专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20120128764A1 CONTROLLED-RELEASE COMPOSITIONS COMPRISING A PROTON PUMP INHIBITOR 审中-公开
标题翻译：控制释放包含原子泵抑制剂的组合物
公开(公告)号：US20120128764A1
公开(公告)日：2012-05-24
申请号：US13202959
申请日：2010-02-23
申请人： Gopi Venkatesh , Michael Gosselin , Jin-Wang Lai , Christian Stollberg , Flavio Fabiani
发明人： Gopi Venkatesh , Michael Gosselin , Jin-Wang Lai , Christian Stollberg , Flavio Fabiani
IPC分类号： A61K9/48 , B05D5/00 , A61K31/4439 , A61K9/20 , A61K9/16
CPC分类号： A61K9/5078 , A61K9/2081
摘要： The present invention relates to pharmaceutical compositions, and methods of preparing such compositions, comprising one or more populations of controlled-release particles comprising one or more proton pump inhibitors. The present invention also relates to pharmaceutical dosage forms, including orally disintegrating tablets, tablets, capsules, and methods for their preparation.
摘要翻译：本发明涉及药物组合物和制备这种组合物的方法，其包含一种或多种包含一种或多种质子泵抑制剂的控制释放颗粒群。本发明还涉及药物剂型，包括口服崩解片剂，片剂，胶囊剂及其制备方法。

2. 发明申请

US20110003006A1 Orally Disintegrating Tablet Compositions Comprising Combinations of Non-Opioid and Opioid Analgesics 有权
标题翻译：口服崩解片组合物包含非阿片类药物和阿片类止痛药的组合
公开(公告)号：US20110003006A1
公开(公告)日：2011-01-06
申请号：US12772776
申请日：2010-05-03
申请人： Gopi Venkatesh , Michael Gosselin , James Clevenger , Jin-Wang Lai
发明人： Gopi Venkatesh , Michael Gosselin , James Clevenger , Jin-Wang Lai
IPC分类号： A61K9/14 , A61K31/485 , A61P29/00 , A61P25/04 , A61K9/28
CPC分类号： A61K9/5047 , A61K9/2081 , A61K9/5073 , A61K9/5078 , A61K9/5084 , A61K31/00 , A61K31/192 , A61K31/196 , A61K31/40 , A61K31/405 , A61K31/407 , A61K31/415 , A61K31/4415 , A61K31/4468 , A61K31/485 , A61K31/5415 , A61K31/60 , A61K45/06 , A61K2300/00
摘要： The present invention is directed to pharmaceutical compositions comprising a plurality of taste-masked non-opioid analgesic/opioid analgesic drug-containing microparticles, dosage forms comprising such pharmaceutical compositions (such as an orally disintegrating tablet), and methods of making the pharmaceutical compositions and dosage forms of the present invention. Dosage forms comprising the pharmaceutical compositions of the present invention are improved homogeneous blends of non-opioid and opioid analgesics which provide for more convenient and palatable administration of drug combinations, for example for treating pain.
摘要翻译：本发明涉及包含多种掩味的非阿片类镇痛/阿片类止痛药物的微粒的药物组合物，包含这种药物组合物的剂型（例如口腔崩解片），以及制备该药物组合物的方法和本发明的剂型。包含本发明的药物组合物的剂型是非阿片类和阿片类止痛剂的改进的均匀共混物，其提供药物组合的更方便和可口的给药，例如用于治疗疼痛。

3. 发明授权

US09572781B2 Orally disintegrating tablet compositions comprising combinations of non-opioid and opioid analgesics 有权
标题翻译：口服崩解片剂组合物，其包含非阿片样物质和阿片样镇痛药的组合
公开(公告)号：US09572781B2
公开(公告)日：2017-02-21
申请号：US12772776
申请日：2010-05-03
申请人： Gopi Venkatesh , Michael Gosselin , James Clevenger , Jin-Wang Lai
发明人： Gopi Venkatesh , Michael Gosselin , James Clevenger , Jin-Wang Lai
IPC分类号： A61K9/16 , A61K9/50
CPC分类号： A61K9/5047 , A61K9/2081 , A61K9/5073 , A61K9/5078 , A61K9/5084 , A61K31/00 , A61K31/192 , A61K31/196 , A61K31/40 , A61K31/405 , A61K31/407 , A61K31/415 , A61K31/4415 , A61K31/4468 , A61K31/485 , A61K31/5415 , A61K31/60 , A61K45/06 , A61K2300/00
摘要： The present invention is directed to pharmaceutical compositions comprising a plurality of taste-masked non-opioid analgesic/opioid analgesic drug-containing microparticles, dosage forms comprising such pharmaceutical compositions (such as an orally disintegrating tablet), and methods of making the pharmaceutical compositions and dosage forms of the present invention. Dosage forms comprising the pharmaceutical compositions of the present invention are improved homogeneous blends of non-opioid and opioid analgesics which provide for more convenient and palatable administration of drug combinations, for example for treating pain.
摘要翻译：本发明涉及包含多种掩味的非阿片类镇痛/阿片类止痛药物的微粒的药物组合物，包含这种药物组合物的剂型（例如口腔崩解片），以及制备该药物组合物的方法和本发明的剂型。包含本发明的药物组合物的剂型是非阿片类和阿片类止痛剂的改进的均匀共混物，其提供药物组合的更方便和可口的给药，例如用于治疗疼痛。

4. 发明申请

US20100330150A1 Orally Disintegrating Tablet Compositions Comprising Combinations of High and Low-Dose Drugs 审中-公开
标题翻译：口服崩解片组合物组合高剂量和低剂量药物
公开(公告)号：US20100330150A1
公开(公告)日：2010-12-30
申请号：US12772770
申请日：2010-05-03
申请人： Gopi Venkatesh , Michael Gosselin , James Clevenger , Jin-Wang Lai
发明人： Gopi Venkatesh , Michael Gosselin , James Clevenger , Jin-Wang Lai
IPC分类号： A61K9/62 , A61K9/50 , A61K9/56 , A61K9/58 , A61K31/445 , A61K31/4355 , A61K31/5415 , A61K31/4965 , A61K31/4453 , A61K31/4436 , A61K31/165 , A61K31/427 , A61K31/505 , A61K31/495 , A61K31/4545 , A61K31/137 , B05D3/00 , A61P3/10 , A61P9/10 , A61P11/00
CPC分类号： A61K9/5047 , A61K9/2081 , A61K9/5073 , A61K9/5078 , A61K9/5084 , A61K31/00 , A61K31/192 , A61K31/196 , A61K31/40 , A61K31/405 , A61K31/407 , A61K31/415 , A61K31/4415 , A61K31/4468 , A61K31/485 , A61K31/5415 , A61K31/60 , A61K45/06 , A61K2300/00
摘要： The present invention is directed to pharmaceutical compositions comprising a plurality of taste-masked high-dose/low-dose drug-containing microparticles, dosage forms comprising such pharmaceutical compositions (such as an orally disintegrating tablet), and methods of making the pharmaceutical compositions and dosage forms of the present invention. Dosage forms comprising the pharmaceutical compositions of the present invention are improved homogeneous blends of high-dose and low-dose drugs which provide for more convenient and palatable administration of drug combinations, for example for treating pain, hyperglycemia, cardiovascular disease, and allergies.
摘要翻译：本发明涉及包含多个掩味的高剂量/低剂量药物的微粒的药物组合物，包含这种药物组合物（例如口腔崩解片剂）的剂型，以及制备该药物组合物的方法和本发明的剂型。包含本发明的药物组合物的剂型是改善的大剂量和低剂量药物的均匀共混物，其提供药物组合的更方便和可口的给药，例如用于治疗疼痛，高血糖症，心血管疾病和过敏症。

5. 发明申请

US20110311626A1 CONTROLLED RELEASE COMPOSITIONS COMPRISING ANTI-CHOLINERGIC DRUGS 审中-公开
标题翻译：包含抗胆碱药物的受控释放组合物
公开(公告)号：US20110311626A1
公开(公告)日：2011-12-22
申请号：US13202957
申请日：2010-02-23
申请人： Gopi Venkatesh , Vincent Parrino , Paolo Gatti , Flavio Fabiani
发明人： Gopi Venkatesh , Vincent Parrino , Paolo Gatti , Flavio Fabiani
IPC分类号： A61K9/22 , A61K31/215 , A61P1/00 , A61P25/04 , A61P25/08 , A61P3/10 , A61P31/00 , A61P25/16 , A61P29/00 , A61P9/00 , A61P25/00 , A61P1/08 , A61P25/18 , A61P11/06 , A61P21/02 , A61K9/14
CPC分类号： A61K9/5078 , A61K9/0056 , A61K9/1676 , A61K9/2081 , A61K9/5042 , A61K9/5047
摘要： The present invention provides compositions comprising dicyclomine, or salts, and/or solvates and methods of making and using the compositions to treat intestinal hypermotility or Irritable Bowel Syndrome (IBS). The present invention also provides once-a-day orally disintegrating dosage forms comprising compositions of the present invention.
摘要翻译：本发明提供包含双环胺或其盐和/或溶剂合物的组合物以及制备和使用该组合物以治疗肠蠕动性或肠易激综合征（IBS）的方法。本发明还提供了包含本发明组合物的每日一次的口腔崩解剂型。

6. 发明授权

US08133506B2 Drug delivery systems comprising weakly basic drugs and organic acids 有权
标题翻译：包括弱碱性药物和有机酸的药物递送系统
公开(公告)号：US08133506B2
公开(公告)日：2012-03-13
申请号：US12209285
申请日：2008-09-12
申请人： Gopi Venkatesh , Jin-Wang Lai , Nehal H. Vyas , Vivek Purohit
发明人： Gopi Venkatesh , Jin-Wang Lai , Nehal H. Vyas , Vivek Purohit
IPC分类号： A61K9/48 , A61K9/16 , A61K31/4178
CPC分类号： A61K31/4178 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/1676 , A61K9/2081 , A61K9/48 , A61K9/5042 , A61K9/5078 , A61K9/5084
摘要： The present invention is directed to pharmaceutical compositions, and methods of making such compositions, wherein the compositions comprise a plurality of TPR and RR particles, wherein: the TPR particles each comprise a core coated with a TPR layer; the core comprises a weakly basic, poorly soluble drug and a pharmaceutically acceptable organic acid separated from each other by an SR layer; the RR particles each comprise the weakly basic, poorly soluble drug, and release at least about 80 wt. % of the weakly basic, poorly soluble drug in about 5 minutes when dissolution tested using United States Pharmacopoeia (USP) dissolution methodology (Apparatus 2—paddles@50 RPM and a two-stage dissolution medium at 37° C. (first 2 hours in 0.1N HCl followed by testing in a buffer at pH 6.8).
摘要翻译：本发明涉及药物组合物和制备这种组合物的方法，其中组合物包含多个TPR和RR颗粒，其中：TPR颗粒各自包含涂覆有TPR层的芯; 核心包括通过SR层彼此分离的弱碱性，难溶性药物和药学上可接受的有机酸; RR颗粒各自包含弱碱性，难溶性的药物，并且释放至少约80wt。当使用美国药典（USP）溶出方法进行溶出测试时，约5分钟内弱碱性，溶解性差的药物的百分比（装置2-桨叶，50RPM，两步溶解培养基在37℃（前2小时 0.1N HCl，然后在pH 6.8的缓冲液中测试）。

7. 发明申请

US20090232885A1 Drug Delivery Systems Comprising Weakly Basic Drugs and Organic Acids 有权
标题翻译：药物递送系统包含弱碱性药物和有机酸
公开(公告)号：US20090232885A1
公开(公告)日：2009-09-17
申请号：US12209285
申请日：2008-09-12
申请人： Gopi Venkatesh , Jin-Wang Lai , Nehal H. Vyas , Vivek Purohit
发明人： Gopi Venkatesh , Jin-Wang Lai , Nehal H. Vyas , Vivek Purohit
IPC分类号： A61K9/48 , A61K9/16 , A61K31/4178
CPC分类号： A61K31/4178 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/1676 , A61K9/2081 , A61K9/48 , A61K9/5042 , A61K9/5078 , A61K9/5084
摘要： The present invention is directed to pharmaceutical compositions, and methods of making such compositions, wherein the compositions comprise a plurality of TPR and RR particles, wherein: the TPR particles each comprise a core coated with a TPR layer; the core comprises a weakly basic, poorly soluble drug and a pharmaceutically acceptable organic acid separated from each other by an SR layer; the RR particles each comprise the weakly basic, poorly soluble drug, and release at least about 80 wt.% of the weakly basic, poorly soluble drug in about 5 minutes when dissolution tested using United States Pharmacopoeia (USP) dissolution methodology (Apparatus 2—paddles@ 50 RPM and a two-stage dissolution medium at 37° C., (first 2 hours in 0.1N HCl followed by testing in a buffer at pH 6.8).
摘要翻译：本发明涉及药物组合物和制备这种组合物的方法，其中组合物包含多个TPR和RR颗粒，其中：TPR颗粒各自包含涂覆有TPR层的芯; 核心包括通过SR层彼此分离的弱碱性，难溶性药物和药学上可接受的有机酸; RR颗粒各自包含弱碱性，难溶性药物，并且在使用美国药典（USP）溶出方法进行溶出测试时，在约5分钟内释放至少约80重量％的弱碱性，难溶性药物（装置2- 桨叶（50RPM）和两步溶解培养基（37℃）（前0.1小时，0.1N盐酸处理，然后在pH6.8的缓冲液中测试）。

8. 发明申请

US20080069878A1 Drug Delivery Systems Comprising Solid Solutions of Weakly Basic Drugs 审中-公开
标题翻译：药物输送系统包含弱碱性药物的固体溶液
公开(公告)号：US20080069878A1
公开(公告)日：2008-03-20
申请号：US11847219
申请日：2007-08-29
申请人： Gopi Venkatesh , Luigi Boltri , Italo Colombo , Jin-Wang Lai , Flavio Flabiani , Luigi Mapelli
发明人： Gopi Venkatesh , Luigi Boltri , Italo Colombo , Jin-Wang Lai , Flavio Flabiani , Luigi Mapelli
IPC分类号： A61K9/22 , A61K31/4406 , A61K31/4422 , A61K31/454 , A61K31/5513 , A61K47/30 , A61K47/38 , A61K9/14
CPC分类号： A61K9/5026 , A61K9/5005 , A61K9/5042 , A61K9/5047 , A61K9/5078 , A61K9/5089 , A61K31/4406 , A61K31/4422 , A61K31/454 , A61K31/5513
摘要： The present invention is directed to pharmaceutical compositions and dosage forms comprising TPR beads, wherein said TPR beads comprise a solid dispersion of at least one active pharmaceutical ingredient in at least one solubility-enhancing polymer, and a TPR coating comprising a water insoluble polymer and an enteric polymer, wherein the active pharmaceutical ingredient comprises a weakly basic active pharmaceutical ingredient having a solubility of not more than 100 μg/mL at pH 6.8.
摘要翻译：本发明涉及包含TPR珠粒的药物组合物和剂型，其中所述TPR珠包含至少一种活性药物成分在至少一种溶解度增强聚合物中的固体分散体，和包含水不溶性聚合物和肠溶性聚合物，其中活性药物成分包含在pH6.8下溶解度不超过100μg/ mL的弱碱性活性药物成分。

9. 发明申请

US20070190145A1 DRUG DELIVERY SYSTEMS COMPRISING WEAKLY BASIC SELECTIVE SEROTONIN 5-HT3 BLOCKING AGENT AND ORGANIC ACIDS 审中-公开
标题翻译：包含弱碱性选择性丝氨酸5-HT3阻断剂和有机酸的药物递送系统
公开(公告)号：US20070190145A1
公开(公告)日：2007-08-16
申请号：US11668167
申请日：2007-01-29
申请人： Gopi Venkatesh , Jin-Wang Lai , Nehal Vyas
发明人： Gopi Venkatesh , Jin-Wang Lai , Nehal Vyas
IPC分类号： A61K9/26
CPC分类号： A61K9/2077 , A61K9/0056 , A61K9/5073 , A61K9/5084 , A61K31/4178
摘要： A pharmaceutical dosage form such as a capsule, a conventional or orally disintegrating tablet capable of delivering a weakly basic, nitrogen (N)-containing selective serotonin 5-HT3 blocking agent having a pKa in the range of from about 5 to 14 and a solubility of not more than about 200 μg/mL at pH 6.8 into the body in a sustained-released fashion, suitable for a once-daily dosing regimen, comprises at least one organic acid, which solubilizes said weakly basic selective serotonin 5-HT3 blocking agent prior to releasing it into the hostile intestinal environment wherein the blocking agent is practically insoluble. The unit dosage form may be composed of a multitude of multicoated particulates (i.e., immediate-release beads, sustained-release beads and/or one or more timed, pulsatile-release bead populations) and is designed in such a way that the weakly basic blocking agent and the organic acid do not come into close contact during processing and/or storage thereby avoiding in-situ formation of acid addition compounds while ensuring that the acid is not depleted prior to completion of the drug release.
摘要翻译：一种药物剂型，例如胶囊，常规或口腔崩解片剂，其能够递送具有pKa范围的弱碱性，含氮（N）的选择性5-羟色胺5-HT 3阻断剂约5至14，并且以持续释放的方式在pH 6.8下不超过约200mug / mL的溶解度适合于每日一次的给药方案，其包含至少一种有机酸，其溶解所述弱化碱性选择性5-羟色胺5-HT 3封闭剂，然后将其释放到敌对的肠道环境中，其中封闭剂几乎不溶。单位剂量形式可以由多种多重微粒（即立即释放珠，缓释珠和/或一个或多个定时，脉冲释放珠群）组成，并且以这样的方式设计：弱碱性封闭剂和有机酸在加工和/或储存期间不会紧密接触，从而避免了原位形成酸加成化合物，同时确保在药物释放完成之前酸不被耗尽。

10. 发明申请

US20060105039A1 Taste-masked pharmaceutical compositions with gastrosoluble pore-formers 审中-公开
标题翻译：口感掩蔽的药物组合物与胃溶性成孔剂
公开(公告)号：US20060105039A1
公开(公告)日：2006-05-18
申请号：US11256653
申请日：2005-10-21
申请人： Jin-Wang Lai , Gopi Venkatesh , Ken Qian
发明人： Jin-Wang Lai , Gopi Venkatesh , Ken Qian
IPC分类号： A61K9/26
摘要： There is provided a method for preparing an orally disintegrating tablet (ODT) composition comprising microparticles of one or more taste-masked active pharmaceutical ingredient(s), rapidly-dispersing microgranules, and other optional, pharmaceutically acceptable excipients wherein the ODT disintegrates on contact with saliva in the buccal cavity forming a smooth, easy-to-swallow suspension. Furthermore, the microparticles (crystals, granules, beads or pellets containing the active), coated with a taste-masking membrane comprising a water-insoluble polymer and one or more gastrosoluble inorganic or organic pore-formers (practically insoluble in water and saliva, but soluble in an acidic buffer), exhibit acceptable taste-masking when placed in the oral cavity and provide rapid, substantially-complete release of the dose on entry into the stomach.
摘要翻译：提供了一种制备包含一种或多种掩味活性药物成分，快速分散微粒和其它任选的药学上可接受的赋形剂的微粒的口腔崩解片（ODT）组合物的方法，其中ODT与颊腔中的唾液形成平滑，易于吞咽的悬浮液。此外，涂覆有包含水不溶性聚合物和一种或多种胃溶性无机或有机成孔剂（实际上不溶于水和唾液，但几乎不溶于水和唾液，但是不溶于水）的掩味膜的微粒（晶体，颗粒，含有活性物质的颗粒或颗粒）可溶于酸性缓冲液），当放置在口腔中时显示出可接受的味道掩蔽，并且在进入胃中提供快速，基本上完全释放的剂量。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式