专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008141682A1 SYNTHESIS OF OLIGONUCLEOTIDES 审中-公开
标题翻译：合成寡核苷酸
公开(公告)号：WO2008141682A1
公开(公告)日：2008-11-27
申请号：PCT/EP2007/062660
申请日：2007-11-21
申请人： GIRINDUS AG , LANGE, Meinolf , HOHLFELD, Andreas , SCHÖNBERGER, Andreas , KIRCHHOFF, Christina , GRÖSSEL, Olaf
发明人： LANGE, Meinolf , HOHLFELD, Andreas , SCHÖNBERGER, Andreas , KIRCHHOFF, Christina , GRÖSSEL, Olaf
IPC分类号： C07H21/00
CPC分类号： C07H21/00
摘要： A method for preparing an oligonucleotide comprising the steps of a) providing a hydroxyl containing compound having the formula (1), wherein B is a heterocyclic base and the radicals R 2 , R 3 and R 5 are as defined in the description; b) reacting said compound with a phosphitylating agent in the presence of an activator having the formula (I) (activator I)), wherein R = alkyl, cycloalkyl, aryl, aralkyl, heteroalkyl, heteroaryl; R 1 , R 2 = either H or form a 5 to 6-membered ring together; X 1 , X 2 = independently either N or CH; Y = H or Si(R 4 ) 3 , with R 4 = alkyl, cycloalkyl, aryl, aralkyl, heteroalkyl, heteroaryl; B = deprotonated acid; to prepare a phosphitylated compound; c) reacting said phosphitylated compound without isolation with a second compound having the formula (1), wherein R 5 , R 3 , R 2 , B are independently selected, but have the same definition as above in the presence of an activator II selected from the group of imidazole imidazolium salts and mixtures thereof.
摘要翻译：一种制备寡核苷酸的方法，包括以下步骤：a）提供具有式（1）的含羟基化合物，其中B是杂环碱基，R 2，R 3， SUB＆gt;和R 5 5如说明书中所定义; b）在具有式（I）的活化剂（活化剂I））的存在下使所述化合物与磷酸酯化剂反应，其中R =烷基，环烷基，芳基，芳烷基，杂烷基，杂芳基; R 1，R 2，H或H或一起形成5至6元环; X 1，X 2独立地是N或CH; Y = H或Si（R 4）3，其中R 4 =烷基，环烷基，芳基，芳烷基，杂烷基，杂芳基; B =去质子酸制备磷酸化化合物; c）使所述磷化物化合物与所述式（1）的第二化合物分离而不分离，其中R 5，R 3，R 2， B独立选择，但在选自咪唑咪唑盐及其混合物的活化剂II的存在下具有与上述相同的定义。

2. 发明申请

WO2006064039A1 SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR 审中-公开
标题翻译：使用四元杂环激活剂合成磷酸化合物
公开(公告)号：WO2006064039A1
公开(公告)日：2006-06-22
申请号：PCT/EP2005/056815
申请日：2005-12-15
申请人： GIRINDUS AG , LANGE, Meinolf , SCHÖNBERGER, Andreas , KIRCHHOFF, Christina , GRÖSSEL, Olaf , OMELCENKO, Nadja , HOHLFELD, Andreas , LINK, Fritz
发明人： LANGE, Meinolf , SCHÖNBERGER, Andreas , KIRCHHOFF, Christina , GRÖSSEL, Olaf , OMELCENKO, Nadja , HOHLFELD, Andreas , LINK, Fritz
IPC分类号： C07H21/00 , C07D233/54
CPC分类号： C07H21/04 , B01J31/0271 , C07H19/10 , C07H19/20 , C07H21/00 , C07H21/02
摘要： A method for preparing a phosphitylated compound comprising the step of: - reacting a hydroxy! containing compound with a phosphitylating agent in the presence of an activator having the formula (I) wherein R = alkyl, cycloalkyl, aryl, aralkyl, heteroalkyl, heteroaryl R 1 , R 2 = either H or form a 5 to 6-membered ring together. X 1, X 2 = independently either N or CH Y = H or Si(R 4 ) 3 , with R 4 = alkyl, cycloalkyl, aryl, aralkyl, heteroalkyl, heteroaryl B = deprotonated acid. The hydroxyl containing compound is preferably a sugar moiety or a nucleoside or an oligomer derived therefrom.
摘要翻译：一种制备磷酸化化合物的方法，包括以下步骤： - 使羟基在具有式（I）的活化剂存在下，将含磷酸化合物与磷酸化剂反应，其中R =烷基，环烷基，芳基，芳烷基，杂烷基，杂芳基R 1，R 2 > = H或形成5至6元环。 X 1，X 2独立地是N或CHY = H或Si（R 4）3， R 4 =烷基，环烷基，芳基，芳烷基，杂烷基，杂芳基B =去质子化的酸。含羟基化合物优选为糖部分或核苷或由其衍生的低聚物。

3. 发明公开

EP1828218A1 SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR 有权
标题翻译：连接操作PHOSPHITYLIERTER使用四进制HETEROZYKLISHEN激活
公开(公告)号：EP1828218A1
公开(公告)日：2007-09-05
申请号：EP05850457.2
申请日：2005-12-15
申请人： Girindus AG
发明人： LANGE, Meinolf , SCHÖNBERGER, Andreas , KIRCHHOFF, Christina , GRÖSSEL, Olaf , OMELCENKO, Nadja , HOHLFELD, Andreas , LINK, Fritz
IPC分类号： C07H21/00 , C07D233/54
CPC分类号： C07H21/04 , B01J31/0271 , C07H19/10 , C07H19/20 , C07H21/00 , C07H21/02
摘要： A method for preparing a phosphitylated compound comprising the step of: - reacting a hydroxy! containing compound with a phosphitylating agent in the presence of an activator having the formula (I) wherein R = alkyl, cycloalkyl, aryl, aralkyl, heteroalkyl, heteroaryl R1, R2 = either H or form a 5 to 6-membered ring together. X1, X2 = independently either N or CH Y = H or Si(R4)3, with R4 = alkyl, cycloalkyl, aryl, aralkyl, heteroalkyl, heteroaryl B = deprotonated acid. The hydroxyl containing compound is preferably a sugar moiety or a nucleoside or an oligomer derived therefrom.

4. 发明授权

EP1828218B1 SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR 有权
标题翻译：连接操作PHOSPHITYLIERTER使用四进制HETEROZYKLISHEN激活
公开(公告)号：EP1828218B1
公开(公告)日：2014-04-30
申请号：EP05850457.2
申请日：2005-12-15
申请人： Girindus AG
发明人： LANGE, Meinolf , SCHÖNBERGER, Andreas , KIRCHHOFF, Christina , GRÖSSEL, Olaf , OMELCENKO, Nadja , HOHLFELD, Andreas , LINK, Fritz
IPC分类号： C07H21/00 , C07D233/54
CPC分类号： C07H21/04 , B01J31/0271 , C07H19/10 , C07H19/20 , C07H21/00 , C07H21/02

5. 发明授权

EP1858909B1 SYNTHESIS OF OLIGONUCLEOTIDES 有权
标题翻译：寡核苷酸合成
公开(公告)号：EP1858909B1
公开(公告)日：2014-09-10
申请号：EP06708653.8
申请日：2006-03-06
申请人： Girindus AG
发明人： LANGE, Meinolf , SCHÖNBERGER, Andreas , HOHLFELD, Andreas , GRÖSSEL, Olaf , KIRCHHOFF, Christina , LINK, Fritz
IPC分类号： C07H21/00
CPC分类号： C07H21/00 , Y02P20/55

6. 发明公开

EP2152723A1 SYNTHESIS OF OLIGONUCLEOTIDES 审中-公开
标题翻译：合成寡核苷酸的
公开(公告)号：EP2152723A1
公开(公告)日：2010-02-17
申请号：EP07822795.6
申请日：2007-11-21
申请人： Girindus AG
发明人： LANGE, Meinolf , HOHLFELD, Andreas , SCHÖNBERGER, Andreas , KIRCHHOFF, Christina , GRÖSSEL, Olaf
IPC分类号： C07H21/00
CPC分类号： C07H21/00
摘要： A method for preparing an oligonucleotide comprising the steps of a) providing a hydroxyl containing compound having the formula (1), wherein B is a heterocyclic base and the radicals R2, R3 and R5 are as defined in the description; b) reacting said compound with a phosphitylating agent in the presence of an activator having the formula (I) (activator I)), wherein R = alkyl, cycloalkyl, aryl, aralkyl, heteroalkyl, heteroaryl; R1, R2 = either H or form a 5 to 6-membered ring together; X1, X2 = independently either N or CH; Y = H or Si(R4)3, with R4= alkyl, cycloalkyl, aryl, aralkyl, heteroalkyl, heteroaryl; B = deprotonated acid; to prepare a phosphitylated compound; c) reacting said phosphitylated compound without isolation with a second compound having the formula (1), wherein R5, R3, R2, B are independently selected, but have the same definition as above in the presence of an activator II selected from the group of imidazole imidazolium salts and mixtures thereof.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式