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    • 6. 发明授权
    • Recording sheet and method of recording image using such recording sheet
    • 记录纸和使用这种记录纸记录图像的方法
    • US6068937A
    • 2000-05-30
    • US10556
    • 1998-01-22
    • Takashi NozawaTetsuya AbeNaoki TanakaShuichi Yamaguchi
    • Takashi NozawaTetsuya AbeNaoki TanakaShuichi Yamaguchi
    • B41M5/00B05D5/04B41M5/50B41M5/52C08J7/04D21H27/00
    • B41M5/5254B41M5/52
    • A recording sheet has a base and a receptive layer disposed on at least one surface of the base. The receptive layer contains at least a water-absorbent copolymer and said water-resistant graft copolymer whose main chain is polyvinyl alcohol. The water-absorbent copolymer absorbs inks, and the water-resistant graft copolymer makes the receptive layer resistant to discoloration, blurring, and gloss or luster irregularities. The water-absorbent graft copolymer comprises a graft copolymer produced by grafting a vinyl monomer having a carboxyl group and a monomer having a functional group reacting with the carboxyl group. The water-absorbent copolymer comprises a copolymer of acrylic acid and vinyl alcohol. The water-resistant graft copolymer and the water-absorbent copolymer are added at a ratio in parts by weight ranging from 20/80 to 80/20, preferably, from 30/70 to 70/30.
    • 记录片材具有设置在基底的至少一个表面上的基底和接收层。 接收层至少含有一种吸水共聚物,其主链是聚乙烯醇的所述防水接枝共聚物。 吸水共聚物吸收油墨,并且耐水接枝共聚物使得接受层对变色,模糊和光泽或光泽不均匀性有抵抗力。 吸水性接枝共聚物包括通过接枝具有羧基的乙烯基单体和具有与羧基反应的官能团的单体制备的接枝共聚物。 吸水共聚物包括丙烯酸和乙烯醇的共聚物。 以20/80至80/20,优选为30/70至70/30的重量比加入防水接枝共聚物和吸水共聚物。
    • 7. 发明申请
    • Method of screening remedy for breast cancer
    • 乳腺癌筛查方法
    • US20070148703A1
    • 2007-06-28
    • US10561504
    • 2004-06-18
    • Ikumi TamaiTakashi Nozawa
    • Ikumi TamaiTakashi Nozawa
    • G01N33/567A61K31/56
    • G01N33/743G01N33/57415G01N2500/04
    • The present invention is a method for screening a remedy for breast cancer which does not require uptake into cells unlike aromatase inhibitors, estrogen sulfatase inhibitors, or estrogen competitive inhibitors such as tamoxifen and toremifene, and which shows excellent drug delivery property and extremely rare adverse effect. In the method, a remedy for breast cancer which inhibits transporter function is screened by the process comprising the steps of: culturing a cultured human breast cancer cell line such as MCF-7 cell line or T-47D cell line in the presence of estrone-3-sulfate and a test substance such as bromosulfophtalein; and evaluating whether the uptake of estrone-3-sulfate into cells via estrone-3-sulfate transporters expressed on the cell surface is inhibited, and whether the proliferation of MCF-7 cell line is suppressed.
    • 本发明是一种筛选与芳香酶抑制剂,雌激素硫酸酯酶抑制剂或雌激素竞争性抑制剂如他莫昔芬和托瑞米芬不同的不需要摄入细胞的乳腺癌治疗方法,其显示出优异的药物递送特性和非常罕见的副作用 。 在该方法中,通过包括以下步骤的方法筛选抑制转运蛋白功能的乳腺癌的治疗方法:在雌酮甾酮化合物的存在下培养培养的人乳腺癌细胞系如MCF-7细胞系或T-47D细胞系, 3-硫酸盐和一种测试物质如溴代磺酰氯; 评估在细胞表面表达的雌酮-3-硫酸转运蛋白对雌激素-3-硫酸盐摄取是否受到抑制,MCF-7细胞增殖是否被抑制。