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1. 发明申请

US20080248046A1 Death domain containing receptor 5 审中-公开
标题翻译：含有受体5的死亡域
公开(公告)号：US20080248046A1
公开(公告)日：2008-10-09
申请号：US12010106
申请日：2008-01-18
申请人： Jian Ni , Reiner L. Gentz , Guo-Liang Yu , Craig A. Rosen
发明人： Jian Ni , Reiner L. Gentz , Guo-Liang Yu , Craig A. Rosen
IPC分类号： A61K39/395 , C12N5/06 , A61P35/00 , A61P31/12
CPC分类号： C07K14/70578 , A61K38/00 , C07K16/2878 , C07K2317/622 , C07K2317/74 , C07K2319/30
摘要： The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR5, which may be agonists and/or antagonists of DR5 activity.
摘要翻译：本发明涉及作为肿瘤坏死因子（TNF）受体家族的成员的新的含有死亡域的受体-5（DR5）蛋白，现在已经显示结合TRAIL。特别地，提供编码人DR5蛋白的分离的核酸分子。还提供了DR5多肽，载体，宿主细胞以及用于制备它们的重组方法。本发明还涉及用于鉴定DR5活性的拮抗剂和拮抗剂的筛选方法。本发明还涉及使用DR5特异性抗体（其可以是DR5活性的激动剂和/或拮抗剂）的减少或增加的细胞凋亡相关疾病的治疗。

2. 发明授权

US07053190B2 Secreted protein HRGDF73 失效
公开(公告)号：US07053190B2
公开(公告)日：2006-05-30
申请号：US09981876
申请日：2001-10-19
申请人： Steven M. Ruben , Craig A. Rosen , Carrie L. Fischer , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Yanggu Shi
发明人： Steven M. Ruben , Craig A. Rosen , Carrie L. Fischer , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Yanggu Shi
IPC分类号： C07K16/28 , C07K14/705
CPC分类号： C07K16/28 , A61K38/00 , C07K14/47 , C07K14/4702 , C07K14/4718 , C12N15/11 , G01N33/68
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

3. 发明授权

US06617132B2 Human cystatin E polynucleotides 失效
标题翻译：人半胱氨酸蛋白酶抑制剂E多核苷酸
公开(公告)号：US06617132B2
公开(公告)日：2003-09-09
申请号：US09940497
申请日：2001-08-29
申请人： Jian Ni , Reiner L. Gentz , Guo-Liang Yu , Craig A. Rosen
发明人： Jian Ni , Reiner L. Gentz , Guo-Liang Yu , Craig A. Rosen
IPC分类号： C12N510
CPC分类号： C07K14/8139 , A61K38/00
摘要： Disclosed is a human CysE polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for treating osteoporosis, tumor metastases, microbial infections, viral infection, septic shock, inflammation, retinal irritation, caries, cachicia and muscle wasting. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
摘要翻译：公开了编码这种多肽的人CysE多肽和DNA（RNA）。还提供了通过重组技术产生这种多肽的方法。还公开了利用这种多肽治疗骨质疏松症，肿瘤转移，微生物感染，病毒感染，败血性休克，炎症，视网膜刺激，龋齿，眼球和肌肉消瘦的方法。还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。

4. 发明授权

US06521742B2 Human endokine alpha 失效
标题翻译：人类受体α
公开(公告)号：US06521742B2
公开(公告)日：2003-02-18
申请号：US09345790
申请日：1999-07-01
申请人： Guo-Liang Yu , Jian Ni , Craig A. Rosen
发明人： Guo-Liang Yu , Jian Ni , Craig A. Rosen
IPC分类号： C07K1452
CPC分类号： C07K14/5255
摘要： The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha protein. Endokine alpha polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods concerning TNF family-related disorders.
摘要翻译：本发明涉及细胞因子的肿瘤坏死因子（TNF）家族的新成员。特别地，提供了分离的核酸分子，其编码内丝蛋白α蛋白。还提供了内含子α多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。还提供了关于TNF家族相关疾病的诊断和治疗方法。

5. 发明授权

US06403770B1 Antibodies to neutrokine-alpha 有权
标题翻译：中性粒细胞α的抗体
公开(公告)号：US06403770B1
公开(公告)日：2002-06-11
申请号：US09589287
申请日：2000-06-08
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen
IPC分类号： C07K1600
CPC分类号： C07K16/24 , A61K38/00 , A61K48/00 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/715 , C07K16/2875 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N33/6863 , G01N2333/52 , G01N2500/00 , G01N2500/02 , G01N2800/245 , Y02A50/473
摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

6. 发明授权

US06287812B1 Nucleic acid molecules encoding cytostatin I 失效
标题翻译：编码细胞抑素I的核酸分子
公开(公告)号：US06287812B1
公开(公告)日：2001-09-11
申请号：US09361737
申请日：1999-07-28
申请人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig A. Rosen
发明人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig A. Rosen
IPC分类号： C12N1512
CPC分类号： C07K14/475 , A61K38/00
摘要： A human cytostatin I polypeptide and DNA encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cancers, particularly breast cancer, leukemias, and other matastases.
摘要翻译：公开了人类细胞抑素I多肽和编码这种多肽的DNA以及通过重组技术产生这种多肽的方法。还公开了利用这种多肽治疗癌症，特别是乳腺癌，白血病和其它母细胞瘤的方法。

7. 发明授权

US06255079B1 Polynucleotides encoding natural killer cell enhancing factor C 失效
标题翻译：编码天然杀伤细胞增强因子C的多核苷酸
公开(公告)号：US06255079B1
公开(公告)日：2001-07-03
申请号：US08467265
申请日：1995-06-06
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
IPC分类号： C07K1452
CPC分类号： C07K14/52 , A61K38/00 , Y10S514/885
摘要： A human natural killer cell enhancing factor C and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating viral infections, inflammation, neoplasia and damage from superoxide radicals. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
摘要翻译：公开了一种编码这种多肽的人类天然杀伤细胞增强因子C和DNA（RNA），以及通过重组技术产生此类多肽的方法。还公开了利用这种多肽预防和/或治疗病毒感染，炎症，瘤形成和超氧自由基损伤的方法。还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

8. 发明授权

US5998171A Polynucleotides encoding human endokine alpha 失效
标题翻译：编码人内因素α的多核苷酸
公开(公告)号：US5998171A
公开(公告)日：1999-12-07
申请号：US912227
申请日：1997-08-15
申请人： Guo-Liang Yu , Jian Ni , Craig A. Rosen
发明人： Guo-Liang Yu , Jian Ni , Craig A. Rosen
IPC分类号： C07K14/525 , C12N15/28 , C12N15/00
CPC分类号： C07K14/5255
摘要： The present invention novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha protein. Endokine alpha polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods concerning TNF family-related disorders.
摘要翻译：本发明细胞因子的肿瘤坏死因子（TNF）家族的新成员。特别地，提供了分离的核酸分子，其编码内丝蛋白α蛋白。还提供了内含子α多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。还提供了关于TNF家族相关疾病的诊断和治疗方法。

9. 发明授权

US5658758A Polynucleotides encoding cytostatin I 失效
标题翻译：编码细胞抑制素I的多核苷酸
公开(公告)号：US5658758A
公开(公告)日：1997-08-19
申请号：US409731
申请日：1995-03-24
申请人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig A. Rosen
发明人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig A. Rosen
IPC分类号： A61K38/00 , C07K14/475 , C12N15/12
CPC分类号： C07K14/475 , A61K38/00
摘要： A human cytostatin I polypeptide and DNA encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cancers, particularly breast cancer, leukemias, and other matastases.
摘要翻译：公开了人类细胞抑素I多肽和编码这种多肽的DNA以及通过重组技术产生这种多肽的方法。还公开了利用这种多肽治疗癌症，特别是乳腺癌，白血病和其它母细胞瘤的方法。

10. 发明授权

US08093363B2 Tumor necrosis factor-gamma 失效
标题翻译：肿瘤坏死因子-γ
公开(公告)号：US08093363B2
公开(公告)日：2012-01-10
申请号：US12879210
申请日：2010-09-10
申请人： Guo-Liang Yu , Jian Ni , Craig A. Rosen , Jun Zhang
发明人： Guo-Liang Yu , Jian Ni , Craig A. Rosen , Jun Zhang
IPC分类号： C07K16/28 , C07K16/18 , C07K16/22 , C07K16/46 , C07K14/525 , C12N5/00 , G01N33/53
CPC分类号： A61K51/08 , C07K16/241 , Y10S930/144
摘要： Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
摘要翻译：公开了人类TNF-γ-α和TNF-γ-β多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这些多肽抑制细胞生长的方法，例如在肿瘤或癌症中，用于促进伤口愈合，提供抗感染，诱导炎症活性和刺激某些细胞类型的生长以治疗疾病，示例再狭窄。还公开了用于检测TNF-γ-α和TNF-γ-β核酸序列中的突变或TNF-γ-α和/或TNF-γ-β多肽的过表达的诊断方法。还公开了抗这些多肽的拮抗剂及其作为治疗性恶病质，败血性休克，脑疟疾，炎症，关节炎和移植排斥的治疗剂的用途。

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