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    • 3. 发明申请
    • Nicotine-Containing Pharmaceutical Compositions
    • 含尼古丁的药物组合物
    • US20110268809A1
    • 2011-11-03
    • US12769335
    • 2010-04-28
    • Paul Andrew BrinkleyAugust Joseph Borschke
    • Paul Andrew BrinkleyAugust Joseph Borschke
    • A61K9/68A24F47/00A61P25/34A61K31/465A61K31/787
    • A61K9/0056A61K9/0058A61K9/006A61K31/19A61K31/465A61K31/787A61M15/009A61M15/0091
    • A composition intended to be employed for therapeutic purposes incorporates a source of nicotine and at least one levulinate moiety. Representative forms of nicotine include free base (e.g., as a mixture of nicotine and microcrystalline cellulose), a nicotine salt (e.g., as nicotine bitartrate) or nicotine polacrilex. The levulinate moiety can have the form of an acid (e.g., levulinic acid), a levulinate salt (e.g., sodium levulinate), or an ester of levulinic acid (e.g., methyl levulinate or ethyl levulinate). The composition can incorporate nicotine and levulinic acid in a salt form (e.g., nicotine levulinate). The composition can be composed of at least two forms of nicotine, and one of the forms of nicotine is in the form of nicotine levulinate. The composition is useful for treatment of central nervous system conditions, diseases, and disorders, and as a nicotine replacement therapy.
    • 旨在用于治疗目的的组合物包含尼古丁来源和至少一个乳酸部分。 尼古丁的代表性形式包括游离碱(例如,作为尼古丁和微晶纤维素的混合物),尼古丁盐(例如,作为酒石酸烟碱)或尼古丁polacrilex。 树脂部分可以具有酸(例如乙酰丙酸),乙酰丙酸盐(例如乙酰丙酸钠)或乙酰丙酸(例如乙酰丙酸甲酯或乙酰丙酸乙酯)的形式。 组合物可以加入盐形式的尼古丁和乙酰丙酸(例如,乙酰丙酸烟碱)。 该组合物可以由至少两种形式的尼古丁组成,其中一种形式的尼古丁是烟酰胺酸盐的形式。 该组合物可用于治疗中枢神经系统疾病和疾病,以及作为尼古丁替代疗法。
    • 7. 发明授权
    • Smokeless tobacco composition
    • 无烟烟草组成
    • US07946295B2
    • 2011-05-24
    • US11781641
    • 2007-07-23
    • Paul Andrew BrinkleyDavid Neil McClanahanJack Gray Flinchum, Jr.
    • Paul Andrew BrinkleyDavid Neil McClanahanJack Gray Flinchum, Jr.
    • A24B15/00
    • A24B15/42A24B15/12A24B15/18A24B15/183
    • The invention provides a process for preparing a tobacco composition suitable for use as a smokeless tobacco composition, including: providing a moist tobacco material; heating the moist tobacco to a temperature of at least about 85° C. for a time sufficient to pasteurize the tobacco material while maintaining the moisture content at a relatively constant level; adding an amount of a base and water to the moist tobacco material sufficient to raise the pH of the slurry to at least about 8.7 and raise the moisture content to at least about 40% by weight, thereby forming a pH-adjusted moist tobacco material; and continuing to heat the pH-adjusted moist tobacco material to a temperature of at least about 55° C. for a time sufficient for the pH of the moist tobacco material to drop to less than about 8.5 while maintaining the moisture content at a relatively constant level.
    • 本发明提供了一种制备适合用作无烟烟草组合物的烟草组合物的方法,包括:提供潮湿的烟草材料; 将潮湿的烟草加热至至少约85℃的温度足以使烟草材料巴氏灭菌同时保持水分含量处于相对恒定的水平; 向湿润的烟草材料中加入一定量的碱和水,足以将浆料的pH提高到至少约8.7,并将水分含量提高至至少约40重量%,从而形成pH调节的湿烟草材料; 并且将经pH调节的湿烟草材料继续加热到至少约55℃的温度足以使湿烟草材料的pH降至小于约8.5的时间,同时保持水分含量相对恒定 水平。
    • 8. 发明申请
    • Smokeless Tobacco Composition
    • 无烟烟草成分
    • US20090025739A1
    • 2009-01-29
    • US11781641
    • 2007-07-23
    • Paul Andrew BrinkleyDavid Neil McClanahanJack Gray Flinchum, JR.
    • Paul Andrew BrinkleyDavid Neil McClanahanJack Gray Flinchum, JR.
    • A24B15/00
    • A24B15/42A24B15/12A24B15/18A24B15/183
    • The invention provides a process for preparing a tobacco composition suitable for use as a smokeless tobacco composition, including: providing a moist tobacco material; heating the moist tobacco to a temperature of at least about 85° C. for a time sufficient to pasteurize the tobacco material while maintaining the moisture content at a relatively constant level; adding an amount of a base and water to the moist tobacco material sufficient to raise the pH of the slurry to at least about 8.7 and raise the moisture content to at least about 40% by weight, thereby forming a pH-adjusted moist tobacco material; and continuing to heat the pH-adjusted moist tobacco material to a temperature of at least about 55° C. for a time sufficient for the pH of the moist tobacco material to drop to less than about 8.5 while maintaining the moisture content at a relatively constant level.
    • 本发明提供了一种制备适合用作无烟烟草组合物的烟草组合物的方法,包括:提供潮湿的烟草材料; 将潮湿的烟草加热至至少约85℃的温度足以使烟草材料巴氏灭菌同时保持水分含量处于相对恒定的水平; 向湿润的烟草材料中加入一定量的碱和水,足以将浆料的pH提高到至少约8.7,并将水分含量提高至至少约40重量%,从而形成pH调节的湿烟草材料; 并且将经pH调节的湿烟草材料继续加热到至少约55℃的温度足以使湿烟草材料的pH降至小于约8.5的时间,同时保持水分含量相对恒定 水平。