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1. 发明申请

US20070191608A1 Process for preparing 3-aminothienopyridone derivatives 失效
标题翻译：制备3-氨基噻吩并吡啶衍生物的方法
公开(公告)号：US20070191608A1
公开(公告)日：2007-08-16
申请号：US10561051
申请日：2004-06-18
申请人： Graham Evans , Ian Smith , Neil Tremayne , Leighton Jones , Marianne Langston
发明人： Graham Evans , Ian Smith , Neil Tremayne , Leighton Jones , Marianne Langston
IPC分类号： C07D471/02 , C07D213/63
CPC分类号： C07D495/04 , C07D213/85
摘要： This invention provides a class of 3-amino-7H-thieno[2,3-b]pyridin-6-one derivatives, substituted in the 7-position by an aryl, heteroaryl, cycloalkyl or heterocycloalkyl moiety, and in the 2-position by a specified range of substituent groups; also provided is a process for preparing those compounds, and the use thereof as intermediates in the manufacture of certain p38 MAP kinase inhibitors.
摘要翻译：本发明提供一类3-位氨基-7H-噻吩并[2,3-b]吡啶-6-酮衍生物，其在7-位被芳基，杂芳基，环烷基或杂环烷基部分取代，并且在2-位上通过指定范围的取代基; 还提供了制备这些化合物的方法，以及作为制备某些p38MAP激酶抑制剂的中间体的用途。

2. 发明授权

US09561336B2 Dose unit, pack of dose units and inhaler for inhalation of combination of drugs 有权
标题翻译：剂量单位，剂量单位包装和吸入器吸入药物组合
公开(公告)号：US09561336B2
公开(公告)日：2017-02-07
申请号：US13380083
申请日：2010-06-24
申请人： Ian Smith
发明人： Ian Smith
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61M15/0003 , A61M15/0031 , A61M15/0048 , A61M15/0051 , A61M15/0061 , A61M2202/064
摘要： Various embodiments relate to a dose unit for a dry powder inhaler including: a dose carrier including a plurality of pockets each adapted to contain a dose of medication powder suitable for inhalation, the pockets being sequentially arranged such that the content of the pockets can be sequentially exposed to a flow of air for successive inhalations and a plurality of medication powder doses arranged in the pockets of the dose carrier. The doses are regularly distributed in the pockets according to a sequence of identical groups, each group including at least one blank pocket and one pocket containing a dose of medication powder. Various embodiments also relate to a pack including one such dose unit and one further dose unit with all pockets containing a medication powder. Various embodiments further relate to a dry powder inhaler including such a pack of dose units.
摘要翻译：各种实施方案涉及用于干粉吸入器的剂量单位，包括：剂量载体，其包括多个口袋，每个口袋适于容纳适于吸入的一定剂量的药用粉末，所述口袋顺序地布置成使得口袋的内容可以顺序地暴露于用于连续吸入的空气流和布置在剂量载体的袋中的多个药粉剂量。剂量根据相同组的顺序规则分布在口袋中，每组包括至少一个空白口袋和一个含有一定剂量的药粉的口袋。各种实施方案还涉及一种包括一种这样的剂量单位和一个另外的剂量单位，其中所有口袋含有药物粉末。各种实施方案进一步涉及包含这样一组剂量单位的干粉吸入器。

3. 发明申请

US20100159272A1 Clad metal sheet and heat exchanger tubing etc. made therefrom 有权
标题翻译：包覆金属板和由其制成的热交换器管等
公开(公告)号：US20100159272A1
公开(公告)日：2010-06-24
申请号：US12653894
申请日：2009-12-17
申请人： Pierre Henri Marois , Kevin Michael Gatenby , Thomas L. Davisson , Andrew D. Howells , Ian Smith
发明人： Pierre Henri Marois , Kevin Michael Gatenby , Thomas L. Davisson , Andrew D. Howells , Ian Smith
IPC分类号： B32B15/01 , B32B1/08 , B32B15/20
CPC分类号： C22C21/10 , B23K1/0012 , B23K35/0238 , B23K35/286 , B32B15/016 , C22C21/00 , C22C21/02 , C22C21/12 , C23F13/08 , C23F13/14 , C23F2213/32 , F28F19/06 , F28F21/084 , F28F21/089 , Y10T428/12736 , Y10T428/1275 , Y10T428/12764
摘要： The exemplary embodiments relate to a multilayer aluminum alloy sheet material suitable for fabrication into coolant-conveying tubes, headers and the like used for heat exchangers, and to the tubes and headers, etc., fabricated from the sheet. The multi-layer metal sheet has a core layer of aluminum alloy having first and second sides. The first side has an interlayer made of a Zn-containing aluminum alloy positioned between a Zn-containing outer layer and the core layer. The alloy of the outer layer is more electronegative than the alloy of the interlayer. The alloy of the interlayer is preferably more electronegative than the alloy of the core layer. The first side clad in this way is the side intended for exposure to the coolant, and provides good resistance to corrosion and erosion.
摘要翻译：示例性实施例涉及适于制造用于热交换器的冷却剂输送管，集管等的多层铝合金板材以及由板制成的管和集管等。多层金属片具有第一和第二侧的铝合金芯层。第一面具有由位于含Zn外层和芯层之间的含Zn铝合金制成的中间层。外层的合金比中间层的合金更具电负性。中间层的合金优选比核心层的合金更具有电负性。以这种方式包覆的第一面是用于暴露于冷却剂的侧面，并且提供良好的耐腐蚀和侵蚀性。

4. 发明申请

US20080138465A1 DEGRADABLE CHEWING GUM 有权
标题翻译：可降温茶
公开(公告)号：US20080138465A1
公开(公告)日：2008-06-12
申请号：US11923229
申请日：2007-10-24
申请人： Paul D. Soper , Vesselin Danailov Miladinov , Jose A. Amarista , Ian Smith , Carole Elleman , Mark Taylor , Nigel Kenneth Harry Slater , Mark Edward Eccleston
发明人： Paul D. Soper , Vesselin Danailov Miladinov , Jose A. Amarista , Ian Smith , Carole Elleman , Mark Taylor , Nigel Kenneth Harry Slater , Mark Edward Eccleston
IPC分类号： A23G4/18
CPC分类号： A23G4/08
摘要： The present invention provides gum base compositions and chewing gum compositions having non stick or reduced-stick properties and/or increased degradability. Methods of preparing the gum base and chewing gum compositions, as well as methods of use, are provided.
摘要翻译：本发明提供了胶基组合物和口香糖组合物，其具有不粘或降粘性质和/或增加的降解性。提供了制备胶基和口香糖组合物的方法，以及使用方法。

5. 发明授权

US07301634B2 Apparatus and methods for detecting overlay errors using scatterometry 有权
标题翻译：使用散射法检测重叠误差的装置和方法
公开(公告)号：US07301634B2
公开(公告)日：2007-11-27
申请号：US10785821
申请日：2004-02-23
申请人： Walter D. Mieher , Ady Levy , Boris Golovanesky , Michael Friedmann , Ian Smith , Michael E. Adel , Christopher F. Bevis , John Fielden , Noah Bareket , Anatoly Fabrikant , Mark Ghinovker , Piotr Zalicki , Dan Wack
发明人： Walter D. Mieher , Ady Levy , Boris Golovanesky , Michael Friedmann , Ian Smith , Michael E. Adel , Christopher F. Bevis , John Fielden , Noah Bareket , Anatoly Fabrikant , Mark Ghinovker , Piotr Zalicki , Dan Wack
IPC分类号： G01B11/00
CPC分类号： G03F9/7088 , G01N21/956 , G01N2021/213 , G03F7/70625 , G03F7/70633 , G03F7/70683 , G03F9/7049 , G03F9/7084
摘要： Disclosed is a method of determining an overlay error between two layers of a multiple layer sample. For a plurality of periodic targets that each have a first structure formed from a first layer and a second structure formed from a second layer of the sample, an interferometer is employed to modulate substantially a plurality of wavelengths of a broadband source and then acquiring one or more images of the periodic targets. There are predefined offsets between the first and second structures. An overlay error between the first and second structures is then determined by analyzing the one or more acquired images from the periodic targets using a scatterometry overlay technique based on the predefined offsets.
摘要翻译：公开了一种确定多层样本的两层之间的覆盖误差的方法。对于每个具有由第一层形成的第一结构和由样本的第二层形成的第二结构的多个周期性目标，使用干涉仪来调制宽带源的基本上多个波长，然后获取一个或更多图像的周期性目标。在第一和第二结构之间有预定义的偏移。然后通过使用基于预定义的偏移的散射测量覆盖技术来分析来自周期性目标的一个或多个获取的图像来确定第一和第二结构之间的重叠误差。

6. 发明申请

US20070191378A1 Anthranilic acid derivatives and their use as activators of the hm74a receptor 审中-公开
标题翻译：邻氨基苯甲酸衍生物及其作为hm74a受体激活剂的用途
公开(公告)号：US20070191378A1
公开(公告)日：2007-08-16
申请号：US10568029
申请日：2004-08-13
申请人： Matthew Campbell , Richard Hatley , Jag Heer , Andrew Mason , Ivan Pinto , Shahzad Rahman , Ian Smith
发明人： Matthew Campbell , Richard Hatley , Jag Heer , Andrew Mason , Ivan Pinto , Shahzad Rahman , Ian Smith
IPC分类号： A61K31/498 , A61K31/47 , A61K31/195 , C07D217/12 , C07D215/08
CPC分类号： C07D209/18 , C07C233/55 , C07C235/24 , C07C235/38 , C07C237/22 , C07C2602/08 , C07C2602/10 , C07D217/12 , C07D217/24 , C07D317/60 , C07D333/60
摘要： Therapeutically active anthranilic acid derivatives of Formula (I), processes for the preparation of said derivatives, pharmaceutical formulations containing the compounds and the use of the compounds in therapy, particularly in the treatment of diseases in which under-activation of the HM74A receptor contributes to the disease or in which activation of the receptor will be beneficial, are disclosed.
摘要翻译：式（I）的治疗活性邻氨基苯甲酸衍生物，所述衍生物的制备方法，含有该化合物的药物制剂以及该化合物在治疗中的用途，特别是用于治疗HM74A受体活化不足的疾病所述疾病或所述受体的活化将是有益的。

7. 发明申请

US20070151537A1 Rotary Valve System and Engine Using the Same 失效
标题翻译：旋转阀系统和使用它的发动机
公开(公告)号：US20070151537A1
公开(公告)日：2007-07-05
申请号：US11457104
申请日：2006-07-12
申请人： John Zajac , Ian Smith
发明人： John Zajac , Ian Smith
IPC分类号： F01L7/00
CPC分类号： F01B31/14 , F01L1/022 , F01L1/024 , F01L1/026 , F01L1/34 , F01L1/352 , F01L7/021 , F01L7/026 , F01L7/027 , F01L7/16 , F01L13/0005 , F01L13/0015 , F01L2101/02 , F01L2800/00 , F01L2820/01 , F01L2820/032 , F02B15/00 , F02B33/06 , F02B41/00 , F02B41/02 , F02B41/06 , F02B75/40 , F02D15/04 , F02F3/28 , F02G1/02 , Y02T10/12 , Y02T10/14 , Y02T10/42
摘要： Rotary valve system for controlling communication with a port in an internal combustion engine which, in one disclosed embodiment, has a crankshaft, compression and expansion pistons connected to the crankshaft for reciprocating movement within compression and expansion chambers, a combustion chamber in which air from the compression chamber is combined with fuel and burned to produce an increased gas volume. The valve system has an outer valve member which is rotatively mounted in a bore and has an opening which moves into and out of communication with the port as the outer valve member rotates, an inner valve member rotatably mounted within the outer valve member with an opening at least partly overlapping the opening in the outer valve member, a flange extending along one edge of the opening in the inner valve member and through the opening in the outer valve member for sealing engagement with the wall of the bore, and means for effecting rotation of the valve members to change the degree of overlap between the openings and thereby control the timing and duration of communication between the openings and the port.
摘要翻译：用于控制与内燃机中的端口的连通的旋转阀系统，其在一个公开的实施例中具有连接到曲轴的曲轴，压缩和膨胀活塞，用于在压缩和膨胀室内往复运动，燃烧室中的空气压缩室与燃料组合并燃烧以产生增加的气体体积。阀系具有外部阀构件，该外部阀构件可旋转地安装在孔中，并且具有与外部阀构件旋转时进入和离开与端口连通的开口;内部阀构件，其可旋转地安装在外部阀构件内，至少部分地与外部阀构件中的开口部分重叠，沿着内部阀构件中的开口的一个边缘延伸的凸缘，并且通过外部阀构件中的开口与孔的密封接合，以及用于进行旋转的装置的阀构件以改变开口之间的重叠程度，从而控制开口和端口之间的连通的定时和持续时间。

8. 发明申请

US20070012020A1 Internal Combustion Engine and Method with Improved Combustion Chamber 失效
公开(公告)号：US20070012020A1
公开(公告)日：2007-01-18
申请号：US11457883
申请日：2006-07-17
申请人： John Zajac , Ian Smith
发明人： John Zajac , Ian Smith
IPC分类号： F02G1/00
CPC分类号： F01B31/14 , F01L1/022 , F01L1/024 , F01L1/026 , F01L1/34 , F01L1/352 , F01L7/021 , F01L7/026 , F01L7/027 , F01L7/16 , F01L13/0005 , F01L13/0015 , F01L2101/02 , F01L2800/00 , F01L2820/01 , F01L2820/032 , F02B15/00 , F02B33/06 , F02B41/00 , F02B41/02 , F02B41/06 , F02B75/40 , F02D15/04 , F02F3/28 , F02G1/02 , Y02T10/12 , Y02T10/14 , Y02T10/42
摘要： Constant pressure internal combustion engine having an elongated combustion chamber which in some embodiments is folded back upon itself and has a rough, twisting interior side wall, a fuel inlet for introducing fuel into the chamber, a compression chamber in communication with the combustion chamber, means for varying the volume of the compression chamber and combustion chamber to form a mixture of fuel and air that burns as it travels through the chamber and is further mixed by the rough, twisting side wall of the chamber, an expansion chamber in communication with the combustion chamber, and an output member in the expansion chamber which is driven by pressure produced by the burning mixture, with the means for varying the volume of the compression chamber and the output member in the expansion chamber being connected together for movement in concert such that the pressure remains substantially constant within the combustion chamber. A gas flow separator near the fuel inlet forms one or more smaller volumes within the combustion chamber where the fuel can mix and burn with only a portion of the air introduced into the chamber. Long, sharp protrusions extend inwardly from the wall of the combustion chamber and form hot spots which help to provide complete combustion of the fuel mixture throughout the combustion chamber, and these protrusions, together with flow turbulators within the chamber, promote complete mixing and, hence, combustion of the fuel and air.

9. 发明申请

US20060237005A1 Air pressure signal monitoring in apparatus for treating sleep disordered breathing 审中-公开
公开(公告)号：US20060237005A1
公开(公告)日：2006-10-26
申请号：US11471620
申请日：2006-06-21
申请人： Alexander Virr , Ian Smith , Perry Lithgow , Richard Jones , Andrew Cheung
发明人： Alexander Virr , Ian Smith , Perry Lithgow , Richard Jones , Andrew Cheung
IPC分类号： A62B7/00
CPC分类号： A61M16/16 , A61M16/0066 , A61M2016/0021 , A61M2205/21
摘要： A humidifier is provided including a first humidifier part, a second humidifier part connectable with the first humidifier part, and a sealing gasket disposed between the first and second humidifier parts. The second humidifier part is configured to hold a volume of liquid therein and the first and second humidifier parts and the sealing gasket define first and second internal passages within the humidifier. The first passage is disposed so as to be exposed to a surface of the volume of liquid and the second passage is isolated from at least one of the first passage and the surface of the volume of liquid. The second passage is configured to communicate with a pressure and/or sound sensing device.

10. 发明申请

US20060123394A1 System and method for identifying viable refactorings of program code using a comprehensive test suite 失效
标题翻译：使用综合测试套件识别程序代码的可行重构的系统和方法
公开(公告)号：US20060123394A1
公开(公告)日：2006-06-08
申请号：US11003254
申请日：2004-12-03
申请人： Eric Nickell , Ian Smith
发明人： Eric Nickell , Ian Smith
IPC分类号： G06F9/44
CPC分类号： G06F8/72
摘要： A system and method for identifying viable refactorings of program code using a comprehensive test suite is presented. Program code is maintained, including program statements written in accordance with a programming language and defining operations executed following transformation into machine code. A test suite associated with the program code is specified and includes one or more additional program operations to determine satisfactory generation of expected results during the operations execution. A plurality of refactorings are speculatively applied to the program code by evaluating one or more of the program statements against a set of refactoring rules and restructuring the program statements pursuant to at least one refactoring rule. The test suite is executed against the program code following each restructuring of the program statements and each refactoring that passes the test suite is determined.
摘要翻译：介绍了使用综合测试套件识别程序代码的可行重构的系统和方法。维护程序代码，包括根据编程语言编写的程序语句，并定义在转换为机器代码之后执行的操作。指定与程序代码相关联的测试套件，并且包括一个或多个额外的程序操作，以在操作执行期间确定令人满意的预期结果生成。通过根据一组重构规则评估一个或多个程序语句并根据至少一个重构规则重组程序语句，推测性地将多个重构应用于程序代码。每个重组程序语句之后，测试套件都针对程序代码执行，并且确定通过测试套件的每个重构。

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