an objective lens is configured to collect light from a region of an object to be imaged, said region having a feature with a known geometric characteristic, wherein the geometric characteristic is known before the feature is imaged by the optical device. A focusing sensor is configured to observe a shape of the feature and a splitter is configured to split the collected light into a first portion and a second portion, and directing said first portion through a weak cylindrical lens to the focusing sensor. A processor is configured to analyze the observed shape and determine whether the observed shape of the feature has a predetermined relationship to the known geometric characteristic and a mechanism is configured to autofocus the optical device by moving at least one of the objective lens and the object to be imaged in response to the analysis and determination of the processor. In some embodiments, the feature can be a fluorescent bead. In some embodiments, the splitting step can be accomplished with a dichroic mirror. In other embodiments, the splitting step can be accomplished with a partial mirror. In some embodiments, the known geometric characteristic of the feature can be substantially spherical, the observed shape can be an oval, and the predetermined relationship can be an allowable aspect ratio of the oval. In some embodiments, the allowable aspect ratio can be approximately one.
摘要翻译：在用于聚焦光学元件的装置和系统中，物镜被配置为从要成像的对象的区域收集光，所述区域具有已知几何特征的特征，其中在将特征成像之前几何特征是已知的光学装置。聚焦传感器被配置为观察特征的形状，并且分离器被配置为将收集的光分成第一部分和第二部分，并且将所述第一部分通过弱圆柱形透镜引导到聚焦传感器。处理器被配置为分析观察到的形状并且确定观察到的特征的形状是否具有与已知几何特征的预定关系，并且机构被配置为通过将物镜和物体中的至少一个移动到自动聚焦光学装置响应于处理器的分析和确定而成像。在一些实施例中，该特征可以是荧光珠。在一些实施例中，分裂步骤可以用二向色镜来完成。在其他实施例中，分割步骤可以用部分反射镜来实现。在一些实施例中，特征的已知几何特征可以是基本上是球形的，观察到的形状可以是椭圆形，并且预定关系可以是椭圆的允许纵横比。在一些实施例中，允许的纵横比可以是大约一个。

10. 发明申请

US20080228404A1 Systems and methods for high-speed image scanning 有权
标题翻译：高速图像扫描的系统和方法
公开(公告)号：US20080228404A1
公开(公告)日：2008-09-18
申请号：US11895470
申请日：2007-08-24
申请人： Guy Garty , Gerhard Randers-Pehrson , David J. Brenner , Oleksandra V. Lyulko
发明人： Guy Garty , Gerhard Randers-Pehrson , David J. Brenner , Oleksandra V. Lyulko
IPC分类号： G01N33/48 , G02B26/08 , G02B21/04 , G02B21/06
CPC分类号： C40B30/10 , C40B60/12
摘要： Systems and methods for high-speed image scanning are disclosed herein One aspect of the invention is directed to a method for high speed image scanning. The method for high speed image scanning includes adjusting an object using a positioning element; directing a portion of an image of the object toward a sensor by positioning a first mirror relative to the object, and by positioning a second mirror relative to the object and the first mirror; controlling the positioning element, the position of the first mirror and the position of the second mirror using a processor; and detecting the portion of the image of the object using the sensor positioned relative to the first mirror and the second mirror. In accord with this method, the first mirror directs the portion of the image of the object in a first direction and the second mirror directs the portion of the image of the object in a second direction.
摘要翻译：本文公开了用于高速图像扫描的系统和方法。本发明的一个方面涉及一种用于高速图像扫描的方法。用于高速图像扫描的方法包括使用定位元件来调整物体; 通过相对于物体定位第一反射镜并通过相对于物体和第一反射镜定位第二反射镜来将物体的图像的一部分引向传感器; 使用处理器控制定位元件，第一反射镜的位置和第二反射镜的位置; 以及使用相对于第一反射镜和第二反射镜定位的传感器来检测物体的图像的部分。根据该方法，第一反射镜将物体的图像的一部分沿第一方向引导，并且第二反射镜将物体的图像的部分沿第二方向引导。

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