专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100049273A1 USE OF LATE PASSAGE MESENCHYMAL STEM CELLS (MSCS) FOR TREATMENT OF CARDIAC RHYTHM DISORDERS 审中-公开
标题翻译：用于治疗心脏疾病的最常用的中枢神经干细胞（MSCS）的使用
公开(公告)号：US20100049273A1
公开(公告)日：2010-02-25
申请号：US12374030
申请日：2007-07-20
申请人： Glenn Gaudette , Irina A. Potapova , Peter R. Brink , Ira S. Cohen , Richard B. Robinson , Michael R. Rosen
发明人： Glenn Gaudette , Irina A. Potapova , Peter R. Brink , Ira S. Cohen , Richard B. Robinson , Michael R. Rosen
IPC分类号： A61N1/02 , C12N5/071 , A61K45/00 , A61P9/00
CPC分类号： C12N5/0663 , A61K35/12 , C12N2502/1329 , C12N2510/00 , C12N2510/02
摘要： The present invention provides methods and compositions relating to the use of late passage mesenchymal stem cells (MSCs) for treatment of cardiac rhythm disorders. The late passage MSCs of the invention may be used to provide biological pacemaker activity and/or provide a bypass bridge in the heart of a subject afflicted with a cardiac rhythm disorder. The biological pacemaker activity and/or bypass bridge may be provided to the subject either alone or in tandem with an electronic pacemaker.
摘要翻译：本发明提供了与晚期传代间充质干细胞（MSC）用于治疗心律失常有关的方法和组合物。本发明的晚期传代MSC可用于提供生物起搏器活动和/或在患有心律失常的受试者的心脏中提供旁路桥。生物起搏器活动和/或旁通桥可以单独提供或与电子起搏器串联提供给受试者。

2. 发明申请

US20100047216A1 COMPOSITIONS OF LATE PASSAGE MESENCHYMAL STEM CELLS (MSCS) 审中-公开
标题翻译：最近一次通过的骨髓间充质干细胞（MSCS）
公开(公告)号：US20100047216A1
公开(公告)日：2010-02-25
申请号：US12374027
申请日：2007-07-20
申请人： Glenn Gaudette , Irina A. Potapova , Peter R. Brink , Ira S. Cohen , Richard B. Robinson , Michael R. Rosen
发明人： Glenn Gaudette , Irina A. Potapova , Peter R. Brink , Ira S. Cohen , Richard B. Robinson , Michael R. Rosen
IPC分类号： A61K35/12 , C12N5/0775 , C12N5/10 , C12N5/00
CPC分类号： C12N5/0663 , A61K35/12 , C12N2501/415 , C12N2510/00 , C12N2510/02
摘要： The present invention provides methods and compositions relating to the use of late passage mesenchymal stem cells (MSCs) for treatment of cardiac disorders. Such late passage MSCs may be administered to the myocardium of a subject for induction of native cardiomyoctye proliferation and repair of cardiac tissue. Additionally, the late passage MSCs may be genetically engineered to express a gene encoding a physiologically active protein of interest and/or may be incorporated with small molecules for delivery to adjacent target cells through gap junctions. The late passage MSCs of the invention may be used to provide biological pacemaker activity and/or provide a bypass bridge in the heart of a subject afflicted with a cardiac rhythm disorder. The biological pacemaker activity and/or bypass bridge may be provided to the subject either alone or in tandem with an electronic pacemaker.
摘要翻译：本发明提供了与晚期传代间充质干细胞（MSC）用于治疗心脏病的方法和组合物。这种晚期传代MSC可以施用于受试者的心肌，以诱导天然心肌细胞增殖和心脏组织的修复。另外，晚期传代的MSC可被遗传工程化以表达编码目标生理活性蛋白质的基因和/或可与小分子结合，以通过间隙连接递送至相邻靶细胞。本发明的晚期传代MSC可用于提供生物起搏器活动和/或在患有心律失常的受试者的心脏中提供旁路桥。生物起搏器活动和/或旁通桥可以单独提供或与电子起搏器串联提供给受试者。

3. 发明申请

US20110165128A1 HOMING IN MESENCHYMAL STEM CELLS 审中-公开
标题翻译：在MESENCHYMAL STEM细胞中呼吸
公开(公告)号：US20110165128A1
公开(公告)日：2011-07-07
申请号：US12921396
申请日：2009-03-06
申请人： Sergey V. Doronin , Irina A. Potapova , Ira S. Cohen , Michael R. Rosen , Richard B. Robinson , Peter R. Brink
发明人： Sergey V. Doronin , Irina A. Potapova , Ira S. Cohen , Michael R. Rosen , Richard B. Robinson , Peter R. Brink
IPC分类号： A61K35/12 , C12N5/0775 , A61P9/00 , A61P9/10
CPC分类号： C12N5/0663
摘要： The present invention relates to expression of CXCR4 in mesenchymal stem cells (MSCs) and homing of MSCs to sites of injury. In particular, the invention provides expanded cultures of MSCs which maintain cell surface expression of CXCR4. The MSCs are capable of homing to sites of injury and are suitable for treatment of ischemic disorders, including cardiac disorders, bone and cartilage disorders, liver disorders, inflammatory disorders, and stroke.
摘要翻译：本发明涉及CXCR4在间充质干细胞（MSC）中的表达以及MSCs归巢到损伤部位。特别地，本发明提供了维持CXCR4的细胞表面表达的MSC的扩增培养物。 MSCs能够归巢到损伤部位，适用于治疗缺血性疾病，包括心脏疾病，骨和软骨疾病，肝脏疾病，炎性疾病和中风。

4. 发明授权

US08170665B2 Quantum dot labeled stem cells for use in providing pacemaker function 有权
标题翻译：用于提供起搏器功能的量子点标记的干细胞
公开(公告)号：US08170665B2
公开(公告)日：2012-05-01
申请号：US12077970
申请日：2008-03-21
申请人： Ira S. Cohen , Amy B. Rosen , Peter R. Brink , Glenn Gaudette , Michael R. Rosen , Richard B. Robinson
发明人： Ira S. Cohen , Amy B. Rosen , Peter R. Brink , Glenn Gaudette , Michael R. Rosen , Richard B. Robinson
IPC分类号： A61N1/00
CPC分类号： G01N33/588 , A61K35/12 , A61N1/372 , B82Y15/00 , C12N5/0663 , C12N2510/00 , G01N33/6872 , G01N2333/705
摘要： The present invention provides methods and compositions relating to the labeling of target cells with nanometer scale fluorescent semiconductors referred to as quantum dots (QDs). Specifically, a delivery system is disclosed based on the use of negatively charged QDs for delivery of a tracking fluorescent signal into the cytosol of target cells via a passive endocytosis-mediated delivery process. In a specific embodiment of the invention the target cell is a stem cell, preferably a mesenchymal stem cell (MSC). Such labeled MSCs provide a means for tracking the distribution and fate of MSCs that have been genetically engineered to express, for example, a hyperpolarization-activated cyclic nucleotide-gated (“HCN”) channel and administered to a subject to create a biological pacemaker. The invention is based on the discovery that MSCs can be tracked in vitro for up to at least 6 weeks. Additionally, QDs delivered in vivo can be tracked for up to at least 8 weeks, thereby permitting for the first time, the complete 3-D reconstruction of the locations of all MSCs following administration into a host.
摘要翻译：本发明提供了与称为量子点（QD）的纳米尺度荧光半导体标记靶细胞有关的方法和组合物。具体地，基于使用带负电荷的量子点，通过被动内吞作用介导的递送过程将跟踪荧光信号传递到靶细胞的胞质溶胶中，公开了递送系统。在本发明的具体实施方案中，靶细胞是干细胞，优选间充质干细胞（MSC）。这种标记的MSC提供了用于跟踪已经被遗传工程化以表达例如超极化激活的环核苷酸门控（“HCN”）信道并且施用于受试者以创建生物起搏器的MSC的分布和命运的手段。本发明基于这样的发现，MSC可以在体外追踪长达至少6周。另外，在体内交付的量测数据可以跟踪至少8周，从而允许在管理到主机之后，所有MSC的位置的完整三维重构。

5. 发明申请

US20110041857A1 FIBROBLAST DERIVED STEM CELLS 审中-公开
标题翻译： FIBROBLAST衍生干细胞
公开(公告)号：US20110041857A1
公开(公告)日：2011-02-24
申请号：US12744568
申请日：2008-11-26
申请人： Adam J.T. Schuldt , Peter R. Brink , Ira S. Cohen , Michael R. Rosen , Richard B. Robinson , Glenn Gaudette
发明人： Adam J.T. Schuldt , Peter R. Brink , Ira S. Cohen , Michael R. Rosen , Richard B. Robinson , Glenn Gaudette
IPC分类号： A61B19/00 , C12N5/02 , C12N5/074 , C12N5/10 , A61K35/12 , A61P9/10
CPC分类号： C12N5/0662 , C12N5/0657 , C12N2506/1307 , C12N2533/32
摘要： The present invention provides methods and compositions relating to the production of stem cells, derived from dedifferentiated fibroblasts, and the use of such stem cells for treatment of a variety of different disorders and conditions. The invention is based on the surprising discovery that a population of stem cells, capable of differentiating into a variety of different cell types, can be generated by culturing fibroblasts under selective culture conditions.
摘要翻译：本发明提供了与衍生于去分化成纤维细胞的干细胞的生产有关的方法和组合物，以及这些干细胞用于治疗各种不同疾病和病症的用途。本发明基于令人惊奇的发现，即可以通过在选择性培养条件下培养成纤维细胞来产生能够分化成多种不同细胞类型的干细胞群体。

6. 发明授权

US08431397B2 Differentiation of human mesenchymal stem cells to cardiac progenitor cells that promote cardiac repair 有权
标题翻译：将人间充质干细胞分化为促进心脏修复的心脏祖细胞
公开(公告)号：US08431397B2
公开(公告)日：2013-04-30
申请号：US11227533
申请日：2005-09-14
申请人： Richard B Robinson , Michael R Rosen , Ira S. Cohen , Peter R. Brink , Glenn Gaudette , Irina Potapova
发明人： Richard B Robinson , Michael R Rosen , Ira S. Cohen , Peter R. Brink , Glenn Gaudette , Irina Potapova
IPC分类号： C12N5/00 , A01N63/00
CPC分类号： C12N5/0657
摘要： A method for treating a subject afflicted with a cardiac disorder, in vivo, comprises (i) inducing differentiation of a progenitor cell, in vitro, to a cardiogenic cell; and (ii) administering a therapeutically effective amount of the cardiogenic cell of step (i) to the subject, thereby treating the cardiac disorder in the subject. This invention further provides related articles of manufacture and methods.
摘要翻译：在体内治疗患有心脏病症的受试者的方法包括（i）诱导祖细胞在体外对心源性细胞的分化; 和（ii）向受试者施用治疗有效量的步骤（i）的心源性细胞，从而治疗受试者的心脏疾病。本发明还提供了相关的制造和方法。

7. 发明申请

US20100330050A1 USE OF HUMAN STEM CELLS AND/OR FACTORS THEY PRODUCE TO PROMOTE ADULT MAMMALIAN CARDIAC REPAIR THROUGH CARDIOMYOCYTE CELL DIVISION 审中-公开
标题翻译：人类干细胞的使用和/或因子他们生产促进成年人通过心脏细胞分裂修复维生素
公开(公告)号：US20100330050A1
公开(公告)日：2010-12-30
申请号：US12781498
申请日：2010-05-17
申请人： Sergey V. Doronin , Glenn Gaudette , Richard B. Robinson , Michael R. Rosen , Ira S. Cohen , Peter R. Brink
发明人： Sergey V. Doronin , Glenn Gaudette , Richard B. Robinson , Michael R. Rosen , Ira S. Cohen , Peter R. Brink
IPC分类号： A61K35/12 , A61K38/02 , A61K38/46 , A61K38/18 , A61K35/00 , A61P9/00
CPC分类号： A61L27/367 , A61K35/28 , A61K35/44 , A61K35/545 , A61L27/3633 , A61L27/3804 , A61L27/3834 , A61L27/3843 , A61L27/3873 , A61L2430/20 , C12N5/0657 , C12N2501/33 , C12N2501/415 , C12N2502/1358 , C12N2510/00 , C12N2533/32 , C12N2533/52 , G01N33/5061 , G01N33/5073
摘要： The present invention relates to methods and compositions for stimulating the proliferation of cardiomyocytes for enhancement of cardiac repair. The invention is based on the discovery that upon contact with stem cells, or conditioned media derived from said stem cells, terminally differentiated cardiomyocytes can be stimulated to enter the cell cycle. Additionally, scaffolds capable of attracting stem cells to the area of implantation have been shown to induce cardiomyocyte proliferation. The present invention further relates to the discovery that the Wnt-5A ligand, which binds to the frizzled receptor (fz), functions to stimulate cardiomyocyte proliferation. The methods and compositions of the invention may be used in the treatment of cardiac disorders including, but not limited to, myocardial dysfunction or infarction. The invention further relates to screening assays designed to identify compounds that modulate the proliferative activity of cardiomyocytes and the use of such compounds in the treatment of cardiac disorders.
摘要翻译：本发明涉及用于刺激心肌细胞增殖以增强心脏修复的方法和组合物。本发明基于以下发现：当与干细胞或源自所述干细胞的条件培养基接触时，可以刺激终末分化的心肌细胞进入细胞周期。另外，能够将干细胞吸引到植入区域的支架已显示出诱导心肌细胞增殖。本发明还涉及发现结合卷曲受体（fz）的Wnt-5A配体起刺激心肌细胞增殖的作用。本发明的方法和组合物可用于治疗心脏疾病，包括但不限于心肌功能障碍或梗死。本发明进一步涉及设计用于鉴定调节心肌细胞增殖活性的化合物的筛选试验以及这些化合物在治疗心脏病中的用途。

8. 发明申请

US20100158805A1 QUANTUM DOT LABELED STEM CELLS FOR USE IN CARDIAC REPAIR 审中-公开
标题翻译：量子标签干细胞用于心脏修复
公开(公告)号：US20100158805A1
公开(公告)日：2010-06-24
申请号：US12532780
申请日：2008-03-21
申请人： Ira S. Cohen , Amy Rosen Kontorovich , Peter R. Brink , Glenn Gaudette , Michael R. Rosen , Richard B. Robinson
发明人： Ira S. Cohen , Amy Rosen Kontorovich , Peter R. Brink , Glenn Gaudette , Michael R. Rosen , Richard B. Robinson
IPC分类号： A61K49/10 , C12N5/071 , A61K35/12 , A61K9/14 , C12N5/077 , A61P9/00
CPC分类号： A61K35/28 , A61K49/0067 , A61K49/0097 , A61K49/0409 , A61K49/0423 , B82Y5/00
摘要： The present invention provides methods and compositions relating to the labeling of target cells with quantum dots (QDs). Specifically, a delivery system is disclosed based on the use of negatively charged QDs for delivery of a tracking fluorescent signal into the cytosol of target cells via a passive endocytosis-mediated delivery process. In a specific embodiment of the invention the target cell is a stem cell, preferably a mesenchymal stem cell (MSC). Such labeled MSCs provide a means for tracking the distribution and fate of MSCs that have been administered to a subject to promote cardiac repair. The invention is based on the discovery that MSCs can be tracked in vitro for up to at least 6 weeks. Additionally, QDs delivered in vivo can be tracked for up to at least 8 weeks, thereby permitting for the first time, the complete 3-D reconstruction of the locations of all MSCs following administration into a host.
摘要翻译：本发明提供了关于用量子点（QD）标记靶细胞的方法和组合物。具体地，基于使用带负电荷的量子点，通过被动内吞作用介导的递送过程将跟踪荧光信号传递到靶细胞的胞质溶胶中，公开了递送系统。在本发明的具体实施方案中，靶细胞是干细胞，优选间充质干细胞（MSC）。这些标记的MSC提供了跟踪已经施用于受试者以促进心脏修复的MSC的分布和命运的手段。本发明基于这样的发现，MSC可以在体外追踪长达至少6周。另外，在体内交付的量测数据可以跟踪至少8周，从而允许在管理到主机之后，所有MSC的位置的完整三维重构。

9. 发明申请

US20090062876A1 Quantum dot labeled stem cells for use in providing pacemaker function 有权
标题翻译：用于提供起搏器功能的量子点标记的干细胞
公开(公告)号：US20090062876A1
公开(公告)日：2009-03-05
申请号：US12077970
申请日：2008-03-21
申请人： Ira S. Cohen , Amy B. Rosen , Peter R. Brink , Glenn Gaudette , Michael R. Rosen , Richard B. Robinson
发明人： Ira S. Cohen , Amy B. Rosen , Peter R. Brink , Glenn Gaudette , Michael R. Rosen , Richard B. Robinson
IPC分类号： A61N1/362 , C12N5/06 , A61K49/00 , A61P9/00
CPC分类号： G01N33/588 , A61K35/12 , A61N1/372 , B82Y15/00 , C12N5/0663 , C12N2510/00 , G01N33/6872 , G01N2333/705
摘要： The present invention provides methods and compositions relating to the labeling of target cells with nanometer scale fluorescent semiconductors referred to as quantum dots (QDs). Specifically, a delivery system is disclosed based on the use of negatively charged QDs for delivery of a tracking fluorescent signal into the cytosol of target cells via a passive endocytosis-mediated delivery process. In a specific embodiment of the invention the target cell is a stem cell, preferably a mesenchymal stem cell (MSC). Such labeled MSCs provide a means for tracking the distribution and fate of MSCs that have been genetically engineered to express, for example, a hyperpolarization-activated cyclic nucleotide-gated (“HCN”) channel and administered to a subject to create a biological pacemaker. The invention is based on the discovery that MSCs can be tracked in vitro for up to at least 6 weeks. Additionally, QDs delivered in vivo can be tracked for up to at least 8 weeks, thereby permitting for the first time, the complete 3-D reconstruction of the locations of all MSCs following administration into a host.
摘要翻译：本发明提供了与称为量子点（QD）的纳米尺度荧光半导体标记靶细胞有关的方法和组合物。具体地，基于使用带负电荷的量子点，通过被动内吞作用介导的递送过程将跟踪荧光信号传递到靶细胞的胞质溶胶中，公开了递送系统。在本发明的具体实施方案中，靶细胞是干细胞，优选间充质干细胞（MSC）。这种标记的MSC提供了用于跟踪已经被遗传工程化以表达例如超极化激活的环核苷酸门控（“HCN”）信道并且施用于受试者以创建生物起搏器的MSC的分布和命运的手段。本发明基于这样的发现，MSC可以在体外追踪长达至少6周。另外，在体内交付的量测数据可以跟踪至少8周，从而允许在管理到主机之后，所有MSC的位置的完整三维重构。

10. 发明授权

US07842673B2 Delivery of DNA or RNA via gap junctions from host cells to target cells and a cell-based delivery system for antisense or siRNA 有权
标题翻译：通过从宿主细胞到靶细胞的间隙连接递送DNA或RNA，以及用于反义或siRNA的基于细胞的递送系统
公开(公告)号：US07842673B2
公开(公告)日：2010-11-30
申请号：US10583369
申请日：2004-12-17
申请人： Peter R. Brink , Michael R Rosen , Richard B Robinson , Ira S. Cohen , Arthur Grollman
发明人： Peter R. Brink , Michael R Rosen , Richard B Robinson , Ira S. Cohen , Arthur Grollman
IPC分类号： A01N43/04 , A61K31/70 , C12Q1/68 , C12P19/34
CPC分类号： A61K48/0083 , C12N15/87
摘要： A method of delivering an oligonucleotide or a plasmid expressing an oligonucleotide into a target cell comprises introducing an oligonucleotide into a donor cell, particularly a stem cell, and contacting the target cell with the donor cell under conditions permitting the donor cell to form a gap junction with the target cell, whereby the oligonucleotide or a product of the oligonucleotide is delivered into the target cell from the donor cell.
摘要翻译：将寡核苷酸或表达寡核苷酸的质粒递送到靶细胞的方法包括将寡核苷酸引入供体细胞，特别是干细胞，并在允许供体细胞形成间隙连接的条件下使靶细胞与供体细胞接触与靶细胞接触，由此寡核苷酸或寡核苷酸的产物从供体细胞输送到靶细胞中。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式