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1. 发明申请

US20090137521A1 Certain Compounds, Compositions and Methods 有权
标题翻译：某些化合物，组合物和方法
公开(公告)号：US20090137521A1
公开(公告)日：2009-05-28
申请号：US12252961
申请日：2008-10-16
申请人： Gregory S. Hamilton , Takashi Tsukamoto , Dana V. Ferraris , Bridget Duvall , Rena Lapidus
发明人： Gregory S. Hamilton , Takashi Tsukamoto , Dana V. Ferraris , Bridget Duvall , Rena Lapidus
IPC分类号： A61K31/7068 , C07H19/073 , C07H19/12 , A61K31/706 , A61P35/00
CPC分类号： C07H19/06 , A61K31/7068 , A61K45/06 , C07B2200/13 , C07H1/00 , C07H19/04 , C07H19/073
摘要： The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds.
摘要翻译：本发明提供某些四氢尿苷衍生物化合物，包含这些化合物的药物组合物和试剂盒，以及制备和使用这些化合物的方法。

2. 发明授权

US08618075B2 Certain compounds, compositions and methods 有权
公开(公告)号：US08618075B2
公开(公告)日：2013-12-31
申请号：US13556404
申请日：2012-07-24
申请人： Gregory S. Hamilton , Takashi Tsukamoto , Dana V. Ferraris , Bridget Duvall , Rena Lapidus
发明人： Gregory S. Hamilton , Takashi Tsukamoto , Dana V. Ferraris , Bridget Duvall , Rena Lapidus
IPC分类号： A01N43/04 , A61K31/70 , C07H19/00
CPC分类号： C07H19/06 , A61K31/7068 , A61K45/06 , C07B2200/13 , C07H1/00 , C07H19/04 , C07H19/073
摘要： The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds.

3. 发明申请

US20120289475A1 Certain Compounds, Compositions and Methods 有权
标题翻译：某些化合物，组合物和方法
公开(公告)号：US20120289475A1
公开(公告)日：2012-11-15
申请号：US13556404
申请日：2012-07-24
申请人： Gregory S. Hamilton , Takashi Tsukamoto , Dana V. Ferraris , Bridget Duvall , Rena Lapidus
发明人： Gregory S. Hamilton , Takashi Tsukamoto , Dana V. Ferraris , Bridget Duvall , Rena Lapidus
IPC分类号： A61K31/7068 , A61P35/00 , C07H19/073
CPC分类号： C07H19/06 , A61K31/7068 , A61K45/06 , C07B2200/13 , C07H1/00 , C07H19/04 , C07H19/073
摘要： The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds.
摘要翻译：本发明提供某些四氢尿苷衍生物化合物，包含这些化合物的药物组合物和试剂盒，以及制备和使用这些化合物的方法。

4. 发明授权

US08268800B2 Certain compounds, compositions and methods 有权
标题翻译：某些化合物，组合物和方法
公开(公告)号：US08268800B2
公开(公告)日：2012-09-18
申请号：US12252961
申请日：2008-10-16
申请人： Gregory S. Hamilton , Takashi Tsukamoto , Dana V. Ferraris , Bridget Duvall , Rena Lapidus
发明人： Gregory S. Hamilton , Takashi Tsukamoto , Dana V. Ferraris , Bridget Duvall , Rena Lapidus
IPC分类号： A01N43/04 , A61K31/70 , C07H19/00
CPC分类号： C07H19/06 , A61K31/7068 , A61K45/06 , C07B2200/13 , C07H1/00 , C07H19/04 , C07H19/073
摘要： The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds.
摘要翻译：本发明提供某些四氢尿苷衍生物化合物，包含这些化合物的药物组合物和试剂盒，以及制备和使用这些化合物的方法。

5. 发明授权

US07968593B2 Thiolactones 失效
标题翻译：硫内酯
公开(公告)号：US07968593B2
公开(公告)日：2011-06-28
申请号：US12472251
申请日：2009-05-26
申请人： Barbara S. Slusher , Takashi Tsukamoto
发明人： Barbara S. Slusher , Takashi Tsukamoto
IPC分类号： A61K31/382 , A61K31/381 , C07D335/06 , C07D335/04
CPC分类号： C07D335/02 , C07D335/06
摘要： This invention provides new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, inhibiting angiogenesis, effecting a TGF-β activity or a neuronal activity, and treating a glutamate abnormality, a compulsive disorder, neuropathy, pain, a prostate disease, cancer, Huntington's disease, diabetes, a retinal disorder or glaucoma.
摘要翻译：本发明提供新的化合物，药物组合物和包含这些化合物的诊断试剂，以及使用这些化合物抑制NAALADase酶活性的方法，检测NAALADase水平被改变的疾病，抑制血管发生，影响TGF- 活动或神经元活动，以及治疗谷氨酸异常，强迫症，神经病，疼痛，前列腺疾病，癌症，亨廷顿氏病，糖尿病，视网膜病症或青光眼。

6. 发明授权

US07207840B2 Plug and waterproof connector with plug 有权
标题翻译：插头和防水连接器插头
公开(公告)号：US07207840B2
公开(公告)日：2007-04-24
申请号：US11181865
申请日：2005-07-15
申请人： Hirotaka Fukushima , Takashi Tsukamoto
发明人： Hirotaka Fukushima , Takashi Tsukamoto
IPC分类号： H01R13/40
CPC分类号： H01R13/5221
摘要： A waterproof connector includes annular plug receiving chambers formed within a connector housing in surrounding relation respectively to outer peripheral surfaces of insulating sheaths of wires, and are disposed adjacent respectively to terminal receiving chambers in a longitudinal direction of the wires, plugs received respectively in the plug receiving chambers, and a cover attached to the connector housing from a side of the other end portions of the wires, covering the plug receiving chambers. The plug includes an annular elastic rubber member and an annular resin member molded integrally with the rubber member in concentric relation thereto. An inner peripheral surface of the rubber member is held in contact with a part of the outer peripheral surface of the insulating sheath of the wire over an entire periphery thereof, while an outer peripheral surface of the rubber member is held in contact with an inner peripheral surface of a peripheral wall of the plug receiving chamber over an entire periphery thereof.
摘要翻译：防水连接器包括分别形成在连接器壳体内的环形插塞接收室，分别围绕导线的绝缘护套的外周表面，并且分别设置在电线的纵向方向上的端子接收室附近，分别容纳在插头中的插头接收室，以及从电线的另一端部的一侧附接到连接器壳体的盖子，覆盖插头接收室。塞子包括环形弹性橡胶构件和与橡胶构件一体地与其成同心关系的环形树脂构件。橡胶构件的内周面在其整个外周与导线的绝缘护套的外周面的一部分保持接触，同时橡胶构件的外周面与内周面插塞接收室的周壁的表面在其整个周边上。

7. 发明授权

US07125907B2 Thiolactones 失效
公开(公告)号：US07125907B2
公开(公告)日：2006-10-24
申请号：US10791278
申请日：2004-03-03
申请人： Barbara S. Slusher , Takashi Tsukamoto
发明人： Barbara S. Slusher , Takashi Tsukamoto
IPC分类号： C07D335/02 , A61K31/382
CPC分类号： C07D335/02 , C07D335/06
摘要： This invention provides new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, inhibiting angiogenesis, effecting a TGF-β activity or a neuronal activity, and treating a glutamate abnormality, a compulsive disorder, neuropathy, pain, a prostate disease, cancer, Huntington's disease, diabetes, a retinal disorder or glaucoma.

8. 发明申请

US20060019535A1 Plug and waterproof connector with plug 有权
标题翻译：插头和防水连接器插头
公开(公告)号：US20060019535A1
公开(公告)日：2006-01-26
申请号：US11181865
申请日：2005-07-15
申请人： Hirotaka Fukushima , Takashi Tsukamoto
发明人： Hirotaka Fukushima , Takashi Tsukamoto
IPC分类号： H01R13/40
CPC分类号： H01R13/5221
摘要： A waterproof connector includes annular plug receiving chambers formed within a connector housing in surrounding relation respectively to outer peripheral surfaces of insulating sheaths of wires, and are disposed adjacent respectively to terminal receiving chambers in a longitudinal direction of the wires, plugs received respectively in the plug receiving chambers, and a cover attached to the connector housing from a side of the other end portions of the wires, covering the plug receiving chambers. The plug includes an annular elastic rubber member and an annular resin member molded integrally with the rubber member in concentric relation thereto. An inner peripheral surface of the rubber member is held in contact with a part of the outer peripheral surface of the insulating sheath of the wire over an entire periphery thereof, while an outer peripheral surface of the rubber member is held in contact with an inner peripheral surface of a peripheral wall of the plug receiving chamber over an entire periphery thereof.
摘要翻译：防水连接器包括分别形成在连接器壳体内的环形插塞接收室，分别围绕导线的绝缘护套的外周表面，并且分别设置在电线的纵向方向上的端子接收室附近，分别容纳在插头中的插头接收室，以及从电线的另一端部的一侧附接到连接器壳体的盖子，覆盖插头接收室。塞子包括环形弹性橡胶构件和与橡胶构件一体地与其成同心关系的环形树脂构件。橡胶构件的内周面在其整个外周与导线的绝缘护套的外周面的一部分保持接触，同时橡胶构件的外周面与内周面插塞接收室的周壁的表面在其整个周边上。

9. 发明申请

US20050251651A1 Microcomputer and dividing circuit 审中-公开
标题翻译：微电脑和分频电路
公开(公告)号：US20050251651A1
公开(公告)日：2005-11-10
申请号：US11120105
申请日：2005-05-03
申请人： Shumpei Kawasaki , Eiji Sakakibara , Kaoru Fukada , Takanaga Yamazaki , Yasushi Akao , Shiro Baba , Toshimasa Kihara , Keiichi Kurakazu , Takashi Tsukamoto , Shigeki Masumura , Yasuhiro Tawara , Yugo Kashiwagi , Shuya Fujita , Katsuhiko Ishida , Noriko Sawa , Yoichi Asano , Hideaki Chaki , Tadahiko Sugawara , Masahiro Kainaga , Kouki Noguchi , Mitsuru Watabe
发明人： Shumpei Kawasaki , Eiji Sakakibara , Kaoru Fukada , Takanaga Yamazaki , Yasushi Akao , Shiro Baba , Toshimasa Kihara , Keiichi Kurakazu , Takashi Tsukamoto , Shigeki Masumura , Yasuhiro Tawara , Yugo Kashiwagi , Shuya Fujita , Katsuhiko Ishida , Noriko Sawa , Yoichi Asano , Hideaki Chaki , Tadahiko Sugawara , Masahiro Kainaga , Kouki Noguchi , Mitsuru Watabe
IPC分类号： G06F9/28 , G06F7/483 , G06F7/52 , G06F7/527 , G06F7/535 , G06F7/537 , G06F9/30 , G06F9/302 , G06F9/305 , G06F9/318 , G06F9/32 , G06F9/38
CPC分类号： G06F7/535 , G06F9/30 , G06F9/3001 , G06F9/30112 , G06F9/3013 , G06F9/30145 , G06F9/30149 , G06F9/3016 , G06F9/30163 , G06F9/30167 , G06F9/30181 , G06F9/30189 , G06F9/322 , G06F9/324 , G06F9/3557 , G06F9/3802 , G06F9/3814 , G06F9/3836 , G06F9/3857 , G06F9/3859 , G06F9/3867 , G06F2207/5352
摘要： Herein disclosed is a microcomputer MCU adopting the general purpose register method. The microcomputer is enabled to have a small program capacity or a high program memory using efficiency and a low system cost, while enjoying the advantage of simplification of the instruction decoding as in the RISC machine having a fixed length instruction format of the prior art, by adopting a fixed length instruction format having a power of 2 but a smaller bit number than that of the maximum data word length fed to instruction execution means. And, the control of the coded division is executed by noting the code bits.
摘要翻译：这里公开了采用通用寄存器方法的微计算机MCU。微型计算机能够使用效率低且系统成本低的程序容量小或高程序存储器，同时具有简化指令解码的优点，如具有现有技术的固定长度指令格式的RISC机器，通过采用固定长度指令格式，其具有功率2但是比馈送到指令执行装置的最大数据字长度的位数更小的位数。并且，通过注意码位来执行编码除法的控制。

10. 发明申请

US20050171065A1 Benzenedicarboxylic acid derivatives 审中-公开
公开(公告)号：US20050171065A1
公开(公告)日：2005-08-04
申请号：US11051188
申请日：2005-02-07
申请人： Paul Jackson , Takashi Tsukamoto , Barbara Slusher , Eric Wang
发明人： Paul Jackson , Takashi Tsukamoto , Barbara Slusher , Eric Wang
IPC分类号： A61P13/08 , A61P21/00 , A61P27/06 , C07C63/307 , C07C63/68 , C07C65/05 , C07C65/40 , C07C229/38 , C07C229/60 , C07C235/80 , C07C259/06 , C07C259/10 , C07C317/44 , C07C323/12 , C07C323/56 , C07C323/62 , C07D231/06 , C07D307/52 , C07F9/38 , C07F9/28 , A61K31/195 , A61K31/4152 , A61K31/66 , C07C237/20
CPC分类号： C07D231/06 , C07C63/307 , C07C63/68 , C07C65/05 , C07C65/40 , C07C229/38 , C07C229/60 , C07C235/80 , C07C259/06 , C07C259/10 , C07C317/44 , C07C323/12 , C07C323/56 , C07C323/62 , C07D307/52 , C07F9/3834 , C07F9/3882
摘要： New benzenedicarboxylic acid derivative compounds; pharmaceutical compositions, diagnostic methods, and diagnostic kits that include those compounds; and methods of using those compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-β activity, inhibiting angiogenesis, and treating glutamate abnormalities, neuropathy, pain, compulsive disorders, prostate diseases, cancers, and glaucoma.

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