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1. 发明授权

US07014862B2 Chewable compositions containing a gel-forming extract of psyllium 失效
公开(公告)号：US07014862B2
公开(公告)日：2006-03-21
申请号：US10368225
申请日：2003-02-18
申请人： Graham John Myatt , Christopher Neil Harrison , Paul Alfred Cimiluca , Theresa Marie Kajs
发明人： Graham John Myatt , Christopher Neil Harrison , Paul Alfred Cimiluca , Theresa Marie Kajs
IPC分类号： A61K9/20 , A61K9/28 , A61K9/48 , A61K47/00
CPC分类号： A61K9/0056 , A61K36/68 , A61K2300/00
摘要： Oral compositions, suitable for chewing, comprising a gel-forming polysaccharide isolated from psyllium seed husks and an excipient that is fast dissolving in the oral cavity, provide good aesthetics and acceptable mouthfeel as perceived by the consumer. The oral compositions are useful for normalizing bowel function, reducing human serum cholesterol levels and treatment of other gastrointestinal disorders.

2. 发明授权

US07098193B2 Compositions comprising a defined polysaccharide component 有权
标题翻译：包含限定多糖组分的组合物
公开(公告)号：US07098193B2
公开(公告)日：2006-08-29
申请号：US10633738
申请日：2003-08-04
申请人： Graham John Myatt , Paul Alfred Cimiluca
发明人： Graham John Myatt , Paul Alfred Cimiluca
IPC分类号： A61K31/715 , A61K47/00
CPC分类号： A61K9/0095 , A61K9/10 , A61K9/1652 , A61K31/715 , A61K47/12 , A61K47/36 , Y10S514/884 , Y10S514/892
摘要： The present disclosure provides compositions comprising an extracted portion of psyllium seed in combination with one or more of a binder, suspending agent, or edible acid. In particular, the present invention is directed to compositions comprising: (a) a polysaccharide component comprising xylose and arabinose, wherein the ratio of xylose to arabinose is at least about 3:1, by weight; and (b) a dispersing component selected from the group consisting of binders, suspending agents, edible acids, and mixtures thereof. In a preferred embodiment, the compositions further comprise an aqueous liquid, for example, water or juice (e.g., fruit or vegetable juice). As such, the present invention further relates to methods of preparing a product comprising admixing the present compositions with an aqueous liquid. The present compositions are useful for the treatment of a variety of benefits, including providing treatment for gastrointestinal conditions or providing other gastrointestinal benefits.
摘要翻译：本公开提供了组合物，其包含与一种或多种粘合剂，悬浮剂或食用酸组合的车前子的提取部分。特别地，本发明涉及包含以下组分的组合物：（a）包含木糖和阿拉伯糖的多糖组分，其中木糖与阿拉伯糖的比例为至少约3:1重量比; 和（b）选自粘合剂，悬浮剂，食用酸及其混合物的分散组分。在优选的实施方案中，组合物还包含水性液体，例如水或果汁（例如水果或蔬菜汁）。因此，本发明还涉及制备产品的方法，包括将本发明组合物与水性液体混合。本发明的组合物可用于治疗各种益处，包括为胃肠道病症提供治疗或提供其它胃肠道益处。

3. 发明授权

US07026303B2 Compositions comprising a polysaccharide component and one or more coating layers 失效
公开(公告)号：US07026303B2
公开(公告)日：2006-04-11
申请号：US10633965
申请日：2003-08-04
申请人： Paul Alfred Cimiluca , Graham John Myatt
发明人： Paul Alfred Cimiluca , Graham John Myatt
IPC分类号： A61K31/715 , A01N25/00
CPC分类号： A61K9/1652 , A61K9/167 , A61K9/5073 , Y10S514/884 , Y10S514/892
摘要： The present disclosure provides compositions comprising a plurality of agglomerates comprising a polysaccharide component comprising xylose and arabinose, wherein the ratio of xylose to arabinose is at least about 3:1, by weight; wherein the compositions further comprise: (i) optionally, a first surrounding layer which surrounds the agglomerate, wherein the first surrounding layer is a hydrophobic layer; and (ii) optionally, a second surrounding layer which surrounds the agglomerate, wherein the second surrounding layer is a hydrophilic layer; wherein the compositions comprise at least one of the first surrounding layer and the second surrounding layer, and wherein when the agglomerate comprises the first surrounding layer and the second surrounding layer then the first surrounding layer is a preceding layer relative to the second surrounding layer. In another embodiment, the disclosure provides compositions comprising a plurality of polysaccharide particles, wherein the polysaccharide particles comprise a polysaccharide component comprising xylose and arabinose, wherein the ratio of the xylose to the arabinose is at least about 3:1, by weight, and wherein the polysaccharide particles have a mean particle size distribution of from about 0.001 microns to about 150 microns, wherein the polysaccharide particles each, independently, comprise: (i) optionally, a first surrounding layer which surrounds the particle, wherein the first surrounding layer is a hydrophobic layer; and (ii) optionally, a second surrounding layer which surrounds the particle, wherein the second surrounding layer is a hydrophilic layer; wherein the polysaccharide particles each, independently, comprise at least one of the first surrounding layer and the second surrounding layer, and wherein when the particle comprises the first surrounding layer and the second surrounding layer then the first surrounding layer is a preceding layer relative to the second surrounding layer. The present compositions are useful for the treatment of a variety of benefits, including providing treatment for gastrointestinal conditions or providing other gastrointestinal benefits.

4. 发明授权

US06982254B2 Compositions comprising a plurality of particles or agglomerates having a defined particle size 有权
标题翻译：包含多个具有规定粒径的颗粒或附聚物的组合物
公开(公告)号：US06982254B2
公开(公告)日：2006-01-03
申请号：US10633970
申请日：2003-08-04
申请人： Paul Alfred Cimiluca , Graham John Myatt , Hasani Gillispie
发明人： Paul Alfred Cimiluca , Graham John Myatt , Hasani Gillispie
IPC分类号： A61K31/715 , A01N25/00
CPC分类号： A61K47/36 , A61K9/0095 , A61K9/1652 , A61K47/12 , Y10S514/884 , Y10S514/892
摘要： The present disclosure provides compositions comprising an extracted portion of psyllium seed in combination with one or more of a binder or edible acid. In particular, the present invention is directed to compositions comprising a polysaccharide component comprising xylose and arabinose, wherein the ratio of the xylose to the arabinose is at least about 3:1, by weight, and wherein the polysaccharide particles have a mean particle size distribution of from about 0.001 microns to about 150 microns. In a further embodiment, the compositions comprise a plurality of agglomerates comprising the polysaccharide component and a dispersing component selected from binders, suspending agents, edible acids, and mixtures thereof. In yet a further embodiment, the compositions comprise agglomerates comprising a polysaccharide component, wherein the agglomerates have a mean particle size distribution of from about 100 to about 500 microns.The present compositions are useful for the treatment of a variety of benefits, including providing treatment for gastrointestinal conditions or providing other gastrointestinal benefits.
摘要翻译：本公开提供了组合物，其包含欧几里德杆菌籽油的提取部分与一种或多种粘合剂或食用酸的组合。特别地，本发明涉及包含包含木糖和阿拉伯糖的多糖组分的组合物，其中木糖与阿拉伯糖的重量比为至少约3:1，其中多糖颗粒具有平均粒度分布为约0.001微米至约150微米。在另一个实施方案中，组合物包含多个附聚物，其包含多糖组分和选自粘合剂，悬浮剂，食用酸及其混合物的分散组分。在又一个实施方案中，组合物包含包含多糖组分的附聚物，其中所述附聚物具有约100至约500微米的平均粒度分布。本发明的组合物可用于治疗各种益处，包括为胃肠道病症提供治疗或提供其它胃肠道益处。

5. 发明授权

US5641512A Soft gelatin capsule compositions 失效
标题翻译：软明胶胶囊组合物
公开(公告)号：US5641512A
公开(公告)日：1997-06-24
申请号：US412627
申请日：1995-03-29
申请人： Paul Alfred Cimiluca
发明人： Paul Alfred Cimiluca
IPC分类号： A61K9/48 , A61K9/66 , A61K31/135 , A61K31/167 , A61K31/19 , A61K31/192 , A61K31/405 , A61K31/485 , A61K31/60 , A61K45/06
CPC分类号： A61K31/616 , A61K31/167 , A61K31/192 , A61K31/405 , A61K45/06 , A61K9/4825
摘要： The present invention relates to improved pharmaceutical compositions containing an analgesic encapsulated within a soft gelatin shell wherein said shell contains a xanthine derivative, such as caffeine.
摘要翻译：本发明涉及包含封闭在软明胶壳内的止痛剂的改进的药物组合物，其中所述壳含有黄嘌呤衍生物，例如咖啡因。

6. 发明申请

US20110192863A1 Ingestible Tablet Dispensers And Methods Of Dispensing Tablets 审中-公开
标题翻译：可食用片剂分配器和分配片剂的方法
公开(公告)号：US20110192863A1
公开(公告)日：2011-08-11
申请号：US12972635
申请日：2010-12-20
申请人： Paul Leslie Barrass , Paul Alfred Cimiluca
发明人： Paul Leslie Barrass , Paul Alfred Cimiluca
IPC分类号： B65D83/04 , B65G59/00 , A23L1/00
CPC分类号： B65D83/0409 , A61J1/03 , A61J7/0084 , A61J2205/20 , A61K9/2072 , B65D2583/0486
摘要： A portable tablet dispenser includes a plurality of cartridges including a first cartridge including a first plurality of ingestible tablets housed therein and a second cartridge including a second plurality of ingestible tablets housed therein. A main housing includes a first cartridge port that receives a dispensing end of the first cartridge and a second cartridge port that receives a dispensing end of the second cartridge. A dispensing mechanism is located in the main housing. The dispensing mechanism is configured to selectively dispense an individual ingestible tablet from one and simultaneously both of the first cartridge and the second cartridge where selection is based on a user input.
摘要翻译：便携式平板电脑分配器包括多个盒，包括第一盒，其包括容纳在其中的第一组多个可摄取片剂，以及包含容纳在其中的第二多个可摄取片剂的第二盒。主壳体包括容纳第一盒的分配端的第一盒端口和容纳第二盒的分配端的第二盒端口。分配机构位于主壳体中。分配机构被配置为从第一盒和第二盒中的一个并且同时选择性地分配单个可摄取的片剂，其中选择基于用户输入。

7. 发明授权

US09078824B2 Composition and method of stabilized sensitive ingredient 有权
标题翻译：稳定敏感成分的组成和方法
公开(公告)号：US09078824B2
公开(公告)日：2015-07-14
申请号：US12235711
申请日：2008-09-23
申请人： Paul Alfred Cimiluca , Sonsoles Arnal , Jorge Zambrano
发明人： Paul Alfred Cimiluca , Sonsoles Arnal , Jorge Zambrano
IPC分类号： A61K9/14 , A61K9/20 , A61K9/48 , A61K31/60 , C08J3/20 , C08K5/00 , C08L3/02 , A61K9/16 , C08L1/02
CPC分类号： A61K9/2013 , A61K9/1694 , A61K9/2054 , A61K9/2059 , A61K31/60 , C08J3/20 , C08J2303/02 , C08K5/0008 , C08L1/02 , C08L3/02 , C08L2666/26
摘要： The present invention comprises a method of achieving ingredient stabilization in a composition comprising the steps of: combining a pregelatinized starch with at least one sensitive ingredient; adsorbing said sensitive ingredient onto the pregelatinized starch; and wherein said sensitive ingredient is evenly distributed throughout said pregelatinized starch.
摘要翻译：本发明包括在组合物中实现成分稳定化的方法，包括以下步骤：将预胶化淀粉与至少一种敏感成分混合; 将所述敏感成分吸附到预胶化淀粉上; 并且其中所述敏感成分均匀分布在整个所述预胶化淀粉中。

8. 发明授权

US08517595B2 Apparatus and method for mixing by producing shear and/or cavitation, and components for apparatus 有权
标题翻译：通过产生剪切和/或空化以及用于装置的部件混合的装置和方法
公开(公告)号：US08517595B2
公开(公告)日：2013-08-27
申请号：US12147629
申请日：2008-06-27
申请人： Lowen Robert Morrison, Jr. , Ke-Ming Quan , Raul Victorino Nunes , Vesselin Nikolov Shanov , Paul Alfred Cimiluca
发明人： Lowen Robert Morrison, Jr. , Ke-Ming Quan , Raul Victorino Nunes , Vesselin Nikolov Shanov , Paul Alfred Cimiluca
IPC分类号： B01F11/00 , B01F15/02
CPC分类号： B01F5/0682 , A61K31/60 , A61K33/245 , B01F3/04978 , B01F3/0819 , B01F3/1242 , B01F5/0688 , B01F11/0208 , B01F2215/0431 , B01F2215/0468 , B01F2215/049 , A61K2300/00
摘要： An apparatus and method for mixing by producing shear and/or cavitation, and components for the apparatus are disclosed. In one embodiment, the apparatus includes a mixing and/or cavitation chamber with an element such as an orifice component that is located adjacent the entrance of the cavitation chamber. The apparatus may further include a blade, such as a knife-like blade, disposed inside the mixing and/or cavitation chamber opposite the orifice component. In one version of such an embodiment, at least some of the portions of the orifice component surrounding the orifice and/or the blade are made of a material or materials that have a Vickers hardness of greater than or equal to about 20 GPa. A process for mixing by producing shear and/or cavitation in a fluid is also contemplated herein.
摘要翻译：公开了一种通过产生剪切和/或空化以及该装置的部件进行混合的装置和方法。在一个实施例中，该装置包括具有诸如孔部件的元件的混合和/或空化室，其邻近空化室的入口定位。该装置还可以包括设置在与孔部件相对的混合和/或空化腔室内的刀片，例如刀状刀片。在这种实施例的一种形式中，围绕孔和/或叶片的孔组件的至少部分部分由维氏硬度大于或等于约20GPa的材料制成。本文还考虑通过在流体中产生剪切和/或空化进行混合的方法。

9. 发明申请

US20090082316A1 Composition and Method Of Stabilized Sensitive Ingredient 有权
标题翻译：稳定敏感成分的组成和方法
公开(公告)号：US20090082316A1
公开(公告)日：2009-03-26
申请号：US12235711
申请日：2008-09-23
申请人： Paul Alfred Cimiluca , Sonsoles Arnal , Jorge Zambrano
发明人： Paul Alfred Cimiluca , Sonsoles Arnal , Jorge Zambrano
IPC分类号： A61K31/60
CPC分类号： A61K9/2013 , A61K9/1694 , A61K9/2054 , A61K9/2059 , A61K31/60 , C08J3/20 , C08J2303/02 , C08K5/0008 , C08L1/02 , C08L3/02 , C08L2666/26
摘要： The present invention comprises a method of achieving ingredient stabilization in a composition comprising the steps of: combining a pregelatinized starch with at least one sensitive ingredient; adsorbing said sensitive ingredient onto the pregelatinized starch; and wherein said sensitive ingredient is evenly distributed throughout said pregelatinized starch.
摘要翻译：本发明包括在组合物中实现成分稳定化的方法，包括以下步骤：将预胶化淀粉与至少一种敏感成分混合; 将所述敏感成分吸附到预胶化淀粉上; 并且其中所述敏感成分均匀分布在整个所述预胶化淀粉中。

10. 发明申请

US20090003123A1 APPARATUS AND METHOD FOR MIXING BY PRODUCING SHEAR AND/OR CAVITATION, AND COMPONENTS FOR APPARATUS 有权
标题翻译：通过生产剪刀和/或加工混合的装置和方法以及装置的组件
公开(公告)号：US20090003123A1
公开(公告)日：2009-01-01
申请号：US12147629
申请日：2008-06-27
申请人： Lowen Robert Morrison, JR. , Ke-Ming Quan , Raul Victorine Nunes , Vesselin Nikolov Shanov , Paul Alfred Cimiluca
发明人： Lowen Robert Morrison, JR. , Ke-Ming Quan , Raul Victorine Nunes , Vesselin Nikolov Shanov , Paul Alfred Cimiluca
IPC分类号： B01F11/00 , B01F15/02
CPC分类号： B01F5/0682 , A61K31/60 , A61K33/245 , B01F3/04978 , B01F3/0819 , B01F3/1242 , B01F5/0688 , B01F11/0208 , B01F2215/0431 , B01F2215/0468 , B01F2215/049 , A61K2300/00
摘要： An apparatus and method for mixing by producing shear and/or cavitation, and components for the apparatus are disclosed. In one embodiment, the apparatus includes a mixing and/or cavitation chamber with an element such as an orifice component that is located adjacent the entrance of the cavitation chamber. The apparatus may further include a blade, such as a knife-like blade, disposed inside the mixing and/or cavitation chamber opposite the orifice component. In one version of such an embodiment, at least some of the portions of the orifice component surrounding the orifice and/or the blade are made of a material or materials that have a Vickers hardness of greater than or equal to about 20 GPa. A process for mixing by producing shear and/or cavitation in a fluid is also contemplated herein.
摘要翻译：公开了一种通过产生剪切和/或空化以及该装置的部件进行混合的装置和方法。在一个实施例中，该装置包括具有诸如孔部件的元件的混合和/或空化室，其邻近空化室的入口定位。该装置还可以包括设置在与孔部件相对的混合和/或空化腔室内的刀片，例如刀状刀片。在这种实施例的一种形式中，围绕孔和/或叶片的孔组件的至少部分部分由维氏硬度大于或等于约20GPa的材料制成。本文还考虑通过在流体中产生剪切和/或空化进行混合的方法。

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