专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5811098A Antibodies to HER4, human receptor tyrosine kinase 失效
标题翻译： HER4抗体，人受体酪氨酸激酶
公开(公告)号：US5811098A
公开(公告)日：1998-09-22
申请号：US484438
申请日：1995-06-07
申请人： Gregory D. Plowman , Jean-Michel Culouscou , Mohammed Shoyab , Clay B. Siegall , Ingegerd Hellstrom , Karl E. Hellstrom
发明人： Gregory D. Plowman , Jean-Michel Culouscou , Mohammed Shoyab , Clay B. Siegall , Ingegerd Hellstrom , Karl E. Hellstrom
IPC分类号： A61K47/48 , C07K14/475 , C07K16/28 , A61K39/00
CPC分类号： C07K14/4756 , A61K47/48561 , C07K16/2863 , G01N2333/4756
摘要： The molecular cloning, expression, and biological characteristics of a novel receptor tyrosine kinase related to the epidermal growth factor receptor, termed HER4/p180.sup.erbB4, are described. Antibodies to HER4 are disclosed. A HER4 ligand capable of inducing cellular differentiation of breast cancer cells is also disclosed. In view of the expression of HER4 in several human cancers and in certain tissues of neuronal and muscular origin, various diagnostic and therapeutic uses of HER4-derived and HER4-related biological compositions are provided.
摘要翻译：描述了与表皮生长因子受体相关的新受体酪氨酸激酶的分子克隆，表达和生物学特征，称为HER4 / p180erbB4。公开了HER4抗体。还公开了能够诱导乳腺癌细胞的细胞分化的HER4配体。鉴于HER4在几种人类癌症和神经元和肌肉起源的某些组织中的表达，提供了HER4衍生和HER4相关生物组合物的各种诊断和治疗用途。

2. 发明授权

US5262177A Recombinant viruses encoding the human melanoma-associated antigen 失效
标题翻译：编码人黑素瘤相关抗原的重组病毒
公开(公告)号：US5262177A
公开(公告)日：1993-11-16
申请号：US7230
申请日：1987-01-27
申请人： Joseph P. Brown , Charles D. Estin , Gregory D. Plowman , Timothy M. Rose , Karl E. Hellstrom , Ingegerd Hellstrom , Anthony F. Purchio , Shiu-Lok Hu , Sridhar Pennathur
发明人： Joseph P. Brown , Charles D. Estin , Gregory D. Plowman , Timothy M. Rose , Karl E. Hellstrom , Ingegerd Hellstrom , Anthony F. Purchio , Shiu-Lok Hu , Sridhar Pennathur
IPC分类号： A61K39/00 , C07K14/79 , C12N1/21 , C12N15/13 , G01N33/574 , A61K39/12 , C12N1/16 , C12N5/00 , C12N7/00 , C12N15/00 , C12P19/34 , C12P21/02
CPC分类号： A61K39/0011 , C07K14/79 , G01N33/5743
摘要： Peptides or proteins related to a melanoma associated antigen are described. These are produced in large quantities via recombinant DNA techniques and/or by chemical synthetic methods. The peptides or proteins can be used as immunogens in vaccine formulations which can induce an immune response that selectively destroys melanoma cells in a vaccinated individual. Where the peptides or proteins are expressed by a recombinant virus, inactivated or live virus vaccine formulations may be prepared.
摘要翻译：描述了与黑素瘤相关抗原相关的肽或蛋白质。这些通过重组DNA技术和/或通过化学合成方法大量生产。肽或蛋白质可用作疫苗制剂中的免疫原，其可以诱导在接种个体中选择性地破坏黑素瘤细胞的免疫应答。当肽或蛋白质由重组病毒表达时，可以制备灭活或活病毒疫苗制剂。

3. 发明授权

US5141742A Vaccines against melanoma 失效
标题翻译：针对黑色素瘤的疫苗
公开(公告)号：US5141742A
公开(公告)日：1992-08-25
申请号：US702142
申请日：1991-05-13
申请人： Joseph P. Brown , Charles D. Estin , Gregory D. Plowman , Timothy M. Rose , Karl E. Hellstrom , Ingegerd Hellstrom , Anthony Purchio , Shiu-Lok Hu , Sridhar Pennathur
发明人： Joseph P. Brown , Charles D. Estin , Gregory D. Plowman , Timothy M. Rose , Karl E. Hellstrom , Ingegerd Hellstrom , Anthony Purchio , Shiu-Lok Hu , Sridhar Pennathur
IPC分类号： A61K39/00 , C07K14/79 , G01N33/574
CPC分类号： C07K14/79 , A61K39/0011 , G01N33/5743
摘要： Peptides or proteins related to a melanoma associated antigen are described. These are produced in large quantities via recombinant DNA techniques and/or by chemical synthetic methods. The peptides or proteins can be used as immunogens in vaccine formulations which can induce an immune response that selectively destroys melanoma cells in a vaccinated individual. Where the peptides or proteins are expressed by a recombinant virus, inactivated or live virus vaccine formulations may be prepared.
摘要翻译：描述了与黑素瘤相关抗原相关的肽或蛋白质。这些通过重组DNA技术和/或通过化学合成方法大量生产。肽或蛋白质可用作疫苗制剂中的免疫原，其可以诱导在接种个体中选择性地破坏黑素瘤细胞的免疫应答。当肽或蛋白质由重组病毒表达时，可以制备灭活或活病毒疫苗制剂。

4. 发明授权

US5965723A DNA encoding epithelins 失效
标题翻译： DNA编码上皮蛋白
公开(公告)号：US5965723A
公开(公告)日：1999-10-12
申请号：US431333
申请日：1995-04-27
申请人： Mohammed Shoyab , Gregory D. Plowman
发明人： Mohammed Shoyab , Gregory D. Plowman
IPC分类号： A61K38/00 , C07K14/475 , C12N15/12 , C12N15/18
CPC分类号： C07K14/475 , A61K38/00
摘要： A novel family of growth regulatory proteins termed "epithelins" are described. The epithelins comprise several distinct members sharing significant structural homology. Two members of the epithelin family, epithelin 1 and epithelin 2, have been purified from natural sources. In addition, cDNA and PCR clones encoding mature and precursor epithelins from various chordate sources have been obtained and sequenced, including the complete human, mouse and rat epithelin precursors. The recombinant expression of rat epithelin precursor and mature forms is described. Purified epithelin 1 is a bifunctional growth regulator, capable of stimulating the growth of some cell types while inhibiting the growth of others. Purified epithelin 2 is functionally similar to epithelin 1 with respect to growth inhibitory bioactivity. In contrast, however, epithelin 2 is apparently not capable of eliciting the growth stimulatory activity characteristic of epithelin 1 and, in fact, antagonizes this epithelin 1 activity.
摘要翻译：描述了称为“上皮蛋白”的新型生长调节蛋白家族。上皮蛋白包含具有重要结构同源性的几个不同成员。上皮蛋白家族的两个成员，上皮蛋白1和上皮蛋白2已经从天然来源中纯化出来。此外，已经获得并测序了编码来自各种脊索动物来源的成熟和前体上皮蛋白的cDNA和PCR克隆，包括完整的人，小鼠和大鼠上皮蛋白前体。描述了大鼠上皮蛋白前体和成熟形式的重组表达。纯化的上皮蛋白1是双功能生长调节剂，其能够刺激一些细胞类型的生长，同时抑制其他细胞的生长。纯化的上皮蛋白2在功能上类似于上皮蛋白1相对于生长抑制生物活性。然而，相比之下，上皮蛋白2显然不能引发上皮蛋白1的特征性生长刺激活性，实际上拮抗了上皮蛋白1的活性。

5. 发明授权

US5885961A Methods of using epithelins to modulate cell proliferation 失效
标题翻译：使用上皮蛋白调节细胞增殖的方法
公开(公告)号：US5885961A
公开(公告)日：1999-03-23
申请号：US429998
申请日：1995-04-27
申请人： Mohammed Shoyab , Gregory D. Plowman
发明人： Mohammed Shoyab , Gregory D. Plowman
IPC分类号： A61K38/00 , C07K14/475 , C12N15/12 , C12N15/18 , A61K38/18
CPC分类号： C07K14/475 , A61K38/00
摘要： A novel family of growth regulatory proteins termed "epithelins" are described. The epithelins comprise several distinct members sharing significant structural homology. Two members of the epithelin family, epithelin 1 and epithelin 2, have been purified from natural sources. In addition, cDNA and PCR clones encoding mature and precursor epithelins from various chordate sources have been obtained and sequenced, including the complete human, mouse and rat epithelin precursors. The recombinant expression of rat epithelin precursor and mature forms is described. Purified epithelin 1 s a bifunctional growth regulator, capable of stimulating the growth of some cell types while inhibiting the growth of others. Purified epithelin 2 is functionally similar to epithelin 1 with respect to growth inhibitory bioactivity. In contrast, however, epithelin 2 is apparently not capable of eliciting the growth stimulatory activity characteristic of epithelin 1 and, in fact, antagonizes this epithelin 1 activity.
摘要翻译：描述了称为“上皮蛋白”的新型生长调节蛋白家族。上皮蛋白包含具有重要结构同源性的几个不同成员。上皮蛋白家族的两个成员，上皮蛋白1和上皮蛋白2已经从天然来源中纯化出来。此外，已经获得并测序了编码来自各种脊索动物来源的成熟和前体上皮蛋白的cDNA和PCR克隆，包括完整的人，小鼠和大鼠上皮蛋白前体。描述了大鼠上皮蛋白前体和成熟形式的重组表达。纯化的上皮蛋白1是双功能生长调节剂，能够刺激一些细胞类型的生长，同时抑制其他细胞的生长。纯化的上皮蛋白2在功能上类似于上皮蛋白1相对于生长抑制生物活性。然而，相比之下，上皮蛋白2显然不能引发上皮蛋白1的特征性生长刺激活性，实际上拮抗了上皮蛋白1的活性。

6. 发明授权

US5830995A Fanphiregulins: a family of heparin-binding epithelial cell growth factors 失效
标题翻译： Fanphiregulins：一类肝素结合上皮细胞生长因子
公开(公告)号：US5830995A
公开(公告)日：1998-11-03
申请号：US885089
申请日：1992-05-18
申请人： Mohammed Shoyab , Vicki Lynn McDonald , James Garrett Bradley , Gregory D. Plowman
发明人： Mohammed Shoyab , Vicki Lynn McDonald , James Garrett Bradley , Gregory D. Plowman
IPC分类号： C12N1/21 , A61K38/00 , A61K39/395 , A61P17/00 , A61P35/00 , A61P43/00 , C07H21/04 , C07K1/20 , C07K7/08 , C07K9/00 , C07K14/435 , C07K14/485 , C07K14/495 , C07K14/52 , C07K16/00 , C07K16/22 , C07K16/24 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/70 , C12N15/85 , C12P21/02 , C12P21/08 , C12R1/19
CPC分类号： C07K14/52 , C07K14/485 , C07K14/495 , C07K16/22 , C12N15/70 , C12N15/85 , A61K38/00 , C07K2319/02 , C12N2800/108
摘要： The present invention is directed to a family of heparin-binding epithelial cell growth factors termed amphiregulins (AR). In particular, it relates to the isolation of AR genes from different animal species, expression of the genes, identification of various forms of biologically active AR products, purification of the AR products, antibodies specific for AR, and uses of AR. AR is detectable in several normal human epithelial cells and in a high percentage of human colon cancers. In addition to stimulating the growth of these cultured epithelial cells, AR may have a wide range of applications including, but not limited to, accelerating the growth of normal epithelial cells. In some tumor cell lines, primarily of breast or ovarian carcinomas, AR serves as a direct growth inhibitor. On the other hand, AR may function as a growth stimulatory molecule in colorectal carcinomas and other pathologies of increased epithelial proliferation. In this regard AR may serve as a useful marker for disease staging and prognosis and reagents that specifically block AR may be of therapeutic use in controlling tumor cell growth and in disorders such as psoriasis.
摘要翻译：本发明涉及称为安非他命（AR）的肝素结合上皮细胞生长因子家族。特别涉及分离来自不同动物物种的AR基因，基因的表达，各种形式的生物活性AR产物的鉴定，AR产物的纯化，AR特异的抗体和AR的用途。 AR在几种正常的人上皮细胞和高百分比的人结肠癌中是可检测的。除了刺激这些培养的上皮细胞的生长之外，AR可以具有广泛的应用，包括但不限于加速正常上皮细胞的生长。在一些肿瘤细胞系中，主要是乳腺癌或卵巢癌，AR用作直接生长抑制剂。另一方面，AR可能在结肠直肠癌和其他增加上皮细胞增殖的病理学中起到促生长分子的作用。在这方面，AR可以用作疾病分期和预后的有用标志物，并且特异性阻断AR可能在控制肿瘤细胞生长和疾病如牛皮癣中具有治疗用途的试剂。

7. 发明授权

US5416192A Epithelins: novel cysteine-rich growth modulating proteins 失效
标题翻译：上皮蛋白：富含半胱氨酸的新生长调节蛋白
公开(公告)号：US5416192A
公开(公告)日：1995-05-16
申请号：US668648
申请日：1991-03-13
申请人： Mohammed Shoyab , Gregory D. Plowman
发明人： Mohammed Shoyab , Gregory D. Plowman
IPC分类号： A61K38/00 , C07K14/475 , C12N15/12 , C12N15/18
CPC分类号： C07K14/475 , A61K38/00
摘要： A novel family of growth regulatory proteins termed "epithelins" are described. The epithelins comprise several distinct members sharing significant structural homology. Two members of the epithelin family, epithelin 1 and epithelin 2, have been purified from natural sources. In addition, cDNA and PCR clones encoding mature and precursor epithelins from various chordate sources have been obtained and sequenced, including the complete human, mouse and rat epithelin precursors. The recombinant expression of rat epithelin precursor and mature forms is described. Purified epithelin 1 is a bifunctional growth regulator, capable of stimulating the growth of some cell types while inhibiting the growth of others. Purified epithelin 2 is functionally similar to epithelin 1 with respect to growth inhibitory bioactivity. In contrast, however, epithelin 2 is apparently not capable of eliciting the growth stimulatory activity characteristic of epithelin 1 and, in fact, antagonizes this epithelin 1 activity.
摘要翻译：描述了称为“上皮蛋白”的新型生长调节蛋白家族。上皮蛋白包含具有重要结构同源性的几个不同成员。上皮蛋白家族的两个成员，上皮蛋白1和上皮蛋白2已经从天然来源中纯化出来。此外，已经获得并测序了编码来自各种脊索动物来源的成熟和前体上皮蛋白的cDNA和PCR克隆，包括完整的人，小鼠和大鼠上皮蛋白前体。描述了大鼠上皮蛋白前体和成熟形式的重组表达。纯化的上皮蛋白1是双功能生长调节剂，其能够刺激一些细胞类型的生长，同时抑制其他细胞的生长。纯化的上皮蛋白2在功能上类似于上皮蛋白1相对于生长抑制生物活性。然而，相比之下，上皮蛋白2显然不能引发上皮蛋白1的特征性生长刺激活性，实际上拮抗了上皮蛋白1的活性。

8. 发明授权

US5115096A Amphiregulin: a bifunctional growth modulating glycoprotein 失效
标题翻译：双调蛋白：双功能生长调节糖蛋白
公开(公告)号：US5115096A
公开(公告)日：1992-05-19
申请号：US297816
申请日：1989-01-17
申请人： Mohammed Shoyab , Vicki L. McDonald , James G. Bradley , Gregory D. Plowman
发明人： Mohammed Shoyab , Vicki L. McDonald , James G. Bradley , Gregory D. Plowman
IPC分类号： A61K38/00 , C07K14/485 , C07K14/495 , C07K14/52 , C07K16/22 , C12N15/70 , C12N15/85 , C12P21/02
CPC分类号： C07K14/485 , C07K14/495 , C07K14/52 , C07K16/22 , C12N15/70 , C12N15/85 , A61K38/00 , C07K2319/02
摘要： A novel cell growth regulatory factor, named Amphiregulin, is described. This extremely hydrophilic glycoprotein, having a median molecular weight of 22,500 daltons, demonstrates unusual biological activity. Amphiregulin is a bifunctional cell growth regulatory factor which exhibits potent inhibitory activity on DNA synthesis in neoplastic cells, yet promotes the growth of certain normal cells. The invention is based, in part, on the discovery that MCF-7 cells, when treated with the tumor promoting agent, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), express and secrete two distinct yet functionally equivalent forms of Amphiregulin. These two forms are structurally identical and perfectly homologous except that the truncated form lacks an amino-terminal hexapeptide found in the larger form. The Amphiregulin gene has been cloned and used to construct plasmids which direct the expression of bioactive Amphiregulin in transformed Escherichia coli cells. A wide variety of uses for Amphiregulin are encompassed by the present invention, including the treatment of wounds and cancers.
摘要翻译：描述了一种称为Amphiregulin的新型细胞生长调节因子。中性分子量为22,500道尔顿的极亲水性糖蛋白表现出不寻常的生物活性。双调蛋白是双功能细胞生长调节因子，其对肿瘤细胞中的DNA合成显示出有效的抑制活性，但促进某些正常细胞的生长。本发明部分基于发现当用肿瘤促进剂12-O-十四酰基 - 佛波醇-13-乙酸酯（TPA）处理时，MCF-7细胞表达和分泌两种不同但功能上等同的形式双调蛋白这两种形式在结构上是完全相同的，除了截短的形式缺少以更大形式发现的氨基末端六肽外。已经克隆了Amphiregulin基因并用于构建转化大肠杆菌细胞中生物活性Amphiregulin表达的质粒。本发明包括双调蛋白的广泛用途，包括伤口和癌症的治疗。

9. 发明申请

US20130095096A1 NOVEL ANTI- ALPHA5BETA1 ANTIBODIES AND USES THEREOF 有权
标题翻译：新型抗ALPHA5BETA1抗体及其用途
公开(公告)号：US20130095096A1
公开(公告)日：2013-04-18
申请号：US13335632
申请日：2011-12-22
申请人： Wei-Ching Liang , Gregory D. Plowman , Yan Wu , Weilan Ye
发明人： Wei-Ching Liang , Gregory D. Plowman , Yan Wu , Weilan Ye
IPC分类号： C07K16/28
CPC分类号： C07K16/2842 , A61K47/6835 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/92 , Y02A50/386 , Y02A50/41 , Y02A50/412
摘要： The present invention provides new anti-α5β1 antibodies, compositions and kits comprising the antibodies, and methods of making and using the antibodies.
摘要翻译：本发明提供新的抗α5β1抗体，包含抗体的组合物和试剂盒，以及制备和使用抗体的方法。

10. 发明授权

US08105785B2 Mylks as modifiers of branching morphogenesis and methods of use 失效
标题翻译： Mylks作为分支形态发生和使用方法的修饰剂
公开(公告)号：US08105785B2
公开(公告)日：2012-01-31
申请号：US10556637
申请日：2004-06-18
申请人： Gregory D. Plowman , Felix D. Karim , Candace Swimmer , Hinrich Alexander Habeck , Thomas I. Koblizek , Stefan Schulte-Merker , Ulrike Eisenmann , Gordon Mark Stott , Torsten Trowe , Andreas Michael Vogel , Joerg Heinrich Odenthal , Jochen Konrad Scheel , Torsten Tilmann Will , Yinsheng Jin , Lynn Margaret Bjerke , Timothy S. Heuer
发明人： Gregory D. Plowman , Felix D. Karim , Candace Swimmer , Hinrich Alexander Habeck , Thomas I. Koblizek , Stefan Schulte-Merker , Ulrike Eisenmann , Gordon Mark Stott , Torsten Trowe , Andreas Michael Vogel , Joerg Heinrich Odenthal , Jochen Konrad Scheel , Torsten Tilmann Will , Yinsheng Jin , Lynn Margaret Bjerke , Timothy S. Heuer
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/5091 , C07K14/47 , G01N33/5008 , G01N33/5011 , G01N33/5026 , Y10T436/143333
摘要： Human MYLK genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MYLK are provided.
摘要翻译：人MYLK基因被鉴定为分支形态发生的调节剂，因此是与缺陷支配形态发生功能相关的病症的治疗靶点。提供了用于鉴定分支形态发生调节剂的方法，包括筛选调节MYLK活性的试剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式