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1. 发明授权

US08273245B2 Microfluidic devices, particularly filtration devices comprising polymeric membranes, and methods for their manufacture and use 有权
标题翻译：微流体装置，特别是包括聚合物膜的过滤装置及其制造和使用的方法
公开(公告)号：US08273245B2
公开(公告)日：2012-09-25
申请号：US13292903
申请日：2011-11-09
申请人： Goran Nadezda Jovanovic , Sundar V. Atre , Brian Kevin Paul , Vincent Thomas Remcho , Chih-hung Chang
发明人： Goran Nadezda Jovanovic , Sundar V. Atre , Brian Kevin Paul , Vincent Thomas Remcho , Chih-hung Chang
IPC分类号： B01D63/00 , B01D61/00 , C02F1/44
CPC分类号： B01D61/18 , A61M1/16 , A61M1/1698 , A61M1/3472 , A61M2205/3334 , A61M2205/3368 , A61M2205/50 , B01D63/08 , B01D63/088 , B01D71/10 , B01D71/68 , B01D2313/21 , B01D2313/38
摘要： The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis. Such devices generally comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters, etc. Examples of devices made according to the present invention included an oxygenator, a dialyzer, microheat exchangers, etc.
摘要翻译：本公开描述了可用于微量流体纯化，分离和合成的装置。这种装置通常包括流体膜，其分离流过与膜操作性相关联的多个微通道的两个或更多个流体。通常，膜是半透膜，例如可以与过滤装置如透析器一起使用。本发明的装置可以与其他微型装置组合以制造系统。例如，这些装置可以与一个或多个微化学微生物，一个或多个微混合器，一个或多个微量加热器等连接。根据本发明制造的装置的实例包括氧合器，透析器，微热交换器等。

2. 发明授权

US08128822B2 MECS dialyzer 有权
标题翻译： MECS透析器
公开(公告)号：US08128822B2
公开(公告)日：2012-03-06
申请号：US11576804
申请日：2005-10-06
申请人： David M. Browning , James R. Curtis , Goran Nadezda Jovanovic , Brian Kevin Paul , Sundar Atre
发明人： David M. Browning , James R. Curtis , Goran Nadezda Jovanovic , Brian Kevin Paul , Sundar Atre
IPC分类号： B01D61/28 , B01D61/24
CPC分类号： A61M1/16 , A61M2205/0244 , B01D61/28 , B01D63/081 , B01D63/082 , B01D2313/08 , B01D2313/14
摘要： The present invention is related to hemodialysis, and more particularly, to a dialyser with improved efficiency of mass transfer across a dialysis membrane utilizing microchannel separation provided in accordance with embodiments of the present invention. In accordance with an embodiment, a dialyzer is provided comprising a plurality of semipermeable membrane sheets and a plurality of flow separators. The membrane sheets and flow are arranged in alternating configuration and coupled into a laminae stack defining a plurality of parallel microchannel layers. Each microchannel layer comprises a plurality of first microchannels and a plurality of second microchannels. The first and second microchannels of each microchannel layer are in fluid communication with each other via one of the plurality of membrane sheets therebetween. The MECS dialyzer is characterized as having a high surface to volume ratio and a high mass transfer coefficient.
摘要翻译：本发明涉及血液透析，更具体地说，涉及使用根据本发明的实施方案提供的利用微通道分离的透析膜的传质效率提高的透析器。根据一个实施例，提供一种透析器，其包括多个半透膜和多个分流器。膜片和流动被布置成交替配置并且耦合到限定多个平行微通道层的薄片叠层中。每个微通道层包括多个第一微通道和多个第二微通道。每个微通道层的第一和第二微通道之间通过多个膜片之一彼此流体连通。 MECS透析器的特征在于具有高的表面与体积比和高的传质系数。

3. 发明申请

US20120223015A1 MECS DIALYZER METHOD 有权
标题翻译： MECS DIALYZER方法
公开(公告)号：US20120223015A1
公开(公告)日：2012-09-06
申请号：US13412597
申请日：2012-03-05
申请人： David M. Browning , James R. Curtis , Goran Nadezda Jovanovic , Brian Kevin Paul , Sundar Atre
发明人： David M. Browning , James R. Curtis , Goran Nadezda Jovanovic , Brian Kevin Paul , Sundar Atre
IPC分类号： B01D61/24
CPC分类号： A61M1/16 , A61M2205/0244 , B01D61/28 , B01D63/081 , B01D63/082 , B01D2313/08 , B01D2313/14
摘要： The present invention provides methods and apparatus for cleansing blood through hemodialysis by the process of diffusion across a membrane into dialysate. This dialyzer also removes solutes from the blood by a process of convection, where fluid and dissolved solutes pass through the membrane out of the blood. In one embodiment in accordance with the present invention, the MECS dialyzer uses a counter-flow between the dialysate and blood through a plurality of microchannels. The dialyzer comprises a plurality of flat semi-permeable membranes interleaved between microchannel sheets to define a plurality of flow channels. The stack of membranes and microchannel sheets are aligned and consolidated to form the MECS dialyzer. The MECS dialyzer acts as a flow manifold with ports and headers to collect the blood and dialysate and direct them to and from the microchannels.
摘要翻译：本发明提供了通过血液透析清洗血液的方法和装置，该方法和装置通过膜扩散到透析液中。这种透析器还可以通过对流过程从血液中除去溶质，其中流体和溶解的溶质通过膜离开血液。在根据本发明的一个实施方案中，MECS透析器通过多个微通道使用透析液和血液之间的逆流。所述透析器包括在微通道片之间交错以形成多个流动通道的多个平坦的半透膜。膜和微通道片的堆叠被对准和固结以形成MECS透析器。 MECS透析器充当具有端口和头部的流量歧管，用于收集血液和透析液，并将其引导到微通道和从微通道引导。

4. 发明申请

US20090165366A1 Microreactor Process for Making Biodiesel 审中-公开
标题翻译：制造生物柴油的微反应器工艺
公开(公告)号：US20090165366A1
公开(公告)日：2009-07-02
申请号：US12227804
申请日：2007-05-30
申请人： Goran Nadezda Jovanovic , Brian Kevin Paul , James Parker , Ahmad Al-Dhubabian
发明人： Goran Nadezda Jovanovic , Brian Kevin Paul , James Parker , Ahmad Al-Dhubabian
IPC分类号： C10L1/19
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00788 , B01J2219/00835 , B01J2219/00837 , B01J2219/00844 , B01J2219/0086 , B01J2219/00891 , B01J2219/00905 , B01J2219/00907 , B01J2219/00959 , B01J2219/00984 , C10G2300/1011 , C10L1/026 , C10L1/19 , C11C3/003 , Y02E50/13 , Y02P30/20
摘要： Embodiments of a method for using a microreactor to produce biodiesel. For example, the method may comprise flowing a first fluid comprising an alcohol and a second fluid comprising an oil to the microreactor. Alcohols typically, but not necessarily, are lower aliphatic alcohols, including methanol, ethanol, amyl alcohol or combinations thereof. Biodiesel production can be under supercritical conditions, where such conditions typically are determined relative to the alcohol component. Suitable sources of oil products include soy, inedible tallow and grease, corn, edible tallow and lard, cotton, rapeseed, sunflower, canola, peanut, safflower, and combinations thereof. Catalysts can be used to facilitate biodiesel production, such as metal oxides, metal hydroxides, metal carbonates, alcoholic metal carbonates, alkoxides, mineral acids and enzymes. Oil conversion to biodiesel typically increases with increasing mean microreactor residence time. Certain embodiments of the present invention can include blending biodiesel produced by the method with petroleum-based products.
摘要翻译：使用微反应器生产生物柴油的方法的实施方案。例如，该方法可以包括将包含醇的第一流体和包含油的第二流体流动到微反应器。醇通常但不一定是低级脂族醇，包括甲醇，乙醇，戊醇或其组合。生物柴油的生产可以在超临界条件下，其中通常相对于醇组分确定这些条件。合适的石油产品来源包括大豆，不可食用的牛油和油脂，玉米，食用油脂和猪油，棉花，油菜籽，向日葵，卡诺拉油菜，花生，红花及其组合。催化剂可用于促进生物柴油生产，例如金属氧化物，金属氢氧化物，金属碳酸盐，醇金属碳酸盐，醇盐，无机酸和酶。石油转化为生物柴油通常随着平均微反应器停留时间的增加而增加。本发明的某些实施方案可以包括将通过该方法生产的生物柴油与石油基产物混合。

5. 发明授权

US08419945B2 MECS dialyzer method 有权
标题翻译： MECS透析器方法
公开(公告)号：US08419945B2
公开(公告)日：2013-04-16
申请号：US13412597
申请日：2012-03-05
申请人： David M. Browning , James R. Curtis , Goran Nadezda Jovanovic , Brian Kevin Paul , Sundar Atre
发明人： David M. Browning , James R. Curtis , Goran Nadezda Jovanovic , Brian Kevin Paul , Sundar Atre
IPC分类号： B01D61/28 , B01D61/24
CPC分类号： A61M1/16 , A61M2205/0244 , B01D61/28 , B01D63/081 , B01D63/082 , B01D2313/08 , B01D2313/14
摘要： The present invention provides methods and apparatus for cleansing blood through hemodialysis by the process of diffusion across a membrane into dialysate. This dialyzer also removes solutes from the blood by a process of convection, where fluid and dissolved solutes pass through the membrane out of the blood. In one embodiment in accordance with the present invention, the MECS dialyzer uses a counter-flow between the dialysate and blood through a plurality of microchannels. The dialyzer comprises a plurality of flat semi-permeable membranes interleaved between microchannel sheets to define a plurality of flow channels. The stack of membranes and microchannel sheets are aligned and consolidated to form the MECS dialyzer. The MECS dialyzer acts as a flow manifold with ports and headers to collect the blood and dialysate and direct them to and from the microchannels.
摘要翻译：本发明提供了通过血液透析清洗血液的方法和装置，该方法和装置通过膜扩散到透析液中。这种透析器还可以通过对流过程从血液中除去溶质，其中流体和溶解的溶质通过膜离开血液。在根据本发明的一个实施方案中，MECS透析器通过多个微通道使用透析液和血液之间的逆流。所述透析器包括在微通道片之间交错以形成多个流动通道的多个平坦的半透膜。膜和微通道片的堆叠被对准和固结以形成MECS透析器。 MECS透析器充当具有端口和头部的流量歧管，用于收集血液和透析液，并将其引导到微通道和从微通道引导。

6. 发明申请

US20180290123A1 CORONA DISCHARGE REACTOR AND METHOD FOR USING 审中-公开
公开(公告)号：US20180290123A1
公开(公告)日：2018-10-11
申请号：US15948776
申请日：2018-04-09
申请人： Goran Nadezda Jovanovic , Alexandre F.T. Yokochi , Yu Miao , Justin Pommerenck , Yousef Alanazi , Peter Kreider
发明人： Goran Nadezda Jovanovic , Alexandre F.T. Yokochi , Yu Miao , Justin Pommerenck , Yousef Alanazi , Peter Kreider
IPC分类号： B01J19/00 , C07C2/80
摘要： Disclosed microreactors operate in an electrical discharge mode, such as a pulse mode, an arc mode or a corona discharge mode, and most preferably in a corona discharge mode. A microreactor may comprise multiple, simultaneously operating corona discharges. The microreactor typically has at least one feature measured on a millimeter scale. Certain disclosed microreactors comprised multiple reactor plates in a stack. Each plate comprised plural corona discharge electrodes positioned in series along each of plural corresponding microchannels. A method for using disclosed microreactors and systems comprising disclosed microreactors, such as for chemical transformations, fluid purifications, or both, also is disclosed.

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