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1. 发明授权

US08440663B2 4-aryl-2-amino-pyrimidines or 4-aryl-2-aminoalkyl-pyrimidines as JAK-2 modulators and methods of use 失效
标题翻译： 4-芳基-2-氨基 - 嘧啶或4-芳基-2-氨基烷基 - 嘧啶作为JAK-2调节剂和使用方法
公开(公告)号：US08440663B2
公开(公告)日：2013-05-14
申请号：US11992224
申请日：2007-01-30
申请人： Grace Mann , Naing Aay , Arlyn Arcalas , S. David Brown , Wai Ki Vicky Chan , Jeff Chen , Hongwang Du , Sergey Epshteyn , Timothy Patrick Forsyth , Adam A. Galan , Tai Phat Huynh , Mohamed Abdulkader Ibrahim , Henry William Beecroft Johnson , Brian Kane , Patrick Kearney , Byung Gyu Kim , Elena S. Koltun , James W. Leahy , Matthew Sangyup Lee , Gary L. Lewis , Lisa E. Meyr , Robin Tammie Noguchi , Michael Pack , Brian Hugh Ridgway , Xian Shi , John Woolfrey , Peiwen Zhou
发明人： Grace Mann , Naing Aay , Arlyn Arcalas , S. David Brown , Wai Ki Vicky Chan , Jeff Chen , Hongwang Du , Sergey Epshteyn , Timothy Patrick Forsyth , Adam A. Galan , Tai Phat Huynh , Mohamed Abdulkader Ibrahim , Henry William Beecroft Johnson , Brian Kane , Patrick Kearney , Byung Gyu Kim , Elena S. Koltun , James W. Leahy , Matthew Sangyup Lee , Gary L. Lewis , Lisa E. Meyr , Robin Tammie Noguchi , Michael Pack , Brian Hugh Ridgway , Xian Shi , John Woolfrey , Peiwen Zhou
IPC分类号： A61K31/535 , C07D239/24 , C07D401/10 , C07D413/10
CPC分类号： C07D239/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/12 , C07D453/02 , C07D487/04
摘要： This invention relates to certain pyrimidine derivative inhibitors of JAK-2, having Formula (I): wherein D, E, L, Z, R1, R2, R25, and n1 are as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof.
摘要翻译：本发明涉及具有式（I）的JAK-2的某些嘧啶衍生物抑制剂：其中D，E，L，Z，R 1，R 2，R 25和n 1如说明书中所定义，其药学上可接受的盐，药物组合物及其使用方法。

2. 发明申请

US20090298830A1 4-Aryl-2-Amino-Pyrimidnes or 4-Aryl-2-Aminoalkyl-Pyrimidines as Jak-2 Modulators and Methods of Use 失效
标题翻译： 4-芳基-2-氨基 - 嘧啶或4-芳基-2-氨基烷基 - 嘧啶作为Jak-2调节剂和使用方法
公开(公告)号：US20090298830A1
公开(公告)日：2009-12-03
申请号：US11992224
申请日：2007-01-30
申请人： Grace Mann , Naing Aay , Arlyn Arcalas , S. David Brown , Wai Ki Vicky Chan , Jeff Chen , Hongwang Du , Sergey Epshteyn , Timothy Patrick Forsyth , Adam A. Galan , Tai Phat Huynh , Mohamed Abdulkader Ibrahim , Henry William Beecroft Johnson , Brian Kane , Patrick Kearney , Byung Gyu Kim , Elena S. Koltun , James W. Leahy , Matthew Sangyup Lee , Gary L. Lewis , Lisa E. Meyr , Robin Tammie Noguchi , Michael Pack , Brian Hugh Ridgway , Xian Shi , John Woolfrey , Peiwen Zhou
发明人： Grace Mann , Naing Aay , Arlyn Arcalas , S. David Brown , Wai Ki Vicky Chan , Jeff Chen , Hongwang Du , Sergey Epshteyn , Timothy Patrick Forsyth , Adam A. Galan , Tai Phat Huynh , Mohamed Abdulkader Ibrahim , Henry William Beecroft Johnson , Brian Kane , Patrick Kearney , Byung Gyu Kim , Elena S. Koltun , James W. Leahy , Matthew Sangyup Lee , Gary L. Lewis , Lisa E. Meyr , Robin Tammie Noguchi , Michael Pack , Brian Hugh Ridgway , Xian Shi , John Woolfrey , Peiwen Zhou
IPC分类号： A61K31/5377 , C07D413/14 , A61P7/00
CPC分类号： C07D239/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/12 , C07D453/02 , C07D487/04
摘要： This invention relates to certain pyrimidine derivative inhibitors of JAK-2, having Formula (I): wherein D, E, L, Z, R1, R2, R25, and n1 are as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof.
摘要翻译：本发明涉及具有式（I）的JAK-2的某些嘧啶衍生物抑制剂：其中D，E，L，Z，R 1，R 2，R 25和n 1如说明书中所定义，其药学上可接受的盐，药物组合物及其使用方法。

3. 发明申请

US20120238570A1 INHIBITORS OF THE HEDGEHOG PATHWAY 有权
标题翻译： HEDGEHOG PATHWAY的抑制剂
公开(公告)号：US20120238570A1
公开(公告)日：2012-09-20
申请号：US13487559
申请日：2012-06-04
申请人： Suleyman Bahceci , William Bajjalieh , Jeff Chen , Sergey Epshteyn , Timothy Patrick Forsyth , Tai Phat Huynh , Byung Gyu Kim , James W. Leahy , Matthew Sangyup Lee , Gary L. Lewis , Morrison B. Mac , Grace Mann , Charles K. Marlowe , Brian Hugh Ridgway , Joan C. Sangalang , Xian Shi , Craig Stacy Takeuchi , Yong Wang
发明人： Suleyman Bahceci , William Bajjalieh , Jeff Chen , Sergey Epshteyn , Timothy Patrick Forsyth , Tai Phat Huynh , Byung Gyu Kim , James W. Leahy , Matthew Sangyup Lee , Gary L. Lewis , Morrison B. Mac , Grace Mann , Charles K. Marlowe , Brian Hugh Ridgway , Joan C. Sangalang , Xian Shi , Craig Stacy Takeuchi , Yong Wang
IPC分类号： A61K31/517 , A61K31/519 , C07D413/04 , A61P35/00 , C07D239/84 , C07D471/04 , C07D403/12 , A61K31/5377 , C07D239/70
CPC分类号： C07D239/42 , C07D239/70 , C07D239/84 , C07D239/95 , C07D401/04 , C07D403/12
摘要： The present invention is directed to a compound of Formula I or a single isomer thereof; where the compound is optionally as a pharmaceutically acceptable salt, hydrate, solvate or combination thereof, in addition to methods of preparing a Compound of Formula I, and methods of using a Compound of Formula I to treat cancer.
摘要翻译：本发明涉及式I化合物或其单一异构体; 其中除了制备式I化合物的方法之外，化合物任选为其药学上可接受的盐，水合物，溶剂合物或其组合，以及使用式I化合物治疗癌症的方法。

4. 发明授权

US08754092B2 Inhibitors of the hedgehog pathway 有权
公开(公告)号：US08754092B2
公开(公告)日：2014-06-17
申请号：US13487594
申请日：2012-06-04
申请人： Suleyman Bahceci , William Bajjalieh , Jeff Chen , Sergey Epshteyn , Timothy Patrick Forsyth , Tai Phat Huynh , Byung Gyu Kim , James W. Leahy , Matthew Sangyup Lee , Gary L. Lewis , Morrison B. Mac , Grace Mann , Charles K. Marlowe , Brian Hugh Ridgway , Joan C. Sangalang , Xian Shi , Craig Stacy Takeuchi , Yong Wang
发明人： Suleyman Bahceci , William Bajjalieh , Jeff Chen , Sergey Epshteyn , Timothy Patrick Forsyth , Tai Phat Huynh , Byung Gyu Kim , James W. Leahy , Matthew Sangyup Lee , Gary L. Lewis , Morrison B. Mac , Grace Mann , Charles K. Marlowe , Brian Hugh Ridgway , Joan C. Sangalang , Xian Shi , Craig Stacy Takeuchi , Yong Wang
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号： C07D239/42 , C07D239/70 , C07D239/84 , C07D239/95 , C07D401/04 , C07D403/12
摘要： The present invention is directed to a compound of Formula I or a single isomer thereof; where the compound is optionally as a pharmaceutically acceptable salt, hydrate, solvate or combination thereof, in addition to methods of preparing a Compound of Formula I, and methods of using a Compound of Formula I to treat cancer.

5. 发明申请

US20090105211A1 INHIBITORS OF HEDGEHOG PATHWAY 有权
标题翻译： HEDGEHOG PATHWAY的抑制剂
公开(公告)号：US20090105211A1
公开(公告)日：2009-04-23
申请号：US12049225
申请日：2008-03-14
申请人： Suleyman Bahceci , William Bajjalieh , Jeff Chen , Sergey Epshteyn , Timothy Patrick Forsyth , Tai Phat Huynh , Byung Gyu Kim , James W. Leahy , Matthew Sangyup Lee , Gary L. Lewis , Morrison B. Mac , Grace Mann , Charles K. Marlowe , Brian Hugh Ridgway , Joan C. Sangalang , Xian Shi , Craig Stacy Takeuchi , Yong Wang
发明人： Suleyman Bahceci , William Bajjalieh , Jeff Chen , Sergey Epshteyn , Timothy Patrick Forsyth , Tai Phat Huynh , Byung Gyu Kim , James W. Leahy , Matthew Sangyup Lee , Gary L. Lewis , Morrison B. Mac , Grace Mann , Charles K. Marlowe , Brian Hugh Ridgway , Joan C. Sangalang , Xian Shi , Craig Stacy Takeuchi , Yong Wang
IPC分类号： C07D239/84 , C07D413/12 , A61K31/517 , A61K31/5377 , A61K31/496 , A61K31/553 , A61K31/55 , C07D401/12 , C07D403/12 , A61P35/00 , C07D401/14
CPC分类号： C07D239/42 , C07D239/70 , C07D239/84 , C07D239/95 , C07D401/04 , C07D403/12
摘要： The present invention is directed to a compound of Formula I or a single isomer thereof; where the compound is optionally as a pharmaceutically acceptable salt, hydrate, solvate or combination thereof, in addition to methods of preparing a Compound of Formula I, and methods of using a Compound of Formula I to treat cancer.
摘要翻译：本发明涉及式I化合物或其单一异构体; 其中除了制备式I化合物的方法之外，化合物任选为其药学上可接受的盐，水合物，溶剂合物或其组合，以及使用式I化合物治疗癌症的方法。

6. 发明授权

US08222263B2 Inhibitors of hedgehog pathway 有权
标题翻译：刺猬途径的抑制剂
公开(公告)号：US08222263B2
公开(公告)日：2012-07-17
申请号：US12049225
申请日：2008-03-14
申请人： Suleyman Bahceci , William Bajjalieh , Jeff Chen , Sergey Epshteyn , Timothy Patrick Forsyth , Tai Phat Huynh , Byung Gyu Kim , James W. Leahy , Matthew Sangyup Lee , Gary L. Lewis , Morrison B. Mac , Grace Mann , Charles K. Marlowe , Brian Hugh Ridgway , Joan C. Sangalang , Xian Shi , Craig Stacy Takeuchi , Yong Wang
发明人： Suleyman Bahceci , William Bajjalieh , Jeff Chen , Sergey Epshteyn , Timothy Patrick Forsyth , Tai Phat Huynh , Byung Gyu Kim , James W. Leahy , Matthew Sangyup Lee , Gary L. Lewis , Morrison B. Mac , Grace Mann , Charles K. Marlowe , Brian Hugh Ridgway , Joan C. Sangalang , Xian Shi , Craig Stacy Takeuchi , Yong Wang
IPC分类号： A61K31/517 , A01N43/54
CPC分类号： C07D239/42 , C07D239/70 , C07D239/84 , C07D239/95 , C07D401/04 , C07D403/12
摘要： The present invention is directed to a compound of Formula I or a single isomer thereof; where the compound is optionally as a pharmaceutically acceptable salt, hydrate, solvate or combination thereof, in addition to methods of preparing a Compound of Formula I, and methods of using a Compound of Formula I to treat cancer.
摘要翻译：本发明涉及式I化合物或其单一异构体; 其中除了制备式I化合物的方法之外，化合物任选为其药学上可接受的盐，水合物，溶剂合物或其组合，以及使用式I化合物治疗癌症的方法。

7. 发明授权

US08796294B2 Inhibitors of the hedgehog pathway 有权
标题翻译：刺猬途径的抑制剂
公开(公告)号：US08796294B2
公开(公告)日：2014-08-05
申请号：US13487559
申请日：2012-06-04
申请人： Suleyman Bahceci , William Bajjalieh , Jeff Chen , Sergey Epshteyn , Timothy Patrick Forsyth , Tai Phat Huynh , Byung Gyu Kim , James W. Leahy , Matthew Sangyup Lee , Gary L. Lewis , Morrison B. Mac , Grace Mann , Charles K. Marlowe , Brian Hugh Ridgway , Joan C. Sangalang , Xian Shi , Craig Stacy Takeuchi , Yong Wang
发明人： Suleyman Bahceci , William Bajjalieh , Jeff Chen , Sergey Epshteyn , Timothy Patrick Forsyth , Tai Phat Huynh , Byung Gyu Kim , James W. Leahy , Matthew Sangyup Lee , Gary L. Lewis , Morrison B. Mac , Grace Mann , Charles K. Marlowe , Brian Hugh Ridgway , Joan C. Sangalang , Xian Shi , Craig Stacy Takeuchi , Yong Wang
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号： C07D239/42 , C07D239/70 , C07D239/84 , C07D239/95 , C07D401/04 , C07D403/12
摘要： The present invention is directed to a compound of Formula I or a single isomer thereof; where the compound is optionally as a pharmaceutically acceptable salt, hydrate, solvate or combination thereof, in addition to methods of preparing a Compound of Formula I, and methods of using a Compound of Formula I to treat cancer.
摘要翻译：本发明涉及式I化合物或其单一异构体; 其中除了制备式I化合物的方法之外，化合物任选为其药学上可接受的盐，水合物，溶剂合物或其组合，以及使用式I化合物治疗癌症的方法。

8. 发明申请

US20120245139A1 INHIBITORS OF THE HEDGEHOG PATHWAY 有权
公开(公告)号：US20120245139A1
公开(公告)日：2012-09-27
申请号：US13487594
申请日：2012-06-04
申请人： Suleyman Bahceci , William Bajjalieh , Jeff Chen , Sergey Epshteyn , Timothy Patrick Forsyth , Tai Phat Huynh , Byung Gyu Kim , James W. Leahy , Matthew Sangyup Lee , Gary L. Lewis , Morrison B. Mac , Grace Mann , Charles K. Marlowe , Brian Hugh Ridgway , Joan C. Sangalang , Xian Shi , Craig Stacy Takeuchi , Yong Wang
发明人： Suleyman Bahceci , William Bajjalieh , Jeff Chen , Sergey Epshteyn , Timothy Patrick Forsyth , Tai Phat Huynh , Byung Gyu Kim , James W. Leahy , Matthew Sangyup Lee , Gary L. Lewis , Morrison B. Mac , Grace Mann , Charles K. Marlowe , Brian Hugh Ridgway , Joan C. Sangalang , Xian Shi , Craig Stacy Takeuchi , Yong Wang
IPC分类号： A61K31/517 , A61P35/00 , A61K31/55 , A61K31/519 , A61K31/5377 , A61K31/553
CPC分类号： C07D239/42 , C07D239/70 , C07D239/84 , C07D239/95 , C07D401/04 , C07D403/12
摘要： The present invention is directed to a compound of Formula I or a single isomer thereof; where the compound is optionally as a pharmaceutically acceptable salt, hydrate, solvate or combination thereof, in addition to methods of preparing a Compound of Formula I, and methods of using a Compound of Formula I to treat cancer.

9. 发明申请

US20100305093A1 Inhibitors of mTOR and Methods of Making and Using 审中-公开
标题翻译： mTOR的抑制剂和制备和使用方法
公开(公告)号：US20100305093A1
公开(公告)日：2010-12-02
申请号：US12756374
申请日：2010-04-08
申请人： Neel Kumar Anand , Arlyn Arcalas , Charles M. Blazey , Chris A. Buhr , Jonah Cannoy , Sergey Ephsteyn , Henry William Beecroft Johnson , Anagha Joshi , Byung Gyu Kim , James W. Leahy , Matthew Sangyup Lee , Sunghoon Ma , Morrison B. Mac , John M. Nuss , Craig Stacy Takeuchi , Longcheng Wang , Yong Wang
发明人： Neel Kumar Anand , Arlyn Arcalas , Charles M. Blazey , Chris A. Buhr , Jonah Cannoy , Sergey Ephsteyn , Henry William Beecroft Johnson , Anagha Joshi , Byung Gyu Kim , James W. Leahy , Matthew Sangyup Lee , Sunghoon Ma , Morrison B. Mac , John M. Nuss , Craig Stacy Takeuchi , Longcheng Wang , Yong Wang
IPC分类号： A61K31/553 , C07D405/10 , A61P35/00 , A61P37/00 , A61P35/02 , A61P27/00
CPC分类号： C07D267/14 , C07D413/04
摘要： The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐或溶剂合物，以及制备和使用该化合物的方法。

10. 发明授权

US07903736B2 Fast mode-searching apparatus and method for fast motion-prediction 失效
标题翻译：用于快速运动预测的快速模式搜索装置和方法
公开(公告)号：US07903736B2
公开(公告)日：2011-03-08
申请号：US11375629
申请日：2006-03-14
申请人： Byung Gyu Kim , Suk Kyu Song , Seon Tae Kim , Pyeong Soo Mah
发明人： Byung Gyu Kim , Suk Kyu Song , Seon Tae Kim , Pyeong Soo Mah
IPC分类号： H04N7/12
CPC分类号： H04N19/107 , H04N19/109 , H04N19/11 , H04N19/147 , H04N19/176 , H04N19/19 , H04N19/61
摘要： Provided is a fast mode-searching apparatus and method for motion-prediction. The fast mode-searching apparatus includes a probability information obtaining unit, a first inter mode searching unit, a second inter mode searching unit, and a selective intra mode searching unit. The probability information obtaining unit detects whether at least one of a macroblock of a previous frame, a macroblock of a current frame, and adjacent macroblocks corresponds to at least one of P16×16, P16×8, and P8×16. The first inter mode searching unit performs an inter mode search on a block that is not detected by the probability information obtaining unit. The second inter mode searching unit determines whether the macroblock of the current frame corresponds to P16×16 as a result of performing the inter mode search on a block detected by the probability information obtaining unit. The selective intra mode searching unit performs an intra mode search if the macroblock of the current frame corresponds to P16×16.
摘要翻译：提供了一种用于运动预测的快速模式搜索装置和方法。快速模式搜索装置包括概率信息获取单元，第一帧间模式搜索单元，第二帧间模式搜索单元和选择性帧内模式搜索单元。概率信息获取单元检测前一帧的宏块，当前帧的宏块和相邻宏块中的至少一个是否对应于P16×16，P16×8和P8×16中的至少一个。第一帧间模式搜索单元对未由概率信息获取单元检测到的块执行帧间模式搜索。作为对由概率信息获取单元检测到的块执行帧间模式搜索的结果，第二帧间模式搜索单元确定当前帧的宏块是否对应于P16×16。如果当前帧的宏块对应于P16×16，则选择性帧内模式搜索单元执行帧内模式搜索。

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