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1. 发明申请

US20120225953A1 Self-Emulsifying Active Ingredient Formulation and the Use of this Formulation 审中-公开
标题翻译：自乳化活性成分配方及使用该配方
公开(公告)号：US20120225953A1
公开(公告)日：2012-09-06
申请号：US13449971
申请日：2012-04-18
申请人： Gunther Berndl , Jörg Breitenbach , Robert Heger , Michael Stadler , Peter Wilke , Jörg Rosenberg
发明人： Gunther Berndl , Jörg Breitenbach , Robert Heger , Michael Stadler , Peter Wilke , Jörg Rosenberg
IPC分类号： A61K47/32 , B29C47/88 , B29B9/02 , A61K47/38
CPC分类号： A61K9/107 , A61K9/1075 , A61K9/1617 , A61K9/1635 , A61K9/1652 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/38 , B29C48/04 , B29C48/919
摘要： The present invention relates to self-emulsifying formulations based on an active ingredient component and a formulation base with a lipid component and with a binder component and to the use of this formulation as dosage form in the life science sector. The invention also describes a process for producing self-emulsifying formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as dosage form advantageously by use of melt extrusion. The formulations spontaneously form emulsions in water or aqueous media.
摘要翻译：本发明涉及基于活性成分组分的自乳化制剂和具有脂质组分和粘合剂组分的制剂基质，以及将该制剂用作生命科学领域中的剂型。本发明还描述了一种通过混合制剂组分以形成塑料混合物并且在适当时通过使用熔体挤出有利地制备配方作为剂型的方法来生产自乳化制剂。制剂在水或水性介质中自发形成乳液。

2. 发明授权

US08197829B2 Self-emulsifying active substance formulation and use of this formulation 有权
公开(公告)号：US08197829B2
公开(公告)日：2012-06-12
申请号：US10296451
申请日：2001-05-29
申请人： Gunther Berndl , Jörg Breitenbach , Robert Heger , Michael Stadler , Peter Wilke , Jörg Rosenberg
发明人： Gunther Berndl , Jörg Breitenbach , Robert Heger , Michael Stadler , Peter Wilke , Jörg Rosenberg
IPC分类号： A61K8/20 , A61K8/73 , A61K8/81
摘要： The present invention relates to self-emulsifying formulations based on an active ingredient component and a formulation base with a lipid component and with a binder component and to the use of this formulation as dosage form in the life science sector. The invention also describes a process for producing self-emulsifying formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as dosage form advantageously by use of melt extrusion. The formulations spontaneously form emulsions in water or aqueous media.

3. 发明授权

US08470347B2 Self-emulsifying active substance formulation and use of this formulation 有权
标题翻译：自乳化活性物质配方及使用该配方
公开(公告)号：US08470347B2
公开(公告)日：2013-06-25
申请号：US10296451
申请日：2001-05-29
申请人： Gunther Berndl , Jörg Breitenbach , Robert Heger , Michael Stadler , Peter Wilke , Jörg Rosenberg
发明人： Gunther Berndl , Jörg Breitenbach , Robert Heger , Michael Stadler , Peter Wilke , Jörg Rosenberg
IPC分类号： A61K8/20 , A61K8/73 , A61K8/81
CPC分类号： A61K9/107 , A61K9/1075 , A61K9/1617 , A61K9/1635 , A61K9/1652 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/38 , B29C47/0011 , B29C47/8895
摘要： The present invention relates to self-emulsifying formulations based on an active ingredient component and a formulation base with a lipid component and with a binder component and to the use of this formulation as dosage form in the life science sector. The invention also describes a process for producing self-emulsifying formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as dosage form advantageously by use of melt extrusion. The formulations spontaneously form emulsions in water or aqueous media.
摘要翻译：本发明涉及基于活性成分组分的自乳化制剂和具有脂质组分和粘合剂组分的制剂基质，以及将该制剂用作生命科学领域中的剂型。本发明还描述了一种通过混合制剂组分以形成塑料混合物并且在适当时通过使用熔体挤出有利地制备配方作为剂型的方法来生产自乳化制剂。制剂在水或水性介质中自发形成乳液。

4. 发明申请

US20110123652A1 SELF-EMULSIFYING ACTIVE SUBSTANCE FORMULATION AND USE OF THIS FORMULATION 审中-公开
标题翻译：自我激活的活性物质配制和使用本制剂
公开(公告)号：US20110123652A1
公开(公告)日：2011-05-26
申请号：US12899227
申请日：2010-10-06
申请人： Gunther Berndl , Jörg Breitenbach , Jörg Rosenberg , Robert Heger , Michael Stadler , Peter Wilke
发明人： Gunther Berndl , Jörg Breitenbach , Jörg Rosenberg , Robert Heger , Michael Stadler , Peter Wilke
IPC分类号： A61K36/752 , A61K31/167
CPC分类号： A61K9/107 , A61K9/1075 , A61K9/1617 , A61K9/1635 , A61K9/1652 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/38 , B29C48/04 , B29C48/919
摘要： The present invention relates to self-emulsifying formulations based on an active ingredient component and a formulation base with a lipid component and with a binder component and to the use of this formulation as dosage form in the life science sector. The invention also describes a process for producing self-emulsifying formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as dosage form advantageously by use of melt extrusion. The formulations spontaneously form emulsions in water or aqueous media.
摘要翻译：本发明涉及基于活性成分组分的自乳化制剂和具有脂质组分和粘合剂组分的制剂基质，以及将该制剂用作生命科学领域中的剂型。本发明还描述了一种通过混合制剂组分以形成塑料混合物并且在适当时通过使用熔体挤出有利地制备配方作为剂型的方法来生产自乳化制剂。制剂在水或水性介质中自发形成乳液。

5. 发明申请

US20080028682A1 Revolving door control system 失效
标题翻译：旋转门控制系统
公开(公告)号：US20080028682A1
公开(公告)日：2008-02-07
申请号：US11823470
申请日：2007-06-27
申请人： Zachary Casella , Michael Stadler , Thomas Schluep
发明人： Zachary Casella , Michael Stadler , Thomas Schluep
IPC分类号： E05F15/20
CPC分类号： E05G5/003 , E05F15/608 , E05F15/74 , E05F2015/767 , E05Y2400/334 , E05Y2600/458 , E05Y2900/132
摘要： In a method and system for controlling a revolving door that has a plurality of chambers defined by wings of a revolver, at least one imaging sensor is provided for acquiring images of a first area where the plurality of chambers rotatably pass by or through. A drive causes the revolver to rotate in a first direction from a first position where a user can enter a first chamber via the first opening. Images are acquired by the one imaging sensor and signals are acquired from a position sensor that is operative for outputting signals indicative of the angular position of the revolver. Based on the signals acquired from the position sensor, each imaging sensor or its output is disabled and/or each image acquired by each imaging sensor is ignored when each door wing is in field-of-view of the imaging sensor.
摘要翻译：在用于控制旋转门的方法和系统中，旋转门具有由左轮手臂的翼限定的多个腔室，提供至少一个成像传感器，用于获取多个腔室可转动地穿过或穿过的第一区域的图像。驱动器使得左轮手枪从第一位置沿第一方向旋转，在第一位置，用户可以经由第一开口进入第一腔室。图像由一个成像传感器获取，并且信号从位置传感器获取，位置传感器用于输出指示左轮手枪的角位置的信号。基于从位置传感器获取的信号，当每个门翼处于成像传感器的视野中时，每个成像传感器或其输出被禁用和/或每个成像传感器获取的每个图像被忽略。

6. 发明申请

US20140134184A1 PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11 (PTPN11) AND TRIPLE-NEGATIVE BREAST CANCER 有权
公开(公告)号：US20140134184A1
公开(公告)日：2014-05-15
申请号：US14124441
申请日：2012-06-05
申请人： Mohamed Bentires-Alj , Nicola Aceto , Michael Stadler
发明人： Mohamed Bentires-Alj , Nicola Aceto , Michael Stadler
IPC分类号： C12N15/113 , C12Q1/68 , C07K16/40
CPC分类号： C12N15/1137 , C07K16/40 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Y301/03048
摘要： The present invention relates to a method for treating breast cancer in a subject having a breast cancer of the triple-negative type, which method comprises the step of administering to said subject a therapeutically effective amount of a modulator of the protein tyrosine phosphatase, non-receptor type 11 (PTPN11) gene or of its gene product (Shp2). The present invention also relates to a method for treating breast cancer in a subject having a breast cancer over-expressing the “SHP2 signature” genes, as compared to normal breast tissue samples, which method comprises the step of administering to said subject a therapeutically effective amount of a modulator of the protein tyrosine phosphatase, non-receptor type 11 (PTPN11) gene or of its gene product (Shp2), wherein said “SHP2 signature” genes consist of the genes SGCB, ZSCAN12, ID4, ZIC3, CPVL, HLA-A, MCOLN3, SPATA18, TMEM45A, GNAL, CYBRD1, TSPAN7, ZEB1, CNTLN, NEFL, CENPV, ARL6, HPRT1, LRRC34, PDPN, BEND7, SLC16A10, FAM27E1, PLEKHA1, HERC5, CHIC1, PHF6, ELOVL4, ANTXR1, PRAME, SCML1, CLIP4, CECR2, CNOT10, IGF2BP3, NAP1L3, GPC3, KIAA1804, DGKE, FAS, EPHA6, KDELC1, CRISPLD1, DOCK3, ACSL4, CNTNAP3, PLEKHM3, RDX, TBX18, RRAGD, HOXB5, SNCA, FUNDC2, ITGA8, HFM1, IGF2BP2, CCND2, SGTB, MKX, CRYBG3, WBP5, LPHN3, BEX4, CPNE8, GLDC, SLC35F1, HOXA13, SERPINF1, NEFM, SYCP2L, FHL1, APOBEC3C, CALD1, FKBP10, HOXD11, DENND2C, LRRC49, FAM55C, KIAA0408, HOXB9, C160RF62, ACN9, TUSC3, ELOVL2, SPOCK3, HOXB6, WDR35, MPP1, FBX038, PRKAA2, SLAIN1, NPHP3, KIAA1524, PRPS1, GJC1, AMOT, SLC9A6, KCTD12, NUP62CL, DZIP3, JAM3, HOXA9, ANKRD19, CDKN2A, BCAT1, OAT, LPHN2, CCDC82, HSD17B11, SAMHD1, WDR17, STK33, GSTP1, TRPC1, CKB, LIN28B, ALDH1L2, SACS, CLGN, MY03A, EPB41L3, SLC25A27, VCAN, GPX8, GALNT13, PVRL3, MOXD1, HEY1, MAP7D3, ESD, MPP6, EYA4, SPG20, ZDBF2, ZNF204, IFT57, AKR1B1, ADAT2, ZNF717, CCDC88A, ZNF215, MIDI, FBN2, LOC100130876, TCEAL8, IGF2BP1, ANKRD18B, PLAGL1, PM20D2, LDHB, C150RF51, PTPN11, EPB41L2, TLE4, GOLM1, C60RF192, HOXD13, SLIT2, UCHL1, DYNC2H1, CPS1, GPR180, PYGL, NRN1, PRTFDC1, SLC16A1, DSC3, TMC01, LRCH2, SLC6A15, DZIP1, HOXA5, HSPA4L, CDR1, PLS3, ECHDC1, SMARCA1, CXORF57, HOXD10, and IRS4.

7. 发明申请

US20090281346A1 METHOD FOR THE PRODUCTION OF CHIRAL AMINOCARBONYL COMPOUNDS 审中-公开
标题翻译：生产磺酰胺化合物的方法
公开(公告)号：US20090281346A1
公开(公告)日：2009-11-12
申请号：US12373955
申请日：2007-07-17
申请人： Benjamin List , Michael Stadler , Jung Woon Yang
发明人： Benjamin List , Michael Stadler , Jung Woon Yang
IPC分类号： C07C271/18
CPC分类号： C07C269/06 , C07C271/18
摘要： Disclosed is a method for producing aminocarbonyl compounds of the general formula (I) wherein R1 and R2 can be identical or different and represents hydrogen, alkyl, alkenyl, alkynyl, or aryl, X represents hydrogen, alkyl, alkenyl, alkynyl, aryl, or OR3, R3 representing hydrogen, alkyl, alkenyl, alkynyl, or aryl. According to said method, an aldehyde of the general formula (II) R1CO (II) wherein R1 has the meaning indicated above, is reacted with an imine of the general formula (III) wherein R2 and X have the meaning indicated above, in the presence of a catalyst.Aminocarbonyles are obtained by means of catalyzed Mannich reactions with aldehydes. For example, if α-unbranched aldehydes are reacted with previously formed N-Boc imines in the presence of (S)-proline as a catalyst, the desired β-amino aldehydes are obtained at excellent yields, diastereoselectivities and enantioselectivities.
摘要翻译：公开了一种制备通式（I）的氨基羰基化合物的方法，其中R 1和R 2可以相同或不同，表示氢，烷基，烯基，炔基或芳基，X表示氢，烷基，烯基，炔基，芳基或 OR3，R3代表氢，烷基，烯基，炔基或芳基。根据所述方法，通式（II）的化合物R1CO（II）的醛，其中R1具有上述含义，与通式（Ⅲ）的亚胺反应，其中R2和X具有上述含义，在存在催化剂。氨基羰基通过与醛的催化曼尼希反应获得。例如，如果在（S） - 脯氨酸作为催化剂的存在下使α-未分支的醛与先前形成的N-Boc亚胺反应，则获得所需的β-氨基醛，其产率优异，非对映选择性和对映选择性。

8. 发明申请

US20070008124A1 Automatic door opening and closing system and method of control thereof 有权
标题翻译：自动开门关闭系统及其控制方法
公开(公告)号：US20070008124A1
公开(公告)日：2007-01-11
申请号：US11365287
申请日：2006-03-01
申请人： Michael Stadler , Thomas Schluep , Joseph DeSisto
发明人： Michael Stadler , Thomas Schluep , Joseph DeSisto
IPC分类号： G08B13/08
CPC分类号： E05F15/43 , E05F15/611 , E05F15/73 , E05F2015/437 , E05F2015/483 , E05Y2600/45 , E05Y2600/46 , E05Y2900/132
摘要： A swinging automatic door control system includes an activation sensor for acquiring images of a first area where the door swings when opening or closing, a presence sensor for detecting motion in a second area that fronts a non-swinging side of the door when said door is closed, and a controller for controlling the opening and closing of the door as a function of the acquired images of a first area and the detection of motion in the second area.
摘要翻译：一种摆动式自动门控制系统，包括一个启动传感器，用于获取打开或关闭门时门摆动的第一区域的图像;存在传感器，用于在所述门是门时在门的非摆动侧面前方的第二区域中检测运动; 关闭，以及用于根据获取的第一区域的图像和第二区域中的运动检测来控制门的打开和关闭的控制器。

9. 发明授权

US09181553B2 Method of treatment of breast cancers over-expressing the SHP2 signature genes 有权
标题翻译：治疗过表达SHP2特征基因的乳腺癌的方法
公开(公告)号：US09181553B2
公开(公告)日：2015-11-10
申请号：US14124441
申请日：2012-06-05
申请人： Mohamed Bentires-Alj , Nicola Aceto , Michael Stadler
发明人： Mohamed Bentires-Alj , Nicola Aceto , Michael Stadler
IPC分类号： A61K39/395 , A61P35/04 , C12N15/113 , C12Q1/68 , C07K16/40
CPC分类号： C12N15/1137 , C07K16/40 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Y301/03048
摘要： A method for treating breast cancer in a subject having a breast cancer over-expressing the “SHP2 signature” genes, as compared to normal breast tissue samples, which method comprises the step of administering to said subject a therapeutically effective amount of a modulator of the protein tyrosine phosphatase, non-receptor type 11 (PTPN11) gene or of its gene product (Shp2).
摘要翻译：与正常乳腺组织样品相比，用于治疗具有过度表达“SHP2特征”基因的乳腺癌的受试者的乳腺癌的方法包括给予所述受试者治疗有效量的调节剂蛋白酪氨酸磷酸酶，非受体型11（PTPN11）基因或其基因产物（Shp2）。

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