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1. 发明申请

US20090208974A1 Human Neuronal Attachment Factor-1 失效
标题翻译：人类神经元附着因子-1
公开(公告)号：US20090208974A1
公开(公告)日：2009-08-20
申请号：US12364360
申请日：2009-02-02
申请人： Gregg Hastings , Patrick J. Dillon
发明人： Gregg Hastings , Patrick J. Dillon
IPC分类号： G01N33/53
CPC分类号： C07K14/47 , A61K38/00 , Y02A50/411
摘要： A human F-spondin-like protein and DNA (RNA) encoding such protein and a procedure for producing such protein by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating spinal cord injuries and damage to peripheral nerves by promoting neural-cell adhesion and neurite extension, inhibiting tumor metastases and tumor angiogenesis, and stimulating wound repair. Antagonists are also disclosed which may be utilized to prevent malaria. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
摘要翻译：公开了一种编码这种蛋白质的人类F-脊椎样蛋白样蛋白和DNA（RNA）以及通过重组技术产生这种蛋白质的方法。还公开了通过促进神经细胞粘附和神经突延伸，抑制肿瘤转移和肿瘤血管发生以及刺激伤口修复来利用这种多肽来治疗脊髓损伤和损伤周围神经的方法。还公开了可用于预防疟疾的拮抗剂。还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

2. 发明授权

US06759512B1 Human neuronal attachment factor-1 失效
标题翻译：人类神经元附着因子-1
公开(公告)号：US06759512B1
公开(公告)日：2004-07-06
申请号：US09170042
申请日：1998-10-13
申请人： Gregg Hastings , Patrick J. Dillon
发明人： Gregg Hastings , Patrick J. Dillon
IPC分类号： C07K14435
CPC分类号： C07K14/47 , A61K38/00 , Y02A50/411
摘要： A human F-spondin-like protein and DNA (RNA) encoding such protein and a procedure for producing such protein by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating spinal cord injuries and damage to peripheral nerves by promoting neural-cell adhesion and neurite extension, inhibiting tumor metastases and tumor angiogenesis, and stimulating wound repair. Antagonists are also disclosed which may be utilized to prevent malaria. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
摘要翻译：公开了一种编码这种蛋白质的人类F-脊椎样蛋白样蛋白和DNA（RNA）以及通过重组技术产生这种蛋白质的方法。还公开了通过促进神经细胞粘附和神经突延伸，抑制肿瘤转移和肿瘤血管发生以及刺激伤口修复来利用这种多肽来治疗脊髓损伤和损伤周围神经的方法。还公开了可用于预防疟疾的拮抗剂。还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

3. 发明授权

US5871969A Nucleic acids encoding human neuronal attachment factor-1 失效
标题翻译：编码人神经元附着因子-1的核酸
公开(公告)号：US5871969A
公开(公告)日：1999-02-16
申请号：US799173
申请日：1997-02-12
申请人： Gregg Hastings , Patrick J. Dillon
发明人： Gregg Hastings , Patrick J. Dillon
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C12N15/63 , C12N15/85
CPC分类号： C07K14/47 , A61K38/00
摘要： A human F-spondin-like protein and DNA (RNA) encoding such protein and a procedure for producing such protein by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating spinal cord injuries and damage to peripheral nerves by promoting neural-cell adhesion and neurite extension, inhibiting tumor metastases and tumor angiogenesis, and stimulating wound repair. Antagonists are also disclosed which may be utilized to prevent malaria. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
摘要翻译：公开了一种编码这种蛋白质的人类F-脊椎样蛋白样蛋白和DNA（RNA）以及通过重组技术产生这种蛋白质的方法。还公开了通过促进神经细胞粘附和神经突延伸，抑制肿瘤转移和肿瘤血管发生以及刺激伤口修复来利用这种多肽来治疗脊髓损伤和损伤周围神经的方法。还公开了可用于预防疟疾的拮抗剂。还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

4. 发明申请

US20070259806A1 Brain-Associated Inhibitor of Tissue-Type Plasminogen Activator 审中-公开
标题翻译：脑组织型纤溶酶原激活物的脑相关抑制剂
公开(公告)号：US20070259806A1
公开(公告)日：2007-11-08
申请号：US11757481
申请日：2007-06-04
申请人： Gregg Hastings , Timothy Coleman , Patrick Dillon , Daniel Lawrence , Maria Sandkvist , Manuel Yepes , Michael Wong
发明人： Gregg Hastings , Timothy Coleman , Patrick Dillon , Daniel Lawrence , Maria Sandkvist , Manuel Yepes , Michael Wong
IPC分类号： A61K38/00 , C07H21/04 , C07K14/00 , C07K16/18 , C12N15/00 , C12N15/87 , C12N5/06 , C12P1/04 , G01N33/53
CPC分类号： C07K16/40 , A61K2039/505 , C07K14/8132 , G01N33/6896 , G01N33/86 , G01N2800/2821 , G01N2800/285 , G01N2800/2857 , G01N2800/2871
摘要： The present invention relates to a novel BAIT protein which is a member of serpin superfamily which is expressed primarily in brain tissue. In particular, isolated nucleic acid molecules are provided encoding the human and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of BAIT activity. Also provided are diagnostic methods for detecting nervous system-related disorders and therapeutic methods for treating nervous system-related disorders. Additionally, the present invention is related to methods of treating patients with BAIT polynucleotides or polypeptides, wherein said patients have had seizures or epilepsy.
摘要翻译：本发明涉及一种新的BAIT蛋白，其是主要在脑组织中表达的丝氨酸蛋白酶超家族的成员。特别地，提供了分离的核酸分子，其编码人和其制备方法。本发明还涉及鉴定BAIT活性的激动剂和拮抗剂的筛选方法。还提供了用于检测神经系统相关疾病的诊断方法和用于治疗神经系统相关疾病的治疗方法。另外，本发明涉及治疗患有BAIT多核苷酸或多肽的患者的方法，其中所述患者具有癫痫发作或癫痫。

5. 发明申请

US20060024299A1 Human osteoclast derived cathepsin 失效
公开(公告)号：US20060024299A1
公开(公告)日：2006-02-02
申请号：US11185877
申请日：2005-07-21
申请人： Gregg Hastings , Mark Adams , Claire Fraser , Norman Lee , Ewen Kirkness , Judith Blake , Lisa Fitzgerald , Fred Drake , Maxine Gowan
发明人： Gregg Hastings , Mark Adams , Claire Fraser , Norman Lee , Ewen Kirkness , Judith Blake , Lisa Fitzgerald , Fred Drake , Maxine Gowan
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , A61K39/395 , C12N9/64
CPC分类号： C12N9/6472 , A61K38/00 , C07K16/40
摘要： Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.

6. 发明申请

US20050239098A1 Novel hyaluronan-binding proteins and encoding genes 失效
标题翻译：新型透明质酸结合蛋白和编码基因
公开(公告)号：US20050239098A1
公开(公告)日：2005-10-27
申请号：US10960275
申请日：2004-10-08
申请人： Gregg Hastings , Gene Liau , Elena Tsifrina
发明人： Gregg Hastings , Gene Liau , Elena Tsifrina
IPC分类号： C07K14/705 , C12Q1/68 , C07H21/04 , C12N9/24
CPC分类号： G01N33/5008 , C07K14/705 , G01N33/502 , G01N33/68 , G01N2333/47
摘要： The present invention relates to full-length WF-HABP, WF-HABP, OE-HABP, and BM-HABP, novel members of the hyaluronan receptor family. The invention provides isolated nucleic acid molecules encoding human to full-length WF-HABP, WF-HABP, OE-HABP, and BM-HABP receptors. Full-length WF-HABP, WF-HABP, OE-HABP, and BM-HABP polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of full-length WF-HABP, WF-HABP, OE-HABP, and BM-HABP receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of full-length WF-HABP, WF-HABP, OE-HABP, and BM-HABP receptors. Further provided are therapeutic methods for treating disease states including, but not limited to, proliferative conditions, metastasis, inflammation, ischemia, host defense dysfunction, immune surveillance dysfunction, arthritis, multiple sclerosis, autoimmunity, immune dysfunction, and allergy.
摘要翻译：本发明涉及全长WF-HABP，WF-HABP，OE-HABP和BM-HABP，是透明质酸受体家族的新成员。本发明提供了编码人全长WF-HABP，WF-HABP，OE-HABP和BM-HABP受体的分离的核酸分子。还提供了全长WF-HABP，WF-HABP，OE-HABP和BM-HABP多肽，载体，宿主细胞和用于制备它们的重组方法也是如此。本发明还涉及用于鉴定全长WF-HABP，WF-HABP，OE-HABP和BM-HABP受体活性的激动剂和拮抗剂的筛选方法。还提供了用于检测与全长WF-HABP，WF-HABP，OE-HABP和BM-HABP受体的异常表达相关的疾病状态的诊断方法。进一步提供治疗疾病状态的治疗方法，包括但不限于增殖性病症，转移，炎症，缺血，宿主防御功能障碍，免疫监视功能障碍，关节炎，多发性硬化，自身免疫，免疫功能障碍和过敏。

7. 发明申请

US20070203070A1 28 HUMAN SECRETED PROTEINS 失效
标题翻译： 28人类分泌蛋白
公开(公告)号：US20070203070A1
公开(公告)日：2007-08-30
申请号：US11744695
申请日：2007-05-04
申请人： Craig Rosen , Steven Ruben , Yi Li , Zhizhen Zeng , Hla Kyaw , Carrie Fischer , Haodong Li , Daniel Soppet , Reiner Gentz , Ying-Fei Wei , Paul Moore , Paul Young , John Greene , Ann Ferrie , Gregg Hastings
发明人： Craig Rosen , Steven Ruben , Yi Li , Zhizhen Zeng , Hla Kyaw , Carrie Fischer , Haodong Li , Daniel Soppet , Reiner Gentz , Ying-Fei Wei , Paul Moore , Paul Young , John Greene , Ann Ferrie , Gregg Hastings
IPC分类号： A61K38/17 , C07H21/04 , C07K16/00 , C07K4/00 , C12N15/00 , C12N15/09 , C12N5/00 , C12N5/08 , C12Q1/00 , C12Q1/68
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , A61K2039/53 , C07K14/4702 , C07K14/4718 , C07K2319/00 , C07K2319/02 , C12N2799/026
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

8. 发明申请

US20050208621A1 28 human secreted proteins 审中-公开
标题翻译： 28人分泌蛋白
公开(公告)号：US20050208621A1
公开(公告)日：2005-09-22
申请号：US10951993
申请日：2004-09-29
申请人： Craig Rosen , Steven Ruben , Yi Li , ZhiZhen Zeng , Hla Kyaw , Carrie Fishcher , Haodong Li , Daniel Soppet , Reiner Gentz , Ying-Fei Wei , Paul Moore , Paul Young , John Greene , Ann Ferrie , Gregg Hastings
发明人： Craig Rosen , Steven Ruben , Yi Li , ZhiZhen Zeng , Hla Kyaw , Carrie Fishcher , Haodong Li , Daniel Soppet , Reiner Gentz , Ying-Fei Wei , Paul Moore , Paul Young , John Greene , Ann Ferrie , Gregg Hastings
IPC分类号： A61K38/00 , A61K48/00 , C07H21/04 , C07K14/47
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , A61K2039/53 , C07K14/4702 , C07K14/4718 , C07K2319/00 , C07K2319/02 , C12N2799/026
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

9. 发明申请

US20050208618A9 Novel integrin ligand ITGL-TSP 审中-公开
标题翻译：新型整合素配体ITGL-TSP
公开(公告)号：US20050208618A9
公开(公告)日：2005-09-22
申请号：US10757450
申请日：2004-01-15
申请人： Zdenka Jonak , Stephen Trulli , James Fornwald , Jonathon Terrett , Gregg Hastings
发明人： Zdenka Jonak , Stephen Trulli , James Fornwald , Jonathon Terrett , Gregg Hastings
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12N9/64 , C12N9/16 , C07H21/04
CPC分类号： C12N9/6489 , A61K38/00 , A61K48/00 , C07K14/4702 , C12Q1/37 , G01N33/5011 , G01N33/502 , G01N33/564 , G01N33/57496 , G01N33/6893 , G01N33/6896 , G01N2500/00 , G01N2800/102 , G01N2800/164 , G01N2800/24 , G01N2800/2821 , G01N2800/323
摘要： ITGL-TSP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed Also disclosed are methods for utilizing ITGL-TSP polypeptides and polynucleotides in the design of protocols for the treatment of, angiogenic diseases (cancer, cancer metasis, chronic inflammatory disorders, rheumatoid arthritis, atherosclerosis, macular degeneration, diabetic retinopathy), restenosis, Alzheimer's disease and tissue remodeling, among others, and diagnostic assays for such conditions.
摘要翻译：公开了ITGL-TSP多肽和用于通过重组技术产生此类多肽的多核苷酸和方法。还公开了在设计用于治疗血管发生疾病（癌症，癌症，慢性炎症性疾病）的方案中使用ITGL-TSP多肽和多核苷酸的方法，类风湿性关节炎，动脉粥样硬化，黄斑变性，糖尿病性视网膜病变），再狭窄，阿尔茨海默病和组织重塑等，以及用于这些病症的诊断测定。

10. 发明申请

US20070213255A1 Novel Hyaluronan-Binding Proteins and Encoding Genes 审中-公开
标题翻译：新型透明质酸结合蛋白和编码基因
公开(公告)号：US20070213255A1
公开(公告)日：2007-09-13
申请号：US11550102
申请日：2006-10-17
申请人： Gregg Hastings , Gene Liau , Elena Tsifrina
发明人： Gregg Hastings , Gene Liau , Elena Tsifrina
IPC分类号： A61K38/00 , C07H21/04 , C07K16/00 , C12N15/00 , C12N5/00 , C12P21/00 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/5008 , C07K14/705 , G01N33/502 , G01N33/68 , G01N2333/47
摘要： The present invention relates to full-length WF-HABP, WF-HABP, OE-HABP, and BM-HABP, novel members of the hyaluronan receptor family. The invention provides isolated nucleic acid molecules encoding human to full-length WF-HABP, WF-HABP, OE-HABP, and BM-HABP receptors. Full-length WF-HABP, WF-HABP, OE-HABP, and BM-HABP polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of full-length WF-HABP, WF-HABP, OE-HABP, and BM-HABP receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of full-length WF-HABP, WF-HABP, OE-HABP, and BM-HABP receptors. Further provided are therapeutic methods for treating disease states including, but not limited to, proliferative conditions, metastasis, inflammation, ischemia, host defense dysfunction, immune surveillance dysfunction, arthritis, multiple sclerosis, autoimmunity, immune dysfunction, and allergy.
摘要翻译：本发明涉及全长WF-HABP，WF-HABP，OE-HABP和BM-HABP，是透明质酸受体家族的新成员。本发明提供了编码人全长WF-HABP，WF-HABP，OE-HABP和BM-HABP受体的分离的核酸分子。还提供了全长WF-HABP，WF-HABP，OE-HABP和BM-HABP多肽，载体，宿主细胞和用于制备它们的重组方法也是如此。本发明还涉及用于鉴定全长WF-HABP，WF-HABP，OE-HABP和BM-HABP受体活性的激动剂和拮抗剂的筛选方法。还提供了用于检测与全长WF-HABP，WF-HABP，OE-HABP和BM-HABP受体的异常表达相关的疾病状态的诊断方法。进一步提供治疗疾病状态的治疗方法，包括但不限于增殖性病症，转移，炎症，缺血，宿主防御功能障碍，免疫监视功能障碍，关节炎，多发性硬化，自身免疫，免疫功能障碍和过敏。

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