专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4328235A Suppressing pain with benzothiazol-2(3H)-ones 失效
标题翻译：用苯并噻唑-2（3H）酮抑制疼痛
公开(公告)号：US4328235A
公开(公告)日：1982-05-04
申请号：US163965
申请日：1980-06-30
申请人： Gunter Trummlitz , Wolfhard Engel , Gunther Schmidt , Wolfgang Eberlein , Ernst Seeger , Gunther Engelhardt , Rainer Zimmermann
发明人： Gunter Trummlitz , Wolfhard Engel , Gunther Schmidt , Wolfgang Eberlein , Ernst Seeger , Gunther Engelhardt , Rainer Zimmermann
IPC分类号： A61K31/425 , A61K31/428 , A61P25/04 , A61P29/00 , C07D277/68
CPC分类号： C07D277/68 , A61K31/425
摘要： There are described pharmaceutical compositions containing as active substances benzothiazol-2(3H)-ones of the general formula ##STR1## wherein R represents a hydrogen atom or a methyl, methoxy, or ethoxy group. The pharmaceutical compositions serve as analgesics and antipyretics and possess little or no methemoglobin-forming activity.
摘要翻译：描述了含有作为活性物质的通式为“IMAGE”的苯并噻唑-2（3H） - 酮的药物组合物，其中R表示氢原子或甲基，甲氧基或乙氧基。药物组合物用作止痛剂和解热药，并且几乎没有或没有高铁血红蛋白形成活性。

2. 发明授权

US4381303A 1,4,9,10-Tetrahydro-pyrazolo [4,3-]pyrido[-3,2-b][1,4]diazepin-10-ones 失效
标题翻译： 1,4,9,10-四氢 - 吡唑并[4,3]吡啶并[-3,2-b] [1,4]二氮杂-10-酮
公开(公告)号：US4381303A
公开(公告)日：1983-04-26
申请号：US377911
申请日：1982-05-13
申请人： Gunther Schmidt , Wolfhard Engel , Wolfgang Eberlein , Gunter Trummlitz , Gunther Engelhardt
发明人： Gunther Schmidt , Wolfhard Engel , Wolfgang Eberlein , Gunter Trummlitz , Gunther Engelhardt
IPC分类号： A61K31/55 , A61K31/5517 , A61P25/04 , A61P29/00 , C07D231/16 , C07D471/14
CPC分类号： C07D471/14 , C07D231/16
摘要： This invention is directed to the compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or an alkyl of from 1 to 6 carbon atoms;R.sub.2 is an alkyl of from 1 to 3 carbon atoms;R.sub.3 is hydrogen or an alkyl of from 1 to 3 carbon atoms; andR.sub.4 is hydrogen or an alkyl of from 1 to 4 carbon atoms.These compounds are useful in pharmaceutical compositions which serve as analgesics, antiphlogistics and antipyretics.
摘要翻译：本发明涉及式（I）的化合物，其中R 1是氢或1至6个碳原子的烷基; R2是1至3个碳原子的烷基; R3是氢或1至3个碳原子的烷基; 且R 4为氢或1至4个碳原子的烷基。这些化合物可用作用作镇痛药，消炎药和解热药的药物组合物。

3. 发明授权

US4353919A Analgesic and antipyretic pharmaceutical compositions containing a benzothiazol-2(3H)-one 失效
标题翻译：含有苯并噻唑-2（3H） - 酮的镇痛药和解热药物组合物
公开(公告)号：US4353919A
公开(公告)日：1982-10-12
申请号：US254539
申请日：1981-04-15
申请人： Wolfhard Engel , Gunter Trummlitz , Wolfgang Eberlein , Gunther Schmidt , Gunther Engelhardt , Rainer Zimmermann
发明人： Wolfhard Engel , Gunter Trummlitz , Wolfgang Eberlein , Gunther Schmidt , Gunther Engelhardt , Rainer Zimmermann
IPC分类号： A61K31/425 , C07D277/68
CPC分类号： C07D277/68 , A61K31/425 , Y10S514/916
摘要： Analgesic and antipyretic pharmaceutical dosage unit compositions containing as an active ingredient a compound of the formula ##STR1## wherein R.sub.5 is methyl or methoxy, and R.sub.4, R.sub.6 and R.sub.7 are hydrogen; orR.sub.6 is fluorine or chlorine, and R.sub.4, R.sub.5 and R.sub.7 are hydrogen; orR.sub.7 is chlorine, and R.sub.4, R.sub.5 and R.sub.6 are hydrogen; orR.sub.5 and R.sub.6 are methoxy, and R.sub.4 and R.sub.7 are hydrogen; orR.sub.4 is methyl or chlorine, and R.sub.5, R.sub.6 and R.sub.7 are hydrogen;and methods of using said compounds as analgesics and antipyretics.
摘要翻译：镇痛药和解热药物单位组合物，其含有下式的化合物作为活性成分：其中R5是甲基或甲氧基，R4，R6和R7是氢; 或R6是氟或氯，R4，R5和R7是氢; 或R 7为氯，R 4，R 5和R 6为氢; 或R5和R6是甲氧基，R4和R7是氢; 或R4是甲基或氯，R5，R6和R7是氢; 以及使用所述化合物作为止痛剂和解热剂的方法。

4. 发明授权

US4137313A 2,5-Dihydro-1,2-thiazino(5,6-b)indole-3-carboxamide-1,1-dioxides and salts thereof 失效
标题翻译： 2,5-二氢-1,2-噻嗪（5,6-b）吲哚-3-甲酰胺-1,1-二氧化物及其盐
公开(公告)号：US4137313A
公开(公告)日：1979-01-30
申请号：US872889
申请日：1978-01-27
申请人： Gunter Trummlitz , Wolfhard Engel , Ernst Seeger , Walter Haarmann , Gunther Engelhardt
发明人： Gunter Trummlitz , Wolfhard Engel , Ernst Seeger , Walter Haarmann , Gunther Engelhardt
IPC分类号： A61K31/54 , A61P7/02 , A61P29/00 , C07D209/42 , C07D513/04 , C07D513/14 , A61K31/38
CPC分类号： C07D513/04 , C07D209/42 , C07D513/14 , Y10S514/822
摘要： Compounds of the formula ##STR1## WHEREIN R.sub.1 is hydrogen, methyl or ethyl;R.sub.2 is methyl or ethyl;Y is hydrogen, fluorine, chlorine, bromine, methoxy, methyl, ethyl or trifluoromethyl; andAr is 2-thiazolyl which may have one or two methyl or ethyl substituents attached thereto; 5,6-dihydro-4H-cyclopentathiazol-2-yl; 4,5,6,7-tetrahydro-2-benzothiazolyl; 2-benzothiazolyl; 3-isothiazolyl which may have a methyl substituent attached thereto; 2-pyridyl which may have a methyl or hydroxyl substituent attached thereto; 3-pyridyl; 4-pyridyl; 4-pyrimidinyl; pyrazinyl; 2-benzimidazolyl; 2-oxazolyl which may have a methyl substituent attached thereto; 2-benzoxazolyl; or phenyl which may have a fluoro, chloro, bromo, methyl, ethyl, trifluoromethyl or methoxy substituent attached thereto; and non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases. The compounds as well as their salts are useful as antiphlogistics and blood platelet aggregation inhibitors.
摘要翻译：式中的化合物，其中R1是氢，甲基或乙基; R2是甲基或乙基; Y是氢，氟，氯，溴，甲氧基，甲基，乙基或三氟甲基; 并且Ar是可以具有一个或两个连接到其上的甲基或乙基取代基的2-噻唑基; 5,6-二氢-4H-环戊基噻唑-2-基; 4,5,6,7-四氢-2-苯并噻唑基; 2-苯并噻唑基可具有与其连接的甲基取代基的3-异噻唑基; 可以具有连接到其上的甲基或羟基取代基的2-吡啶基; 3-吡啶基; 4-吡啶基; 4-嘧啶基; 吡嗪基 2-苯并咪唑基; 可具有与其连接的甲基取代基的2-恶唑基; 2-苯并恶唑基; 或可具有与其连接的氟，氯，溴，甲基，乙基，三氟甲基或甲氧基取代基的苯基; 和与无机或有机碱形成的无毒的，药学上可接受的盐。化合物及其盐可用作消炎剂和血小板聚集抑制剂。

5. 发明授权

US4259336A 4-Hydroxy-2H-[1]-benzothieno [2,3-e]-1,2-thiazine-3-carboxamide-1,1-dioxides and salts thereof 失效
标题翻译： 4-羟基-2H- [1] - 苯并噻吩并[2,3-e] -1,2-噻嗪-3-甲酰胺-1,1-二氧化物及其盐
公开(公告)号：US4259336A
公开(公告)日：1981-03-31
申请号：US86743
申请日：1979-10-22
申请人： Wolfhard Engel , Gunter Trummlitz , Ernst Seeger , Walter Haarmann , Gunther Engelhardt , Rainer Zimmermann
发明人： Wolfhard Engel , Gunter Trummlitz , Ernst Seeger , Walter Haarmann , Gunther Engelhardt , Rainer Zimmermann
IPC分类号： A61K31/54 , A61P9/08 , A61P9/10 , A61P29/00 , C07D333/70 , C07D513/04 , A61K31/38
CPC分类号： C07D513/04 , C07D333/70 , Y10S514/822
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, halogen or alkyl of 1 to 3 carbon atoms; R.sub.2 is hydrogen or alkyl of 1 to 3 carbon atoms; andR.sub.3 is aromatic hydrocarbyl of 6 to 10 carbon atoms or an aromatic heterocycle of 2 to 9 carbon atoms and 1 to 2 nitrogen atoms and/or an oxygen or a sulfur atom, where each of said aromatic substituents may in turn be substituted with one or two alkyls of 1 to 6 carbon atoms, halogen, hydroxyl, trifluoromethyl, halophenyl or alkoxy of 1 to 3 carbon atoms;and non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases; the compounds as well as their salts are useful as analgesics, antipyretics, antithrombotic and antiphlogistics.
摘要翻译：其中R 1是氢，卤素或1至3个碳原子的烷基; R2是氢或1至3个碳原子的烷基; 并且R 3是6至10个碳原子的芳族烃基或2至9个碳原子和1至2个氮原子和/或氧或硫原子的芳族杂环，其中每个所述芳族取代基可以依次被一个或两个1至6个碳原子的烷基，卤素，羟基，三氟甲基，卤代苯基或具有1至3个碳原子的烷氧基; 和与无机或有机碱形成的无毒的，药理学上可接受的盐; 化合物及其盐可用作镇痛药，解热药，抗血栓和消炎药。

6. 发明授权

US4233299A 4-Hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxides and salts thereof 失效
标题翻译： 4-羟基-2H-1,2-苯并噻嗪-3-甲酰胺-1,1-二氧化物及其盐
公开(公告)号：US4233299A
公开(公告)日：1980-11-11
申请号：US966963
申请日：1978-12-06
申请人： Gunter Trummlitz , Wolfhard Engel , Ernst Seeger , Gunther Engelhardt
发明人： Gunter Trummlitz , Wolfhard Engel , Ernst Seeger , Gunther Engelhardt
IPC分类号： A61K31/427 , A61K31/54 , A61K31/5415 , A61P29/00 , C07D275/06 , C07D279/02 , C07D417/12 , C07D513/14 , A61K31/38
CPC分类号： C07D275/06 , C07D279/02 , C07D417/12 , C07D513/14
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, methyl or ethyl;R.sub.2 is methyl, ethyl or n-propyl; andY is hydrogen, methyl, methoxy, fluorine or chlorine;and non-toxic, pharmacologically acceptable salts thereof formed with an inorganic or organic base. The compounds as well as their salts are useful as antiphlogistics.
摘要翻译：其中R 1是氢，甲基或乙基; R2是甲基，乙基或正丙基; Y为氢，甲基，甲氧基，氟或氯; 和与无机或有机碱形成的无毒的，药学上可接受的盐。化合物及其盐可用作消炎剂。

7. 发明授权

US3992535A 4-Hydroxy-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxides and salts thereof 失效
标题翻译： 4-羟基-2H-萘并（{2,1-e {9-1,2-噻嗪-3-甲酰胺-1,1-二氧化物及其盐
公开(公告)号：US3992535A
公开(公告)日：1976-11-16
申请号：US626623
申请日：1975-10-29
申请人： Gunter Trummlitz , Helmut Teufel , Wolfhard Engel , Ernst Seeger , Walter Haarmann , Gunther Engelhardt
发明人： Gunter Trummlitz , Helmut Teufel , Wolfhard Engel , Ernst Seeger , Walter Haarmann , Gunther Engelhardt
IPC分类号： C07D275/06 , C07D279/02 , C07D417/12 , C07D513/04 , A61K31/54
CPC分类号： C07D275/06 , C07D279/02
摘要： Compounds of the formula ##SPC1##WhereinR.sub.1 is hydrogen, methyl or ethyl, andAr is phenyl, 3-chlorophenyl, 3-bromophenyl, 2-fluorophenyl, 3-fluorophenyl, 4-fluorophenyl, 3-tolyl, 2-methoxyphenyl, 3-methoxyphenyl, 2-pyridyl, 4-methyl-2-pyridyl, 6-methyl-2-pyridyl, 3-hydroxy-2-pyridyl, 3-pyridyl, 4-pyridyl, 6-chloro-3-pyridazinyl, 2-pyrazinyl, 6-chloro-2-pyrazinyl, 6-chloro-4-pyrimidinyl, 2-thiazolyl, 4-methyl-2-thiazolyl, 4-ethyl-2-thiazolyl, 5-methyl-2-thiazolyl, 5-ethyl-2-thiazolyl, 4,5-dimethyl-2-thiazolyl, 4-ethyl-5-methyl-2-thiazolyl, 5-ethyl-4-methyl-2-thiazolyl, 2-benzothiazolyl, 4,5,6,7-tetrahydro-2-benzothiazolyl, 5,6-dihydro-7H-thiopyrano[4,3-d]thiazol-2-yl, 3-methyl-5-isothiazolyl, 1,3,4-thiadiazolyl, 5-methyl-1,3,4-thiadiazol-2-yl or 5-methyl-3-isoxazolyl,And non-toxic, pharmacologically acceptable salts thereof formed with an inorganic or organic base; the compounds as well as their salts are useful as inhibitors of platelet adhesion and aggregation.
摘要翻译：式WHERE R1的化合物是氢，甲基或乙基，Ar是苯基，3-氯苯基，3-溴苯基，2-氟苯基，3-氟苯基，4-氟苯基，3-甲苯基，2-甲氧基苯基，3-甲氧基苯基， 2-吡啶基，4-甲基-2-吡啶基，6-甲基-2-吡啶基，3-羟基-2-吡啶基，3-吡啶基，4-吡啶基，6-氯-3-哒嗪基，2-吡嗪基，6-吡啶基， 4-氯-2-吡嗪基，6-氯-4-嘧啶基，2-噻唑基，4-甲基-2-噻唑基，4-乙基-2-噻唑基，5-甲基-2-噻唑基，5-乙基-2-噻唑基， 4,5-二甲基-2-噻唑基，4-乙基-5-甲基-2-噻唑基，5-乙基-4-甲基-2-噻唑基，2-苯并噻唑基，4,5,6,7-四氢-2- 苯并噻唑基，5,6-二氢-7H-噻喃并[4,3-d]噻唑-2-基，3-甲基-5-异噻唑基，1,3,4-噻二唑基，5-甲基-1,3,4-噻二唑基，噻二唑-2-基或5-甲基-3-异恶唑基，以及与无机或有机碱形成的非毒性，药理学上可接受的盐; 化合物作为它们的盐作为板材粘合和聚集的抑制剂有用。

8. 发明授权

US3950427A Araliphatic ketones and carbinols 失效
标题翻译：脂肪族酮和甲醇
公开(公告)号：US3950427A
公开(公告)日：1976-04-13
申请号：US532174
申请日：1974-12-12
申请人： Wolfhard Engel , Josef Nickl , Helmut Teufel , Gunther Engelhardt , Ernst Seeger , Gunter Trummlitz
发明人： Wolfhard Engel , Josef Nickl , Helmut Teufel , Gunther Engelhardt , Ernst Seeger , Gunter Trummlitz
IPC分类号： C07C49/20 , C07C27/00 , C07C29/136 , C07C29/143 , C07C29/145 , C07C29/17 , C07C29/40 , C07C33/18 , C07C33/24 , C07C33/28 , C07C33/30 , C07C33/34 , C07C33/38 , C07C33/40 , C07C33/46 , C07C33/48 , C07C33/50 , C07C45/00 , C07C45/29 , C07C45/30 , C07C45/62 , C07C45/67 , C07C49/233 , C07C49/235 , C07C49/237 , C07C67/00 , C25B3/04 , C07C49/76 , C07C49/80
CPC分类号： C25B3/04 , C07C29/143 , C07C29/145 , C07C29/17 , C07C29/175 , C07C29/40 , C07C33/24 , C07C33/28 , C07C33/30 , C07C33/34 , C07C33/38 , C07C33/46 , C07C33/483 , C07C33/486 , C07C33/50 , C07C45/004 , C07C45/29 , C07C45/513 , C07C45/62 , C07C45/74 , C07C49/215 , C07C49/217 , C07C49/225 , C07C49/233 , C07C49/235 , C07C49/237 , C07B2200/09 , C07C2101/14 , C07C2101/18
摘要： Compounds of the formula ##SPC1##WhereinR.sub.1 is isobutyl, phenyl, o-fluoro-phenyl, o-chloro-phenyl, cyclopentyl, cyclohexyl, methyl-cyclo-hexyl or cycloheptyl,R.sub.2 is hydrogen, fluorine, chlorine or bromine,R.sub.3 is methyl, ethyl or, when R.sub.1 is phenyl, fluoro-phenyl or chloro-phenyl, or R.sub.1 is cyclohexyl and R.sub.2 is halogen, also hydrogen,Z.sub.1 and Z.sub.2 are hydrogen or together form an additional carbon-to-carbon bond,A is ##EQU1## or ##EQU2## and M IS 2, 4, 6, 8 OR WHEN R.sub.1 is halo-phenyl, isobutyl, cyclohexyl, methyl-cyclohexyl, cyclopentyl or cycloheptyl and/or R.sub.2 is halogen and/or R.sub.3 is methyl or ethyl and/or A is --CH(OH)--, also O; the compounds are useful as antiphlogistics.
摘要翻译：式WHERE R1的化合物是异丁基，苯基，邻 - 氟 - 苯基，邻 - 氯 - 苯基，环戊基，环己基，甲基 - 环己基或环庚基，R2是氢，氟，氯或溴，R3是甲基，乙基或者当R 1为苯基，氟代苯基或氯代苯基或R 1为环己基且R 2为卤素时，氢，Z 1和Z 2为氢或一起形成另外的碳 - 碳键，A为O并原-C - 或HOH ANGLE -C-和M为2,4,6,8或当R 1为卤代苯基，异丁基，环己基，甲基 - 环己基，环戊基或环庚基和/或R 2为卤素和/或R 3为甲基或乙基和/或A是-CH（OH） - ，也是O; 该化合物可用作消炎药。

9. 发明授权

US5468766A 1,5,6,7-tetrahydro-4H-indazol-4-ones 失效
标题翻译： 1,5,6,7-四氢-4H-吲唑-4-酮
公开(公告)号：US5468766A
公开(公告)日：1995-11-21
申请号：US128506
申请日：1993-09-29
申请人： Wolfgang Eberlein , Wolfhard Engel , Gerhard Mihm , Klaus Rudolf , Gunther Engelhardt
发明人： Wolfgang Eberlein , Wolfhard Engel , Gerhard Mihm , Klaus Rudolf , Gunther Engelhardt
IPC分类号： A61K31/415 , A61P25/04 , A61P29/00 , C07D231/54 , C07D231/56
CPC分类号： A61K31/415
摘要： Pharmaceutical compositions are described which contain 1,5,6,7-tetrahydro-4H-indazol-4-ones of the formula ##STR1## some of these substances themselves being new. The pharmaceutical compositions may be used as analgesics, antipyretics and antiphlogistics.
摘要翻译：描述了包含式（I）的1,5,6,7-四氢-4H-吲唑-4-酮的药物组合物（I）这些物质中的一些本身是新的。药物组合物可用作止痛剂，解热药和消炎药。

10. 发明授权

US3969419A 3-(2-Halo-4-biphenylyl)-1-butanols and derivatives thereof 失效
标题翻译： 3-（2-卤代-4-联苯基）-1-丁醇及其衍生物
公开(公告)号：US3969419A
公开(公告)日：1976-07-13
申请号：US497716
申请日：1974-08-15
申请人： Wolfhard Engel , Helmut Teufel , Ernst Seeger , Gunther Engelhardt
发明人： Wolfhard Engel , Helmut Teufel , Ernst Seeger , Gunther Engelhardt
IPC分类号： C07C69/007 , C07C27/00 , C07C29/147 , C07C33/46 , C07C43/178 , C07C45/71 , C07C51/41 , C07C67/00 , C07C69/12 , C07C69/22 , C07C69/76 , C07C69/773 , C07D213/55 , C07D213/79 , C07C31/14 , C07C69/14 , C07C69/24 , C07C69/78
CPC分类号： C07D213/79 , C07C43/1786 , C07C45/71
摘要： Compounds of the formula formula ##EQU1## wherein R.sub.1 is chlorine or fluorine, and R.sub.2 is hydrogen, alkanoyl of 1 to 10 carbon atoms, benzoyl, nicotinoyl or isonicotinoyl,Or, when R.sub.2 contains a basic nitrogen atom, a non-toxic, pharmacologically acceptable salt thereof formed with an inorganic or organic acid; the compounds as well as the salts are useful as antiphlogistics.
摘要翻译：化学式为CH 3 | CH-CH 2 -CH 2 -OR 2的化合物，其中R 1是氯或氟，R 2是氢，1-10个碳原子的烷酰基，苯甲酰基，烟酰基或异烟酰基，OR，当R 2含有碱性氮原子时，由无机或有机酸形成的无毒的药学上可接受的盐; 化合物以及盐可用作消炎剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式