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1. 发明授权

US07070951B2 Dewaxing kit for immunostaining tissue specimens 失效
标题翻译：用于免疫染色组织标本的脱蜡试剂盒
公开(公告)号：US07070951B2
公开(公告)日：2006-07-04
申请号：US10652854
申请日：2003-08-29
申请人： Guangrong Zhang , Cheng-Zhi Yu , Sheng-Hui Su , Krishan L. Kalra , Ding Zhou
发明人： Guangrong Zhang , Cheng-Zhi Yu , Sheng-Hui Su , Krishan L. Kalra , Ding Zhou
IPC分类号： G01N1/30
CPC分类号： C11D1/143 , C11D1/62 , C11D1/72 , C11D3/187 , C11D3/188 , C11D3/201 , C11D3/2044 , G01N1/30 , G01N1/36 , Y10S435/975
摘要： Compositions and methods are provided for dewaxing wax-embedded biological specimens prior to histochemical analysis. The compositions and methods provided can effectively remove wax or improved wax-based embedding materials, particularly paraffin-based, from specimens during preparation for histochemical or other diagnostic analyses, while minimizing danger to users, achieving compatibility with automated use, and maintaining compatibility with downstream histochemical analyses, particularly immunostaining. Compositions of the invention comprise a paraffin-solubilizing organic solvent, a polar organic solvent, and a surfactant. Compositions can further comprise water. The method involves contacting a wax-embedded specimen with the dewaxing composition to solubilize the wax impregnating the specimen prior to histochemical analysis. The method can comprise the further step of washing the dewaxed specimen immediately after dewaxing with an aqueous wash composition comprising a detergent to remove residual dewaxing composition. Also provided is a kit for dewaxing a wax-embedded specimen, which comprises a dewaxing composition and can further comprise a second composition of (1) an immunostaining reagent or (2) an aqueous wash solution comprising a detergent for removing residual dewaxing solution.
摘要翻译：提供组合物和方法，用于在组织化学分析前对蜡嵌入的生物样品进行脱蜡。所提供的组合物和方法可以在用于组织化学或其他诊断分析的准备期间有效地从标本中去除蜡或改进的蜡基嵌入材料，特别是基于石蜡的包埋材料，同时最小化对使用者的危害，实现与自动使用的兼容性并保持与下游的兼容性组织化学分析，特别是免疫染色。本发明的组合物包含石蜡溶解性有机溶剂，极性有机溶剂和表面活性剂。组合物还可以包含水。该方法包括使蜡包埋的样品与脱蜡组合物接触，以在组织化学分析之前溶解浸渍样品的蜡。该方法可以包括在用包含洗涤剂的水性洗涤组合物脱蜡之后立即洗涤脱蜡样品以除去残余脱蜡组合物的步骤。还提供了一种用于脱蜡蜡包埋样品的试剂盒，其包含脱蜡组合物，并且还可以包含（1）免疫染色试剂的第二组合物或（2）包含用于除去残余脱蜡溶液的洗涤剂的水性洗涤溶液。

2. 发明授权

US06632598B1 Deparaffinization compositions and methods for their use 失效
标题翻译：脱蜡组合物及其使用方法
公开(公告)号：US06632598B1
公开(公告)日：2003-10-14
申请号：US08212175
申请日：1994-03-11
申请人： Guangrong Zhang , Cheng-Zhi Yu , Sheng-Hui Su , Krishan L. Kalra , Ding Zhou
发明人： Guangrong Zhang , Cheng-Zhi Yu , Sheng-Hui Su , Krishan L. Kalra , Ding Zhou
IPC分类号： C12Q100
CPC分类号： C11D1/143 , C11D1/62 , C11D1/72 , C11D3/187 , C11D3/188 , C11D3/201 , C11D3/2044 , G01N1/30 , G01N1/36 , Y10S435/975
摘要： Compositions and methods are provided for dewaxing wax-embedded biological specimens prior to histochemical analysis. The compositions and methods provided can effectively remove wax or improved wax-based embedding materials, particularly paraffin-based, from specimens during preparation for histochemical or other diagnostic analyses, while minimizing danger to users, achieving compatibility with automated use, and maintaining compatibility with downstream histochemical analyses, particularly immunostaining. Compositions of the invention comprise a paraffin-solubilizing organic solvent, a polar organic solvent, and a surfactant. Compositions can further comprise water. The method involves contacting a wax-embedded specimen with the dewaxing composition to solubilize the wax impregnating the specimen prior to histochemical analysis. The method can comprise the further step of washing the dewaxed specimen immediately after dewaxing with an aqueous wash composition comprising a detergent to remove residual dewaxing composition. Also provided is a kit for dewaxing a wax-embedded specimen, which comprises a dewaxing composition and can further comprise a second composition of (1) an immunostaining reagent or (2) an aqueous wash solution comprising a detergent for removing residual dewaxing solution.
摘要翻译：提供组合物和方法，用于在组织化学分析前对蜡嵌入的生物样品进行脱蜡。所提供的组合物和方法可以在用于组织化学或其他诊断分析的准备期间有效地从标本中去除蜡或改进的蜡基嵌入材料，特别是基于石蜡的包埋材料，同时最小化对使用者的危害，实现与自动使用的兼容性并保持与下游的兼容性组织化学分析，特别是免疫染色。本发明的组合物包含石蜡溶解性有机溶剂，极性有机溶剂和表面活性剂。组合物还可以包含水。该方法包括使蜡包埋的样品与脱蜡组合物接触，以在组织化学分析之前溶解浸渍样品的蜡。该方法可以包括在用包含洗涤剂的水性洗涤组合物脱蜡之后立即洗涤脱蜡样品以除去残余脱蜡组合物的步骤。还提供了一种用于脱蜡蜡包埋样品的试剂盒，其包含脱蜡组合物，并且还可以包含第二组合物（1）免疫染色试剂或（2）包含用于除去残余脱蜡溶液的洗涤剂的水性洗涤溶液。 / PTEXT>

3. 发明申请

US20060019332A1 Deparaffinization compositions for dewaxing tissue specimens 审中-公开
标题翻译：用于脱蜡组织标本的脱蜡组合物
公开(公告)号：US20060019332A1
公开(公告)日：2006-01-26
申请号：US11186392
申请日：2005-07-20
申请人： Guangrong Zhang , Cheng-Zhi Yu , Sheng-Hui Su , Krishan Kalra , Ding Zhou
发明人： Guangrong Zhang , Cheng-Zhi Yu , Sheng-Hui Su , Krishan Kalra , Ding Zhou
IPC分类号： G01N1/30 , G01N33/48 , C23G5/00
CPC分类号： C11D1/143 , C11D1/62 , C11D1/72 , C11D3/187 , C11D3/188 , C11D3/201 , C11D3/2044 , G01N1/30 , G01N1/36 , Y10S435/975
摘要： Compositions and methods are provided for dewaxing wax-embedded biological specimens prior to histochemical analysis. The compositions and methods provided can effectively remove wax or improved wax-based embedding materials, particularly paraffin-based, from specimens during preparation for histochemical or other diagnostic analyses, while minimizing danger to users, achieving compatibility with automated use, and maintaining compatibility with downstream histochemical analyses, particularly immunostaining. Compositions of the invention comprise a paraffin-solubilizing organic solvent, a polar organic solvent, and a surfactant. Compositions can further comprise water. The method involves contacting a wax-embedded specimen with the dewaxing composition to solubilize the wax impregnating the specimen prior to histochemical analysis. The method can comprise the further step of washing the dewaxed specimen immediately after dewaxing with an aqueous wash composition comprising a detergent to remove residual dewaxing composition. Also provided is a kit for dewaxing a wax-embedded specimen, which comprises a dewaxing composition and can further comprise a second composition of (1) an immunostaining reagent or (2) an aqueous wash solution comprising a detergent for removing residual dewaxing solution.
摘要翻译：提供组合物和方法，用于在组织化学分析前对蜡嵌入的生物样品进行脱蜡。所提供的组合物和方法可以在用于组织化学或其他诊断分析的准备期间有效地从标本中去除蜡或改进的蜡基嵌入材料，特别是基于石蜡的包埋材料，同时最小化对使用者的危害，实现与自动使用的兼容性并保持与下游的兼容性组织化学分析，特别是免疫染色。本发明的组合物包含石蜡溶解性有机溶剂，极性有机溶剂和表面活性剂。组合物还可以包含水。该方法包括使蜡包埋的样品与脱蜡组合物接触，以在组织化学分析之前溶解浸渍样品的蜡。该方法可以包括在用包含洗涤剂的水性洗涤组合物脱蜡之后立即洗涤脱蜡样品以除去残余脱蜡组合物的步骤。还提供了一种用于脱蜡蜡包埋样品的试剂盒，其包含脱蜡组合物，并且还可以包含（1）免疫染色试剂的第二组合物或（2）包含用于除去残余脱蜡溶液的洗涤剂的水性洗涤溶液。

4. 发明申请

US20150018328A1 THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE 有权
标题翻译：治疗活性化合物及其使用方法
公开(公告)号：US20150018328A1
公开(公告)日：2015-01-15
申请号：US14328885
申请日：2014-07-11
申请人： Zenon D. Konteatis , Janeta Popovici-Muller , Jeremy Travins , Robert Zahler , Zhenwei Cai , Ding Zhou
发明人： Zenon D. Konteatis , Janeta Popovici-Muller , Jeremy Travins , Robert Zahler , Zhenwei Cai , Ding Zhou
IPC分类号： C07D417/04 , A61K31/53 , A61K45/06 , C07D251/18 , C07D413/04 , C07D405/14 , C07D405/12 , C07D403/04 , A61K31/5377 , C07D401/04 , C07D401/14
CPC分类号： A61K31/53 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D251/18 , C07D251/48 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
摘要翻译：提供的是用于治疗癌症的化合物和治疗癌症的方法，包括向有需要的受试者施用本文所述的化合物。

5. 发明授权

US08703742B2 Boron-containing small molecules 有权
标题翻译：含硼的小分子
公开(公告)号：US08703742B2
公开(公告)日：2014-04-22
申请号：US13227444
申请日：2011-09-07
申请人： Vincent S. Hernandez , Charles Ding , Jacob J. Plattner , Michael Richard Kevin Alley , Fernando Rock , Suoming Zhang , Eric Easom , Xianfeng Li , Ding Zhou
发明人： Vincent S. Hernandez , Charles Ding , Jacob J. Plattner , Michael Richard Kevin Alley , Fernando Rock , Suoming Zhang , Eric Easom , Xianfeng Li , Ding Zhou
IPC分类号： A61K31/69 , A61P31/04 , A61P31/00 , A61P31/06 , C07F5/02 , C12N9/99
CPC分类号： C07F5/025
摘要： This invention relates to, among other items, benzoxaborole compounds and their use for treating bacterial infections.
摘要翻译：本发明涉及苯并恶唑化合物及其用于治疗细菌感染的用途。

6. 发明申请

US20160009708A1 COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO TRPA1 有权
标题翻译：用于治疗与TRPA1相关的疾病的化合物
公开(公告)号：US20160009708A1
公开(公告)日：2016-01-14
申请号：US14616100
申请日：2015-02-06
申请人： Xinyuan Wu , Spencer David Kimball , Ping Chen , Ding Zhou , Shaoping Peng
发明人： Xinyuan Wu , Spencer David Kimball , Ping Chen , Ding Zhou , Shaoping Peng
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K31/519 , C07D239/70
摘要： Compounds and compositions for treating disorders related to TRPA1 are described herein.
摘要翻译：本文描述了用于治疗与TRPA1相关的疾病的化合物和组合物。

7. 发明授权

US09020835B2 Search-powered connection targeting 有权
标题翻译：搜索引擎连接定位
公开(公告)号：US09020835B2
公开(公告)日：2015-04-28
申请号：US13549061
申请日：2012-07-13
申请人： Ding Zhou
发明人： Ding Zhou
IPC分类号： G06Q30/02
CPC分类号： G06Q30/0269 , G06Q30/0203 , G06Q30/0251 , G06Q30/0252 , G06Q30/0255 , G06Q30/0277 , G06Q50/01
摘要： A social networking system extends the reach of an ad by allowing an advertiser to seed a search for suggesting targeting criteria for an ad. Using the seeds, the social networking system identifies a set of seed objects from a social graph. The social networking system traverses the social graph to compute the similarity between the seed objects and candidate objects related to the seed objects. Based on the computed similarity, the social networking system suggests a set of target objects to the advertiser. The social networking system receives a selection of one or more target objects from the advertiser. From the selected target objects the social networking system determines one or more targeting criteria for the ad, so users with an edge in the social graph to any of the selected target objects are eligible to receive the ad.
摘要翻译：一个社交网络系统通过允许广告客户搜索广告的建议定位标准来搜索广告，从而扩大广告的覆盖范围。使用种子，社交网络系统从社交图中识别一组种子对象。社交网络系统遍历社交图，计算种子对象和与种子对象相关的候选对象之间的相似度。基于计算出的相似度，社交网络系统向广告客户建议一组目标对象。社交网络系统从广告商接收一个或多个目标对象的选择。从选定的目标对象中，社交网络系统确定广告的一个或多个定位条件，因此在社交图中具有边缘的用户对任何所选目标对象都有资格接收广告。

8. 发明授权

US09012465B1 Compounds useful for treating disorders related to TRPA1 有权
标题翻译：可用于治疗与TRPA1相关的疾病的化合物
公开(公告)号：US09012465B1
公开(公告)日：2015-04-21
申请号：US13963586
申请日：2013-08-09
申请人： Xinyuan Wu , Spencer David Kimball , Ping Chen , Ding Zhou , Shaoping Peng
发明人： Xinyuan Wu , Spencer David Kimball , Ping Chen , Ding Zhou , Shaoping Peng
IPC分类号： A61K31/519 , C07D471/04
CPC分类号： C07D471/04 , A61K31/519 , C07D239/70
摘要： Compounds and compositions for treating disorders related to TRPA1 are described herein.
摘要翻译：本文描述了用于治疗与TRPA1相关的疾病的化合物和组合物。

9. 发明授权

US08868752B2 Resource management of social network applications 有权
标题翻译：社会网络应用的资源管理
公开(公告)号：US08868752B2
公开(公告)日：2014-10-21
申请号：US13617537
申请日：2012-09-14
申请人： Thomas Scott Whitnah , Alexander Matthew Rush , Ding Zhou , Ruchi Sanghvi
发明人： Thomas Scott Whitnah , Alexander Matthew Rush , Ding Zhou , Ruchi Sanghvi
IPC分类号： G06F15/173 , G06Q10/10 , H04L12/58 , H04L29/08
CPC分类号： H04L51/12 , G06F17/3053 , G06Q10/10 , H04L47/783 , H04L51/32 , H04L67/16 , H04L67/20 , H04L67/306 , H04L67/34
摘要： Applications in social networks support interaction between members through various types of channels such as notifications, newsfeed, and so forth. For each channel, applications are ranked based on their user affinity measures. User affinity is based on measuring positive and negative interactions by users as both senders and recipients of messages generated by applications. Metrics are computed for the different types of messages and interactions provided by applications. For each channel, an application receives user affinity score based on specific weighted combination of the metrics. Applications use channel resources to send messages to increase their user base. Given the large number of applications that are available, the extent to which applications are allowed to use channels is controlled, limiting their resource consumption. User affinity scores of applications calculated for a channel are used to decide the allocation of channel resources for an application.
摘要翻译：社交网络中的应用通过各种渠道（如通知，新闻馈送等）来支持成员之间的互动。对于每个通道，应用程序根据用户亲和度测量进行排名。用户关联性基于用户测量由应用程序生成的消息的发送者和收件人的正面和负面交互。针对应用程序提供的不同类型的消息和交互计算度量。对于每个渠道，应用程序根据指标的特定加权组合来接收用户关联度分数。应用程序使用信道资源发送消息以增加用户群。鉴于可用的大量应用程序，允许应用程序允许使用通道的程度受到控制，从而限制了其资源消耗。用于为频道计算的应用程序的用户亲和度分数用于决定应用程序的信道资源分配。

10. 发明授权

US08307086B2 Resource management of social network applications 有权
标题翻译：社会网络应用的资源管理
公开(公告)号：US08307086B2
公开(公告)日：2012-11-06
申请号：US12253149
申请日：2008-10-16
申请人： Thomas Scott Whitnah , Alexander Matthew Rush , Ding Zhou , Ruchi Sanghvi
发明人： Thomas Scott Whitnah , Alexander Matthew Rush , Ding Zhou , Ruchi Sanghvi
IPC分类号： G06F15/173
CPC分类号： H04L51/12 , G06F17/3053 , G06Q10/10 , H04L47/783 , H04L51/32 , H04L67/16 , H04L67/20 , H04L67/306 , H04L67/34
摘要： Applications in social networks support interaction between members through various types of channels such as notifications, newsfeed, and so forth. For each channel, applications are ranked based on their user affinity measures. User affinity is based on measuring positive and negative interactions by users as both senders and recipients of messages generated by applications. Metrics are computed for the different types of messages and interactions provided by applications. For each channel, an application receives user affinity score based on specific weighted combination of the metrics. Applications use channel resources to send messages to increase their user base. Given the large number of applications that are available, the extent to which applications are allowed to use channels is controlled, limiting their resource consumption. User affinity scores of applications calculated for a channel are used to decide the allocation of channel resources for an application.
摘要翻译：社交网络中的应用通过各种渠道（如通知，新闻馈送等）来支持成员之间的互动。对于每个通道，应用程序根据用户亲和度测量进行排名。用户关联性基于用户测量由应用程序生成的消息的发送者和收件人的正面和负面交互。针对应用程序提供的不同类型的消息和交互计算度量。对于每个渠道，应用程序根据指标的特定加权组合来接收用户关联度分数。应用程序使用信道资源发送消息以增加用户群。鉴于可用的大量应用程序，允许应用程序允许使用通道的程度受到控制，从而限制了其资源消耗。用于为频道计算的应用程序的用户亲和度分数用于决定应用程序的信道资源分配。

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