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    • 9. 发明申请
    • RENAL DENERVATION CATHETER AND METHOD USING pH ALTERATION
    • RENAL DENERVATION CATHETER和使用pH改变的方法
    • US20120136349A1
    • 2012-05-31
    • US13295185
    • 2011-11-14
    • Roger Hastings
    • Roger Hastings
    • A61B18/00
    • A61B18/1492A61B2018/00404A61B2018/00434A61B2018/00511A61B2018/00577A61B2018/1472
    • A catheter includes a multiplicity of leads having exposed distal elements defining an anode and a cathode positionable relative to an outer wall of a renal artery. A power supply is configured to couple to the multiplicity of leads. The power supply generates a DC current that flows between the anode and cathode to create an acidic region at the anode sufficient to cause necrosis of perivascular renal nerve tissue in the vicinity of the anode, and to create a basic region at the cathode sufficient to cause necrosis of perivascular renal nerve tissue in the vicinity of the cathode. The catheter may be configured to deliver a biocompatible electrolytic fluid to each of the cathode and anode, thereby increasing an extent of perivascular renal nerve tissue ablation in the vicinity of the cathode and anode.
    • 导管包括多个引线,其具有限定相对于肾动脉外壁定位的阳极和阴极的暴露的远端元件。 电源被配置为耦合到多个引线。 电源产生在阳极和阴极之间流动的直流电流,以在阳极处产生足以引起阳极附近的血管周围肾神经组织坏死的酸性区域,并且在阴极处产生足以引起 阴极附近的血管周围肾神经组织坏死。 导管可以被配置为将生物相容性电解液输送到阴极和阳极中的每一个,从而增加阴极和阳极附近的血管周围肾神经组织消融的程度。