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    • 7. 发明授权
    • Sentinel node identification using fluorescent nanoparticles
    • 使用荧光纳米粒子的前哨淋巴结识别
    • US08239008B2
    • 2012-08-07
    • US11771472
    • 2007-06-29
    • James W. VoegeleCarl J. Shurtleff
    • James W. VoegeleCarl J. Shurtleff
    • A61B1/06
    • A61K41/0052A61B1/043A61B1/3132A61B5/0071A61B5/0075A61B5/0084A61B5/415A61B5/418A61K49/0017A61K49/0093
    • Various compositions, methods, and devices are provided that use fluorescent nanoparticles, which can function as markers, indicators, and light sources. The fluorescent nanoparticles can be formed from a fluorophore core surrounded by a biocompatible shell, such as a silica shell. In one embodiment, the fluorescent nanoparticles can be delivered to tissue to mark the tissue, enable identification and location of the tissue, and/or illuminate an area surrounding the tissue. In another embodiment, the fluorescent nanoparticles can be used on a device or implant to locate the device or implant in the body, indicate an orientation of the device or implant, and/or illuminate an area surrounding the device or implant. The fluorescent nanoparticles can also be used to provide a therapeutic effect.
    • 提供使用可用作标记物,指示剂和光源的荧光纳米颗粒的各种组合物,方法和装置。 荧光纳米颗粒可以由包围生物相容的外壳如二氧化硅壳的荧光团芯形成。 在一个实施方案中,荧光纳米颗粒可以被递送到组织以标记组织,使得能够识别和定位组织,和/或照亮组织周围的区域。 在另一个实施方案中,荧光纳米颗粒可用于装置或植入物以将装置或植入物定位在体内,指示装置或植入物的取向,和/或照亮装置或植入物周围的区域。 荧光纳米颗粒也可用于提供治疗效果。