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1. 发明申请

US20090169620A1 ORALLY DISINTEGRATING TABLET COMPOSITIONS OF TEMAZEPAM 审中-公开
标题翻译：口服组胺消炎药组合物
公开(公告)号：US20090169620A1
公开(公告)日：2009-07-02
申请号：US12339908
申请日：2008-12-19
申请人： Gopi M. VENKATESH , James M. Clevenger , Jin-Wang Lai , Vivek Purohit
发明人： Gopi M. VENKATESH , James M. Clevenger , Jin-Wang Lai , Vivek Purohit
IPC分类号： A61K9/20 , A61K31/5513
CPC分类号： A61K31/5513 , A61K9/0056 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/2018 , A61K9/2027 , A61K9/205 , A61K9/2077 , A61K9/5047
摘要： The compositions of the present invention are orally disintegrating tablet compositions comprising a therapeutically effective amount of at least one drug such as temazepam, 0.5-3% of an ODT binder polymer, a sugar alcohol and/or saccharide, and a disintegrant.
摘要翻译：本发明的组合物是包含治疗有效量的至少一种药物如替马西泮，0.5-3％的ODT粘合剂聚合物，糖醇和/或糖和崩解剂的口腔崩解片组合物。

2. 发明申请

US20120282335A1 RAPIDLY DISPERSING GRANULES, ORALLY DISINTEGRATING TABLETS AND METHODS 审中-公开
标题翻译：快速分散颗粒，ORALLY DISPATTING DISPATTING AND METHODS
公开(公告)号：US20120282335A1
公开(公告)日：2012-11-08
申请号：US13310632
申请日：2011-12-02
申请人： Gopi M. Venkatesh , Vijaya Swaminathan , Jin-Wang Lai , James M. Clevenger
发明人： Gopi M. Venkatesh , Vijaya Swaminathan , Jin-Wang Lai , James M. Clevenger
IPC分类号： A61K9/14 , A61K31/445 , A61K31/485 , A61K9/20 , A61K31/167
摘要： This invention relates to rapidly dispersing microgranules comprising at least one sugar alcohol or saccharide, at least one super disintegrant, and a pharmaceutically acceptable additive with multi-functionality (e.g., starch acting as a binder, disintegrant, diluent/filler, glidant, etc) at a low level, which can be formed by not only eliminating a wet milling step but also avoiding an extensive dry milling step. Furthermore, such rapidly dispersing microgranules could also comprise a pharmaceutically active agent thereby providing for a pharmaceutical composition, or the rapidly dispersing microgranules thus produced are suitable for blending with a pharmaceutically active agent that is optionally taste-masked and/or controlled release coated microparticles to also provide for a pharmaceutical composition and the invention is also directed to a method for manufacturing such rapidly dispersing microgranules in a high useable yield, as well as orally disintegrating tablets comprising such rapidly dispersing microgranules. The rapidly dispersing microgranules are also free flowing.
摘要翻译：本发明涉及快速分散包含至少一种糖醇或糖，至少一种超级崩解剂和具有多官能度的药学上可接受的添加剂（例如，作为粘合剂的淀粉，崩解剂，稀释剂/填充剂，助流剂等）的微粒体，在低水平，其可以通过不仅消除湿磨步骤而且可以避免广泛的干磨步骤形成。此外，这种快速分散的微粒还可以包含药物活性剂，从而提供药物组合物，或由此制备的快速分散的微粒适合于与任选地掩蔽和/或控释的微粒的药物活性剂混合，还提供药物组合物，并且本发明还涉及以高可用产率制造这种快速分散的微粒的方法，以及包含这种快速分散的微粒的口腔崩解片。快速分散的微粒也是自由流动的。

3. 发明申请

US20110129530A1 Compressible-Coated Pharmaceutical Compositions and Tablets and Methods of Manufacture 审中-公开
标题翻译：可压缩涂层药物组合物和片剂及其制造方法
公开(公告)号：US20110129530A1
公开(公告)日：2011-06-02
申请号：US12956543
申请日：2010-11-30
申请人： Gopi M. Venkatesh , Jin-Wang Lai , James M. Clevenger , Craig Kramer
发明人： Gopi M. Venkatesh , Jin-Wang Lai , James M. Clevenger , Craig Kramer
IPC分类号： A61K9/26 , A61K9/50 , A61K9/28 , A61K31/485 , A61K31/445 , A61K31/455 , A61K31/341 , A61K31/215 , A61K31/138 , A61P25/00 , A61P29/00 , A61P3/04 , A61P31/00 , A61P3/10 , A61P9/00 , A61P1/00 , A61P25/28 , A61P25/26 , A61P25/18 , A61P25/24
CPC分类号： A61K9/0056 , A61K9/2081 , A61K9/5015 , A61K9/5073 , A61K9/5078 , A61K31/137 , A61K31/167 , A61K31/192 , A61K31/221 , A61K31/341 , A61K31/455 , A61K31/485 , A61K45/06 , A61K2300/00
摘要： There is provided a method for preparing a pharmaceutical composition comprising compressible coated, taste-masked and/or controlled-release coated drug-containing particles, rapidly-dispersing microgranules comprising a disintegrant and a sugar alcohol, a saccharide, or a mixture thereof, and other optional, pharmaceutically acceptable excipients wherein the orally disintegrating tablet (ODT) or rapidly dispersing tablet (RDT) composition having acceptable tableting, organoleptic, and pharmacokinetic properties.
摘要翻译：提供了一种制备药物组合物的方法，所述药物组合物包含可压缩涂覆，掩味和/或控释包衣的含药颗粒，包含崩解剂和糖醇，糖或其混合物的快速分散微粒，以及其它任选的药学上可接受的赋形剂，其中具有可接受的压片，感官和药代动力学性质的口腔崩解片（ODT）或快速分散片剂（RDT）组合物。

4. 发明申请

US20100151021A1 Compositions Comprising Melperone 审中-公开
标题翻译：包含Melperone的组合物
公开(公告)号：US20100151021A1
公开(公告)日：2010-06-17
申请号：US12639496
申请日：2009-12-16
申请人： Gopi M. Venkatesh , Phillip J. Stevens , Jin-Wang Lai
发明人： Gopi M. Venkatesh , Phillip J. Stevens , Jin-Wang Lai
IPC分类号： A61K31/4515 , A61K9/30 , A61K9/14 , A61K9/22 , A61P25/18 , A61P25/16
CPC分类号： A61K9/1676 , A61K9/2081 , A61K9/5078 , A61K31/4515
摘要： The present invention is directed to pharmaceutical compositions, and methods of making such compositions, comprising microparticles containing melperone and/or a pharmaceutically acceptable salt, solvate, or ester thereof; a layer of alkaline buffer, and a controlled-release coating. The present invention is also directed to pharmaceutical dosage forms, including orally disintegrating tablets, conventional tablets, and capsules, and methods for their preparation.
摘要翻译：本发明涉及药物组合物和制备这种组合物的方法，其包含含有蜜蜂酮和/或其药学上可接受的盐，溶剂化物或酯的微粒; 一层碱性缓冲液和一种控释膜。本发明还涉及药物剂型，包括口腔崩解片，常规片剂和胶囊剂及其制备方法。

5. 发明授权

US07919115B2 Orally disintegrating tablet compositions of lamotrigine 有权
标题翻译：口服崩解拉莫三嗪的片剂组合物
公开(公告)号：US07919115B2
公开(公告)日：2011-04-05
申请号：US12166757
申请日：2008-07-02
申请人： Gopi M. Venkatesh , Nehal H. Vyas , Michael Gosselin , Jin-Wang Lai
发明人： Gopi M. Venkatesh , Nehal H. Vyas , Michael Gosselin , Jin-Wang Lai
IPC分类号： A61K9/46 , A61K9/26
CPC分类号： A61K31/53 , A61K9/0007 , A61K9/0056 , A61K9/2072 , A61K9/2077 , A61K9/2081 , A61K9/2095 , A61K9/5005 , A61K9/5015 , A61K9/5026 , A61K9/5031 , A61K9/5042 , A61K9/5047 , A61K9/5084 , A61K9/5089
摘要： The compositions of the present invention composition comprise a therapeutically effective amount of particles comprising lamotrigine, in combination with granules comprising a disintegrant, and a sugar alcohol and/or a saccharide. These compositions are useful in treating epilepsy and bipolar disorder, particularly for patients with dysphagia, and to improve compliance with bipolar patients.
摘要翻译：本发明组合物的组合物包含治疗有效量的包含拉莫三嗪的颗粒，以及包含崩解剂和糖醇和/或糖类的颗粒。这些组合物可用于治疗癫痫和双相障碍，特别是对于吞咽困难的患者，并改善对双相患者的依从性。

6. 发明申请

US20100303905A1 Orally Disintegrating Tablet Compositions of Lamotrigine 有权
标题翻译：拉莫三嗪的口腔崩解片组合物
公开(公告)号：US20100303905A1
公开(公告)日：2010-12-02
申请号：US12628677
申请日：2009-12-01
申请人： Gopi M. Venkatesh , Nehal H. Vyas , Michael Gosselin , Jin-Wang Lai
发明人： Gopi M. Venkatesh , Nehal H. Vyas , Michael Gosselin , Jin-Wang Lai
IPC分类号： A61K9/20 , A61K31/53 , C07D253/07 , A61K9/16 , A61P25/18 , A61P25/08
CPC分类号： A61K31/53 , A61K9/0007 , A61K9/0056 , A61K9/2072 , A61K9/2077 , A61K9/2081 , A61K9/2095 , A61K9/5005 , A61K9/5015 , A61K9/5026 , A61K9/5031 , A61K9/5042 , A61K9/5047 , A61K9/5084 , A61K9/5089
摘要： The compositions of the present invention composition comprise a therapeutically effective amount of particles comprising lamotrigine, in combination with granules comprising a disintegrant, and a sugar alcohol and/or a saccharide. These compositions are useful in treating epilepsy and bipolar disorder, particularly for patients with dysphagia, and to improve compliance with bipolar patients.
摘要翻译：本发明组合物的组合物包含治疗有效量的包含拉莫三嗪的颗粒，以及包含崩解剂和糖醇和/或糖类的颗粒。这些组合物可用于治疗癫痫和双相障碍，特别是对于吞咽困难的患者，并改善对双相患者的依从性。

7. 发明申请

US20090092672A1 ORALLY DISINTEGRATING TABLET COMPOSITIONS OF LAMOTRIGINE 有权
标题翻译：洛伐他汀的片剂组合物的ORALLY DISINCAGE
公开(公告)号：US20090092672A1
公开(公告)日：2009-04-09
申请号：US12166757
申请日：2008-07-02
申请人： Gopi M. Venkatesh , Nehal H. Vyas , Michael Gosselin , Jin-Wang Lai
发明人： Gopi M. Venkatesh , Nehal H. Vyas , Michael Gosselin , Jin-Wang Lai
IPC分类号： A61K31/53 , A61K9/14 , A61P25/00
CPC分类号： A61K31/53 , A61K9/0007 , A61K9/0056 , A61K9/2072 , A61K9/2077 , A61K9/2081 , A61K9/2095 , A61K9/5005 , A61K9/5015 , A61K9/5026 , A61K9/5031 , A61K9/5042 , A61K9/5047 , A61K9/5084 , A61K9/5089
摘要： The compositions of the present invention composition comprise a therapeutically effective amount of particles comprising lamotrigine, in combination with granules comprising a disintegrant, and a sugar alcohol and/or a saccharide. These compositions are useful in treating epilepsy and bipolar disorder, particularly for patients with dysphagia, and to improve compliance with bipolar patients.
摘要翻译：本发明组合物的组合物包含治疗有效量的包含拉莫三嗪的颗粒，以及包含崩解剂和糖醇和/或糖类的颗粒。这些组合物可用于治疗癫痫和双相障碍，特别是对于吞咽困难的患者，并改善对双相患者的依从性。

8. 发明授权

US08840925B2 Orally disintegrating tablet compositions of lamotrigine 有权
标题翻译：口服崩解拉莫三嗪的片剂组合物
公开(公告)号：US08840925B2
公开(公告)日：2014-09-23
申请号：US13455942
申请日：2012-04-25
申请人： Gopi M. Venkatesh , Nehal H. Vyas , Michael Gosselin , Jin-Wang Lai
发明人： Gopi M. Venkatesh , Nehal H. Vyas , Michael Gosselin , Jin-Wang Lai
IPC分类号： A61K9/16 , A61K9/26 , A61K9/46 , A61K9/00 , A61K9/50 , A61K9/20
CPC分类号： A61K31/53 , A61K9/0007 , A61K9/0056 , A61K9/2072 , A61K9/2077 , A61K9/2081 , A61K9/2095 , A61K9/5005 , A61K9/5015 , A61K9/5026 , A61K9/5031 , A61K9/5042 , A61K9/5047 , A61K9/5084 , A61K9/5089
摘要： The compositions of the present invention composition comprise a therapeutically effective amount of particles comprising lamotrigine, in combination with granules comprising a disintegrant, and a sugar alcohol and/or a saccharide. These compositions are useful in treating epilepsy and bipolar disorder, particularly for patients with dysphagia, and to improve compliance with bipolar patients.
摘要翻译：本发明组合物的组合物包含治疗有效量的包含拉莫三嗪的颗粒，以及包含崩解剂和糖醇和/或糖类的颗粒。这些组合物可用于治疗癫痫和双相障碍，特别是对于吞咽困难的患者，并改善对双相患者的依从性。

9. 发明申请

US20130108703A1 Orally Disintegrating Tablet Compositions of Lamotrigine 有权
标题翻译：拉莫三嗪的口腔崩解片组合物
公开(公告)号：US20130108703A1
公开(公告)日：2013-05-02
申请号：US13455942
申请日：2012-04-25
申请人： Gopi M. Venkatesh , Nehal H. Vyas , Michael Gosselin , Jin-Wang Lai
发明人： Gopi M. Venkatesh , Nehal H. Vyas , Michael Gosselin , Jin-Wang Lai
IPC分类号： A61K9/50
CPC分类号： A61K31/53 , A61K9/0007 , A61K9/0056 , A61K9/2072 , A61K9/2077 , A61K9/2081 , A61K9/2095 , A61K9/5005 , A61K9/5015 , A61K9/5026 , A61K9/5031 , A61K9/5042 , A61K9/5047 , A61K9/5084 , A61K9/5089
摘要： The compositions of the present invention composition comprise a therapeutically effective amount of particles comprising lamotrigine, in combination with granules comprising a disintegrant, and a sugar alcohol and/or a saccharide. These compositions are useful in treating epilepsy and bipolar disorder, particularly for patients with dysphagia, and to improve compliance with bipolar patients.
摘要翻译：本发明组合物的组合物包含治疗有效量的包含拉莫三嗪的颗粒，以及包含崩解剂和糖醇和/或糖类的颗粒。这些组合物可用于治疗癫痫和双相障碍，特别是对于吞咽困难的患者，并改善对双相患者的依从性。

10. 发明申请

US20100151015A1 Compositions Comprising Melperone and Controlled-Release Dosage Forms 审中-公开
标题翻译：包括美乐酮和受控释放剂型的组合物
公开(公告)号：US20100151015A1
公开(公告)日：2010-06-17
申请号：US12639470
申请日：2009-12-16
申请人： Gopi M. Venkatesh , Phillip J. Stevens , Jin-Wang Lai
发明人： Gopi M. Venkatesh , Phillip J. Stevens , Jin-Wang Lai
IPC分类号： A61K9/54 , A61K9/14 , A61K31/4515 , A61P25/18
CPC分类号： A61K31/4515 , A61K9/5042 , A61K9/5047 , A61K9/5078
摘要： The present invention is directed to pharmaceutical compositions, and methods of making such compositions, comprising microparticles containing a core comprising melperone and a controlled-release coating. The present invention is also directed to pharmaceutical dosage forms comprising melperone, including orally disintegrating tablets, conventional tablets, and capsules, and methods for their preparation.
摘要翻译：本发明涉及药物组合物和制备这种组合物的方法，其包含含有包含梅乐酮和控释包衣的核心的微粒。本发明还涉及包含梅尔酮的药物剂型，包括口服崩解片，常规片剂和胶囊剂及其制备方法。

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