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1. 发明授权

US07449560B2 Phosophoinositoglycan binding proteins 有权
标题翻译：磷酸正辛糖结合蛋白
公开(公告)号：US07449560B2
公开(公告)日：2008-11-11
申请号：US11377531
申请日：2006-03-16
申请人： Guenter Mueller , Wendelin Frick , Stefan Petry , Rudolf Schneider , Matthias Urmann
发明人： Guenter Mueller , Wendelin Frick , Stefan Petry , Rudolf Schneider , Matthias Urmann
IPC分类号： C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00
CPC分类号： C07K14/4713 , A61K38/1709
摘要： The invention refers to a protein from plasma membrane of adipocytes. The protein has specific binding affinity to phosphoinositoylglycans. It regulates glucose uptake by circumventing the insulin signaling cascade.
摘要翻译：本发明涉及脂肪细胞质膜的蛋白质。该蛋白质对磷酸肌醇蛋白具有特异性结合亲和力。它通过绕过胰岛素信号级联来调节葡萄糖摄取。

2. 发明授权

US07049416B2 Phosophoinositoglycan binding proteins 有权
公开(公告)号：US07049416B2
公开(公告)日：2006-05-23
申请号：US10470606
申请日：2003-07-03
申请人： Guenter Mueller , Wendelin Frick , Stefan Petry , Rudolf Schneider , Matthias Urmann
发明人： Guenter Mueller , Wendelin Frick , Stefan Petry , Rudolf Schneider , Matthias Urmann
IPC分类号： C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00
CPC分类号： C07K14/4713 , A61K38/1709
摘要： The invention refers to a protein from plasma membrane of adipocytes. The protein has specific binding affinity to phosphoinositoylglycans. It regulates glucose uptake by circumventing the insulin signaling cascade.

3. 发明申请

US20060160142A1 Phosophoinositoglycan binding proteins 有权
标题翻译：磷酸正辛糖结合蛋白
公开(公告)号：US20060160142A1
公开(公告)日：2006-07-20
申请号：US11377531
申请日：2006-03-16
申请人： Guenter Mueller , Wendelin Frick , Stefan Petry , Rudolf Schneider , Matthias Urmann
发明人： Guenter Mueller , Wendelin Frick , Stefan Petry , Rudolf Schneider , Matthias Urmann
IPC分类号： G01N33/53
CPC分类号： C07K14/4713 , A61K38/1709
摘要： The invention refers to a protein from plasma membrane of adipocytes. The protein has specific binding affinity to phosphoinositoylglycans. It regulates glucose uptake by circumventing the insulin signaling cascade.
摘要翻译：本发明涉及脂肪细胞质膜的蛋白质。该蛋白质对磷酸肌醇蛋白具有特异性结合亲和力。它通过绕过胰岛素信号级联来调节葡萄糖摄取。

4. 发明授权

US08017350B2 Glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase C regulation 有权
标题翻译：格列美脲和胰岛素诱导的糖基磷脂酰肌醇特异性磷脂酶C调节
公开(公告)号：US08017350B2
公开(公告)日：2011-09-13
申请号：US11464245
申请日：2006-08-14
申请人： Guenter Mueller , Wendelin Frick , Rudolf Schneider
发明人： Guenter Mueller , Wendelin Frick , Rudolf Schneider
IPC分类号： C12Q1/00 , C12Q1/34
CPC分类号： C07F9/657181 , G01N33/5041 , G01N33/566
摘要： The present invention relates to a method for identification of a chemical compound which modulates the activity of mammalian GPI-PLC whereina] a mammalian cell is incubated with glimepiride;b] hcDIGs of the cells of a] are prepared;c] the hcDIGs from b] are incubated with a chemical compound;d] the activity of the GPI-PLC from the hcDIGs of c] is determined.
摘要翻译：本发明涉及一种用于鉴定调节哺乳动物GPI-PLC的活性的化合物的方法，其中哺乳动物细胞与格列美脲一起孵育; b] a]的细胞的hcDIGs被制备; c]来自b]的hcDIGs与化合物一起温育; d]确定GPI-PLC从c]的hcDIGs的活动。

5. 发明申请

US20070154919A1 PIM-3 KINASE AS A TARGET FOR TYPE 2 DIABETES MELLITUS 有权
标题翻译： PIM-3激酶作为2型糖尿病的目标
公开(公告)号：US20070154919A1
公开(公告)日：2007-07-05
申请号：US11609652
申请日：2006-12-12
申请人： Marc Korn , Guenter Mueller , Rudolf Schneider , Georg Tschank
发明人： Marc Korn , Guenter Mueller , Rudolf Schneider , Georg Tschank
IPC分类号： C12Q1/68 , C12Q1/48 , C07H21/04 , C12P21/06 , C12N9/12
CPC分类号： C12Q1/6883 , C12N9/1205
摘要： The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3 activity and having a definite amino acid sequence, as well as to the use of PIM-3 as a screening agent for identifying anti-type 2 diabetes mellitus drugs and for preparing a medicament for the treatment of insulin resistance or type 2 diabetes mellitus.
摘要翻译：本发明涉及分离的核酸分子和宿主包含这种核酸分子的细胞。此外，本发明涉及具有PIM-3活性并具有确定氨基酸序列的多肽，以及使用PIM-3作为鉴定抗2型糖尿病药物的筛选剂，并且用于制备用于治疗胰岛素抵抗或2型糖尿病。

6. 发明授权

US08580251B2 PIM-3 kinase as a target for type 2 diabetes mellitus 有权
公开(公告)号：US08580251B2
公开(公告)日：2013-11-12
申请号：US12581314
申请日：2009-10-19
申请人： Marc Korn , Guenter Mueller , Rudolf Schneider , Georg Tschank
发明人： Marc Korn , Guenter Mueller , Rudolf Schneider , Georg Tschank
IPC分类号： A61K38/45 , A61K35/00 , C12N9/12
CPC分类号： C12Q1/6883 , C12N9/1205
摘要： The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3 activity and having a definite amino acid sequence, as well as to the use of PIM-3 as a screening agent for identifying anti-type 2 diabetes mellitus drugs and for preparing a medicament for the treatment of insulin resistance or type 2 diabetes mellitus.

7. 发明授权

US07629126B2 PIM-3 kinase as a target for type 2 diabetes mellitus 有权
标题翻译： PIM-3激酶作为2型糖尿病的靶标
公开(公告)号：US07629126B2
公开(公告)日：2009-12-08
申请号：US11609652
申请日：2006-12-12
申请人： Marc Korn , Guenter Mueller , Rudolf Schneider , Georg Tschank
发明人： Marc Korn , Guenter Mueller , Rudolf Schneider , Georg Tschank
IPC分类号： C12Q1/68 , C12Q1/48 , C12N15/54
CPC分类号： C12Q1/6883 , C12N9/1205
摘要： The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3 activity and having a definite amino acid sequence, as well as to the use of PIM-3 as a screening agent for identifying anti-type 2 diabetes mellitus drugs and for preparing a medicament for the treatment of insulin resistance or type 2 diabetes mellitus.
摘要翻译：本发明涉及分离的核酸分子和宿主包含这种核酸分子的细胞。此外，本发明涉及具有PIM-3活性并具有确定氨基酸序列的多肽，以及使用PIM-3作为鉴定抗2型糖尿病药物的筛选剂，并且用于制备用于治疗胰岛素抵抗或2型糖尿病。

8. 发明授权

US07227006B2 PIM-3 kinase as a target for type 2 diabetes mellitus 有权
标题翻译： PIM-3激酶作为2型糖尿病的靶标
公开(公告)号：US07227006B2
公开(公告)日：2007-06-05
申请号：US10348081
申请日：2003-01-21
申请人： Marcus Korn , Guenter Mueller , Rudolf Schneider , Georg Tschank
发明人： Marcus Korn , Guenter Mueller , Rudolf Schneider , Georg Tschank
IPC分类号： C07H21/04 , C12N5/00 , C12P19/34
CPC分类号： C12Q1/6883 , C12N9/1205
摘要： The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3 activity and having a definite amino acid sequence, as well as to the use of PIM-3 as a screening agent for identifying anti-type 2 diabetes mellitus drugs and for preparing a medicament for the treatment of insulin resistance or type 2 diabetes mellitus.
摘要翻译：本发明涉及分离的核酸分子和宿主包含这种核酸分子的细胞。此外，本发明涉及具有PIM-3活性并具有确定氨基酸序列的多肽，以及使用PIM-3作为鉴定抗2型糖尿病药物的筛选剂，并且用于制备用于治疗胰岛素抵抗或2型糖尿病。

9. 发明授权

US06827189B2 Electromagnetically actuated, single-surface friction coupling, without a rotor slip ring 失效
标题翻译：电磁致动，单面摩擦联接，无转子滑环
公开(公告)号：US06827189B2
公开(公告)日：2004-12-07
申请号：US10362535
申请日：2003-02-21
申请人： Rudolf Schneider , Helmut Fronius
发明人： Rudolf Schneider , Helmut Fronius
IPC分类号： F16D27112
CPC分类号： F16D27/112 , F16D2027/008
摘要： The invention proposes an electromagnetically actuated, single-surface friction coupling without a rotor slip-ring, having a rotor element (2), a fixed magnet body (6) and a pot-shaped armature element (28) mounted so that it can be displaced axially. A cylindrical jacket shaped area (28B) of the armature element (28) extends with a narrow air gap along an outer jacket surface (12) of the magnet body (6). Between the armature element (28) and a friction surface (30) of the rotor element there is a working air gap (S) that can be bridged. To keep the moment of inertia on the drive output side as small as possible, it is proposed to arrange the rotor element (2) on the drive output side and the armature element (28) on the drive input side.
摘要翻译：本发明提出一种没有转子滑环的电磁致动的单面摩擦联接器，其具有转子元件（2），固定磁体（6）和罐形电枢元件（28），其安装成可以是轴向位移。电枢元件（28）的圆柱形护套形状区域（28B）沿着磁体（6）的外护套表面（12）以窄的气隙延伸。在电枢元件（28）和转子元件的摩擦表面（30）之间存在能够桥接的工作气隙（S）。为了使驱动输出侧的惯性力尽可能小，建议将驱动输出侧的转子元件（2）和驱动输入侧的电枢元件（28）配置。

10. 发明授权

US5792926A Virus/herbicide resistance genes, processes for producing same and their use 失效
标题翻译：病毒/除草剂抗性基因，生产方法及其用途
公开(公告)号：US5792926A
公开(公告)日：1998-08-11
申请号：US458695
申请日：1995-06-02
申请人： Rudolf Schneider , Gunter Donn , Hubert Mullner
发明人： Rudolf Schneider , Gunter Donn , Hubert Mullner
IPC分类号： C07K14/08 , C12N9/10 , C12N15/82 , A01H5/00
CPC分类号： C07K14/005 , C12N15/8277 , C12N15/8283 , C12N9/1029 , C12N2770/00022
摘要： Virus genes, such as coat protein genes, which confer viral resistance or bring about a reduction in the signs of infection by the corresponding virus can be combined with herbicide-resistance genes, such as the phosphinothricin resistance gene, for the transformation of plants. A combination of a viral gene and a herbicide-resistance gene facilitates the selection of transgenic plants. In addition, in practical field cultivation, the vitality of the plants is increased by the virus tolerance, and an improved plant protection is possible due to the herbicide resistance gene.
摘要翻译：赋予病毒抗性或引起相应病毒感染迹象降低的病毒基因（例如外壳蛋白基因）可以与用于转化植物的除草剂抗性基因（例如膦丝菌素抗性基因）结合。病毒基因和除草剂抗性基因的组合促进了转基因植物的选择。此外，在实际的田间种植中，植物的活力由于病毒耐受性而增加，并且由于除草剂抗性基因可以改善植物保护。

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