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    • 3. 发明授权
    • Functionalization of polyglycolides by “click” chemistry
    • 通过“点击”化学功能化聚乙交酯
    • US08927682B2
    • 2015-01-06
    • US12229544
    • 2008-08-25
    • Gregory L. BakerMilton R. Smith, IIIXuwei JiangErin B. Vogel
    • Gregory L. BakerMilton R. Smith, IIIXuwei JiangErin B. Vogel
    • C08G63/08C08G63/82
    • C08G63/08C08G63/823
    • Poly(glycolide) polymers are disclosed. The polymers generally include a polymerized alkynyl-substituted glycolide having a polymer backbone with one or more alkynyl groups appended thereto. The alkynyl groups provide reactive sites for further functionalization of the polymer, for example by reaction with azide derivatives (e.g., azide-substituted organic compounds). Alkynyl and azide groups react via the “click” chemistry mechanism to form functional groups covalently bonded to the polymer via a triazole link. The polymers are biodegradable and can be used to deliver drugs or other therapeutic substances (e.g., large biomolecules such as single strand RNA) at targeted locations in a patient's body and/or at controlled release rates.
    • 公开了聚(乙交酯)聚合物。 聚合物通常包括聚合的炔基取代的乙交酯,其具有带有一个或多个炔基的聚合物主链。 炔基提供用于聚合物进一步官能化的反应位点,例如通过与叠氮化物衍生物(例如叠氮取代的有机化合物)反应。 炔基和叠氮基通过“点击”化学机理反应以形成通过三唑连接共价键合到聚合物上的官能团。 聚合物是可生物降解的,并且可以用于在患者身体的目标位置和/或以控制释放速率递送药物或其它治疗物质(例如大的生物分子,例如单链RNA)。
    • 5. 发明申请
    • Functional polyglycolide nanoparticles derived from unimolecular micelles
    • 衍生自单分子胶束的功能聚乙交酯纳米颗粒
    • US20090325292A1
    • 2009-12-31
    • US12460655
    • 2009-07-22
    • Gregory L. BakerMilton R. Smith, IIIErin Vogel
    • Gregory L. BakerMilton R. Smith, IIIErin Vogel
    • C12N5/06C08G63/08A61K9/00
    • C08G63/08A61K9/1075A61K9/5153A61K47/34A61K47/6907A61K47/6931A61K47/6935B82Y5/00C08G63/6852
    • Poly(glycolide) polymers are disclosed. The polymers generally include a glycolide-based polymer backbone that includes one or more functional groups such as alkynyl groups, hydrophilic organic triazole groups, hydrophobic organic triazole groups (also including amphiphilic organic triazole groups), di-triazole organic crosslinking groups, and triazole-substituted drug derivatives. The alkynyl groups provide reactive sites for further functionalization of the polymer, for example by reaction with azide derivatives. The polymers can further encapsulate a drug for delivery to a patient (i.e., as compared to drug derivatives that are covalently attached to the polymer). The polymers can be in the form of thermodynamically stable unimolecular micelles or crosslinked nanoparticles. The polymer compositions are completely biodegradable and hold great potential for use in biomedical applications.
    • 公开了聚(乙交酯)聚合物。 聚合物通常包括基于乙交酯的聚合物主链,其包括一个或多个官能团,例如炔基,亲水有机三唑基,疏水性有机三唑基团(也包括两亲性有机三唑基团),二 - 三唑有机交联基团和三唑 - 取代的药物衍生物。 炔基提供用于聚合物进一步官能化的反应位点,例如通过与叠氮化物衍生物反应。 聚合物可以进一步包封用于递送给患者的药物(即,与共价连接到聚合物上的药物衍生物相比)。 聚合物可以是热力学稳定的单分子胶束或交联纳米颗粒的形式。 聚合物组合物是完全可生物降解的,并且具有用于生物医学应用的巨大潜力。
    • 6. 发明授权
    • Composite channel waveguides
    • 复合通道波导
    • US4834480A
    • 1989-05-30
    • US184286
    • 1988-04-21
    • Gregory L. BakerJanet L. JackelNicholas E. Schlotter
    • Gregory L. BakerJanet L. JackelNicholas E. Schlotter
    • G02F1/065
    • G02F1/065
    • A channel waveguide structure comprises a substrate, a channel pattern defined in the substrate adjacent the top surface of the substrate, and a planar film layer on top substrate. The channel pattern comprises channels having a high index of refraction, while the film layer is made from a nonlinear organic material. In a preferred embodiment, the substrate is glass and the channel pattern comprises ion-exchanged channels. In this preferred embodiment, the nonlinear organic material is a soluble polydiacetylene, such as poly(3BCMU), poly(4BCMU), or poly(TS12). The thicknesses of the ion-exchanged channels and of the film layer can be adjusted so that the channel waveguide structure functions as a single mode waveguide for light having a wavelength in the range of 1.3 to 1.67 microns.
    • 通道波导结构包括基板,限定在基板中的与基板的顶表面相邻的沟道图案,以及在顶部基板上的平面薄膜层。 通道图案包括具有高折射率的通道,而膜层由非线性有机材料制成。 在优选实施例中,衬底是玻璃,并且沟道图案包括离子交换的通道。 在该优选实施方案中,非线性有机材料是可溶性聚二乙炔,例如聚(3BCMU),聚(4BCMU)或聚(TS12)。 可以调节离子交换通道和膜层的厚度,使得通道波导结构用作波长在1.3至1.67微米范围内的光的单模波导。
    • 9. 发明申请
    • Functionalization of polyglycolides by
    • 通过“点击”化学功能化聚乙交酯
    • US20090054619A1
    • 2009-02-26
    • US12229544
    • 2008-08-25
    • Gregory L. BakerMilton R. Smith, IIIXuwei JiangErin B. Vogel
    • Gregory L. BakerMilton R. Smith, IIIXuwei JiangErin B. Vogel
    • C08G63/08
    • C08G63/08C08G63/823
    • Poly(glycolide) polymers are disclosed. The polymers generally include a polymerized alkynyl-substituted glycolide having a polymer backbone with one or more alkynyl groups appended thereto. The alkynyl groups provide reactive sites for further functionalization of the polymer, for example by reaction with azide derivatives (e.g., azide-substituted organic compounds). Alkynyl and azide groups react via the “click” chemistry mechanism to form functional groups covalently bonded to the polymer via a triazole link. The polymers are biodegradable and can be used to deliver drugs or other therapeutic substances (e.g., large biomolecules such as single strand RNA) at targeted locations in a patient's body and/or at controlled release rates.
    • 公开了聚(乙交酯)聚合物。 聚合物通常包括聚合的炔基取代的乙交酯,其具有带有一个或多个炔基的聚合物主链。 炔基提供用于聚合物进一步官能化的反应位点,例如通过与叠氮化物衍生物(例如叠氮取代的有机化合物)反应。 炔基和叠氮基通过“点击”化学机理反应以形成通过三唑连接共价键合到聚合物上的官能团。 聚合物是可生物降解的,并且可以用于在患者身体的目标位置和/或以控制释放速率递送药物或其它治疗物质(例如大的生物分子,例如单链RNA)。