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1. 发明授权

US06692834B1 Method for coating implantable devices 失效
公开(公告)号：US06692834B1
公开(公告)日：2004-02-17
申请号：US09340441
申请日：1999-06-28
申请人： Gonzalo Martinez , Catherine E. Taylor , Kenneth W. Keeney , Markus Haller
发明人： Gonzalo Martinez , Catherine E. Taylor , Kenneth W. Keeney , Markus Haller
IPC分类号： B32B904
CPC分类号： B05D1/62 , A61L31/08 , B05D3/142 , C23C16/0245 , C23C16/30
摘要： Coating an implantable device, such as micro electromechanical devices, is highly desirable to protect the implantable device from corrosion. A coating method includes depositing, preferably by plasma glow discharge, a reactant monomer on at least one surface of an implantable device, preferably at ambient temperature. The method will likely decrease the manufacturing time required for assembling such devices because completely assembled devices can be coated.

2. 发明授权

US06263249B1 Medical electrical lead having controlled texture surface and method of making same 有权
标题翻译：具有控制纹理表面的医用电线及其制造方法
公开(公告)号：US06263249B1
公开(公告)日：2001-07-17
申请号：US09258515
申请日：1999-02-26
申请人： Mark T. Stewart , Vernon B. Iverson , Kenneth W. Keeney , Catherine E. Taylor
发明人： Mark T. Stewart , Vernon B. Iverson , Kenneth W. Keeney , Catherine E. Taylor
IPC分类号： A61N105
CPC分类号： A61N1/05 , Y10T29/49002
摘要： An elongate elastomeric structure having controlled surface texture. Plasma deposition is used to create controlled features, such as ridges, on the external surface of an elongate elastomeric surface, such as the external surface of silicone tubing. The invention has particular applicability in the medical device field, such as the fabrication of implantable leads, catheters, and medical devices incorporating them.
摘要翻译：具有受控表面纹理的细长弹性体结构。等离子体沉积用于在细长弹性体表面的外表面（例如硅胶管的外表面）上产生可控特征，例如脊。本发明在诸如制造可植入引线，导管和结合它们的医疗装置之类的医疗装置领域中具有特别的适用性。

3. 发明授权

US06801809B2 Extractable implantable medical lead 有权
标题翻译：可提取植入式医用铅
公开(公告)号：US06801809B2
公开(公告)日：2004-10-05
申请号：US09854999
申请日：2001-05-14
申请人： Timothy G. Laske , Steven L. Waldhauser , Mark T. Stewart , Catherine E. Taylor , Kenneth W. Keeney
发明人： Timothy G. Laske , Steven L. Waldhauser , Mark T. Stewart , Catherine E. Taylor , Kenneth W. Keeney
IPC分类号： A61N105
CPC分类号： A61N1/056 , A61N2001/0578
摘要： A medical electrical lead with a tip-ring assembly optimized to resist damage during extraction. The lead includes an elongated plastic tube and at least two elongated conductors mounted in the plastic tube. A tip-ring assembly is mounted to the distal end of the tube, the tip-ring assembly including a ring electrode coupled to one of the conductors, a tip electrode located distal to the ring electrode and coupled to another of the conductors and two molded plastic components separately fabricated of a plastic harder than the plastic tube, adhered to one another and together defining a circumferential groove in which the ring electrode is located and mechanically coupled to the tip electrode. The tip electrode may be provided with a proximally extending electrode shank covered by a tine sleeve which is fabricated of a plastic softer than the molded plastic components and is adhered to more distally located molded plastic component. The more distally located molded plastic component preferably overlaps the electrode shank to provide a stronger structure.
摘要翻译：具有尖端环组件的医疗电气引线，优化以防止在提取期间的损坏。引线包括细长塑料管和安装在塑料管中的至少两根细长导体。尖端环组件安装到管的远端，尖端环组件包括耦合到一个导体的环形电极，位于环形电极远侧并连接到另一个导体的尖端电极，以及两个模制分别由比塑料管更硬的塑料制成的塑料部件彼此粘合在一起并且一起形成环形电极所在的并且机械地联接到尖端电极的周向槽。尖端电极可以设置有由齿形套筒覆盖的近端延伸的电极柄，其由比模制的塑料部件更软的塑料制成并且被粘附到更远端定位的模制塑料部件上。更远端定位的模制塑料部件优选地与电极柄重叠以提供更强的结构。

4. 发明授权

US06549811B2 Medical electrical lead having controlled texture surface and method of making same 失效
标题翻译：具有控制纹理表面的医用电线及其制造方法
公开(公告)号：US06549811B2
公开(公告)日：2003-04-15
申请号：US09760077
申请日：2001-01-12
申请人： Mark T. Stewart , Vernon B. Iverson , Kenneth W. Keeney , Catherine E. Taylor
发明人： Mark T. Stewart , Vernon B. Iverson , Kenneth W. Keeney , Catherine E. Taylor
IPC分类号： A61N105
CPC分类号： A61N1/05 , Y10T29/49002
摘要： An elongate elastomeric structure having controlled surface texture. Plasma deposition is used to create controlled features, such as ridges, on the external surface of an elongate elastomeric surface, such as the external surface of silicone tubing. The invention has particular applicability in the medical device field, such as the fabrication of implantable leads, catheters, and medical devices incorporating them.
摘要翻译：具有受控表面纹理的细长弹性体结构。等离子体沉积用于在细长弹性体表面的外表面（例如硅胶管的外表面）上产生可控特征，例如脊。本发明在诸如制造可植入引线，导管和结合它们的医疗装置之类的医疗装置领域中具有特别的适用性。

5. 发明授权

US06256542B1 Extractable implantable medical lead 有权
公开(公告)号：US06256542B1
公开(公告)日：2001-07-03
申请号：US09507960
申请日：2000-02-22
申请人： Mark T. Marshall , Bret R. Shoberg , Clare E. Padgett , Timothy G. Laske , Steven L. Waldhauser , Mark T. Stewart , Catherine E. Taylor , Kenneth W. Keeney
发明人： Mark T. Marshall , Bret R. Shoberg , Clare E. Padgett , Timothy G. Laske , Steven L. Waldhauser , Mark T. Stewart , Catherine E. Taylor , Kenneth W. Keeney
IPC分类号： A61N105
CPC分类号： A61N1/0563 , A61N1/056
摘要： A medical electrical lead with a tip-ring assembly optimized to resist damage during extraction. The lead includes an elongated plastic tube and at least two elongated conductors mounted in the plastic tube. A tip-ring assembly is mounted to the distal end of the tube, the tip-ring assembly including a ring electrode coupled to one of the conductors, a tip electrode located distal to the ring electrode and coupled to another of the conductors and two molded plastic components separately fabricated of a plastic harder than the plastic tube, adhered to one another and together defining a circumferential groove in which the ring electrode is located and mechanically coupled to the tip electrode. The tip electrode may be provided with a proximally extending electrode shank covered by a tine sleeve which is fabricated of a plastic softer than the molded plastic components and is adhered to more distally located molded plastic component. The more distally located molded plastic component preferably overlaps the electrode shank to provide a stronger structure.

6. 发明申请

US20080234811A1 WETTABLE ePTFE MEDICAL DEVICES 有权
标题翻译：湿巾ePTFE医疗器械
公开(公告)号：US20080234811A1
公开(公告)日：2008-09-25
申请号：US11742433
申请日：2007-04-30
申请人： Kathryn J. Kitching , Catherine E. Taylor
发明人： Kathryn J. Kitching , Catherine E. Taylor
IPC分类号： A61F2/82 , B05D3/06
CPC分类号： B05D3/144 , A61L27/16 , A61L27/34 , A61L31/048 , A61L31/10 , B05D3/147 , B05D5/04 , B05D7/02 , Y10T428/1393 , Y10T428/31544 , C08L27/18 , C08L33/14
摘要： Methods are provided for surface modifying a hydrophobic polymer substrate to increase wettability comprising the steps of pre-treating the hydrophobic polymer substrate with a radio frequency (RF)-generated first plasma and a RF-generated second plasma wherein the first plasma and the second plasma are applied sequentially, coating the hydrophobic polymer substrate with a hydrophilic coating; and polymerizing the hydrophilic coating on the hydrophobic polymer substrate by exposure to a RF-generated third plasma.
摘要翻译：提供了用于表面改性疏水性聚合物基材以增加润湿性的方法，包括以下步骤：用射频（RF）生成的第一等离子体和RF产生的第二等离子体预处理疏水聚合物基材，其中第一等离子体和第二等离子体依次施加，用亲水涂层涂覆疏水性聚合物基材; 并通过暴露于RF产生的第三等离子体在疏水聚合物基底上聚合亲水涂层。

7. 发明授权

US08679518B2 Antimicrobial compounds having protective or therapeutic leaving groups 有权
标题翻译：具有保护性或治疗性离去基团的抗微生物化合物
公开(公告)号：US08679518B2
公开(公告)日：2014-03-25
申请号：US13407961
申请日：2012-02-29
申请人： Paul Hsien-Fu Wu , Catherine E. Taylor , Linnus Cheruiyot , Jianwei Li , Terese A. Bartlett , Matt Bergan
发明人： Paul Hsien-Fu Wu , Catherine E. Taylor , Linnus Cheruiyot , Jianwei Li , Terese A. Bartlett , Matt Bergan
IPC分类号： A61F2/00 , A61L27/54 , A61L27/44
CPC分类号： A61L27/54 , A61K31/575 , A61K31/695 , A61K47/6957 , A61L27/443 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/216 , A61L2300/222 , A61L2300/404 , A61L2300/41 , A61L2300/416 , C07F7/1804
摘要： Antimicrobial compounds, such as silanol or alcohol, include a protecting or leaving group that can protect the compound from degradation during the process of preparing a medical device containing the compound or reduce the volatility of the compound relative to its counterpart without the leaving group. Nearly any hydrolysable leaving group may be employed. The leaving group may be an agent that may serve a therapeutic function in addition to protecting or retaining the antimicrobial agents.
摘要翻译：抗微生物化合物，例如硅烷醇或醇，包括保护或离去基团，其可以在制备含有化合物的医疗装置的过程中保护化合物免于降解，或降低化合物相对于其对应物在不离开基团的情况下的挥发性。可以使用几乎任何可水解的离去基团。除了保护或保留抗微生物剂之外，离去基团可以是可以起到治疗功能的药剂。

8. 发明授权

US07955512B2 Medical devices having textured surfaces 有权
标题翻译：具有纹理表面的医疗设备
公开(公告)号：US07955512B2
公开(公告)日：2011-06-07
申请号：US11674607
申请日：2007-02-13
申请人： Eunsung Park , Catherine E. Taylor , Kevin Casey
发明人： Eunsung Park , Catherine E. Taylor , Kevin Casey
IPC分类号： B44C1/22
CPC分类号： A61L27/50 , A61B17/68 , A61B17/7002 , A61B17/7059 , A61B17/86 , A61B17/866 , A61C8/0012 , A61F2/0077 , A61F2/30767 , A61F2/3094 , A61F2/3099 , A61F2/38 , A61F2/44 , A61F2/82 , A61F2002/30677 , A61F2002/30925 , A61F2002/3097 , A61F2240/001 , A61F2250/0067 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00071 , A61F2310/00089 , A61F2310/00101 , A61F2310/00131 , A61F2310/00149 , A61F2310/00395 , A61F2310/0052 , A61F2310/00574 , A61F2310/0058 , A61F2310/00598 , A61F2310/0073 , A61F2310/00856 , A61F2310/00976 , A61L29/14 , A61L31/14 , A61N1/00
摘要： Disclosed are medical devices having textured surfaces and related methods for texturing. Methods of surface texturing using gas-phase plasma provide medical devices with myriad complex surface morphologies.
摘要翻译：公开了具有纹理表面的医疗装置和用于纹理的相关方法。使用气相等离子体的表面纹理方法为医疗器械提供了无数复杂的表面形态。

9. 发明申请

US20110060402A1 Wettable ePTFE Medical Devices 有权
标题翻译：可湿性ePTFE医疗器械
公开(公告)号：US20110060402A1
公开(公告)日：2011-03-10
申请号：US12946585
申请日：2010-11-15
申请人： Kathryn J. Kitching , Catherine E. Taylor
发明人： Kathryn J. Kitching , Catherine E. Taylor
IPC分类号： A61F2/82 , B05D3/06 , A61B18/00 , B32B1/08 , B32B27/08
CPC分类号： B05D3/144 , A61L27/16 , A61L27/34 , A61L31/048 , A61L31/10 , B05D3/147 , B05D5/04 , B05D7/02 , Y10T428/1393 , Y10T428/31544 , C08L27/18 , C08L33/14
摘要： Methods are provided for surface modifying a hydrophobic polymer substrate to increase wettability comprising the steps of pre-treating the hydrophobic polymer substrate with a radio frequency (RF)-generated first plasma and a RF-generated second plasma wherein the first plasma and the second plasma are applied sequentially, coating the hydrophobic polymer substrate with a hydrophilic coating; and polymerizing the hydrophilic coating on the hydrophobic polymer substrate by exposure to a RF-generated third plasma.
摘要翻译：提供了用于表面改性疏水性聚合物基材以增加润湿性的方法，包括以下步骤：用射频（RF）生成的第一等离子体和RF产生的第二等离子体预处理疏水聚合物基材，其中第一等离子体和第二等离子体依次施加，用亲水涂层涂覆疏水性聚合物基材; 并通过暴露于RF产生的第三等离子体在疏水聚合物基底上聚合亲水涂层。

10. 发明申请

US20120157373A1 ANTIMICROBIAL COMPOUNDS HAVING PROTECTIVE OR THERAPEUTIC LEAVING GROUPS 有权
标题翻译：具有保护性或治疗性组合的抗微生物化合物
公开(公告)号：US20120157373A1
公开(公告)日：2012-06-21
申请号：US13407961
申请日：2012-02-29
申请人： Paul Hsien-Fu Wu , Catherine E. Taylor , Linnus Cheruiyot , Jianwei Li , Terese A. Bartlett , Matt Bergan
发明人： Paul Hsien-Fu Wu , Catherine E. Taylor , Linnus Cheruiyot , Jianwei Li , Terese A. Bartlett , Matt Bergan
IPC分类号： A61K31/695 , A61K31/216 , A61K31/65 , A61K31/496 , A61K31/7048 , A61K31/43 , A61K31/546 , A61K31/407 , A61K31/427 , A61K31/7036 , A61K38/02 , A61K31/28 , A61K31/573 , A61K31/58 , C07C69/92 , C07D307/54 , C07D333/24 , C07D207/337 , C07J5/00 , C07J71/00 , C07D307/42 , C07D333/16 , A61P31/00 , A61P29/00 , A61P9/12 , A61P35/00 , A61L33/00 , A61K31/24
CPC分类号： A61L27/54 , A61K31/575 , A61K31/695 , A61K47/6957 , A61L27/443 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/216 , A61L2300/222 , A61L2300/404 , A61L2300/41 , A61L2300/416 , C07F7/1804
摘要： Antimicrobial compounds, such as silanol or alcohol, include a protecting or leaving group that can protect the compound from degradation during the process of preparing a medical device containing the compound or reduce the volatility of the compound relative to its counterpart without the leaving group. Nearly any hydrolysable leaving group may be employed. The leaving group may be an agent that may serve a therapeutic function in addition to protecting or retaining the antimicrobial agents.
摘要翻译：抗微生物化合物，例如硅烷醇或醇，包括保护或离去基团，其可以在制备含有化合物的医疗装置的过程中保护化合物免于降解，或降低化合物相对于其对应物的挥发性而不用离去基团。可以使用几乎任何可水解的离去基团。除了保护或保留抗微生物剂之外，离去基团可以是可以起到治疗功能的药剂。

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