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1. 发明申请

US20140248623A1 System and Method for Determining Copies-per-Unit-Volume Using PCR and Flow Control of Droplets 有权
标题翻译：使用PCR和流量控制液滴确定每单位体积份数的系统和方法
公开(公告)号：US20140248623A1
公开(公告)日：2014-09-04
申请号：US14009304
申请日：2012-03-30
申请人： Gordon A. Janaway , Mark Andersen , Kornelija Zgonc , Michael Pallas , Marcin Sikora , Casey McFarland , Ferrier N. Le , Haopeng Wang , Jian Gong , Gothami Padmabandu
发明人： Gordon A. Janaway , Mark Andersen , Kornelija Zgonc , Michael Pallas , Marcin Sikora , Casey McFarland , Ferrier N. Le , Haopeng Wang , Jian Gong , Gothami Padmabandu
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/686 , C12Q2600/158 , C12Q2600/178 , G01N21/6486 , C12Q2537/16 , C12Q2563/143 , C12Q2563/159 , C12Q2565/626
摘要： Methods and systems for quantification of a target nucleic acid in a sample are provided. The method includes forming a plurality of discrete sample portions. Each of the plurality of discrete sample portions comprising a portion of the sample, and a reaction mixture. The method further includes amplifying the plurality of discrete sample portions to form a plurality of discrete processed sample portions. At least one discrete processed sample portion containing nucleic acid amplification reaction products. Fluorescence signals are detected from the at least one of the plurality of discrete processed sample portions to determine a presence of the at least one target nucleic acid. The method also includes determining the respective volumes of the plurality of the plurality of discrete processed sample portions, and estimating the number of copies-per-unit-volume of the at least one target nucleic acid in the sample. Estimating the number of copies-per-unit-volume is based on the number of discrete processed sample portions determined to contain the at least one target nucleic acid therein.
摘要翻译：提供了用于定量样品中靶核酸的方法和系统。该方法包括形成多个离散的样本部分。多个离散样品部分中的每一个包含样品的一部分和反应混合物。该方法还包括放大多个离散样本部分以形成多个离散处理的样本部分。至少一个离散加工的样品部分含有核酸扩增反应产物。从所述多个离散处理样品部分中的至少一个检测荧光信号以确定所述至少一种靶核酸的存在。该方法还包括确定多个多个离散处理的样本部分的相应体积，以及估计样品中至少一个靶核酸的每单位体积的拷贝数。估计每单位体积的拷贝数是基于确定为在其中含有至少一种靶核酸的离散加工样品部分的数量。

2. 发明授权

US09322055B2 System and method for determining copies-per-unit-volume using PCR and flow control of droplets 有权
标题翻译：使用PCR和液滴的流量控制来确定每单位体积份数的系统和方法
公开(公告)号：US09322055B2
公开(公告)日：2016-04-26
申请号：US14009304
申请日：2012-03-30
申请人： Gordon A. Janaway , Mark Andersen , Kornelija Zgonc , Michael Pallas , Marcin Sikora , Casey McFarland , Ferrier N. Le , Haopeng Wang , Jian Gong , Gothami Padmabandu
发明人： Gordon A. Janaway , Mark Andersen , Kornelija Zgonc , Michael Pallas , Marcin Sikora , Casey McFarland , Ferrier N. Le , Haopeng Wang , Jian Gong , Gothami Padmabandu
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6886 , C12Q1/686 , C12Q2600/158 , C12Q2600/178 , G01N21/6486 , C12Q2537/16 , C12Q2563/143 , C12Q2563/159 , C12Q2565/626
摘要： Methods and systems for quantification of a target nucleic acid in a sample are provided. The method includes forming a plurality of discrete sample portions. Each of the plurality of discrete sample portions comprising a portion of the sample, and a reaction mixture. The method further includes amplifying the plurality of discrete sample portions to form a plurality of discrete processed sample portions. At least one discrete processed sample portion containing nucleic acid amplification reaction products. Fluorescence signals are detected from the at least one of the plurality of discrete processed sample portions to determine a presence of the at least one target nucleic acid. The method also includes determining the respective volumes of the plurality of the plurality of discrete processed sample portions, and estimating the number of copies-per-unit-volume of the at least one target nucleic acid in the sample. Estimating the number of copies-per-unit-volume is based on the number of discrete processed sample portions determined to contain the at least one target nucleic acid therein.
摘要翻译：提供了用于定量样品中靶核酸的方法和系统。该方法包括形成多个离散的样本部分。多个离散样品部分中的每一个包含样品的一部分和反应混合物。该方法还包括放大多个离散样本部分以形成多个离散处理的样本部分。至少一个离散加工的样品部分含有核酸扩增反应产物。从所述多个离散处理样品部分中的至少一个检测荧光信号以确定所述至少一种靶核酸的存在。该方法还包括确定多个多个离散处理的样本部分的相应体积，以及估计样品中至少一个靶核酸的每单位体积的拷贝数。估计每单位体积的拷贝数是基于确定为在其中含有至少一种靶核酸的离散加工样品部分的数量。

3. 外观设计

USD638953S1 Laboratory apparatus 有权
公开(公告)号：USD638953S1
公开(公告)日：2011-05-31
申请号：US29350190
申请日：2009-11-12
申请人： Gil Cavada , Morten Egeberg , Jamie Hogan , Espir Kahatt , Lars Nøkleby , Lars Norderhaug , Tommy Rivrud , Kornelija Zgonc
设计人： Gil Cavada , Morten Egeberg , Jamie Hogan , Espir Kahatt , Lars Nøkleby , Lars Norderhaug , Tommy Rivrud , Kornelija Zgonc

4. 发明授权

US07171586B1 Method and apparatus for identifying mechanisms responsible for “no-trouble-found” (NTF) events in computer systems 有权
标题翻译：用于识别负责计算机系统中“无故障发现”（NTF）事件的机制的方法和装置
公开(公告)号：US07171586B1
公开(公告)日：2007-01-30
申请号：US10739827
申请日：2003-12-17
申请人： Kenny C. Gross , Aleksey M. Urmanov , Kornelija Zgonc
发明人： Kenny C. Gross , Aleksey M. Urmanov , Kornelija Zgonc
IPC分类号： G06F11/00
CPC分类号： G06F11/3414 , G06F11/3452 , G06F11/3466 , G06F2201/86 , G06F2201/87 , G06F2201/885
摘要： One embodiment of the present invention provides a technique for detecting anomalies during operation of a test computer system. Initially, a golden system and the test system are equipped with the same hardware configuration, wherein the golden system has gone through extensive qualification testing and is presumed to be operating correctly. Next, a deterministic load is executed on the golden system, and values for performance parameters from the golden system are monitored while the deterministic load is executing. Similarly, the deterministic load is also executed on the test system, and values for performance parameters from the test system are monitored while the deterministic load is executing. Next, pairwise differences are computed between values for performance parameters received from the test system and values for performance parameters received from the golden system. Finally, change detection techniques are applied to the pairwise differences to detect anomalies during operation of the test system.
摘要翻译：本发明的一个实施例提供一种用于在测试计算机系统的操作期间检测异常的技术。最初，黄金系统和测试系统配备相同的硬件配置，其中黄金系统已经经过广泛的资格测试，并被认为是正常运行。接下来，在黄金系统上执行确定性负载，并且在执行确定性负载时监视来自黄金系统的性能参数的值。类似地，确定性负载也在测试系统上执行，并且在执行确定性负载时监视来自测试系统的性能参数的值。接下来，在从测试系统接收的性能参数的值和从黄金系统接收的性能参数的值之间计算成对差异。最后，将变化检测技术应用于成对差异，以检测测试系统运行过程中的异常情况。

5. 发明申请

US20110287447A1 APPARATUS FOR AND METHOD OF AUTOMATED PROCESSING OF BIOLOGICAL SAMPLES 有权
标题翻译：自动处理生物样品的装置和方法
公开(公告)号：US20110287447A1
公开(公告)日：2011-11-24
申请号：US13147084
申请日：2010-05-11
申请人： Lars Norderhaug , Morten Egeberg , Tommy Rivrud , Lars Nokleby , Espir Kahatt , Jamie Hogan , Kornelija Zgonc , Norman Trolson
发明人： Lars Norderhaug , Morten Egeberg , Tommy Rivrud , Lars Nokleby , Espir Kahatt , Jamie Hogan , Kornelija Zgonc , Norman Trolson
IPC分类号： G01N33/53 , G01N27/72 , C12Q1/37 , G01N33/553 , B01L3/02 , G01N35/00
CPC分类号： B01L3/0275 , B01L3/0293 , B01L3/50273 , B01L3/563 , B01L9/543 , B01L2300/0819 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , G01N35/0098 , G01N2035/00227 , G01N2035/00237 , G01N2035/0436 , G01N2035/0498 , G01N2035/103 , G01N2035/1039 , Y10T436/11
摘要： Provided herein is a bioprocessing device, bioprocessing card, and fluidics cartridge for performing automated bioprocessing of a sample. The bioprocessing card may include a plurality of pipette tips; and at least one pump in fluid communication with the plurality of pipette tips. In some embodiments, the pumps and the pipette tips are in fluid communication through a processing channel which may be a microscale channel. Also provided herein is an automated bioprocessing device comprising: at least one bioprocessing card; at least one fluidic cartridge; and an automated control system configured to control automated bioprocessing of a sample. Further provided herein are methods of use of the device, card, and cartridge.
摘要翻译：本文提供了用于进行样品的自动生物处理的生物处理装置，生物处理卡和流体盒。生物处理卡可以包括多个移液器吸头; 以及与所述多个移液管尖端流体连通的至少一个泵。在一些实施例中，泵和移液管尖端通过可以是微型通道的处理通道流体连通。本文还提供了一种自动生物处理装置，其包括：至少一个生物处理卡; 至少一个流体盒; 以及被配置为控制样品的自动生物处理的自动化控制系统。此处还提供了使用装置，卡和盒的方法。

6. 外观设计

USD646778S1 Magnetic separation apparatus 有权
标题翻译：磁选机
公开(公告)号：USD646778S1
公开(公告)日：2011-10-11
申请号：US29388118
申请日：2011-03-24
申请人： Gaute Brede , Darren Ellis , Tine Hildisch , Jeremy (Jez) Mundy , Lars Nokleby , Erlend Ragnhildstveit , Richard Toften , Kornelija Zgonc
设计人： Gaute Brede , Darren Ellis , Tine Hildisch , Jeremy (Jez) Mundy , Lars Nokleby , Erlend Ragnhildstveit , Richard Toften , Kornelija Zgonc

7. 发明申请

US20100264090A1 MAGNETISING PORTION FOR A MAGNETIC SEPARATION DEVICE 有权
标题翻译：磁选分离装置的磁化部分
公开(公告)号：US20100264090A1
公开(公告)日：2010-10-21
申请号：US12601772
申请日：2008-05-29
申请人： Darren Ellis , Tine Borgen Hildisch , Jez Mundy , Erlend Ragnhildstveit , Richard Johan Toften , Kornelija Zgonc , Malin Karlson , Gaute Brede , Lars Nokleby
发明人： Darren Ellis , Tine Borgen Hildisch , Jez Mundy , Erlend Ragnhildstveit , Richard Johan Toften , Kornelija Zgonc , Malin Karlson , Gaute Brede , Lars Nokleby
IPC分类号： B03C1/031
CPC分类号： B03C1/288 , B01L9/06 , B03C1/0332 , B03C2201/18 , B03C2201/26
摘要： The present disclosure relates to a magnetising portion for providing a high-gradient magnetic field in a magnetic separation device. The magnetising portion comprises at least one magnetic assembly. The at least one magnetic assembly comprises: a plurality of magnets whereby each magnet has a north pole, south pole and a magnet axis extending between the north and south poles, and the plurality of magnets are arranged one above the other in a direction at least substantially perpendicular to the axis of each magnet in such a manner that the north and south poles of adjacent magnets are arranged alternately and a space is provide between adjacent magnets; and at least one non-magnetic spacing means arranged in the space between adjacent magnets. The present disclosure also relates to magnetic separation devices comprising at least one of the said magnetising portions and to a method of isolating magnetically labelled particles using the magnetic separation devices.
摘要翻译：本公开涉及一种用于在磁选机中提供高梯度磁场的磁化部分。磁化部分包括至少一个磁性组件。所述至少一个磁性组件包括：多个磁体，其中每个磁体具有北极，南极和在所述北极和南极之间延伸的磁体轴线，并且所述多个磁体在至少一个方向上彼此上下排列基本上垂直于每个磁体的轴线，使得相邻磁体的北极和南极交替布置并且在相邻磁体之间提供空间; 以及布置在相邻磁体之间的空间中的至少一个非磁性间隔装置。本公开还涉及包括至少一个所述磁化部分的磁分离装置以及使用磁分离装置分离磁性标记颗粒的方法。

8. 外观设计

USD743533S1 Magnetic separation apparatus 有权
标题翻译：磁选机
公开(公告)号：USD743533S1
公开(公告)日：2015-11-17
申请号：US29388210
申请日：2011-03-25
申请人： Gaute Brede , Darren Ellis , Tine Hildisch , Jez Mundy , Lars Nokleby , Erlend Ragnhildstveit , Richard Toften , Kornelija Zgonc
设计人： Gaute Brede , Darren Ellis , Tine Hildisch , Jez Mundy , Lars Nokleby , Erlend Ragnhildstveit , Richard Toften , Kornelija Zgonc

9. 发明授权

US08845984B2 Apparatus for and method of processing biological samples 有权
标题翻译：生物样品处理装置及其处理方法
公开(公告)号：US08845984B2
公开(公告)日：2014-09-30
申请号：US13615500
申请日：2012-09-13
申请人： Joseph Amshey , Daniel Bezdek , Espir Kahatt , Alexander Khorlin , Lance Parsons , Todd Peterson , Timothy Powers , Michael Thacker , Timothy Updyke , Kornelija Zgonc
发明人： Joseph Amshey , Daniel Bezdek , Espir Kahatt , Alexander Khorlin , Lance Parsons , Todd Peterson , Timothy Powers , Michael Thacker , Timothy Updyke , Kornelija Zgonc
IPC分类号： B01L9/00 , B01L3/00 , B01L7/00 , G01N35/00 , G01N35/10
CPC分类号： B01L3/502715 , B01L3/50273 , B01L7/00 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2200/10 , B01L2200/16 , B01L2300/0636 , B01L2300/0681 , B01L2300/0867 , B01L2300/088 , B01L2300/123 , B01L2400/0481 , B01L2400/0487 , B01L2400/0605 , B01L2400/0655 , G01N2035/00306 , G01N2035/1037 , Y10T436/2575
摘要： The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to: immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food safety analysis and automatic bead based separation. In some embodiments, the invention provides automated systems, automated devices, automated cartridges and automated methods of western blot processing. Other embodiments include automated systems, automated devices, automated cartridges and automated methods for separation, preparation and purification of nucleic acids, such as DNA or RNA or fragments thereof, including plasmid DNA, genomic DNA, bacterial DNA, viral DNA and any other DNA, and for automated systems, automated devices, automated cartridges and automated methods for processing, separation and purification of proteins, peptides and the like.
摘要翻译：本发明提供了用于自动化生物处理的系统，装置，装置和方法。适用于本发明的方案和生物处理方法的实例包括但不限于：免疫沉淀，染色质免疫沉淀，重组蛋白分离，核酸分离和分离，蛋白标记，分离和分离，细胞分离和分离，食品安全分析和自动珠基分离。在一些实施方案中，本发明提供自动化系统，自动化装置，自动化盒和western印迹处理的自动化方法。其他实施方案包括自动化系统，自动化装置，自动化盒和用于分离，制备和纯化核酸例如DNA或RNA或其片段的自动化方法，包括质粒DNA，基因组DNA，细菌DNA，病毒DNA和任何其它DNA，以及用于自动化系统，自动化设备，自动化盒和用于处理，分离和纯化蛋白质，肽等的自动化盒和自动化方法。

10. 发明申请

US20130040376A1 APPARATUS FOR AND METHOD OF PROCESSING BIOLOGICAL SAMPLES 有权
标题翻译：装置和处理生物样品的方法
公开(公告)号：US20130040376A1
公开(公告)日：2013-02-14
申请号：US13615500
申请日：2012-09-13
申请人： Joseph AMSHEY , Daniel Bezdek , Espir Kahatt , Alexander Khorlin , Lance Parsons , Todd Peterson , Timothy Powers , Michael Tacher , Timothy Updyke , Kornelija Zgonc
发明人： Joseph AMSHEY , Daniel Bezdek , Espir Kahatt , Alexander Khorlin , Lance Parsons , Todd Peterson , Timothy Powers , Michael Tacher , Timothy Updyke , Kornelija Zgonc
IPC分类号： C12M1/34 , C12M1/04 , C12M1/00
CPC分类号： B01L3/502715 , B01L3/50273 , B01L7/00 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2200/10 , B01L2200/16 , B01L2300/0636 , B01L2300/0681 , B01L2300/0867 , B01L2300/088 , B01L2300/123 , B01L2400/0481 , B01L2400/0487 , B01L2400/0605 , B01L2400/0655 , G01N2035/00306 , G01N2035/1037 , Y10T436/2575
摘要： The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to: immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food safety analysis and automatic bead based separation. In some embodiments, the invention provides automated systems, automated devices, automated cartridges and automated methods of western blot processing. Other embodiments include automated systems, automated devices, automated cartridges and automated methods for separation, preparation and purification of nucleic acids, such as DNA or RNA or fragments thereof, including plasmid DNA, genomic DNA, bacterial DNA, viral DNA and any other DNA, and for automated systems, automated devices, automated cartridges and automated methods for processing, separation and purification of proteins, peptides and the like.
摘要翻译：本发明提供了用于自动化生物处理的系统，装置，装置和方法。适用于本发明的方案和生物处理方法的实例包括但不限于：免疫沉淀，染色质免疫沉淀，重组蛋白分离，核酸分离和分离，蛋白标记，分离和分离，细胞分离和分离，食品安全分析和自动珠基分离。在一些实施方案中，本发明提供自动化系统，自动化装置，自动化盒和western印迹处理的自动化方法。其他实施方案包括自动化系统，自动化装置，自动化盒和用于分离，制备和纯化核酸例如DNA或RNA或其片段的自动化方法，包括质粒DNA，基因组DNA，细菌DNA，病毒DNA和任何其它DNA，以及用于自动化系统，自动化设备，自动化盒和用于处理，分离和纯化蛋白质，肽等的自动化盒和自动化方法。

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