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1. 发明申请

US20100274022A1 G PROTEIN-COUPLED RECEPTOR INHIBITOR AND PHARMACEUTICAL PRODUCT 审中-公开
标题翻译： G蛋白偶联受体抑制剂和药物产品
公开(公告)号：US20100274022A1
公开(公告)日：2010-10-28
申请号：US12597570
申请日：2008-04-24
申请人： Gozo Tsujimoto , Akira Hirasawa , Naoki Miyata , Takayoshi Suzuki , Yoshiyuki Takahara
发明人： Gozo Tsujimoto , Akira Hirasawa , Naoki Miyata , Takayoshi Suzuki , Yoshiyuki Takahara
IPC分类号： C07D213/55
CPC分类号： C07D213/74 , C07D263/58
摘要： Disclosed are a substance and a pharmaceutical product inhibiting activation of a G protein-coupled receptor. Specifically disclosed is a G protein-coupled receptor inhibitor containing a specific compound represented by the following formula (1):
摘要翻译：公开了抑制G蛋白偶联受体活化的物质和药物。具体公开了含有下式（1）表示的特定化合物的G蛋白偶联受体抑制剂：

2. 发明授权

US08318781B2 G-protein-conjugated receptor agonist 失效
标题翻译： G蛋白偶联受体激动剂
公开(公告)号：US08318781B2
公开(公告)日：2012-11-27
申请号：US12597281
申请日：2008-04-25
申请人： Gozoh Tsujimoto , Akira Hirasawa , Naoki Miyata , Takayoshi Suzuki , Yoshiyuki Takahara , Masaji Ishiguro , Mie Hata
发明人： Gozoh Tsujimoto , Akira Hirasawa , Naoki Miyata , Takayoshi Suzuki , Yoshiyuki Takahara , Masaji Ishiguro , Mie Hata
IPC分类号： A01N43/40 , A01N43/78 , A01N37/12 , A01N37/44 , A01N43/00 , A61K31/445 , A61K31/425 , A61K31/33 , C07D213/72 , C07D213/78 , C07D277/82 , C07C63/00 , C07C65/00
CPC分类号： C07C311/51 , C07C217/18 , C07D213/74 , C07D215/12 , C07D257/04
摘要： Disclosed is a novel aralkyl carboxylic acid compound which has an agonistic activity on GPR-120 and/or GPR-40, particularly GPR-120, and is therefore useful as an appetite regulator, an anti-obesity agent, a therapeutic agent for diabetes, a pancreatic beta differentiating cell growth enhancer, a therapeutic agent for metabolic syndrome, a therapeutic agent for a gastrointestinal disease, a therapeutic agent for a neuropathy, a therapeutic agent for a mental disorder, a therapeutic agent for a pulmonary disease, a therapeutic agent for a pituitary hormone secretion disorder or a lipid flavoring/seasoning agent. The aralkyl carboxylic acid compound is represented by the general formula (I). (I) wherein the ring Q represents a pyridyl or the like; R1 represents a C1-6 alkyl group or the like; R2 represents a hydrogen atom, a C1-4 alkyl group or a C1-4 alkoxy group; m and n independently represent an integer of 1 to 5; and X represents an oxygen atom, a sulfur atom or —NR3— [wherein R3 represents a hydrogen atom or a C1-4 alkyl group].
摘要翻译：公开了一种对GPR-120和/或GPR-40，特别是GPR-120具有激动作用的新的芳烷基羧酸化合物，因此可用作食欲调节剂，抗肥胖剂，糖尿病治疗剂，胰腺β分化细胞生长增强剂，代谢综合征治疗剂，胃肠道疾病治疗剂，神经病变治疗剂，精神障碍治疗剂，肺病治疗剂，治疗剂垂体激素分泌障碍或脂质调味剂/调味剂。芳烷基羧酸化合物由通式（I）表示。（I）其中环Q表示吡啶基等; R1表示C1-6烷基等; R2表示氢原子，C1-4烷基或C1-4烷氧基; m和n独立地表示1〜5的整数。 X表示氧原子，硫原子或-NR 3 - [其中R 3表示氢原子或C 1-4烷基]。

3. 发明申请

US20110184031A1 G-Protein-Conjugated Receptor Agonist 失效
标题翻译： G蛋白共轭受体激动剂
公开(公告)号：US20110184031A1
公开(公告)日：2011-07-28
申请号：US12597281
申请日：2008-04-25
申请人： Gozoh Tsujimoto , Akira Hirasawa , Naoki Miyata , Takayoshi Suzuki , Yoshiyuki Takahara , Masaji Ishiguro , Yoshie Hata
发明人： Gozoh Tsujimoto , Akira Hirasawa , Naoki Miyata , Takayoshi Suzuki , Yoshiyuki Takahara , Masaji Ishiguro , Yoshie Hata
IPC分类号： A61K31/44 , C07D211/72 , C07D277/82 , C07C63/33 , A61K31/428 , A61K31/195 , A61P3/04 , A61P3/10 , A61P35/00 , A61P1/00 , A61P11/00 , A61P25/18
CPC分类号： C07C311/51 , C07C217/18 , C07D213/74 , C07D215/12 , C07D257/04
摘要： Disclosed is a novel aralkyl carboxylic acid compound which has an agonistic activity on GPR-120 and/or GPR-40, particularly GPR-120, and is therefore useful as an appetite regulator, an anti-obesity agent, a therapeutic agent for diabetes, a pancreatic beta differentiating cell growth enhancer, a therapeutic agent for metabolic syndrome, a therapeutic agent for a gastrointestinal disease, a therapeutic agent for a neuropathy, a therapeutic agent for a mental disorder, a therapeutic agent for a pulmonary disease, a therapeutic agent for a pituitary hormone secretion disorder or a lipid flavoring/seasoning agent. The aralkyl carboxylic acid compound is represented by the general formula (I). (I) wherein the ring Q represents a pyridyl or the like; R1 represents a C1-6 alkyl group or the like; R2 represents a hydrogen atom, a C1-4 alkyl group or a C1-4 alkoxy group; m and n independently represent an integer of 1 to 5; and X represents an oxygen atom, a sulfur atom or —NR3— [wherein R3 represents a hydrogen atom or a C1-4 alkyl group].
摘要翻译：公开了一种对GPR-120和/或GPR-40，特别是GPR-120具有激动作用的新的芳烷基羧酸化合物，因此可用作食欲调节剂，抗肥胖剂，糖尿病治疗剂，胰腺β分化细胞生长增强剂，代谢综合征治疗剂，胃肠道疾病治疗剂，神经病变治疗剂，精神障碍治疗剂，肺病治疗剂，治疗剂垂体激素分泌障碍或脂质调味剂/调味剂。芳烷基羧酸化合物由通式（I）表示。（I）其中环Q表示吡啶基等; R1表示C1-6烷基等; R2表示氢原子，C1-4烷基或C1-4烷氧基; m和n独立地表示1〜5的整数。 X表示氧原子，硫原子或-NR 3 - [其中R 3表示氢原子或C 1-4烷基]。

4. 发明申请

US20080004227A1 Pharmaceutical Composition for Lowering Blood Sugar Level 审中-公开
标题翻译：用于降低血糖水平的药物组合物
公开(公告)号：US20080004227A1
公开(公告)日：2008-01-03
申请号：US10591186
申请日：2004-09-03
申请人： Akira Hirasawa , Gozo Tsujimoto
发明人： Akira Hirasawa , Gozo Tsujimoto
IPC分类号： A61K48/00 , A61P43/00 , C07H21/04 , C07K14/00 , C12N15/00 , G01N33/566
CPC分类号： C07K14/605 , A61K38/00 , C07K14/705 , C07K14/723 , G01N33/74 , G01N2333/726 , G01N2500/00 , G01N2800/042
摘要： An object of the invention is to provide a pharmaceutical composition and a kit therefor for the lowering of elevated blood sugar level associated with diabetes and for the prevention of the elevation of blood sugar level. The invention provides a pharmaceutical composition containing a ligand (agonist or antagonist) for a GT01 polypeptide, particularly a free fatty acid as a GT01 polypeptide-specific ligand, or a GT01 gene or the GT01 polypeptide, for treating the hyperglycemia associated with diabetes, and a kit therefor. The invention also provides a ligand specific for the GT01 polypeptide, and a screening method exerting an influence on the binding of the specific ligand to the GT01 polypeptide.
摘要翻译：本发明的目的是提供一种药物组合物及其用于降低与糖尿病相关的升高的血糖水平和用于预防血糖水平升高的试剂盒。本发明提供一种药物组合物，其含有用于治疗与糖尿病相关的高血糖症的GT01多肽，特别是游离脂肪酸作为GT01多肽特异性配体或GT01基因或GT01多肽的配体（激动剂或拮抗剂），以及一个工具包。本发明还提供了对GT01多肽特异性的配体，以及对特异性配体与GT01多肽的结合产生影响的筛选方法。

5. 发明申请

US20080041545A1 Sanitary paper 有权
标题翻译：卫生纸
公开(公告)号：US20080041545A1
公开(公告)日：2008-02-21
申请号：US11973695
申请日：2007-10-09
申请人： Akira Hirasawa
发明人： Akira Hirasawa
IPC分类号： D21H17/00
CPC分类号： D21H21/22 , A47K10/16 , D21H21/14 , D21H21/38 , D21H27/002
摘要： It is intended to provide sanitary paper which is excellent in texture such as moistness and softness and scarcely causes skin irritation or blushing even if it is brought into contact with the skin frequently. Namely, sanitary paper having an oil absorbance specified in JIS P8141 of 7 mm or less and a moisture content of from 9.50 to 15.00% (measured in accordance with JIS P8127 after conditioning in accordance with JIS P8111); carrying a solution, which contains a moistening agent, a softener, an antioxidant and so on, coated in a dose of 46.0 to 160.0 mg/cm3 of the paper base; and having a bending hardness B measured with the use of a pure bending machine of from 0.0040 to 0.0060 g·cm2/cm.
摘要翻译：本发明提供湿润柔软等质地优异的卫生纸，即使经常与皮肤接触，也几乎不引起皮肤刺激或白化。即，JIS P8141中规定的吸油量为7mm以下，湿度为9.50〜15.00％（根据JIS P8127，按照JIS P8111调理后测定）的卫生纸; 携带含有作为纸基的46.0〜160.0mg / cm3的剂量的润湿剂，软化剂，抗氧化剂等的溶液。并且具有使用纯度为0.0040至0.0060克/厘米2厘米的纯弯曲机测得的弯曲硬度B。

6. 发明授权

US5646203A Microcapsule-containing oil-based coating liquid, ink, coated sheet, and method of preparing the same 失效
标题翻译：含微胶囊的油性涂料液，油墨，涂布片及其制备方法
公开(公告)号：US5646203A
公开(公告)日：1997-07-08
申请号：US413690
申请日：1995-03-30
申请人： Kei Etoh , Akira Hirasawa , Hisano Higurashi , Makoto Kawamura
发明人： Kei Etoh , Akira Hirasawa , Hisano Higurashi , Makoto Kawamura
IPC分类号： B41M5/165 , B41M5/28 , C09D11/02 , C08K5/053 , B32B5/18 , C08J9/32 , C08K7/22
CPC分类号： C09D11/02 , B41M5/165 , B41M5/287 , Y10T428/249997 , Y10T428/2984 , Y10T428/2985 , Y10T428/2987 , Y10T428/2989
摘要： A microcapsule-containing oil-based coating liquid wherein the coating liquid comprises a hydrophobic core material-containing microcapsule particles dispersed individually in a state of primary particle in an oil varnish for ink use or a resin for coating use, and a solvent having an affinity for both the varnish or the resin and the surface of the microcapsule wall material in a state of having been attracted with the affinity to both the varnish or the resin and the surface layer of the microcapsule wall material. The preferred solvent is a lower divalent or multivalent alcohol.A preparative method of the foregoing coating liquid by utilizing vacuum distillation is also proposed.A sheet, like a duplicating sheet of paper coated with the foregoing oil-based coating liquid is further provided.According to the present invention, a water-based microcapsules system can be advantageously converted into an oil-based one without coagulating the primary microcapsule particles. There is no hardening and breakdown of the wall material during the process, and the original strength and the flexibility of the microcapsule wall material can be retained intact. Conventional pressure transferring-type printing machine may be employed to printing a selected area of the sheet.
摘要翻译：一种含微胶囊的油性涂布液，其中，所述涂布液包含分散在油墨用油性油墨中的一次粒子状态的分散的含疏水性芯材料的微胶囊粒子，或者涂布用树脂，以及具有亲和性的溶剂对于清漆或树脂以及微胶囊壁材料的表面以与清漆或树脂和微胶囊壁材料的表面层的亲和性吸引的状态。优选的溶剂是低级二价或多价醇。还提出了通过利用真空蒸馏的上述涂布液的制备方法。进一步提供如同涂覆有上述油性涂料的复印纸一样的片材。根据本发明，可以有利地将水性微胶囊体系转化为油性微胶囊体系而不使一级微胶囊颗粒凝结。在该过程中没有壁材料的硬化和分解，并且微胶囊壁材料的原始强度和柔韧性可以保持完整。传统的压力传送型印刷机可用于印刷片材的选定区域。

7. 发明授权

US09338855B2 Lighting apparatus and light emission control method 有权
标题翻译：照明装置和发光控制方法
公开(公告)号：US09338855B2
公开(公告)日：2016-05-10
申请号：US14241847
申请日：2011-08-31
申请人： Akira Hirasawa , Yuhki Terao
发明人： Akira Hirasawa , Yuhki Terao
IPC分类号： H01L27/32 , H05B33/08
CPC分类号： H05B33/0896 , H01L27/3211 , H01L2251/5361 , H05B33/0857
摘要： A lighting apparatus includes: a plurality of light emission units that respectively emit lights in luminescent colors different from each other; and a control unit that controls in luminance the respective light, which are emitted from said plurality of light emission units, for the respective luminescent colors. In response to a control input, said control unit switches between a first light emission mode that it makes said light emission units emit light with luminance set for the respective luminescent colors and a second light emission mode that makes it light emission units corresponding to at least one luminescent color turn off or emit light with luminance lower than the luminance in the first light emission mode.
摘要翻译：照明装置包括：多个发光单元，其分别发射彼此不同的发光颜色的光; 以及控制单元，其控制从所述多个发光单元发射的各个发光颜色的各个亮度的亮度。响应于控制输入，所述控制单元在其使得所述发光单元发光的第一发光模式与针对各个发光颜色设定的亮度之间切换，并且使其使得至少对应于发光单元的第二发光模式一种发光颜色在亮度低于第一发光模式下的亮度时熄灭或发光。

8. 发明申请

US20080252204A1 Organic Electroluminescence Device and Manufacturing Method of the Same 审中-公开
标题翻译：有机电致发光器件及其制造方法
公开(公告)号：US20080252204A1
公开(公告)日：2008-10-16
申请号：US11887411
申请日：2006-03-30
申请人： Ayako Yoshida , Akira Hirasawa , Satoshi Miyaguchi
发明人： Ayako Yoshida , Akira Hirasawa , Satoshi Miyaguchi
IPC分类号： H01L51/54 , B32B38/16
CPC分类号： H05B33/28 , H01L27/3244 , H01L27/3281 , H01L51/5203 , H01L51/5209 , H01L51/5218 , H01L51/5225 , H01L51/5237 , H01L2251/5315 , H05B33/22
摘要： An organic EL device of top emission type having a structure of a transparent conductive layer on a metal reflecting layer, and particularly an organic EL device having a high luminance with the stability capable of maintaining the high luminance over the long period of time is provided. The organic EL device includes a metal electrode layer serving as a metal reflecting film, a transparent conductive layer, an organic functional layer having an organic EL layer, and a transparent electrode layer which are successively laminated on a substrate, and a formation area of the metal electrode layer resides inside a protection area where the transparent conductive layer is formed on the substrate.
摘要翻译：提供了一种在金属反射层上具有透明导电层结构的顶部发射型有机EL器件，特别是具有能够长时间保持高亮度的稳定性的具有高亮度的有机EL器件。有机EL器件包括用作金属反射膜的金属电极层，透明导电层，具有有机EL层的有机功能层和依次层压在基板上的透明电极层，以及形成区域金属电极层位于在基板上形成透明导电层的保护区域的内部。

9. 发明申请

US20080207867A1 Household Thin Paper 有权
标题翻译：家用薄纸
公开(公告)号：US20080207867A1
公开(公告)日：2008-08-28
申请号：US11661008
申请日：2005-08-24
申请人： Tetsuya Uehara , Akira Hirasawa , Hiroshi Ono , Abdolreza Nezamoleslami , Kazuaki Fujimori
发明人： Tetsuya Uehara , Akira Hirasawa , Hiroshi Ono , Abdolreza Nezamoleslami , Kazuaki Fujimori
IPC分类号： C08G67/00
CPC分类号： D21H17/53 , A47K10/16 , D21H21/18 , D21H21/20 , D21H27/002
摘要： The household thin paper comprising a polyester-based compound represented by General Formula (1): wherein R1 is HO— or HO(R2O)a-, R2 is an alkylene group having 2 or 3 carbon atoms, only a single type of R2O or two types of R2O can be attached randomly or as a block, “a” is 1 to 200, all “a”s may be same or different in an identical molecule, b is 2 to 100, and R3 is a hydrogen atom or the like.
摘要翻译：家用薄纸包括由通式（1）表示的聚酯类化合物：其中R 1是HO-或HO（R 2 O）a - ，R“ SUB> 2是具有2或3个碳原子的亚烷基，可以仅连接单一类型的R 2 O或两种类型的R 2 O 2 随机或以块形式，“a”为1至200，所有“a”在相同分子中可以相同或不同，b为2至100，R 3为氢原子或类似。

10. 发明授权

US07300544B2 Sanitary paper 有权
标题翻译：卫生纸
公开(公告)号：US07300544B2
公开(公告)日：2007-11-27
申请号：US10497461
申请日：2002-12-02
申请人： Akira Hirasawa
发明人： Akira Hirasawa
IPC分类号： D21F11/00
CPC分类号： D21H21/22 , A47K10/16 , D21H21/14 , D21H21/38 , D21H27/002
摘要： It is intended to provide sanitary paper which is excellent in texture such as moistness and softness and scarcely causes skin irritation or blushing even if it is brought into contact with the skin frequently. Namely, sanitary paper having an oil absorbance specified in JIS P8141 of 7 mm or less and a moisture content of from 9.50 to 15.00% (measured in accordance with JIS P8127 after conditioning in accordance with JIS P8111); carrying a solution, which contains a moistening agent, a softener, an antioxidant and so on, coated in a dose of 46.0 to 160.0 mg/cm3 of the paper base; and having a bending hardness B measured with the use of a pure bending machine of from 0.0040 to 0.0060 g·cm2/cm.
摘要翻译：其目的在于提供湿度和柔软度等质地优异的卫生纸，即使经常与皮肤接触，也几乎不引起皮肤刺激或白化。即，JIS P8141中规定的吸油量为7mm以下，湿度为9.50〜15.00％（根据JIS P8127，按照JIS P8111调理后测定）的卫生纸; 携带含有作为纸基的46.0〜160.0mg / cm3的剂量的润湿剂，软化剂，抗氧化剂等的溶液。并且具有使用纯度为0.0040至0.0060克/厘米2厘米的纯弯曲机测得的弯曲硬度B。

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