专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20080081070A1 PHARMACEUTICAL FORMULATION WITH ENHANCED SOLUBILITY FOR THE DELIVERY OF CORTICOSTEROIDS 审中-公开
标题翻译：具有增强溶解性的药用配方用于输送角质素
公开(公告)号：US20080081070A1
公开(公告)日：2008-04-03
申请号：US11680276
申请日：2007-02-28
申请人： Glynn Wilson , Gerhard Renner , Hema Ravishankar , Preeti Patil
发明人： Glynn Wilson , Gerhard Renner , Hema Ravishankar , Preeti Patil
IPC分类号： A61K9/32 , A61K31/56 , A61P1/00
CPC分类号： A61K9/5073 , A61K9/5078 , A61K31/56
摘要： Formulations have been developed to improve the solubility of corticosteroids such as fluticasone proprionate in a composition designed to achieve localized release of the drug in the small intestine and/or colon. In one embodiment, solid dispersions of fluticasone are prepared wherein the drug is blended with or coated onto a highly water soluble substrate such as nonpareil (sugar beads) then coated with a layer of polymer soluble in small intestinal fluid, then coated with an enteric coating. The inner polymer layer controls release of the drug, and the enteric coating, a pH sensitive polymer that is broken down in the ileum and colon, controls localized release of drug at various sites within the gastrointestinal tract. The multilayer pharmaceutical composition can be in the form of pellets, tablets compressed from pellets or pellets packed into capsules. The release profile of the drug can be manipulated by (1) altering size or shape (i.e., surface area) and solubility of the inert substrate; (2) the ratio of drug to polymer, the polymer composition and solubility, the porosity of the polymer; (3) the drug form (i.e., free base or salt, or which salt); and the thickness and/or surface area of the drug/polymer and/or enteric coating. In a preferred embodiment, the composition is administered orally. This may also be packaged to provide for an escalating or tapering dosage.
摘要翻译：已经开发了用于改善皮质类固醇（例如丙酸氟替卡松）在旨在实现药物在小肠和/或结肠中的局部释放的组合物中的溶解度的制剂。在一个实施方案中，制备氟替卡松的固体分散体，其中将药物与高水溶性底物如非乳糖（糖珠）混合或涂覆在其上，然后用可溶于小肠液的聚合物层涂覆，然后用肠溶衣。内部聚合物层控制药物的释放，并且肠溶衣（在回肠和结肠中分解的pH敏感聚合物）控制药物在胃肠道内各处的局部释放。该多层药物组合物可以是丸粒形式，从颗粒或丸剂包装的胶囊中压制的片剂。可通过（1）改变惰性底物的尺寸或形状（即表面积）和溶解度来操纵药物的释放曲线; （2）药物与聚合物的比例，聚合物组成和溶解度，聚合物的孔隙率; （3）药物形式（即游离碱或盐，或其盐）; 以及药物/聚合物和/或肠溶衣的厚度和/或表面积。在优选的实施方案中，组合物经口施用。这也可以被包装以提供逐渐升高或渐细的剂量。

2. 发明授权

US07339127B2 Contact piece made of tungsten provided with a corrosion-resistant layer made of a base metal 失效
标题翻译：由钨制成的接触件具有由贱金属制成的耐腐蚀层
公开(公告)号：US07339127B2
公开(公告)日：2008-03-04
申请号：US10554175
申请日：2004-04-19
申请人： Gerhard Renner , Udo Siefken , Martin Müller
发明人： Gerhard Renner , Udo Siefken , Martin Müller
IPC分类号： H01H1/021
CPC分类号： H01H1/02 , Y10T29/49105
摘要： A contact piece is formed by a tungsten overlay soldered onto a support, wherein at least portions of the solder layer and optionally of the support are covered by a layer of a less noble metal than tungsten. The corrosion resistance of the tungsten overlay is considerably improved.
摘要翻译：接触片由焊接在载体上的钨覆层形成，其中焊料层和任选的载体的至少一部分被比钨低的贵金属层覆盖。钨覆盖层的耐腐蚀性大大提高。

3. 发明申请

US20110217383A1 PH-DEPENDENT CONTROLLED RELEASE PHARMACEUTICAL OPIOID COMPOSITION WITH RESISTANCE AGAINST THE INFLUENCE OF ETHANOL 有权
标题翻译： PH依赖性控释药物抗药性组合物对乙醇的影响
公开(公告)号：US20110217383A1
公开(公告)日：2011-09-08
申请号：US13062591
申请日：2008-09-24
申请人： Hans Bär , Thomas Fürst , Gerhard Renner , Michael Gottschalk
发明人： Hans Bär , Thomas Fürst , Gerhard Renner , Michael Gottschalk
IPC分类号： A61K9/50 , A61K9/00 , A61P25/32 , A61P25/36 , A61K31/485 , A61K31/137 , A61K31/222 , A61K31/451 , A61K31/5377 , A61K31/454 , A61K31/4545 , A61K31/439 , A61K31/24 , A61K31/4535 , A61K31/55 , A61K31/445 , A61P25/04 , B29C43/20
CPC分类号： A61K9/5078
摘要： The invention relates to a pH-dependent controlled release pharmaceutical composition, comprising a core, and an opioid, wherein the core is coated at least by one coating layer, controlling the release of the pharmaceutical composition, wherein the coating layer comprises a polymer mixture of i) 40 95% by weight, based on dry weight of the polymer mixture, of at least one water insoluble essentially neutral vinyl polymer, and ii) 5 60% by weight, based on dry weight of the polymer mixture, of at least one anionic polymer or copolymer, which is insoluble in a buffered medium below pH 4.0 and soluble at least in the range from pH 7.0 to pH 8.0, characterized in that the coating layer further comprises 110 to 250 % by weight of a non-porous inert lubricant, 1 to 35 % by weight of a neutral cellulosic compound and 1 to 25 % by weight of an emulsifier, each calculated on dry weight of the polymer mixture.
摘要翻译：本发明涉及一种pH依赖性控释药物组合物，其包含核心和阿片样物质，其中所述核心至少涂覆一层涂层，以控制药物组合物的释放，其中所述涂层包含： i）40 95重量％，基于聚合物混合物的干重，至少一种水不溶性基本上中性的乙烯基聚合物，和ii）基于聚合物混合物的干重计，60重量％的至少一种阴离子聚合物或共聚物，其不溶于低于pH 4.0的缓冲介质，并且至少可溶于pH 7.0至pH 8.0，其特征在于，所述涂层还包含110至250重量％的无孔惰性润滑剂，1至35重量％的中性纤维素化合物和1至25重量％的乳化剂，其各自以聚合物混合物的干重计算。

4. 发明授权

US06475964B1 Motor oil with high dispersivity and good wear protection characteristics 失效
标题翻译：机油具有高分散性和良好的防磨损特性
公开(公告)号：US06475964B1
公开(公告)日：2002-11-05
申请号：US08510272
申请日：1995-08-02
申请人： Peter Neudoerfl , Horst Pennewiss , Gerhard Renner
发明人： Peter Neudoerfl , Horst Pennewiss , Gerhard Renner
IPC分类号： C10M16100
CPC分类号： C10M161/00 , C10M137/10 , C10M143/00 , C10M143/04 , C10M145/14 , C10M2205/00 , C10M2205/02 , C10M2205/024 , C10M2207/028 , C10M2209/084 , C10M2215/04 , C10M2215/086 , C10M2215/26 , C10M2215/28 , C10M2217/046 , C10M2217/06 , C10M2219/046 , C10M2223/045 , C10N2210/02 , C10N2240/10 , C10N2240/101 , C10N2240/104 , C10N2240/106
摘要： Motor oils and transmission oils of the usual commercial SAE single- and multiple viscosity classes, which oils contain polymeric additives and which have high dispersivity and good wear protection characteristics, said oils containing the following additives: (i) at least one heavy-duty (HD) additive, which contains phosphorus compounds; and (ii) as dispersive polymeric components PC, cooligomers copolymers, or combinations thereof comprised of: (a) units of C6-24 alkyl (meth)acrylates, (b) units of at least one functionalized alkyl (meth)acrylate, (c) units of one or more C1-5-alkyl (meth)acrylate monomers, and (d) units of 1-alkenes, with the following provisions: (1) the units of formulas I and II together comprise 100 wt. %, (2) the content of polymer components) PC in the additive-containing mineral oils is in the range 0.5-50 wt. %, and (3) the content of phosphorus in the additive-containing mineral oils is less than or equal to 0.08 wt. %.
摘要翻译：含有以下添加剂的油的通常商业SAE单一和多重粘度等级的机油和传动油，其中油含有聚合物添加剂并具有高分散性和良好的耐磨损保护特性，所述油包含以下添加剂：（i）至少一种重载 HD）添加剂，含有磷化合物; 和（ii）作为分散聚合物组分PC，冷却体共聚物或其组合，其包含：（a）（甲基）丙烯酸C 6-24烷基酯单元，（b）至少一个官能化的（甲基）丙烯酸烷基酯单元，（c ）单元，和（d）1-烯烃单元，其具有以下规定：（1）式I和II的单元一起包含100重量％的（甲基）丙烯酸C 1〜％，（2）含添加剂的矿物油中的聚合物组分的含量PC在0.5-50wt。％，和（3）含添加剂矿物油中的磷含量小于或等于0.08重量％。％。

5. 发明申请

US20110229562A1 PH-DEPENDENT CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION FOR NON-OPIOIDS WITH RESISTANCE AGAINST THE INFLUENCE OF ETHANOL 审中-公开
标题翻译：对依赖于乙醇的影响的非依赖性药物的PH依赖性控制释放药物组合物
公开(公告)号：US20110229562A1
公开(公告)日：2011-09-22
申请号：US13120112
申请日：2008-09-24
申请人： Hans Bär , Thomas Fürst , Gerhard Renner , Michael Gottschalk
发明人： Hans Bär , Thomas Fürst , Gerhard Renner , Michael Gottschalk
IPC分类号： A61K9/48 , B29C43/02 , A61K9/00 , A61K9/36 , A61K9/14 , A61K31/138
CPC分类号： A61K9/5078
摘要： The invention relates to a pH-dependent controlled release pharmaceutical composition, comprising at least one pharmaceutical active ingredient, with the exception of opioids, wherein the core is coated at least by one coating layer, controlling the release of the pharmaceutical composition, wherein the coating layer comprises a polymer mixture of i) 40-95% by weight, based on dry weight of the polymer mixture, of at least one water insoluble essentially neutral vinyl polymer or copolymer, and ii) 5-60% by weight, based on dry weight of the polymer mixture, of at least one anionic polymer or copolymer, which is insoluble in a buffered medium below pH 4.0 and soluble at least in the range from pH 7.0 to pH 8.0, characterized in that the coating layer further comprises 110 to 250% by weight of a non-porous inert lubricant, 1 to 35% by weight of at least one neutral cellulosic compound and 1 to 25% by weight of at least one emulsifier, each calculated on dry weight of the polymer mixture.
摘要翻译：本发明涉及pH依赖性控释药物组合物，其包含除阿片样物质以外的至少一种药物活性成分，其中核心至少涂覆一层涂层，以控制药物组合物的释放，其中涂层至少一种不溶于水的基本上中性的乙烯基聚合物或共聚物，和ii）5-60重量％，基于干燥的聚合物混合物，i）40-95重量％，基于聚合物混合物的干重，聚合物混合物的重量，至少一种阴离子聚合物或共聚物，其不溶于低于pH 4.0的缓冲介质中并且可溶于至少在7.0至8.0的范围内，其特征在于所述涂层还包含110至250 重量％的无孔惰性润滑剂，1至35重量％的至少一种中性纤维素化合物和1至25重量％的至少一种乳化剂，其各自以聚合物混合物的干重计算。

6. 发明授权

US5101003A Method for forming polythiophosphazene macromolecules 失效
标题翻译：形成聚硫磷腈大分子的方法
公开(公告)号：US5101003A
公开(公告)日：1992-03-31
申请号：US474411
申请日：1990-02-02
申请人： Harry R. Allcock , Jeffrey A. Dodge , Ian Manners , Gerhard Renner , Oskar Nuyken
发明人： Harry R. Allcock , Jeffrey A. Dodge , Ian Manners , Gerhard Renner , Oskar Nuyken
IPC分类号： C08G79/02
CPC分类号： C08G79/02
摘要： The synthesis of the first examples of a new class of inorganic macromolecules, the polythiophosphazenes, is reported. When heated at 90.degree. C., the cyclothiophosphazene N.sub.3 P.sub.2 SCl.sub.5 undergoes ring-opening polymerization to yield the high polymeric polythiophosphazene [N.sub.3 P.sub.2 SCl.sub.5 ].sub.n. The latter functions as a reactive macromolecular intermediate and undergoes halogen replacement with sodium phenoxide and sodium o-phenylphenoxide to afford the polymers [N.sub.3 P.sub.2 S(OPh).sub.5 ].sub.n and [N.sub.3 P.sub.2 S(OC.sub.6 H.sub.4 Ph--o).sub.3.25 Cl.sub.1.75 ].sub.n, respectively.
摘要翻译：报道了一类新的无机大分子，即聚硫代磷腈的合成。当在90℃下加热时，环硫基磷腈N 3 P 2 SCl 5进行开环聚合，得到高分子聚硫代磷腈[N 3 P 2 SCl 5] n。后者用作反应性大分子中间体，并用苯酚钠和邻苯基苯酚钠进行卤素置换，分别得到聚合物[N 3 P 2 S（OPh）5] n和[N 3 P 2 S（OC 6 H 4 Ph-o）3.25 Cl1.75] n。

7. 发明授权

US4365157A Fluid analyzer utilizing a laser beam 失效
标题翻译：使用激光束的流体分析仪
公开(公告)号：US4365157A
公开(公告)日：1982-12-21
申请号：US271376
申请日：1981-06-08
申请人： Eberhard Unsold , Gerhard Renner , Reiner Wechsung
发明人： Eberhard Unsold , Gerhard Renner , Reiner Wechsung
IPC分类号： G01N21/71 , B01D59/44
CPC分类号： G01N21/718
摘要： A method for studying a fluid by forming a stream of the fluid, exciting the stream by causing a laser beam to impinge thereon to produce secondary particles or quanta, and subjecting the resulting secondary particles or quanta to an analysis operation in an analyzer.
摘要翻译：一种用于通过形成流体流来研究流体的方法，通过使激光束在其上冲击以产生二次粒子或量子来激发流，以及使得到的二次粒子或量子在分析器中进行分析操作。

8. 发明申请

US20120045506A1 CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION WITH RESISTANCE AGAINST THE INFLUENCE OF ETHANOL EMPLOYING A COATING COMPRISING NEUTRAL VINYL POLYMERS AND EXCIPIENTS 有权
标题翻译：控制释放的药物组合物具有抵抗乙酸乙酯对包含中性乙烯基聚合物和其特性的涂料的影响
公开(公告)号：US20120045506A1
公开(公告)日：2012-02-23
申请号：US13256694
申请日：2009-03-18
申请人： Hans Baer , Thomas Fuerst , Gerhard Renner , Michael Gottschalk
发明人： Hans Baer , Thomas Fuerst , Gerhard Renner , Michael Gottschalk
IPC分类号： A61K9/52 , A61K9/14 , A61K31/485 , B05D5/00 , A61K9/36 , A61P25/04 , B05D1/02 , A61K9/00 , A61K31/138
CPC分类号： A61K9/5078
摘要： The invention relates to a controlled release pharmaceutical composition, comprising a core, comprising a pharmaceutical active ingredient, whereby the core is coated by an ethanol resistance conferring coating layer which has the effect of conferring the release profile of the pharmaceutical active ingredient to be resistant against the influence of ethanol, whereby the ethanol resistance conferring coating layer comprises at least 70% by weight of a mixture of a polymeric portion a) and an excipients portion b), with the polymeric portion a) is consisting of a water insoluble essentially neutral vinyl polymer or vinyl copolymer and the excipients portion b) is consisting of the excipients b1) 100 to 250% by weight of a non-porous inert lubricant, b2) 1 to 35% by weight of a cellulosic compound, b3) 0.1 to 25% by weight of an emulsifier and additionally or alternatively to b3), b4) 0.1 to 30% by weight of a plasticizer whereby the excipients of the excipients portion b) are each calculated on the dry weight of the polymer portion a).
摘要翻译：本发明涉及一种控释药物组合物，其包含核心，其包含药物活性成分，由此核心由赋予乙醇抗性的涂层涂覆，其具有赋予药物活性成分的释放特性以抵抗乙醇的影响，其中赋予涂料的乙醇抗性包含至少70重量％的聚合物部分a）和赋形剂部分b）的混合物，聚合物部分a）由不溶于水的基本上为中性的乙烯基聚合物或乙烯基共聚物和赋形剂部分b）由赋形剂b1）100-250重量％的无孔惰性润滑剂组成，b2）1至35重量％的纤维素化合物，b3）0.1至25重量％的b），b4）0.1〜30重量％的增塑剂，其中赋形剂部分b）的赋形剂各自计算以聚合物部分a）的干重计。

9. 发明申请

US20110311631A1 CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION WITH RESISTANCE AGAINST THE INFLUENCE OF ETHANOL EMPLOYING A COATING COMPRISING A POLYMER MIXTURE AND EXCIPIENTS 审中-公开
标题翻译：控制释放药物组合物对乙烯醇对包含聚合物混合物和涂料的涂料的影响具有电阻
公开(公告)号：US20110311631A1
公开(公告)日：2011-12-22
申请号：US13203760
申请日：2009-03-18
申请人： Hans Baer , Thomas Fuerst , Thomas Rupp , Gerhard Renner , Michael Gottschalk
发明人： Hans Baer , Thomas Fuerst , Thomas Rupp , Gerhard Renner , Michael Gottschalk
IPC分类号： A61K9/14 , A61K31/485 , B05D5/00 , A61K31/138 , A61K31/522 , A61K31/609 , A61K31/554
CPC分类号： A61K9/5078
摘要： The invention relates to a controlled release pharmaceutical composition, comprising a core, comprising a pharmaceutical active ingredient, whereby the core is coated by an ethanol resistance conferring coating layer which has the effect of conferring the release profile of the pharmaceutical active ingredient to be resistant against the influence of ethanol. The coating layer comprises a polymeric portion consisting of a water-insoluble neutral vinyl polymer or vinyl copolymer and an amino methacrylate copolymer and an excipients portion consisting of a lubricant, an emulsifier, a plasticizer and optionally a cellulosic compound.
摘要翻译：本发明涉及一种控释药物组合物，其包含核心，其包含药物活性成分，由此核心由赋予乙醇抗性的涂层涂覆，其具有赋予药物活性成分的释放特性以抵抗乙醇的影响。涂层包括由不溶于水的中性乙烯基聚合物或乙烯基共聚物和氨基甲基丙烯酸酯共聚物组成的聚合物部分和由润滑剂，乳化剂，增塑剂和任选的纤维素化合物组成的赋形剂部分。

10. 发明授权

US5093438A Polycarbophosphazenes 失效
标题翻译：聚碳磷腈
公开(公告)号：US5093438A
公开(公告)日：1992-03-03
申请号：US547708
申请日：1990-07-03
申请人： Harry R. Allcock , Ian Manners , Gerhard Renner , Oskar Nuyken
发明人： Harry R. Allcock , Ian Manners , Gerhard Renner , Oskar Nuyken
IPC分类号： C08G79/02
CPC分类号： C08G79/025
摘要： The synthesis of a new class of macromolecules, the polycarbophosphazenes, is reported. When heated at 120.degree. C., the cyclocarbophosphazene N.sub.3 P.sub.2 CCl.sub.5 undergoes ring-opening polymerization to afford the high polymeric polycarbophosphazene [N.sub.3 P.sub.2 CCl.sub.5 ].sub.n. The latter functions as a reactive macromolecular intermediate and undergoes halogen replacement with sodium phenoxide or aniline to afford the hydrolytically stable derivatives [N.sub.3 P.sub.2 C(OPh).sub.5 ].sub.n and [N.sub.3 P.sub.2 C(NHPh).sub.5 ].sub.n.
摘要翻译：据报道，新一类大分子的合成，即聚碳磷腈。当加热到120℃时，环磷酰腈N 3 P 2 CCl 5进行开环聚合，得到高聚合物多碳代膦腈[N 3 P 2 CCl 5] n。后者用作反应性大分子中间体，并用苯酚盐或苯胺进行卤素取代，得到水解稳定的衍生物[N 3 P 2 C（OPh）5] n和[N 3 P 2 C（NHPh）5] n。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式