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1. 发明申请

US20060069132A1 Azolecarboxamide herbicides 审中-公开
标题翻译：偶氮甲酰胺除草剂
公开(公告)号：US20060069132A1
公开(公告)日：2006-03-30
申请号：US11096104
申请日：2005-03-31
申请人： Gregory Armel , Mark Casini , Dominic Chan , Balreddy Kamireddy , Hyeong Kim , Kanu Patel , Paula Sharpe , Thomas Stevenson , Ming Xu
发明人： Gregory Armel , Mark Casini , Dominic Chan , Balreddy Kamireddy , Hyeong Kim , Kanu Patel , Paula Sharpe , Thomas Stevenson , Ming Xu
IPC分类号： A61K31/4196 , A61K31/4192 , A61K31/415 , C07D249/04
CPC分类号： C07D231/06 , A01N43/56 , C07D231/14 , C07D249/04 , C07D277/56 , C07D401/12 , C07D403/12
摘要： Compounds of Formula I, and their N-oxides and agriculturally suitable salts, are disclosed which are useful for controlling undesired vegetation and R1a, R1b, R1c, R2a, R2b, R3, R4, R5, T, U, W, Y and Z are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula I and a method for controlling undesired vegetation which involves contacting the vegetation or its environment with an effective amount of a compound of Formula I. Also disclosed are mixtures and compositions comprising a herbicidally effective amount of a compound of Formula Iz wherein J, R1a, R1b, R1c, R2a, R2b, R3, R4, R5, T, U, W, Y and Z are as defined in the disclosure; and an effective amount of another herbicide or herbicide safener. Also disclosed is a method for selectively controlling undesired vegetation in a crop that involves contacting the locus of a crop with an effective amount of a compound of Formula Iz and a effective amount of a safener.
摘要翻译：公开了式I化合物及其N-氧化物和农业上合适的盐，其可用于防治不期望的植物

2. 发明申请

US20050075372A1 Method for controlling particular insect pest by applying anthranilamide compounds 审中-公开
标题翻译：通过施用邻氨基苯甲酰胺化合物控制特定害虫的方法
公开(公告)号：US20050075372A1
公开(公告)日：2005-04-07
申请号：US10483115
申请日：2002-08-13
申请人： George Lahm , Stephen McCan , Kanu Patel , Thomas Selby , Thomas Stevenson
发明人： George Lahm , Stephen McCan , Kanu Patel , Thomas Selby , Thomas Stevenson
IPC分类号： A01N43/56 , A01N43/60 , A01N43/76 , A01N43/78 , A01N43/80 , A01N43/90 , A01N47/12 , A01N53/06 , A01N57/28 , A01N63/00 , A01P7/02 , C07C251/76 , C07D213/77 , C07D231/06 , C07D231/08 , C07D231/14 , C07D231/16 , C07D233/96 , C07D401/04 , C07D413/04 , C07D413/14 , A01N43/40
CPC分类号： A01N43/56 , A01N43/54 , A01N43/58 , A01N43/86 , C07C251/76 , C07D213/77 , C07D231/06 , C07D231/08 , C07D231/14 , C07D231/16 , C07D401/04 , C07D413/04 , C07D413/14
摘要： This invention pertains to a method for controlling lepidopteran, homopteran, hemipteran, thysanopteran and coleopteran insect pests comprising contacting the insects or their environment with an arthropodicidally effective amount of a compound of Formula I, its N-oxide or an agriculturally suitable salt thereof wherein A and B and R1 through R8 are as defined in the disclosure. This invention further relates to a bezoxazinone compound of Formula 10 wherein R4 through R8 are as defined in the disclosure, useful for preparation of a compound of Formula I.
摘要翻译：本发明涉及一种控制鳞翅目，同翅目，半翅目，鳞翅目和鞘翅目昆虫害虫的方法，包括使昆虫或其环境与节肢动物学有效量的式I化合物，其N-氧化物或农业上合适的盐接触，其中A 并且B和R 1至R 8如本公开所定义。本发明还涉及式10的唑嗪酮化合物，其中R 4至R 8如本公开所定义，可用于制备式I化合物。

3. 发明申请

US20100145256A1 METHODS AND COMPOSITIONS FOR TATTOO REMOVAL 有权
标题翻译：去除TATTOO的方法和组合物
公开(公告)号：US20100145256A1
公开(公告)日：2010-06-10
申请号：US12631698
申请日：2009-12-04
申请人： Stephen G. Carter , Zhen Zhu , Kanu Patel , Diane L. Kozwich , Laura Stephens , John J. Masiz , David H. Donabedian
发明人： Stephen G. Carter , Zhen Zhu , Kanu Patel , Diane L. Kozwich , Laura Stephens , John J. Masiz , David H. Donabedian
IPC分类号： A61M37/00 , A61K8/18 , A61Q19/00
CPC分类号： A61K8/4926 , A61B18/203 , A61B2017/00769 , A61B2018/00452 , A61B2018/0047 , A61K8/0208 , A61K8/26 , A61K8/342 , A61K8/498 , A61K8/585 , A61K8/678 , A61K8/73 , A61K8/922 , A61K2800/51 , A61K2800/74 , A61K2800/81 , A61K2800/91 , A61M37/0092 , A61N1/325 , A61N5/062 , A61Q1/145 , A61Q19/02
摘要： Methods and formulations for removing a tattoo by using a cell disrupter in combination with a vasodilator, and optionally one or more of an osmotic modifying agent, a chelation agent, and an occlusive modifying agent. Embodiments optionally further include using one or more of an antibiotic, anesthetic, penetration enhancer, excipient, carrier and vehicle.
摘要翻译：通过使用细胞破坏剂与血管扩张剂组合，以及任选的一种或多种渗透调节剂，螯合剂和闭塞性修饰剂来去除纹身的方法和制剂。实施方案任选进一步包括使用抗生素，麻醉剂，渗透增强剂，赋形剂，载体和载体中的一种或多种。

4. 发明申请

US20100076035A1 Transdermal Drug Delivery using an Osmolyte and Vasoactive Agent 有权
标题翻译：透皮药物输送使用渗透液和血管活性剂
公开(公告)号：US20100076035A1
公开(公告)日：2010-03-25
申请号：US12564841
申请日：2009-09-22
申请人： Stephen G. Carter , Zhen Zhu , Kanu Patel , John J. Masiz
发明人： Stephen G. Carter , Zhen Zhu , Kanu Patel , John J. Masiz
IPC分类号： A61K31/426 , A61K31/05 , A61K31/19 , A61P43/00
CPC分类号： A61K31/192 , A61F2013/00906 , A61K9/0014 , A61K9/06 , A61K31/05 , A61K31/19 , A61K31/415 , A61K31/426 , A61K31/427 , A61K31/455 , A61K45/06 , A61K47/02 , A61K47/22 , A61K47/26 , A61K2300/00
摘要： A formulation and method for delivery of bioactive substances when applied to, or within, the skin or other exterior region of a mammal. for example, a patient, includes a vasoactive agent; an osmolyte; and an active ingredient. The formulation is sufficiently hygroscopic so as to create a condition of hypertonicity when absorbed by the skin. When the formulation is applied to the skin, the vasoactive agent can be delivered to the dermis so as to contact the vasculature of a patient.
摘要翻译：当施用于哺乳动物的皮肤或其它外部区域或其内部时，递送生物活性物质的制剂和方法。例如，患者包括血管活性剂; 渗透剂和活性成分。该制剂具有足够的吸湿性，以便在被皮肤吸收时产生高渗性的状况。当将配方施用于皮肤时，可将血管活性剂递送至真皮以接触患者的脉管系统。

5. 发明授权

US09561174B2 Ibuprofen for topical administration 有权
标题翻译：布洛芬用于局部给药
公开(公告)号：US09561174B2
公开(公告)日：2017-02-07
申请号：US13604040
申请日：2012-09-05
申请人： Stephen G. Carter , Zhen Zhu , Kanu Patel , Diane Kozwich
发明人： Stephen G. Carter , Zhen Zhu , Kanu Patel , Diane Kozwich
IPC分类号： A61K31/192 , A61K47/32 , A61P29/00 , A61K9/00 , A61K9/70
CPC分类号： A61K31/192 , A61K9/0014 , A61K9/7023 , A61K47/16 , A61K47/22 , A61K47/32
摘要： Set forth herein is a preparation of ibuprofen (2-(4-isobutylphenyl) propionic acid) in the free acid form that is suitable for topical administration. The topical ibuprofen formulation is prepared by dissolving the free acid form of ibuprofen, or preparing a homogeneous suspension of the free acid form of ibuprofen, in the presence of a pharmaceutically acceptable solvent so as to produce a topical drug formulation compatible with the penetration of 2-(4-isobutylphenyl) propionic acid through the skin tissue. Topical formulations of ibuprofen can be based on a pharmaceutically acceptable solvent such as, e.g., a pyrrolidone solvent or dimethylacetamide.
摘要翻译：本文所述是适用于局部给药的游离酸形式的布洛芬（2-（4-异丁基苯基）丙酸）的制剂。通过在游离酸形式的布洛芬溶解游离酸形式的布洛芬或在药学上可接受的溶剂的存在下制备游离酸形式的均匀悬浮液来制备局部布洛芬制剂，以产生与渗透2相兼容的局部药物制剂 - （4-异丁基苯基）丙酸通过皮肤组织。布洛芬的局部制剂可以基于药学上可接受的溶剂，例如吡咯烷酮溶剂或二甲基乙酰胺。

6. 发明授权

US08367122B2 Control of blood vessel physiology to treat skin disorders 有权
标题翻译：控制血管生理学治疗皮肤病
公开(公告)号：US08367122B2
公开(公告)日：2013-02-05
申请号：US12483073
申请日：2009-06-11
申请人： Laura Stephens , John J. Masiz , Stephen G. Carter , Zhen Zhu , Kanu Patel
发明人： Laura Stephens , John J. Masiz , Stephen G. Carter , Zhen Zhu , Kanu Patel
IPC分类号： A61K36/886
CPC分类号： A61K41/0028 , A61K9/0014 , A61K31/137 , A61K31/17 , A61K31/198 , A61K31/295 , A61K31/401 , A61K31/4164 , A61K31/4166 , A61K31/425 , A61K31/455 , A61K31/522 , A61K36/14 , A61K36/16 , A61K36/185 , A61K36/28 , A61K36/53 , A61K36/62 , A61K36/734 , A61K36/752 , A61K36/88 , A61K36/886 , A61K36/8969 , A61K36/9068 , A61M37/00 , A61N5/062 , A61N7/00
摘要： In a method for treating an affected skin region of a patient having a skin disorder, a vasodilation composition is applied to an affected skin region of a patient, the affected skin region exhibiting a skin disorder characterized by at least one abnormal blood vessel, and the affected skin region is then treated so as to non-invasively disrupt tissue architecture, e.g., by inducing ischemia, of the at least one abnormal blood vessel. A vasoconstriction composition can then be applied to the skin region to cause vasoconstriction of the at least one blood vessel in order to promote healing.
摘要翻译：在用于治疗患有皮肤病的患者的受影响的皮肤区域的方法中，将血管舒张组合物施用于患者的受影响的皮肤区域，所述受影响的皮肤区域呈现以至少一种异常血管为特征的皮肤病，然后治疗受影响的皮肤区域，以便非侵入性地破坏至少一个异常血管的组织结构，例如通过诱导缺血。然后可以将血管收缩组合物施用于皮肤区域以引起至少一个血管的血管收缩以促进愈合。

7. 发明授权

US08343486B2 Methods and compositions for topical treatment of medical conditions including wounds and inflammation 有权
标题翻译：用于局部治疗包括伤口和炎症的医学病症的方法和组合物
公开(公告)号：US08343486B2
公开(公告)日：2013-01-01
申请号：US12358078
申请日：2009-01-22
申请人： Stephen G. Carter , Zhen Zhu , Kanu Patel , Diane L. Kozwich
发明人： Stephen G. Carter , Zhen Zhu , Kanu Patel , Diane L. Kozwich
IPC分类号： A61K38/43
CPC分类号： A61K31/07 , A61K31/122 , A61K31/198 , A61K31/203 , A61K31/455 , A61K45/06 , A61K2300/00
摘要： A method for treating a patient suffering from a wound, ulcer, or inflammation includes providing a topical formulation comprising a carrier and a combination of active ingredients that includes at least one retinoid and at least one blood vessel dilator, and applying the topical formulation to the skin of the patient to cause healing, accelerated healing or prevention of the wound, ulcer or inflammation. Additional active ingredients may include a promoter of mitochondrial function or an antioxidant.
摘要翻译：用于治疗患有伤口，溃疡或炎症的患者的方法包括提供包含载体和包含至少一种类视色素和至少一种血管扩张剂的活性成分的组合的局部制剂，并将该局部制剂施用于患者的皮肤导致愈合，加速愈合或预防伤口，溃疡或炎症。另外的活性成分可以包括线粒体功能的启动子或抗氧化剂。

8. 发明申请

US20100137443A1 Ibuprofen for Topical Administration 审中-公开
标题翻译：布洛芬用于局部治疗
公开(公告)号：US20100137443A1
公开(公告)日：2010-06-03
申请号：US12557470
申请日：2009-09-10
申请人： Stephen G. Carter , Zhen Zhu , Kanu Patel , Diane L. Kozwich
发明人： Stephen G. Carter , Zhen Zhu , Kanu Patel , Diane L. Kozwich
IPC分类号： A61K31/192 , A61P29/00
CPC分类号： A61K31/192 , A61K9/0014 , A61K9/7023 , A61K47/16 , A61K47/22 , A61K47/32
摘要： Set forth herein is a preparation of ibuprofen (2-(4-isobutylphenyl)propionic acid) in the free acid form that is suitable for topical administration. The topical ibuprofen formulation is prepared by dissolving the free acid form of ibuprofen, or preparing a homogeneous suspension of the free acid form of ibuprofen, in the presence of a pharmaceutically acceptable solvent so as to produce a topical drug formulation compatible with the penetration of 2-(4-isobutylphenyl) propionic acid through the skin tissue. Topical formulations of ibuprofen can be based on a pharmaceutically acceptable solvent such as, e.g., a pyrrolidone solvent or dimethylacetamide.
摘要翻译：本文所述是适用于局部给药的游离酸形式的布洛芬（2-（4-异丁基苯基）丙酸）的制剂。通过在游离酸形式的布洛芬溶解游离酸形式的布洛芬或在药学上可接受的溶剂的存在下制备游离酸形式的均匀悬浮液来制备局部布洛芬制剂，以产生与渗透2相兼容的局部药物制剂 - （4-异丁基苯基）丙酸通过皮肤组织。布洛芬的局部制剂可以基于药学上可接受的溶剂，例如吡咯烷酮溶剂或二甲基乙酰胺。

9. 发明申请

US20060013769A1 Transdermal drug delivery formulations and method of determining optimal amounts of vasodilators therein 审中-公开
标题翻译：透皮药物递送制剂和其中确定最佳量的血管扩张剂的方法
公开(公告)号：US20060013769A1
公开(公告)日：2006-01-19
申请号：US10893733
申请日：2004-07-16
申请人： Stephen Carter , Zhen Zhu , Kanu Patel
发明人： Stephen Carter , Zhen Zhu , Kanu Patel
IPC分类号： A61K49/00
CPC分类号： A61K31/355 , A61K31/192 , A61K31/4174 , A61K31/472 , A61K49/0004 , A61K2300/00
摘要： A method for determining and demonstrating the role of vasodilator chemical agents in the development and practice of transdermal drug delivery systems. Vasodilator chemicals applied topically dilate the blood vessels in the skin tissue, which have been shown to facilitate or inhibit systemic or skin tissue deposition of drug substances. The level of stimulation and/or inhibition has been found to be dependent on the concentration and the identity of the specific vasodilator chemical(s) used as well as the drug molecule(s) to be delivered. This work teaches the need to consider specific formulation requirements when dealing with vasodilator chemicals for the creation of successful delivery vehicles in the transdermal drug delivery system. These requirements for very low concentrations of vasodilators were an unexpected and a surprise finding, in contrast to the concentrations of the vasodilators typically used to elicit an increase in skin blood flow.
摘要翻译：一种确定和证明血管扩张剂化学药剂在透皮给药系统开发和实践中的作用的方法。施用的血管扩张剂化学品局部地扩张皮肤组织中的血管，已经显示出促进或抑制药物物质的全身或皮肤组织沉积。已经发现刺激和/或抑制水平取决于所使用的特定血管扩张剂化学物质的浓度和特征以及待递送的药物分子。这项工作教导了在处理血管扩张剂化学品以在透皮药物递送系统中创造成功的递送载体时，需要考虑具体的配方要求。对于非常低浓度的血管扩张剂的这些要求是意想不到的和惊奇的发现，与通常用于引起皮肤血流增加的血管扩张剂的浓度相反。

10. 发明授权

US09566256B2 Transdermal drug delivery using an osmolyte and vasoactive agent 有权
标题翻译：使用渗透液和血管活性剂的透皮药物递送
公开(公告)号：US09566256B2
公开(公告)日：2017-02-14
申请号：US12564841
申请日：2009-09-22
申请人： Stephen G. Carter , Zhen Zhu , Kanu Patel , John J. Masiz
发明人： Stephen G. Carter , Zhen Zhu , Kanu Patel , John J. Masiz
IPC分类号： A61K47/26 , A61K31/192 , A61K31/415 , A61K9/00 , A61K9/06 , A61K31/05 , A61K31/19 , A61K31/426 , A61K45/06 , A61K47/02 , A61K31/455 , A61K31/427 , A61K47/22 , A61F13/00
CPC分类号： A61K31/192 , A61F2013/00906 , A61K9/0014 , A61K9/06 , A61K31/05 , A61K31/19 , A61K31/415 , A61K31/426 , A61K31/427 , A61K31/455 , A61K45/06 , A61K47/02 , A61K47/22 , A61K47/26 , A61K2300/00
摘要： A formulation and method for delivery of bioactive substances when applied to, or within, the skin or other exterior region of a mammal. for example, a patient, includes a vasoactive agent; an osmolyte; and an active ingredient. The formulation is sufficiently hygroscopic so as to create a condition of hypertonicity when absorbed by the skin. When the formulation is applied to the skin, the vasoactive agent can be delivered to the dermis so as to contact the vasculature of a patient.
摘要翻译：当施用于哺乳动物的皮肤或其它外部区域或其内部时，递送生物活性物质的制剂和方法。例如，患者包括血管活性剂; 渗透剂和活性成分。该制剂具有足够的吸湿性，以便在被皮肤吸收时产生高渗性的状况。当将配方施用于皮肤时，可将血管活性剂递送至真皮以接触患者的脉管系统。

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