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1. 发明申请

US20120244578A1 MONOMERIC ANTIBODY FC 有权
标题翻译：单体抗体FC
公开(公告)号：US20120244578A1
公开(公告)日：2012-09-27
申请号：US13511133
申请日：2010-11-22
申请人： Gunasekaran Kannan , Hongxing Zhou , Nancy Sun
发明人： Gunasekaran Kannan , Hongxing Zhou , Nancy Sun
IPC分类号： C07K16/00 , C12N15/63 , C12P21/02 , C12N1/19 , C12N1/15 , C12N5/10 , C12N15/13 , C12N1/21
CPC分类号： C07K16/00 , C07K2317/52
摘要： The invention relates to monomeric Fc polypeptides and methods of making and using such polypeptides. The polypeptides comprise substitution of one or more hydrophobic interface residues in the CH3 region with a polar amino acid.
摘要翻译：本发明涉及单体Fc多肽以及制备和使用这些多肽的方法。多肽包含用极性氨基酸取代CH3区域中的一个或多个疏水界面残基。

2. 发明授权

US09200060B2 Monomeric antibody Fc 有权
标题翻译：单体抗体Fc
公开(公告)号：US09200060B2
公开(公告)日：2015-12-01
申请号：US13511133
申请日：2010-11-22
申请人： Gunasekaran Kannan , Hongxing Zhou , Nancy Sun
发明人： Gunasekaran Kannan , Hongxing Zhou , Nancy Sun
IPC分类号： C07K1/00 , C07K16/00 , C12P21/08 , C07K14/00
CPC分类号： C07K16/00 , C07K2317/52
摘要： The invention relates to monomeric Fc polypeptides and methods of making and using such polypeptides. The polypeptides comprise substitution of one or more hydrophobic interface residues in the CH3 region with a polar amino acid.
摘要翻译：本发明涉及单体Fc多肽以及制备和使用这些多肽的方法。多肽包含用极性氨基酸取代CH3区域中的一个或多个疏水界面残基。

3. 发明授权

US09308258B2 Stable and aggregation free antibody FC molecules through CH3 domain interface engineering 有权
标题翻译：稳定和无聚集抗体FC分子通过CH3结构域界面工程
公开(公告)号：US09308258B2
公开(公告)日：2016-04-12
申请号：US13382876
申请日：2010-06-29
申请人： Gunasekaran Kannan , Hongxing Zhou
发明人： Gunasekaran Kannan , Hongxing Zhou
IPC分类号： C12N15/13 , C12N15/63 , A61K39/395
CPC分类号： A61K39/39591 , C07K2317/52
摘要： The present invention relates to methods of increasing stability and reducing aggregation in compositions comprising antibody Fc molecules and to composition comprising such molecules. Certain amino acid substitutions in the CH3 domain result in increased stability and reduced aggregation of compositions containing polypeptides comprising a CH3 domain, e.g., an antibody or Fc-fusion protein.
摘要翻译：本发明涉及增加包含抗体Fc分子的组合物的稳定性和减少聚集的方法以及包含这种分子的组合物。在CH3结构域中某些氨基酸取代导致包含CH 3结构域（例如抗体或Fc-融合蛋白）的多肽的组合物的稳定性增加和聚集减少。

4. 发明申请

US20120116057A1 DESIGN OF STABLE AND AGGREGATION FREE ANTIBODY FC MOLECULES THROUGH CH3 DOMAIN INTERFACE ENGINEERING 有权
标题翻译：通过CH3域界面工程设计稳定和无抗体免疫抗体FC分子
公开(公告)号：US20120116057A1
公开(公告)日：2012-05-10
申请号：US13382876
申请日：2010-06-29
申请人： Gunasekaran Kannan , Hongxing Zhou
发明人： Gunasekaran Kannan , Hongxing Zhou
IPC分类号： C07K19/00 , C12N15/13 , C12P21/00 , C12N1/21 , C12N5/10 , C07K16/18 , C12N15/63
CPC分类号： A61K39/39591 , C07K2317/52
摘要： The present invention relates to methods of increasing stability and reducing aggregation in compositions comprising antibody Fc molecules and to composition comprising such molecules. Certain amino acid substitutions in the CH3 domain result in increased stability and reduced aggregation of compositions containing polypeptides comprising a CH3 domain, e.g., an antibody or Fc-fusion protein.
摘要翻译：本发明涉及增加包含抗体Fc分子的组合物的稳定性和减少聚集的方法以及包含这种分子的组合物。在CH3结构域中某些氨基酸取代导致包含CH 3结构域（例如抗体或Fc-融合蛋白）的多肽的组合物的稳定性增加和聚集减少。

5. 发明授权

US07872113B2 Nucleic acids encoding antibodies that bind interleukin-4 receptor 有权
标题翻译：编码结合白细胞介素-4受体的抗体的核酸
公开(公告)号：US07872113B2
公开(公告)日：2011-01-18
申请号：US12535648
申请日：2009-08-04
申请人： Paul J. Carter , Hongxing Zhou
发明人： Paul J. Carter , Hongxing Zhou
IPC分类号： C07H21/04
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76
摘要： The present invention relates to antibodies that bind to the IL-4 receptor, fragments, muteins, and derivatives of such antibodies, nucleic acids encoding such antibodies, fragments, muteins and derivatives, and methods of making and using such antibodies, fragments, muteins, derivatives and nucleic acids. Methods for treating medical conditions induced by interleukin-4 involve administering an IL-4 receptor binding antibody, or an IL-4 receptor binding fragment, mutein, or derivative of an IL-4 receptor binding antibody, to a patient afflicted with such a condition. Particular antibodies provided herein include human monoclonal antibodies. Certain of the antibodies inhibit both IL-4-induced and IL-13-induced biological activities.
摘要翻译：本发明涉及结合IL-4受体的抗体，这些抗体的片段，突变蛋白和衍生物，编码这些抗体，片段，突变蛋白和衍生物的核酸，以及制备和使用这些抗体，片段，突变蛋白，衍生物和核酸。用于治疗由白细胞介素-4诱导的医学病症的方法包括向患有这种病症的患者施用IL-4受体结合抗体或IL-4受体结合片段，突变蛋白或IL-4受体结合抗体的衍生物。本文提供的特异性抗体包括人单克隆抗体。某些抗体抑制IL-4诱导的和IL-13诱导的生物活性。

6. 发明申请

US20100203590A1 ANTIBODIES THAT BIND INTERLEUKIN-4 RECEPTOR 有权
标题翻译：阻断白细胞介素-4受体的抗体
公开(公告)号：US20100203590A1
公开(公告)日：2010-08-12
申请号：US12535648
申请日：2009-08-04
申请人： PAUL J. CARTER , Hongxing Zhou
发明人： PAUL J. CARTER , Hongxing Zhou
IPC分类号： C12P21/00 , C07H21/04 , C12N15/74 , C12N5/16 , C12N5/10
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76
摘要： The present invention relates to antibodies that bind to the IL-4 receptor, fragments, muteins, and derivatives of such antibodies, nucleic acids encoding such antibodies, fragments, muteins and derivatives, and methods of making and using such antibodies, fragments, muteins, derivatives and nucleic acids. Methods for treating medical conditions induced by interleukin-4 involve administering an IL-4 receptor binding antibody, or an IL-4 receptor binding fragment, mutein, or derivative of an IL-4 receptor binding antibody, to a patient afflicted with such a condition. Particular antibodies provided herein include human monoclonal antibodies. Certain of the antibodies inhibit both IL-4-induced and IL-13-induced biological activities.
摘要翻译：本发明涉及结合IL-4受体的抗体，这些抗体的片段，突变蛋白和衍生物，编码这些抗体，片段，突变蛋白和衍生物的核酸，以及制备和使用这些抗体，片段，突变蛋白，衍生物和核酸。用于治疗由白细胞介素-4诱导的医学病症的方法包括向患有这种病症的患者施用IL-4受体结合抗体或IL-4受体结合片段，突变蛋白或IL-4受体结合抗体的衍生物。本文提供的特异性抗体包括人单克隆抗体。某些抗体抑制IL-4诱导的和IL-13诱导的生物活性。

7. 发明授权

US5759947A Bifunctional catalyst containing multimetal oxides 失效
标题翻译：含双金属氧化物的双功能催化剂
公开(公告)号：US5759947A
公开(公告)日：1998-06-02
申请号：US586913
申请日：1996-03-18
申请人： Hongxing Zhou
发明人： Hongxing Zhou
IPC分类号： B01D53/86 , B01D53/94 , B01J21/12 , B01J23/83 , B01J23/86 , B01J23/889 , B01J37/02 , B01J37/08 , B01J23/00 , B01J23/32 , B01J23/42 , B01J23/72
CPC分类号： B01D53/945 , B01D53/865 , B01J21/12 , B01J23/868 , B01J23/8892 , B01J37/0203 , B01J23/83 , Y02T10/22
摘要： A bifunctional catalyst containing multimetal oxides, and a method for preparing the same, includes a support of a moulded mixture of silica and alumina in a weight ratio of 1:1.2-2.5, and upon the support is deposited 3-30% by weight of metal oxides based on the total weight of the catalyst. The metal elements of the metal oxides are at least two selected from transition metal of period 4 of the periodic table and lanthanide. The metal oxides of the catalyst exist in the state of non-composite oxides.
摘要翻译：含有多金属氧化物的双功能催化剂及其制备方法包括以1:1.2-2.5的重量比的二氧化硅和氧化铝的模制混合物的载体，并且在载体上沉积3-30重量％基于催化剂总重量的金属氧化物。金属氧化物的金属元素是选自元素周期4的过渡金属和镧系元素中的至少两种。催化剂的金属氧化物以非复合氧化物的状态存在。

8. 发明授权

US07638606B2 Antibodies that bind interleukin-4 receptor 有权
标题翻译：结合白细胞介素-4受体的抗体
公开(公告)号：US07638606B2
公开(公告)日：2009-12-29
申请号：US10578410
申请日：2004-11-04
申请人： Paul J. Carter , Hongxing Zhou
发明人： Paul J. Carter , Hongxing Zhou
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76
摘要： The present invention relates to antibodies that bind to the IL-4 receptor, fragments, muteins, and derivatives of such antibodies, nucleic acids encoding such antibodies, fragments, muteins and derivatives, and methods of making and using such antibodies, fragments, muteins, derivatives and nucleic acids. Methods for treating medical conditions induced by interleukin-4 involve administering an IL-4 receptor binding antibody, or an IL-4 receptor binding fragment, mutein, or derivative of an IL-4 receptor binding antibody, to a patient afflicted with such a condition. Particular antibodies provided herein include human monoclonal antibodies. Certain of the antibodies inhibit both IL-4-induced and IL-13-induced biological activities.
摘要翻译：本发明涉及结合IL-4受体的抗体，这些抗体的片段，突变蛋白和衍生物，编码这些抗体，片段，突变蛋白和衍生物的核酸，以及制备和使用这些抗体，片段，突变蛋白，衍生物和核酸。用于治疗由白细胞介素-4诱导的医学病症的方法包括向患有这种病症的患者施用IL-4受体结合抗体或IL-4受体结合片段，突变蛋白或IL-4受体结合抗体的衍生物。本文提供的特异性抗体包括人单克隆抗体。某些抗体抑制IL-4诱导的和IL-13诱导的生物活性。

9. 发明申请

US20070274996A1 Antibodies That Bind Interleukin-4 Receptor 有权
标题翻译：绑定白细胞介素-4受体的抗体
公开(公告)号：US20070274996A1
公开(公告)日：2007-11-29
申请号：US10578410
申请日：2004-11-04
申请人： Paul Carter , Hongxing Zhou
发明人： Paul Carter , Hongxing Zhou
IPC分类号： C07K16/28 , A61K38/00 , A61K39/395 , A61P35/00 , C12N15/63 , C12N5/12 , C12N5/00 , C12N1/00 , A61P37/00 , C07H21/04
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76
摘要： The present invention relates to antibodies that bind to the IL-4 receptor, fragments, muteins, and derivatives of such antibodies, nucleic acids encoding such antibodies, fragments, muteins and derivatives, and methods of making and using such antibodies, fragments, muteins, derivatives and nucleic acids. Methods for treating medical conditions induced by interleukin-4 involve administering an IL-4 receptor binding antibody, or an IL-4 receptor binding fragment, mutein, or derivative of an IL-4 receptor binding antibody, to a patient afflicted with such a condition. Particular antibodies provided herein include human monoclonal antibodies. Certain of the antibodies inhibit both IL-4-induced and IL-13-induced biological activities.
摘要翻译：本发明涉及结合IL-4受体的抗体，这些抗体的片段，突变蛋白和衍生物，编码这些抗体，片段，突变蛋白和衍生物的核酸，以及制备和使用这些抗体，片段，突变蛋白，衍生物和核酸。用于治疗由白细胞介素-4诱导的医学病症的方法包括向患有这种病症的患者施用IL-4受体结合抗体或IL-4受体结合片段，突变蛋白或IL-4受体结合抗体的衍生物。本文提供的特定抗体包括人单克隆抗体。某些抗体抑制IL-4诱导的和IL-13诱导的生物活性。

10. 发明申请

US20050282181A1 Methods for identifying functional antibodies 有权
标题翻译：识别功能性抗体的方法
公开(公告)号：US20050282181A1
公开(公告)日：2005-12-22
申请号：US11019027
申请日：2004-12-21
申请人： Wei Yan , Wenyan Shen , Hongxing Zhou , Chen Zhou , David Cosman , Paul Carter , Francis Martin
发明人： Wei Yan , Wenyan Shen , Hongxing Zhou , Chen Zhou , David Cosman , Paul Carter , Francis Martin
IPC分类号： C07H21/04 , C07K16/00 , C07K16/06 , C07K16/18 , C07K16/28 , C12N15/10 , C12Q1/68 , G01N33/53 , G01N33/68
CPC分类号： C07K16/005 , C07K16/2863 , C07K16/2866 , C07K16/2875 , C07K16/2878 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/80 , C07K2319/00 , C12N15/1037 , G01N33/6854
摘要： The invention provides methods for screening multimeric antibodies produced by mammalian cells to find those that exhibit a biological function. The methods can be used to screen large numbers of antibodies, which may be cell surface, secreted, or intracellular antibodies. Antibodies can be screened to find those that bind antigen more avidly or those that compete with a ligand that binds to the antigen for binding. Any biological function that can be tested in vitro can be used to screen the antibodies. Nucleic acids encoding the antibodies that exhibit the biological function can be obtained in a number of ways.
摘要翻译：本发明提供了筛选由哺乳动物细胞产生的多聚体抗体以找到表现出生物功能的抗体的方法。该方法可用于筛选大量抗体，其可能是细胞表面，分泌的或细胞内的抗体。可以筛选抗体以找到更加狂热地结合抗原的抗体或与结合抗原结合的配体竞争的抗体。可以在体外测试的任何生物学功能可用于筛选抗体。可以以多种方式获得编码表现出生物功能的抗体的核酸。

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